Table of Content

01 June 2025, Volume 43 Issue 11

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Visualization Analysis on Research Literature of TCM Treatment of Glaucoma

LI Wen-juan, PENG Qing-hua

2025, 43(11):  1-5. 

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Objective To analyze the current research status, hot topics, and development trends of TCM Treatment of Glaucoma. Methods To analyze the literature with the full text database of Chinese academic journals as the search source and knowledge graph based approach CiteSpace software. Results A total of 1 267 Chinese literature were included, and the number of articles published showed anoverall upward trend; 804 authors were involved, and the author with the most articles was Peng Qinghua, forming research teams with Peng Jun, Yao Xiaolei and Li Xiang as the cores respectively; the main research institutions were Hunan University of Chinese Medicine, Eye Hospital of China Academy of Chinese Medical Sciences, Heilongjiang, Chendu University of Chinese Medicine and so on, but there was little cooperation among them. High-frequency keywords included glaucoma, acupuncture, IOP, gangrene, Chinese medicine, etc., forming 18 clusters such as IOP, Supplementing qi and nourishing yin, resveratrol and so on. The focus of research was acupuncture, IOP, autophagy. Conclusion The research heat of TCM in the treatment of glaucoma has gradually increased, and the modern research in this field from 1951 to 2023, such acupuncture and molecular biology based on big data platform, is the research hotspot in this field.

Influence of Cichorium Intybus and Bamboo Leaf Extract on Postoperative Urinary Function in Patients with Benign Prostatic Hyperplasia

CHEN Yong, LI Jiang, LONG Yi, LI Jian-sheng, JIANG Chuan, GUO Lin, CHI Chun-hua, GUAN Qing-lei

2025, 43(11):  6-8. 

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Objective The aim of this study was to investigate the potential benefits of chicory and bamboo leaf extract in facilitating the recovery of urinary function following surgery for patients with benign prostatic hyperplasia (BPH). Methods A total of 120 patients diagnosed with BPH and admitted to Jinan Hospital of Integrated Traditional and Western Medicine between September 2023 and August 2024 were enrolled in this study. The patients were randomly assigned to either a control group or an experimental group, with 60 patients in each group. The control group received only standard postoperative care, whereas the experimental group received standard postoperative care plus additional treatment with chicory and bamboo leaf extract. The efficacy of the treatment, assessed through the International Prostate Symptom Score (IPSS), Traditional Chinese Medicine (TCM) syndrome score, urinary function indicators, and levels of inflammatory factors, was compared between the two groups. Results The overall effective rate in the experimental group was significantly higher than that in the control group. After four weeks of treatment, the experimental group showed higher scores on the IPSS, TCM syndrome score, maximum urinary flow rate, and average urinary flow rate compared to the control group. Furthermore, the levels of IFN-γ and TNF-α in the experimental group were also higher than those in the control group, with statistically significant differences observed (P<0.05). Conclusion The findings of this study suggest that chicory and bamboo leaf extract has a positive effect on improving urinary function recovery after surgery for patients with BPH. The higher efficacy rate and improved urinary function indicators in the experimental group indicate that the addition of chicory and bamboo leaf extract to standard postoperative care may provide an effective therapeutic approach for enhancing postsurgical recovery in BPH patients. Further research is needed to elucidate the mechanisms underlying these effects and to confirm the long-term benefits of this treatment. This study highlights the potential of natural extracts in complementing conventional medical treatments and offers promising avenues for future research in the field of urology and integrative medicine.

Research Progress on Anti-Fatigue Effect of Chinese Medicine

TANG Shan-shan

2025, 43(11):  9-12. 

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Fatigue caused by the fast pace of modern social development and competitive pressure has become an important factor affecting people's quality of life. Fatigue not only affects people's life and work, but also endangers people's physical and mental health. Long-term fatigue can induce a variety of diseases if it is not relieved in time. Traditional Chinese medicine has a reliable clinical effect in anti-fatigue and alleviating secondary diseases. In this paper, the understanding of fatigue and the complex mechanism of anti-fatigue of traditional Chinese medicine are reviewed. The application of some representative single Chinese medicine and compound Chinese medicine in anti-fatigue is summarized, and its mechanism of action in anti-fatigue is analyzed. In order to provide reference for further study of traditional Chinese medicine anti-fatigue.

