Table of Content

16 May 2025, Volume 43 Issue 10

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Mitochondrial Dysfunction and Lipid Metabolism Disorder in Podocytes of Diabetic Nephropathy and Exploration of Traditional Chinese Medicine Treatment

HUANG Zhen-yu, ZHU Cai-feng, LI Ya-yu, YIN Jia-zhen, YU Cao

2025, 43(10):  1-6. 

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Diabetic nephropathy (DN), one of the microvascular complications of diabetes, is clinically characterized by progressive decrease of albuminuria and glomerular filtration rate. In recent years, the role of podocyte injury in the pathogenesis of DN has become a focus of research. Hemodynamic abnormalities, oxidative stress, autophagy, apoptosis, mitochondrial dysfunction and lipid metabolism disorders all lead to podocyte injury. This paper discusses the relationship between podocyte injury and mitochondrial dysfunction and lipid metabolism disorder in diabetic nephropathy, and summarizes the existing Chinese medicine monomers and compound therapies targeting this pathway and protecting podocyte. The findings summarized here may provide potential therapeutic targets and strategies for the management of DN associated with podocyte injury.

Expression of Long Non-Coding RNA MEG3 in Papillary Thyroid Carcinoma and Its Relationship with Clinical Prognosis

CHEN Ying, DUAN Wen-ping, WANG Fang-fang, WU Xi-jiang, HUANG Ting-ting, ZHANG Feng-ying

2025, 43(10):  7-11. 

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Objective To investigate the expression level of long non-coding RNA MEG3 in patients with papillary thyroid carcinoma (PTC) and its relationship with clinicopathological features and prognosis. Methods A total of 78 patients who were treated for papillary thyroid cancer in my Hospital from April 2020 to March 2022 were selected as the study objects. Cancer tissue and para-cancer tissue (distance from the edge of cancer tissue>1cm) were taken from patients during operation; lncRNA MEG3 expression levels were detected by fluorescence quantitative PCR. The PTC patients were followed up for 24 months. Clinical data and clinicopathological features of patients were collected and analyzed. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of MEG3 on PTC patients Kaplan-Meier and multi-factor Logistics regression analysis were used to analyze the 3-year survival of patients and the factors affecting the poor prognosis of PTC. Results MEG3 expression level in patients with PTC was lower than that in control group , and the difference was statistically significant (P<0.05); The expression level of MEG3 was correlated with tumor differentiation, TNM stage and lymph node metastasis in PTC patients (P<0.05), was not related to patient gender, age, tumor diameter, number of lesions (P>0.05), the MEG3 expression level in the poor prognosis group was lower than that in the favourable prognosis group , and the difference was statistically significant (P<0.05). The area under ROC curve of MEG3 for the diagnosis of thyroid papillary carcinoma was 0.882, the diagnostic sensitivity was 82.1%, and the specificity was 79.5%. The survival rate of patients with high MEG3 expression was significantly higher than that of patients with low MEG3 expression. Low MEG3 expression, low tumor differentiation, TNM stage Ⅲ-Ⅳ, and lymph node metastasis were independent risk factors for poor prognosis in patients with papillary thyroid carcinoma (P<0.05). Conclusion MEG3 is low expression in patients with PTC, which may be involved in the occurrence and development of PTC. MEG3 is an independent risk factor affecting the prognosis of patients with PTC, and can be used as a potential marker for the prognosis evaluation of PTC.

Research Progress on Influencing Factors and Intervention Strategies for Fear of Disease Progression in Patients with Acute Myocardial Infarction

JIAO Lin-lin, LIU Li-li, SUI Yuan-da, NIE Jing, YANG Chun-ling

2025, 43(10):  11-16. 

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Acute myocardial infarction is the most serious manifestation of coronary artery disease, and its incidence is rising and showing a younger trend. AMI patients are prone to fear of disease progression after onset. Some progress has been made in the research on the progression of fear disease in AMI patients abroad, while it is still in its infancy in China. Therefore, this article reviews the concept, current situation, evaluation tools, influencing factors, and intervention strategies of fear of disease progression in AMI patients, in order to provide theoretical basis for the development of fear of disease progression in AMI patients.

