Exploring the Clinical Medication Patterns of Traditional Chinese Medicine in the Treatment of Ulcerative Colitis with the “Duiyao” Theory based on the Neo4j Knowledge Graph Theory
XU Tao, ZHANG Wei
2025, 43(9):
1-6.
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Objective Through the Neo4j knowledge graph, explore the "medication" pattern of traditional Chinese medicine in treating ulcerative colitis. Method Retrieve clinical research literature on the treatment of ulcerative colitis with traditional Chinese medicine from the China National Knowledge Infrastructure (CNKI) database from January 1, 2020 to December 1, 2024. Collect data on traditional Chinese medicine prescriptions, syndrome types, combined traditional Chinese medicine operations, and combined Western medicine. Perform statistical analysis on the properties, flavors, meridians, and efficacy of traditional Chinese medicine in the prescription data. Perform frequency, frequency, and weighted frequency statistics on all data. Calculate the weight, confidence, and enhancement of the relationship between traditional Chinese medicine oral formulas, traditional Chinese medicine enema formulas, and traditional Chinese medicine prescriptions themselves. Then import the data into the Neo4j graph database. Result A total of 242 valid data were collected, and the oral Chinese medicines with a frequency of≥50% included Atractylodes macrocephala, Coptis chinensis, and Paeonia lactiflora; The enema herbs with a frequency of ≥50% include Bai Ji and Huang Bai; The only type of syndrome with a frequency of ≥10% is damp heat in the large intestine; Other operations with a frequency of ≥10% include moxibustion, acupuncture, ear acupressure, and acupoint embedding; The only Western medicine with a frequency of ≥10% is mesalazine. After importing the knowledge graph, the relationship between traditional Chinese medicine oral formulas that meet the criteria of frequency ≥10%, confidence ≥65%, improvement≥1, and ranked first in descending order of previously placed word frequency is from Paeonia lactiflora to Atractylodes macrocephala; The relationship between traditional Chinese medicine enema formula and traditional Chinese medicine enema formula is Bai Ji → Huang Bai; The top 5 in terms of meridian frequency are spleen, liver, stomach, lungs, and large intestine; The top 5 in terms of frequency of medicinal properties are cold, warm, flat, cool, and hot; The top 5 medicinal flavors are bitter, sweet, spicy, astringent, and sour; The top 5 efficacy frequencies for splitting are detoxification, clearing heat, relieving pain, drying dampness, and stopping bleeding. Conclusion The analysis using the Neo4j knowledge graph reveals the "pairing drug" patterns in TCM for treating UC. The oral herbs Atractylodes, Peony, and Coptis, along with the enema herbs Bletilla and Phellodendron, were frequently used. The Spleen, Liver, Stomach, and Large Intestine meridians were commonly involved in the treatment process. This study provides a theoretical basis for TCM in the treatment of UC and offers clinical reference for drug selection.