A Study on the Regularity of Traditional Chinese Patent Medicines and Simple Preparations in the Treatment of Palpitations Based on Data Mining

ZHOU Qian, YE Xiao-hong

2025, 43(11):  31-35. 

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Objective To discuss the medication rule of traditional Chinese patent medicines and simple preparations in the treatment of palpitation, and provide a reference for clinical application. Methods Collect the prescriptions of traditional Chinese patent medicines and simple preparations for the treatment of palpitations in Formulated Preparations of Traditional Chinese Medicine, input the drugs into the traditional Chinese medicine inheritance calculation platform (V3.5), and analyze the data of the drugs. Results There were 182 prescriptions of traditional Chinese patent medicines and simple preparations for palpitation.From the perspective of taste, the most frequently used are warm and sweet drugs, followed by mild and bitter drugs;From the perspective of meridian regulation, the most frequently used drugs are those for the heart meridian, followed by those for the kidney meridian, and then those for the liver meridian;In terms of medication frequency, the top 10 traditional Chinese medicines are Angelica sinensis, Schisandra chinensis, ginseng, Poria cocos, Astragalus membranaceus, licorice, Ophiopogon japonicus, Radix Codonopsis pilosula, and Radix Rehmanniae;In terms of efficacy, the most frequently used traditional Chinese medicines are those that tonify deficiency, followed by those that calm the nerves, and then those that promote blood circulation and remove blood stasis;From the perspective of drug combinations, Schisandra chinensis is often used in combination with Ophiopogon japonicus, while Angelica sinensis is used in combination with Poria cocos, Astragalus membranaceus, and licorice;Set the support level to≥15% and confidence level to≥0.7, and obtain a networked display of drug patterns consisting of "Huangqi, Fuling, Danggui, Suanzaoren, Licorice, Rehmannia glutinosa, Yuanzhi, Schisandra chinensis, Ophiopogon japonicus, and Ginseng";Obtain three new songs. Conclusion The etiology of palpitations is related to emotions, diet, and long-term physical weakness. The basic pathological mechanism is heart block and loss of mental and spiritual nourishment.Traditional Chinese patent medicines and simple preparations focuses on the heart, kidney, liver, lung and spleen in the treatment of heart palpitations. Deficiency syndrome is mainly used to supplement the qi, blood, yin and yang of the human body. The excess syndrome is mainly used to eliminate the visible and real evils of the human body. It is added or subtracted based on Shengmai Decoction, Guipi Decoction and Zhigancao Decoction.

Analysis of the Effect of Sacubitril/Valsartan on Anemia in Patients

Yin Cong-cong, Wang Juan, Fan Rong

2025, 43(11):  46-51. 

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Objective This study aims to investigate the relationship between the angiotensin receptor enkepriliase inhibitor Sacubitril/Valsartan and the occurrence of anemia in patients with chronic heart failure (CHF) through a prospective trial, and Explore the possible influencing factors. Methods A total of 406 CHF patients who met the inclusion and exclusion criteria from Linyi People's Hospital and Linyi Hospital of Traditional Chinese Medicine from January 2021 to June 2023 were selected as the research subjects. According to the random number table method the research subjects were randomly divided into the ARNI group and the ARB group at a 1:1 ratio. At the beginning of enrollment, both groups received conventional treatment. On this basis, 203 cases in the ARB group were treated with valsartan, and 203 cases in the ARNI group were treated with sacubitril/valsartan. Before treatment and 12 months after treatment, the levels of hemoglobin content, serum ferritin, serum iron and other anemia and iron metabolism-related indicators, as well as erythropoietin (EPO), vitamin B₁₂, folic acid levels and inflammatory indicators (IL-6) were detected in both groups. The differences in the incidence and degree of anemia in the two groups 12 months after treatment were analyzed. Binary logistic regression was used to analyze the related influencing factors of anemia occurrence, and further comparative analysis was conducted on the meaningful factors. Results After 12 months of treatment, the levels of EPO, ferritin, and IL-6 in the anemic patients in both groups were all increased compared with those before treatment. In the non-anemic patients in the ARNI group, the ferritin level showed a decreasing trend after treatment, while in the ARB group, it showed an increasing trend. The inflammatory indicator IL-6 in the non-anemic groups of both groups showed a decreasing trend. All the above differences were statistically significant (P<0.05). The incidence of anemia in the ARNI group was lower than that in the ARB group, and the degree of anemia in the ARNI group was milder than that in the ARB group, with statistically significant differences (P<0.05). Binary logistic regression analysis indicated that higher EPO levels, increased ferritin levels, and a high inflammatory state were common predictive factors for the occurrence of anemia in patients in both groups. While advanced age (≥65 years old) and poorer cardiac function classification were only risk factors for the occurrence of anemia in the ARB group. The increase level of EPO before and after treatment in anemic patients in the ARNI group was significantly higher than that in the ARB group, while the increase levels of ferritin and inflammatory indicators before and after treatment in anemic patients in the ARB group were significantly higher than those in the ARNI group, with statistically significant differences (P<0.05). Conclusion Both sacubitril/valsartan and valsartan have the risk of causing anemia in patients with chronic heart failure, but the incidence and degree of anemia caused by sacubitril/valsartan are lower. Higher EPO level, increased ferritin level, and high inflammatory state are common predictive factors for anemia in patients with chronic heart failure caused by the two drugs, but advanced age and poorer cardiac function classification are only risk factors for anemia caused by taking valsartan orally. This difference may be attributed to the fact that sacubitril/valsartan can affect the secretion of EPO, the absorption and utilization of iron, and the inhibition of inflammation in patients with heart failure.

