Table of Content

16 March 2024, Volume 42 Issue 6

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Observation on Therapeutic Effect of Yishen Fuyang Powder Medicine-Separated Moxibustion on Edema of Nephrotic Syndrome

MIN Jing-jing, DU Lin-dong, NIE Cheng-mei

2024, 42(6):  1-4. 

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Objective To explore the clinical effect of Yishen Fuyang powder medicine-separated moxibustion on edema of nephrotic syndrome. Method Sixty patients cases of 2023 edema due to deficiency of spleen and kidney Yang were selected from the Department of Nephrology, Suizhou Hospital of traditional Chinese medicine from January to August in the 2023, the patients were randomly divided into control group (n = 30) and observation group (n = 30) . The treatment time was 2 weeks in both groups. The scores of TCM syndromes, body weight, 24 h urine volume, 24 h urine protein, serum albumin and clinical efficacy were compared between the two groups. Results After 2 weeks of treatment, the edema score, waist and knee pain score, chills and cold limbs score, vertigo score, loose stool score and fatigue score in the observation group were lower than those in the control group(P<0.05). The body weight and 24 h urine protein in the observation group were significantly lower than those in the control group (P<0.05), while the 24 h urine volume and serum albumin were significantly higher than those in the control group (P<0.05).The total effective rate of clinical efficacy in the observation group was higher than that in the control group(P<0.05). Conclusion Yishen Fuyang powder moxibustion can effectively improve the TCM syndrome of edema in nephrotic syndrome, increase urine volume, reduce urinary protein, improve plasma albumin and clinical efficacy.

SWOT Analysis on the Promotion of Hufu Copper Scraping from the Perspective of Healthy

WU Jun-chao, FEI Jing-lan, LI Dao-zheng, ZHANG Hui, CHEN Qian, ZHAO Ting-ting, WANG Yu

2024, 42(6):  4-6. 

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Objective To explore the current situation of scraping promotion of Hufu Tongluo from the perspective of healthy, and put forward corresponding countermeasures according to the analysis results, so as to provide reference for the subsequent scraping promotion. Methods SWOT analysis was used to analyze the internal strengths, weaknesses, external opportunities and threats of the promotion of Hufu Copper Scraping. Results The internal advantages of community promotion of scrapping were: wide range of functions and obvious effect; Simple operation, safety and economy; Theoretical innovation and obvious advantages. Disadvantages: the operating standards are not uniform and the assessment system is not perfect; The operation method is easy to learn, and the scraping technique is difficult to refine. Opportunity: national policy support; Increased health needs; Development of information technology. Threat: the national culture is not confident; Insufficient talent reserve. Conclusion The coexistence of advantages and disadvantages in the promotion of scrapping in community can only be achieved by grasping the opportunity and keeping innovation.

Effect of Microneedle Combined with Halometasone Cream and Bailing Tablet in the Treatment of Acrovitiligo and Analysis

ZHANG Jian-zhong, REN Ming-yuan, WANG Xin, XU Yan-yan, LI Xiao-jing, Miao Guo-ying, WANG Li-tao

2024, 42(6):  9-12. 

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Objective To observe the clinical effect of microneedle combined with halometasone cream and bailing tablet in the Treatment of acrovitiligo. Methods Totally 80 patients with stable acrovitiligo were divided randomly into two groups: treatment group and control group. Patients in each group used halometasone cream and Bailing Tablet, but the 40 patients in the treatment group were microneedle treatment once a month. All the patients go to the hospital every month and we observe the clinical effects and the pigment score after 6 months. Results After 6 months, the effective rate of treatment group was significantly higher than that of the control group, the difference was statistically significant(P<0.05). The pigment score and area reduction of the treatment group were better than those of the control group, The difference was statistically significant(P<0.05). No serious adverse reaction occurred during the treatment. Conclusion Microneedles combined with halometasone cream and Bailing tablet in the treatment of acrovitiligo skin lesions improved obviously, the effect was accurate, and the adverse reactions were less.

