Abstract: Objective To explore and analysis the diagnostic and prognostic significance of nuclear factor κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3) proteins in endometrial cancer (EC) tissue. Method From September 2019 to November 2022, 88 cases of patients with endometrial cancer who were diagnosed and treated in The First Affiliated Hospital of Shihezi University were selected as the research subjects. Fresh endometrial cancer tumor tissue samples (tumor group) and normal endometrial tissue adjacent to cancer (adjacent group) were taken from all patients who underwent surgery, and the NF-κB, STAT3 proteins were detected using immunohistochemistry, investigated the pathological characteristics of patients, followed up prognosis, and conducted correlation analysis. Result The positive rates of NF-κB and STAT3 proteins in the tumor group were 63.64% and 56.82%, and were 15.91% and 13.64% in the adjacent cancer group that the tumor group were significantly higher than the adjacent cancer group (P<0.05). In the 88 patients, There were significant difference in the positive rate of NF-κB and STAT3 protein expression in the different age, clinical stage, degree of differentiation, muscle infiltration, and lymph node metastasis patients (P<0.05). All patients were followed up until June 1, 2023, the positive rate of NF-κB and STAT3 protein expression in the surviving patients were significantly lower than that of death patients (P<0.05). Cox regression analysis showspositive rate of NF-κB and STAT3 protein expression were the important factor affected the median survival time of prognosis (P<0.05). Conclusion Endometrial cancer tissue are often accompanied by the high expression of NF-κB and STAT3, and are correlated with the clinical pathological characteristics and prognosis of patients.

Key words: endometrial cancer, nuclear factor κB, signal transduction and transcription activating factor 3, pathological characteristics, median survival time, relativity