Clinical Effect of Ultrasound-Guided Needle-Knife Release in the Treatment of Flexor Tendon Stricture Tenosynovitis of Thumb

HU Qiong, HE Zhi-rong, HU Xue

2025, 43(11):  51-55. 

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Objective To investigate the clinical effect of ultrasound-guided needle-knife release therapy on patients with constricted tenosynovitis of flexor tendon of thumb. Methods A total of 60 patients with constricted tenosynovitis of flexor tendon of thumb admitted to Pingliang Hospital of Traditional Chinese Medicine from January 2023 to January 2024 were randomly divided into control group and study group,each consisting of 30 cases. The control group was given blind needle-knife release treatment, and the study group was given ultrasound-guided needle-knife release treatment.The clinical efficacy, pain degree, finger function, total active range of motion (TAM),A1 trochlear parameters and complications were compared between the two groups. Results The total effective rate of treatment in the study group was higher than that in the control group, with a statistically significant difference (P<0.05). After treatment, both groups showed a decrease in the Numerical Rating Scale (NRS) for pain intensity, and the NRS score in the study group was lower than that in the control group, with a statistically significant difference (P<0.05). The finger function and TAM of the study group were better than those of the control group, with a statistically significant difference (P<0.05). After treatment, both groups experienced a reduction in A1 trochlear length and thickness, and the study group had lower values for all indicators compared to the control group, with a statistically significant difference (P<0.05). The incidence of complications in the study group was lower than that in the control group, with a statistically significant difference (P<0.05). Conclusion Ultrasound-guided needle-knife release therapy can improve clinical efficacy, reduce pain, improve finger function, TAM, adjust A1 trochlear parameters, and has high safety in patients with flexor tendon stenosis tenosynovitis of thumb.

Application of Follow Up Rehabilitation Training Guided by Newman System Mode in Hemiplegic Patients with Cerebral Infarction

GAO Ying, ZHAO Rong

2025, 43(11):  76-79. 

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Objective To explore the application effect of follow-up rehabilitation training guided by Newman system mode in patients with cerebral infarction hemiplegia. Methods A total of 120 patients with cerebral infarction hemiplegia admitted to Jinan Eighth People′s hospital from February 2023 to February 2024 were selected and divided into study group (n=60) and control group (n=60) by random number table method. The control group was given routine rehabilitation training, and the study group was given follow-up rehabilitation training under the guidance of Newman system model. The limb function, self-efficacy and quality of life of the two groups were compared. Results Before intervention, there was no statistical significance in Fugl-Meyer Motor Function Assessment Scale (FMA) scores of upper limbs, FMA scores of lower limbs, General Self-efficacy Scale (GSES) scores and Stroke Specific Quality of Life Scale (SS-QOL) scores of stroke between the two groups (P>0.05). After intervention, the upper limb FMA score, lower limb FMA score, GSES score and SS-QOL score of both groups were higher than before intervention, and the study group was higher than the control group, the difference was statistically significant (P<0.05). Conclusion Follow up rehabilitation training guided by the Newman system model can improve limb function, self-efficacy, and quality of life in patients with cerebral infarction hemiplegia.