The Diagnostic and Prognostic Significance of Nuclear Factor KB and Signal Transducer and Activator of Transcription 3 Proteins in Endometrial Cancer Tissue

LIANG Wei-hua, ZHANG Hai-jun, PEI Xue-lian

2024, 42(6):  12-16. 

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Objective To explore and analysis the diagnostic and prognostic significance of nuclear factor κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) proteins in endometrial cancer (EC) tissue. Method From September 2019 to November 2022, 88 cases of patients with endometrial cancer who were diagnosed and treated in The First Affiliated Hospital of Shihezi University were selected as the research subjects. Fresh endometrial cancer tumor tissue samples (tumor group) and normal endometrial tissue adjacent to cancer (adjacent group) were taken from all patients who underwent surgery, and the NF-κB, STAT3 proteins were detected using immunohistochemistry, investigated the pathological characteristics of patients, followed up prognosis, and conducted correlation analysis. Result The positive rates of NF-κB and STAT3 proteins in the tumor group were 63.64% and 56.82%, and were 15.91% and 13.64% in the adjacent cancer group that the tumor group were significantly higher than the adjacent cancer group (P<0.05). In the 88 patients, There were significant difference in the positive rate of NF-κB and STAT3 protein expression in the different age, clinical stage, degree of differentiation, muscle infiltration, and lymph node metastasis patients (P<0.05). All patients were followed up until June 1, 2023, the positive rate of NF-κB and STAT3 protein expression in the surviving patients were significantly lower than that of death patients (P<0.05). Cox regression analysis showspositive rate of NF-κB and STAT3 protein expression were the important factor affected the median survival time of prognosis (P<0.05). Conclusion Endometrial cancer tissue are often accompanied by the high expression of NF-κB and STAT3, and are correlated with the clinical pathological characteristics and prognosis of patients.

Influence of Integrated Traditional Chinese and Western Medicine Medical Care Integration Model on the Prognosis of Stroke Patients with Swallowing Disorders

WANG Dao-xing, CHENG You-cai, XU Li-li, ZHANG Li, ZHU Pei

2024, 42(6):  16-20. 

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Objective To explore and analysis the influence of integrated traditional Chinese and western medicine medical care integration model on the prognosis of stroke patients with swallowing disorders. Method 200 cases of stroke patients with swallowing disorders who were hospitalized in our hospital from February 2019 to September 2022 were selected as the research subjects. Accorded to the principle of 1:1 random drawing, 200 cases of patients were divided into the intervention group and the control group with 100 cases each. The control group received routine intervention, while the intervention group received integrated traditional Chinese and Western medicine and nursing intervention based on the intervention of the control group. Both groups were observed for 3 months and were to determine the patient's nutritional level and satisfaction. Result After 3 months of intervention, the total effective rates of the intervention group were higher than that in the control group (P<0.05). The serum albumin and prealbumin levels in both groups increased after the intervention compared with those before the intervention (P<0.05), and the levels of the above indexes were higher in the intervention group than in the control group after 3 months of intervention (P<0.05). The incidence of inhalation pneumonia in the intervention group and the control group during the 3-month intervention period were significantly lower than that in the control group (P<0.05). The intervention satisfaction of the intervention group after 3 months of intervention were higher than that of the control group (P<0.05). Conclusion The application of integrated traditional Chinese and Western medicine in stroke patients can improve intervention satisfaction, overall intervention efficacy, nutritional level, and reduce the incidence of aspiration pneumonia.

The Curative Effect of Compound Salvia Miltiorrhiza Dropping Pills Combined with Amlodipine in the Treatment of PrimaryHypertension and its Effect on Serum Hcy, β2-microglobulin and VEGF levels

YIN Chun-cai

2024, 42(6):  23-26. 

