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Meta-analysis of Clinical Efficacy of Duzhong Yaotong Pill on Lumbar Disc Herniation
ZHAO Ji-rong, CHEN Qian-wen, YAN Chun-juan, SHAO hong, MA Jun-fei, YANG Zheng-han
ZHONGHUA YANGSHENG BAOJIAN
2022, 40 (22):
22-26.
Objective The efficacy of Duzhong Yaotong Pill in the treatment of lumbar disc herniation was systematically evaluated. Methods According to the requirements of Meta-analysis, CNKI, CBM, WanFang, VIP, PubMed, Web of Science, Cochrane Library and Embase were searched for literatures on randomized controlled trials of Duzhong Yaotong Pill in the treatment of lumbar disc herniation published from the establishment of databases to May 2022. The Cochrane Collaboration bias risk tool was used for risk assessment, and the modified Jadad scale score was used for literature quality assessment. Review Manager 5.3 statistical software was used for Meta-analysis of literatures with modified Jadad scale score ≥ 3, and publication bias was analyzed by Begg’s test. Results Finally, eight eligible literatures were retrieved, of which five were Jadad ≥ 3, with a total of 652 patients ; meta-analysis results showed that compared with other conservative treatment control groups, Duzhong Yaotong pill combined with traditional Chinese and western medicine could significantly improve the effective rate of main clinical symptoms in patients with LDH [RR=1.11,95% CI(0.97,1.26), P>0.05 ] ; in addition, VAS score (MD=-0.65,95% CI(-0.93, -0.37), P<0.05 ) and JOA score (RR=0.87,95% CI(0.60,1.13), P<0.05 ) were significantly better than the control group. Begg’s test showed that there was no significant publication bias between studies [clinical effective rate (Z=1.042, P=0.296) ;VAS score (Z=0.000, P=1.000); JOA score (Z=0.000, P=1.000)]. Conclusion The existing evidence shows that Duzhong Yaotong Pill has certain advantages in the treatment of lumbar disc herniation, which can alleviate the pain of patients, significantly reduce the VAS score of patients and improve the JOA score and worthy of clinical application.
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