The Application and Effect of BOPPPS Course Objective Pre-Setting in the Training of Aseptic Technique for Nursing Students in Operating Room

LIU Jing, CHEN Xue-li

2025, 43(11):  92-95. 

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Objective To explore the application method and effect of course goal presetting based on BOPPPS teaching mode in the aseptic technology training of nursing students in operating rooms. Methods A total of 107 nursing students practicing in the operating room of our hospital were selected as the study objects, 53 nursing students from November 2023 to May 2024 were set as the control group, and 54 nursing students from July 2024 to January 2025 were set as the observation group. The control group adopted the traditional training mode, that is, the classroom face-to-face teaching + on-site demonstration + after-class theoretical and operational assessment mode. The observation group constructed the teaching model diagram, focused on the five curriculum objectives of memory, understanding, application, analysis and evaluation, so as to predict the training focus and implement BOPPPS participatory learning. The two groups of nursing students were compared in terms of their theoretical and operational performance, the time of wearing sterile surgical gowns without contact and wearing gloves, and their self-learning ability. Results After training, the theoretical and operational scores of the observation group were higher than those of the control group, and the difference was statistically significant (P<0.05). The nursing students in the observation group wore sterile surgical clothes and gloves without contact for a shorter time than the control group, and the difference was statistically significant (P<0.05). After training, the scores of self-management ability, information ability, learning cooperation ability and self-learning ability of the observation group were higher than those of the control group, and the differences were statistically significant (P<0.05). Conclusion The pre-setting of course objectives based on BOPPPS teaching model can improve the theory, operational performance and autonomous learning ability of nursing students in operating room, shorten the quantifiable operation time of aseptic technology, and achieve good teaching and training effects.

Analysis of Gesell Assessment Results in 409 Children Aged 0 ~ 6 Years

WEI Qiu-lian

2025, 43(11):  96-101. 

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Objective To analyze the developmental problems of 0~6 years old children by Gesell development scale assessment, analyze the distribution of developmental lag in children of different months and genders, and provide evidence for early effective intervention. Methods A total of 409 children with developmental problems aged 0 to 6 years old screened by Fangshan District Community Health Service Center from 2019 to 2023 were calculated using the Software for Evaluation of Developmental Diagnosis for children aged 0 to 6 years old, published in March 2009 by Beijing Maternal and Child Health Hospital. The content of the test included five areas of adaptability, gross motor, fine motor, language and personal-social ability, and the developmental lag of each area was analyzed statistically. Results Children of 3 to 11 months of age, 12 to 23 months of age, 24 to 35 months of age, 36 to 72 months of age had higher rates of adaptive and personal-social developmental lag than normal, fine motor and gross motor lag than normal, and language lag was lower than normal, with statistical significance (P<0.05). The fine motor development of boys aged 12 to 23 months and 36 to 72 months was inferior, and the individual-social development of boys aged 24 to 35 months and 36 to 72 months was higher than that of girls. The fine motor development lag of girls aged 24 to 35 months was higher than that of boys, and the difference was statistically significant (P<0.05). The proportion of gross motor, fine motor and personal-social developmental retardation at 3 to 11 months, 12 to 23 months, 24 to 35 months and 36 to 72 months was higher than that of moderate or above. The proportion of moderate and above retarded language development increased with age, and was higher than that of mild language development at 36 to 72 months. Conclusion Children aged 3 to 11 months have higher than normal rates of adaptive, individual-social, fine motor and gross motor retardation, but lower than normal rates of language retardation. With age, fine motor and gross motor delay decrease and speech delay increases. In terms of sex, boys lag behind in fine motor development at 12 to 23 months and 36 to 72 months and girls lag behind in personal-social development at 24 to 35 months and 36 to 72 months. Girls lag behind in fine motor development at 24 to 35 months than boys. The degree of developmental lag: mild developmental delay was more than moderate or above in all age groups, and the language development delay increased with age, and the proportion of moderate or above in 36~72 months increased significantly.

Effect of 1% Iced Lemonade Spray at 0 ~4℃on Relieving Thirst in Patients after Nasal Endoscopic Surgery

YANG Xiao-yan, YOU Xiu-hua, LI Na

2025, 43(11):  111-115. 