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Objective To study the effect of compound salvia miltiorrhiza dropping pills combined with amlodipine in the treatment of essential hypertension and its effect on serum Hcy, β2-microglobulin and VEGF levels. Methods Selected 80 essential hypertension patients admitted to Golmud People's Hospital from January 2020 to December 2022 were selected, and the random number table was divided into observation group and control group, with 40 patients in each group. The control group used amlodipine, and the observation group used compound Danshen dropping based on the control group. Evaluate the symptoms of dizziness, stiff neck and back, numbness in limbs, and chest tightness and pain in both groups, and irritability symptoms of both groups, and test for serum Hcy β 2-Microglobulin and VEGF levels. Results The effective rate of the observation group was significantly higher than control group (P<0.05). Before treatment, there was no significant difference in the symptom scores of dizziness, stiff neck and back, numbness in limbs, and chest tightness and chest pain between the two groups (P>0.05). After treatment, the symptom scores of dizziness, stiff neck and back, numbness in limbs, and chest tightness and chest pain in both groups were significantly reduced (P<0.05), and the symptom scores of dizziness, stiff neck and back, numbness in limbs, and chest tightness and chest pain in the observation group were lower (P<0.05). Before treatment, there was no significant difference in the levels of serum Hcy, β2-microglobulin and VEGF (P>0.05). After treatment, the levels of serum Hcy, β2-microglobulin and VEGF were significantly reduced (P<0.05), and the levels of serum Hcy, β2-microglobulin and VEGF were significantly lower than those of the control group (P<0.05). Conclusion Compound Danshen dripping pills combined with amlodipine have significant effect on primary hypertension, and can significantly reduce the levels of serum Hcy, β2-microglobulin and VEGF levels.

The Therapeutic Dffect and Mechanism of Azdrostatin Combined with Shufeng Qingre Formula in the Treatment of Pediatric Allergic Conjunctivitis

HAN Ying, CHEN Xia, WANG Miao, WANG Zhen, YE Zhuang, YANG Mei, YANG Yan-hui, CHEN Li-ping

2024, 42(6):  27-30. 

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Objective To study the effect mechanism of Azdrostatin combined with Shufeng Qingre formula in the treatment of pediatric allergic conjunctivitis. Methods 80 cases of patients with pediatric allergic conjunctivitis admitted to Zibo Maternal and Child Health Hospital from January 2021 to December 2022 were selected for prospective study, and were divided into two groups randomly by using lottery method. The control group was treated with Azazelastine, while the observation group was treated with Shufeng Qingre Formula on the basis of Azazelastine. The corneal fluorescein staining test (FL) score, tear film break time (BUT) , the symptom score were compared between the two groups. The tear immunoglobulin A (IgE), eosinophil cationic protein (ECP), leukotriene B4 (LTB4) and histamine (HA) levels were detected and compared between the two groups. Results The effective rate of the observation group was significantly higher than control group (P<0.05). Before treatment, there was no significant difference in FL score and BUT between the two groups (P>0.05). After treatment, the FL score and BUT of both groups were significantly improved (P<0.05), and the FL score and BUT of the observation group were significantly better (P<0.05). Before treatment, there was no significant difference in the scores of eye itching, burning pain, eyelid swelling, tearing, fear of light, friction, and foreign body sensation between the two groups (P>0.05). After treatment, the scores of the symptom above between the two groups were significantly reduced (P<0.05), and the scores of the symptom above in the observation group were lower (P<0.05). Before treatment, there was no significant difference in the levels of tear IgE, ECP, LTB4, and HA between the two groups (P>0.05). After treatment, the levels of tear IgE, ECP, LTB4, and HA in both groups were significantly reduced (P<0.05), and the levels of tear IgE, ECP, LTB4, and HA in the observation group were lower (P<0.05). Conclusion The combination of Azostatin and Shufeng Qingre Formula has a better therapeutic effect on pediatric allergic conjunctivitis, which can significantly alleviate symptoms and promote the recovery of tear film stability. Its mechanism may be related to the reduction of tear IgE, ECP, LTB4, and HA levels.

Effect of Jianpi Yishen Recipe Combined with Silybrin on AIDS of Spleen and Kidney Deficiency Type

YANG Bing

2024, 42(6):  30-33. 