An Empirical Analysis on the Treatment of Chronic Throat Impediment Based on the Theory of "Three Talents"

WEN Jin-ling, YUAN Yue-peng, HONG Ya-li, FA Qiang, LI Jie, JIA Fu-tao, ZHANG Zhen-yu, ZHANG Ying-peng

2025, 43(10):  20-23. 

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The theory of Three Elements in Traditional Chinese Medicine refers to the interrelationship and unity among "Heaven, Earth and Man". In Traditional Chinese Medicine theory, Heaven represents the natural environment and the laws of the universe, Earth represents the growth environment and the material basis, and Man is the subject in this system and also the core of medical attention. The three interact with each other to jointly maintain the healthy state of the human body. Meanwhile, as a theory, it also guides the treatment of human diseases in Traditional Chinese Medicine. Chronic Laryngeal Obstruction, also known as chronic pharyngitis, is a common and difficult-to-cure laryngeal disease. Its symptoms are mostly manifested as dry throat, sore throat, itchy throat, foreign body sensation in the throat, etc., which seriously affects the quality of life of patients. This article will explore the experience in treating Chronic Laryngeal Obstruction based on the "Three Elements" theory.

Clinical Efficacy of Diammonium Glycyrrhizinate Capsules in the Treatment of Elderly Liver Dysfunction

YAO Zai-rong, BAI Li-jun

2025, 43(10):  60-64. 

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Objective To explore the clinical efficacy of using diammonium glycyrrhizinate capsules for the treatment of elderly patients with liver dysfunction. Methods A total of 80 elderly patients with liver dysfunction from March 2020 to March 2023 who were admitted in Binzhou Bincheng District People's Hospital were selected, and randomly divided into the study group and the control group, each group consisted of 40 cases. The control group was treated with glucuronic acid tablets, and the study group was treated with diammonium glycyrrhizinate capsules.The clinical efficacy,liver function, oxidative stress indicators,and adverse reactions in both groups were compared. Results The total effective rate of treatment in the study group was higher than that in the control group, and the difference was statistically significant(P<0.05). After treatment,the alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil), and gamma glutamyl transpeptidase (γ-GT) levels in both groups were decreased(P<0.05), and in comparison of the control group, the study group was lower,and the study group was lower than the control group, with a statistically significant difference(P<0.05). After treatment,the superoxide dismutase (SOD) and glutathione (GSH) levels in both groups were increased, the malondialdehyde (MDA) levels were decreased The levels of SOD and GSH in the study group were higher than those in the control group, and the level of MDA was lower, with statistical significance (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The application of diammonium glycyrrhetinic acid capsules in the treatment of elderly liver dysfunction can improve clinical efficacy,improve patient liver function, alleviate oxidative stress reactions,and not lead to an increase in adverse reactions.

Analysis of Dried Fruit Taste Efficacy and Health Preservation Application in Compendium of Materia Medica

LI Yi-wen, CHEN Di-ping, LI Yao, LENG Xin, GUO Ping, FAN Jia-qi, WANG Ya-jun, MIN Jun, LU Xiang-yu

2025, 43(10):  85-89. 

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“Compendium of Materia Medica” is the precious heritage of ancient Chinese medicine and botany. The book contains 19 kinds of dried fruits. It is found that dried fruits have the characteristics of flat and warm, sweet or bitter taste, and can supplement and reap astringent. Modern studies at home and abroad have found that the modern ingredients of dried fruit are rich in protein, fat, carbohydrates and multiple vitamins, etc. Combining traditional medicine with modern medicine, this paper analyzes and summarizes the choice and condications suitable for different people to eat dried fruit, such as cough, insomnia, forgetfulness, diarrhea, constipation, etc. In order to provide a useful reference for the in-depth study of “Compendium of Materia Medica”, the application of dried fruit in health and the development of dried fruit products in China.

A Study on the Effect of Traditional Chinese Medicine Emotional Nursing Application in Psychological Nursing of Emergency Patients

SU Qian

2025, 43(10):  122-125. 