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Objective To evaluate the effect of 1% iced lemonade spray at 0 ℃~4 ℃ on relieving thirst in patients after nasal endoscopic surgery. Methods A total of 144 inpatients in the otolaryngology department of a Grade A hospital in Fujian Province from March to August 2023 were selected as the study subjects by convenience sampling method. According to the order of admission time, patients receiving routine care from March to May 2023 were set as the control group, and those receiving iced lemonade spray from June to August 2023 were set as the test group. The scores of thirst, oral mucosa humidity and nursing service satisfaction were compared between the two groups before and after intervention at 0.5 h, 2 h, 4 h and 6 h. Results Before intervention, there was no significant difference in thirst score and oral mucosa humidity classification between 2 groups (P>0.05). At 0.5 h, 2 h, 4 h and 6 h after intervention, the thirst score of the experimental group was lower than that of the control group (P<0.001), and the thirst score of the experimental group gradually decreased with time (P<0.001), and there was an interaction between the groups and time (P<0.001). The oral mucosa moisture grade and nursing service satisfaction of experimental group were better than those of control group (P<0.05). Conclusion 1% iced lemon water spray at 0~4 ℃ can effectively reduce thirst, improve oral mucosa wetness and nursing service satisfaction compared with conventional cotton swabs.

The Impact of Early Enteral Nutrition Combined with Systematic Health Guidance on the Prognosis and Incidence of Adverse Reactions in Patients with Severe Cerebral Hemorrhage

HU Fang, LI Hong-wei

2025, 43(11):  115-118. 

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Objective To explore the impact of early enteral nutrition combined with systematic health guidance on the prognosis and incidence of adverse reactions in patients with severe cerebral hemorrhage. Methods Selected 96 patients admitted to the Second People's Hospital of Guiyang City, all of whom were severe cerebral hemorrhage; the grouping method used the random number table scheme, and the number of cases in each group was 48 cases. On the basis of routine care, the control group was given systematic health guidance and routine parenteral nutritional support; the observation group was given early enteral nutritional support on the basis of the control group; and the two groups were compared in terms of nutritional and physical conditions, adverse reactions and so on. Results The hemoglobin (Hb), albumin (Alb), prealbumin, and nitrogen balance (Nb) levels as well as upper arm muscle circumference, triceps skin muscle fold thickness (TSF), and body mass of the observation group were higher than those of the control group at 2 weeks after the operation (P<0.05). The psychological state of the observation group was better than that of the control group, and the adverse reactions were lower than that of the control group (P<0.05). And there was no difference in the comparison of the prognostic outcomes of the two groups at 28 d postoperatively (P>0.05). Conclusion The use of early enteral nutrition combined with systematic health guidance for patients with severe cerebral hemorrhage improves the nutritional status of patients, reduces the occurrence of adverse reactions, and has no adverse effect on the prognostic outcome of patients.

Study the Effect of Moxibustion Combined with Acupoint Application in Postoperative Constipation Patients with Mixed Hemorrhoids

WU Jun-yuan, ZHOU Jian

2025, 43(11):  119-122. 

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Objective To observe the clinical efficacy of moxibustion combined with acupoint application in treating constipation after mixed hemorrhoids ligation and external hemorrhoidectomy. Methods From May 2002 to April 2023,120 patients underwent mixed hemorrhoid ligation and external hemorrhoidectomy in the Department of Anorectal Surgery ofNanjing University of Traditional Chinese Medicine Affiliated Hospital of Integrated Traditional Chinese and Western were selected and randomly divided into a control group and an observation group. The control group received routine postoperative care and intervention for mixed hemorrhoids, while the observation group intervened with moxibustion combined with acupoint application after surgery. Results The recovery of constipation symptoms in the observation group was relatively ideal, and the defecation status, satisfaction, and psychological state of the patients were better than those in the control group. Conclusion Moxibustion combined with acupoint application can effectively alleviate postoperative constipation in patients with hemorrhoids, improve gastrointestinal function, and improve their psychological state.

Study on the Effect of Traditional Chinese Medicine Massage Combined with Sports Acupuncture on Characteristic Nursing of Iumbar Disc Herniation

QU Shi-chun

2025, 43(11):  129-133. 