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Objective To explore the application effect of Jianpi Yishen Recipe combined with Silymarin on AIDS of spleen and kidney deficiency type. Methods From May 2021 to May 2023, 80 patients with AIDS treated in Changzhou Third People's Hospital were selected as research objects, and they were randomly divided into an observation group and a control group, with 40 cases in each group. The control group patients were treated with conventional antiretroviral therapy combined with Silybin, while the observation group patients were treated with Jianpi Yishen Formula combined with Silybin on the basis of conventional antiretroviral therapy. The changes in traditional Chinese medicine syndrome scores, CD3⁺CD4⁺, CD3⁺CD8⁺, CD8⁺CD38⁺lymphocyte count, and liver and kidney function were compared between the two groups before and after treatment. Result Before treatment, there was no significant difference in the scores of traditional Chinese medicine syndromes related to soreness and weakness in the waist and knees, diarrhea, poor appetite, and fatigue between the two groups of patients (P>0.05). After treatment, the scores of traditional Chinese medicine syndromes related to soreness and weakness in the waist and knees, diarrhea, poor appetite, and fatigue in both groups of patients decreased, and the observation group was lower than the control group (P<0.05); Before treatment, there was no significant difference in the number of CD3⁺CD4⁺, CD3⁺CD8⁺, and CD8⁺CD38⁺ T lymphocytes between the two groups of patients (P>0.05). After treatment, the number of CD3⁺CD4⁺ T lymphocytes were increased in the two groups of patients, and the number of CD3⁺CD8⁺ T lymphocytes and CD8⁺CD38+ T lymphocytes were decreased in the observation group compared to the control group; the number of all T lymphocytes in the observation group was higher than that of the control group (P<0.05). Before treatment, there was no significant difference between the two groups in the levels of glutamic transaminase (ALT), glutamic transaminase (AST), blood creatinine (Scr) and urea nitrogen (BUN) (P>0.05). After treatment, the levels of ALT, AST, SCR and BUN in the two groups were lower than those in the control group (P<0.05). Conclusion The combination of Jianpi Yishen Recipe and Silymarin Bingan has a significant therapeutic effect on AIDS of spleen and kidney deficiency type, which can alleviate the clinical symptoms of patients, improve the immune function and liver kidney function, and is worthy of clinical application and promotion.

Analysis of Safety and Efficacy of Red and Blue Light Combined with Systemic Drugs in the Treatment of Herpes Zoster

XIAO Zi-hao, FU Wei, HUANG Deng-xia, LIU De-wu

2024, 42(6):  40-44. 

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Objective To evaluate the clinical efficacy and safety of red and blue light combined system drug in the treatment of herpes zoster by meta-analysis. Methods The Cochrane Library, EMbase database, Pubmed database, China Biomedical Literature Database and China national knowledge infrastructure (CNKI) were searchedA randomized controlled trial (RCT) about red and blue light combined systemic drug therapy for herpes zoster was included, and methodological quality was evaluated, and statistical analysis was performed using RevMan 5.4 software, according to the database, Wip database, and Wanfang database. Results 8 RCT articles were included in this study, with a total of 1240 cases. The results of meta-analysis showed that the total effective rate (OR=4.92, 95%CI:2.95-8.21, P<0.00001) and recovery rate (OR=2.17, 95%CI:1.66-2.85, P<0.00001), vesicle regression time (MD=-1.16, 95%CI:-1.33-0.98, P<0.00001), scab time (MD=-1.47, 95%CI:-1.80-1.14, P<0.00001), pain relief time (MD=-2.05, 95%CI:-2.54-1.56, P<0.00001), and the effect was significantly better than that of the group using basic drugs alone, the difference was statistically significant (P<0.05). Conclusion The combination of red and blue light system drug treatment of herpes zoster is effective, and better than the system drug group, is an effective method of photoelectric combination drug treatment of herpes zoster.

Detection of Circadian Spontaneous Gonadotropin Levels in Girls with Precocious Puberty in Zunyi in 2021 to 2023

TU Bin

2024, 42(6):  80-83. 