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Objective To explore the effect of traditional Chinese medicine massage combined with sports acupuncture in patients with lumbar disc herniation. Methods Patients with lumbar disc herniation who went to the acupuncture and Massage Department of Heze Hospital of Traditional Chinese Medicine from June 2022 to July 2024 were selected and divided into the control group (n=36) by random number table method to implement routine nursing mode, and the observation group (n=36) to implement traditional Chinese massage combined with sports acupuncture characteristic nursing mode. The straight leg raise height, dysfunction, functional status and clinical efficacy of the two groups were compared. Results Before intervention, there was no significant difference between the two groups in straight leg lift height and Oswestry disability index(ODI) score (P>0.05). After intervention, the straight leg lifting height of both groups was higher than before intervention, and the observation group was higher than the control group, the difference was statistically significant (P<0.05). After intervention, the ODI scores of both groups were lower than before intervention, and the observation group was lower than the control group, with statistical significance (P<0.05). Before intervention, there was no significant difference in the Japanese Orthopaedie Association(JOA) between the two groups (P>0.05). After intervention, JOA scores of both groups were higher than before intervention, and the observation group was higher than the control group, the difference was statistically significant (P<0.05). The total effective rate of the observation group was higher than control group, the difference was statistically significant (P<0.05). Conclusion Compared with conventional nursing and traditional Chinese massage combined with sports acupuncture characteristic nursing for patients with lumbar disc herniation, traditional Chinese massage combined with sports acupuncture characteristic nursing can effectively lift the height of the patients' straight legs, reduce the dysfunction, adjust the functional state and improve the clinical efficiency.

Application Effect of Continuous Care Based on Orem Theory in Patients with Chronic Gastritis

WANG Jun-xian

2025, 43(11):  141-144. 

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Objective To investigate the effect of continuous care based on Orem theory in patients with chronic gastritis. Methods A total of 84 patients with chronic gastritis admitted to Laiyang Central Hospital from May 2021 to May 2024 were selected and divided into routine group and Orem theoretical group by random number table method, with 42 cases.The routine group was given routine continuity nursing intervention,and the Orem theory group was given continuity nursing based on Orem theory.The scores of Connor-Davidson Resilience Scale (CD-RISC),Exercise of Self-care Ability Scale(ESCA) and Quality of Life Measurement Brief Table (QOL-BREF)were compared between the two groups before intervention and 3 months after intervention. Results After 3 months of intervention,the CD-RISC score of the Orem theory group was higher than that of the conventional group, and the difference was statistically significant(P<0.05).The ESCA score of Orem theory group was higher than that of the conventional group, and the difference was statistically significant (P<0.05).The QOL-BREF score of Orem theory group was higher than that of the conventional group,and the difference was statistically significant(P<0.05). Conclusion Continuous nursing based on Orem theory for patients with chronic gastritis can help improve their psychological resilience, optimize their self-care ability, and improve their quality of life, which has a high application advantage.

Study on the Relationship between Immune Tlymphocyte Subsets and the Efficacy and Prognosis of Chemotherapy Combined Targeted Therapy in Patients with Advanced Colorectal Cancer

CAO Ting, XIAO Yin, ZHANG Cheng, ZHENG Guang, WANG Jue, HUANG Shi-ying, HE Xin

2025, 43(11):  173-176. 

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Objective To explore the relationship between immune T lymphocyte subsets and the efficacy and prognosis of patients with advanced colorectal (CRC) cancer treated with chemotherapy combined with targeted therapy. Methods A total of 85 patients with advanced CRC were selected from January 2024 to October 2024. All patients received chemotherapy combined with targeted therapy. After 4 cycles, the efficacy of the two groups was compared. According to the efficacy of the patients, they were divided into a control group (55 cases, complete response + partial response + stable disease) and an ineffective group (30 cases, disease progression). The immune function and tumor indexes were compared between the two groups. Results Before treatment, there was no significant difference in the levels of CD3⁺T cells, CD4⁺T cells, CD8⁺T cells and CD4⁺/CD8⁺ between the two groups (P>0.05). After treatment, the levels of CD3⁺T cells, CD4⁺T cells and CD4⁺/CD8⁺ in the control group were higher than ineffective group, and the levels of CD8⁺T cells in the control group were lower than those in the ineffective group, with statistical significance (P< 0.05). Before treatment, there was no significant difference in tumor abnormal protein (TAP), Carbohydrate antigen 125 (CA125) and Carbohydrate antigen 199 (CA199) levels between the two groups (P>0.05). After treatment, TAP, CA125 and CA199 levels in the control group were lower than ineffective group, and the difference was statistically significant (P<0.05). After treatment, the levels of CD3⁺ T cells, CD4⁺ T cells, CD4⁺/CD8⁺ were negatively correlated with the therapeutic effect (P<0.05), and the levels of CD8⁺ T cells were positively correlated with the therapeutic effect (P<0.05). Conclusion Immune T lymphocyte subsets are potentially related to the efficacy of chemotherapy combined with targeted therapy in patients with advanced colorectal cancer, which is of great significance for the prognosis of patients.