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Objective To explore and analyze the value of circadian spontaneous gonadotropin level detection in Zunyi city of girls with precocious puberty from 2021 to 2023. Methods From September 2021 to March 2023,78 cases of precocious puberty girls in Zunyi who were treated and treated in Zunyi Maternal and Child Health Hospital were selected as the precocious puberty group, and 78 cases of healthy girls who underwent physical examination in Zunyi Maternal and Child Health Hospital were selected as the health group. The levels of spontaneous Gonadotropin, 25 hydroxyvitamin D and androgen binding globulin were detected in both groups, and the follicular growth of all girls were determined. Results The uterine length diameter, ovarian volume, total follicle number, and maximum follicle diameter of the precocious puberty group were significantly higher than those of the healthy group (P<0.05). The levels of serum luteinizing hormone and follicle stimulating hormone in spontaneous blood at night and in spontaneous blood at daytime in precocious puberty group were significantly higher than those in healthy group (P<0.05). The fasting serum levels of 25 hydroxyvitamin D and androgen binding globulin in the precocious puberty group were lower than those in the healthy group (P<0.05). In 78 girls with precocious puberty, Spearman analysis showed a correlation between nighttime spontaneous blood, serum LH, OH content, uterine diameter, ovarian volume, total follicles, maximum follicle diameter, 25 hydroxyvitamin D, sex hormone-bound globulin and sex precocious puberty (r=0.744,0.699,0.714,0.766,0.794,0.636,0.715,0.677, -0.688, -0.714, P<0.05). Conclusion Zunyi 2021—2023 precocious girls with uterine long diameter, ovarian volume, total follicle number, maximum follicle diameter increase, also accompanied by increased spontaneous gonadotrophins levels and serum 25 hydroxyvitamin D, sex hormone combined with globulin content decreased, precocious girls of spontaneous spontaneous gonadotropin level detection has important clinical value.

Study on the Clinical Application Value of Hydration Therapy Based on the Collapse Rate of Inferior Vena Cava to Prevent Contrast Nephropathy after Interventional Surgery

YIN Fang, HOU Xing-zhi, SONG Zhi-ping

2024, 42(6):  155-158. 

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Objective To study the clinical application value of hydration therapy based on the collapse rate of Inferior vena cava to prevent contrast nephropathy after interventional surgery. Methods A total of 460 patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI) in our hospital from November 2021 to November 2023 were selected and divided into control group (n=232) and observation group (n=228) according to random number table method. The control group received hydration therapy guided by traditional methods. The observation group was guided by the measurement of inferior vena cava collapse rate (CI-IVC). The serum creatinine (SCr), endogenous creatinine clearance (eGFR), serum homocysteine (CysC), urea nitrogen (BUN), hypersensitive C-reactive protein (hs-CRP) and serum N-terminal B-type natriuretic peptide precursor (NT-proBNP) of the two groups were compared before and after surgery. Total contrast agent, total hydration; Left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD). Contrast agent nephropathy. Results Before surgery, there was no statistically significant difference in the levels of SCr, eGFR, CysC, BUN, hs CRP, and NT proBNP between the two groups of patients (P>0.05). There was no statistically significant difference in LVEF and LVEDD between the two groups of patients (P>0.05). After surgery, the SCr, eGFR, CysC, BUN, hs CRP, NT proBNP water levels in the observation group were significantly higher than those in the control group (P<0.05). There was no statistically significant difference in the total amount of contrast agent between the two groups of patients (P>0.05). The total amount of hydration in the observation group was significantly higher than that in the control group, with statistical significance (P<0.05). The incidence of contrast-enhanced nephropathy in the observation group was significantly reduced compared to the control group, with a significant difference (P<0.05). Conclusion Guiding patients to do hydration therapy by measuring the collapse rate of inferior vena cava can effectively reduce the incidence of contrast agent nephropathy, which is of high application value and worth popularizing.

The Value of 3D-ASL Technology in Postoperative Recurrence of High-grade Glioma

MENG Fan-ran, WANG Wei, FENG Hui-yu, MENG Shao-lin, HE Chen-xi, XU Wei, GAO Fei

2024, 42(6):  164-168. 