Value of Combined Detection of Serum Tumor Markers CA125, HE4 and CEA in the Diagnosis and Treatment of Ovarian Cancer

HU Yong-chao, ZHANG Rong-hua, KANG Cong-li

2025, 43(11):  180-184. 

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Objective To investigate the value of combined detection of serum tumor marker carbohydrate antigen 125 (CA125), human epididymis protein 4 (HE4) and carcinoembryonic antigen (CEA) in the diagnosis, treatment and prognosis of ovarian cancer (OC). Methods A total of 103 OC patients diagnosed and treated for the first time in Rizhao People's Hospital from January 2018 to June 2019 were selected as the study subjects (OC group), among which 63 OC patients received neoadjuvant chemotherapy before surgery, 45 patients in the effective chemotherapy group and 18 patients in the ineffective chemotherapy group. At the same time, 52 patients with benign ovarian lesions who came to the hospital during the same period were selected as the benign control group, all of whom had serum CA125, HE4 and CEA examination data. Results The serum levels of CA125, HE4 and CEA in OC group were higher than those in control group, and the difference was statistically significant (P<0.05). The levels of serum CA125, HE4 and CEA in OC group with clinical high stage (Ⅲ~Ⅳ) were higher than those in clinical low stage (Ⅰ~Ⅱ), and the difference was statistically significant (P<0.05). There was no statistically significant difference in serum CA125, HE4 and CEA levels between the effective group and the ineffective group before neoadjuvant chemotherapy (P>0.05). There was no statistically significant difference in serum marker levels between the ineffective group after neoadjuvant chemotherapy and before chemotherapy (P>0.05). Serum marker levels in the effective group after chemotherapy were lower than those before chemotherapy. The difference was statistically significant (P<0.05). Receiver operating characteristic (ROC) curve showed that the area under the curve (AUC) of the combined detection of serum CA125, HE4 and CEA was 0.910 and the sensitivity was 91.26%, which was higher than that of each single detection, and the difference was statistically significant (P<0.05). The 5-year incident-free rate of serum CA125, HE4 and CEA in high expression group was lower than that in low expression group, and the difference was statistically significant (P<0.05). Conclusion The combined detection of serum CA125, HE4 and CEA can improve the diagnostic value of OC, and can guide the clinical formulation of treatment and prognosis evaluation according to the expression level.

Application of PDCA Cycle Method in Hospital Public Health Management

ZHAO Yan

2025, 43(11):  193-196. 

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Objective To explore the application methods and effects of PDCA cycle method during hospital public health management. Methods 50 medical staff responsible for public health management in Ganjiakou Community Health Service Center from January 2022 to January 2023 were selected as cases for study and analysis. According to the PDCA cycle method before and after implementation, it was defined as a conventional group and an experimental group.The conventional group adopted a basic public health management model, and the experimental group applied the PDCA cycle management model.Analyze and compare the satisfaction of the two groups of staff with the management model, management quality scores, and scores on health management projects. Results The satisfaction of staff in the experimental group with health management was significantly higher than that of the conventional group, and the data comparison was statistically significant(P<0.05). The score of the management quality of the experimental group was significantly better than that of the conventional group, and the data comparison was statistically significant(P<0.05). The score results of health management items in the experimental group were significantly higher than those in the conventional group, and the data comparison was statistically significant(P<0.05). Conclusion Applying the PDCA cycle method during hospital public health management can effectively improve the overall management quality.Not only can you effectively improve staff recognition of the management model, but it can also significantly improve the overall management quality and ensure the overall level of health management.