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Objective To explore the application value of three-dimensional arterial spin labeled perfusion imaging (3D-ASL) in postoperative tumor recurrence of high-grade gliomas (HHG). Methods Retrospective analysis of 31 patients with postoperative recurrence of advanced glioblastoma in our hospital from December 2019 to December 2021. All patients underwent magnetic resonance plain scan, enhanced scan, and 3D-ASL examination to measure the recurrence area of high-grade gliomas after surgery, as well as the cerebral blood flow (CBF) of contralateral normal brain tissue, for statistical analysis. Diagnosis was made by combining conventional magnetic resonance imaging and conventional magnetic resonance imaging with 3D-ASL imaging, and the diagnostic accuracy was analyzed for statistical comparison. Results The CBF in the postoperative recurrence group of high-grade gliomas was significantly higher than that in the normal group, with a significant statistical difference (P<0.05). The diagnostic accuracy of conventional magnetic resonance imaging combined with 3D-ASL film reading in diagnosing postoperative recurrence of high-grade gliomas was significantly improved compared to conventional magnetic resonance imaging, and there was a significant statistical difference between the two (P<0.05). Conclusion 3D-ASL technology has high diagnostic efficacy in postoperative recurrence of high-grade gliomas and has important clinical application value.

To Evaluate the Clinical Effect of Individualized Treatment of Trimalleolar Fractures Assisted by 3D Printing Technology

LI De-qiang, ZHONG Hua, MA Su-shuang, YANG Xi-duan

2024, 42(6):  171-173. 

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Objective To compare the clinical efficacy of individualized treatment assisted by 3D printing technology and conventional treatment of trimalleolar fracture in the follow-up of 3 months after operation. Methods Patients with trimalleolar fractures who were hospitalized for surgical treatment in our hospital from June 21, 2019 to June 20, 2021 were enrolled.According to the surgical plan,the patients were divided into the control group (conventional treatment) and the observation group (3D printing technology-assisted personalized treatment). The operation and recovery of ankle function at 3 months were compared in the two groups. Results A total of 50 patients were included in the study, including 25 patients in the control group and 25 patients in the observation group. The operation time, hospitalization time and starting activity time of the observation group were shorter than those of the control group, and the differences were statistically significant (P<0.05). The intraoperative blood loss of the observation group was less than that of the control group, and the difference was statistically significant (P<0.05). The ankle function was better than the control group,the differences were statistically significant (P<0.05). Conclusion 3D printing technology assisted in the treatment of trimalleolar fractures can promote the recovery of ankle joint activity, shorten the operation time and hospitalization time, reduce the amount of bleeding, and early rehabilitation activities.

Analysis of Clinical Test Results of Serum Immunoglobulin Level in Hepatitis B Patients

ZHANG Yu, WANG Wen-juan

2024, 42(6):  174-176. 

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Objective To analyze the clinical results of serum immunoglobulin level in hepatitis B patients. Methods 500 patients with hepatitis B admitted to Tai 'an Hospital of Traditional Chinese Medicine from January 2019 to January 2023 were selected as the observation group and divided into 265 patients with cirrhosis and 235 patients without cirrhosis according to whether cirrhosis occurred.Cirrhosis was divided into groups according to the development stage of cirrhosis. Among the cirrhosis group, 140 patients were in the compensatory stage. 125 cases were decompensated,and 300 healthy persons (control group) were selected during the same period to analyze the immunoglobulin detection levels in different groups. Results Compared with the control group, the levels of IgG, IgA and IgM in the observation group were significantly higher (P<0.05). The levels of IgG, IgA and IgM in liver cirrhosis were significantly higher than those in non-liver cirrhosis (P<0.05). Compared with the decompensated stage, the levels of IgG, IgA and IgM in the decompensated stage were significantly higher (P<0.05). Conclusion The results of serum immunoglobulin detection can be used to analyze the actual lesions of hepatitis B patients, so as to judge the damage of liver cells, and provide reference for the diagnosis and treatment of the disease.