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Objective To explore the effect and clinical value of emotional nursing of traditional Chinese medicine in psychological nursing of emergency patients. Methods From October 2021 to October 2023 in the emergency department of Dezhou Traditional Chinese Medicine Hospital, 110 patients were randomly collected as observation objects, and the observation objects were divided into two groups according to the order of admission-control group and study group. For 55 patients who were included in the control group, they were given routine emergency measures and nursing intervention. For 55 patients who were included in the study group, they were given emotional care of traditional Chinese medicine on the basis of patients in the control group, and the two groups were compared. Results The scores of tension, anger, fatigue, depression and panic in the study group were significantly lower than those in the control group, and the scores of energy were significantly higher than those in the control group, and the difference was statistically significant (P<0.05). The statistical results of symptom control time and hospitalization time in the study group were significantly shorter than those in the control group, and the difference was statistically significant (P<0.05). The satisfaction scores of the patients in the study group on the service attitude, nursing comfort, psychological support and health education of nurses were significantly higher than those in the control group, and the difference was statistically significant (P<0.05). Conclusion The emotional nursing of TCM in the psychological nursing of emergency patients can effectively improve the patients' bad psychological state during the period of medical treatment, promote the prognosis of patients' diseases and improve the satisfaction of patients' nursing quality.

Application Effect and Nursing Observation of Thunder Fire Moxibustion Combined with Warm Umbilical Patch in Patients with Spleen and Stomach Deficiency Cold Type Stomach Duct Pain

JIA Ying, ZHAO Zhu-hua

2025, 43(10):  129-133. 

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Objective To analyze the clinical value of combined intervention of thunder fire moxibustion and warm umbilical patch on gastric duct pain (spleen and stomach deficiency cold type). Methods A total of 86 patients with gastric epigastric pain (spleen and stomach asthenic cold type) admitted to Xuzhou Hospital of Traditional Chinese Medicine from June 2023 to March 2024 were divided into two groups by random number table: control group (43) with routine nursing intervention, observation group (43) with the addition of thunk-fire moxibustion + warm umbilical patch intervention; The clinical efficacy, symptom score, pain degree, quality of life and patient satisfaction of the two groups were analyzed. Results The clinical effective rate of the observation group was higher than that of the control group (P<0.05). The TCM syndrome score in the observation group was lower than that in the control group (P<0.05). The pain score (VAS) of the inspection group was lower than that of the control group (P<0.05). The quality of life score of the observation group was higher than that of the control group (P<0.05).The satisfaction of patients in the observation group was higher than that in the control group (P<0.05). Conclusion The combined intervention effect of thunder fire moxibustion and warm umbilical patch on gastric epigastric pain (spleen and stomach asthenic cold type) is significant, which can reduce the pain degree of patients, improve their clinical symptoms, and enhance the quality of life, which is recognized and has the value of popularization and implementation.

The Impact of Appropriate Traditional Chinese Medicine Techniques Combined with Palliative Care on Negative Emotions and Quality of Life in End-Stage Cancer Patients

ZHANG Tang-juan

2025, 43(10):  140-143. 

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Objective To explore the impact of appropriate traditional Chinese medicine techniques combined with palliative care on negative emotions and quality of life in end-stage cancer patients. Methods A retrospective analysis was used. A total of 116 cases of terminal malignant tumour patients who were hospitalized in the oncology department of the hospital from February 2021 to January 2024 were selected as research subjects. Different nursing programmes were used to divide them into a control group and an observation group, with 52 cases in the control group adopting hospice care; 64 cases in the observation group adopting appropriate techniques of Chinese medicine on the basis of the control group; the two groups were intervened continuously for 8 weeks. Compare the quality of life, changes in negatire emotions, sense of life meaning of the two groups. Result Comparison of negative emotion, quality of life and meaning of life scores between the two groups before intervention, the difference was not statistically significant (P>0.05).After 8 weeks of intervention, the negative mood scores of both groups were lower than those before intervention, and the quality of life and sense of meaning of life were higher than those before intervention, and the depression, anxiety, interpersonal disorders, and scepticism of the observation group were lower than those of the control group, and the acceptance and adaptation to life, attitude to life, self-control, interpersonal relationships, and goals of life, and the scores of physical, role, cognitive, and social functioning were higher than those of the control group, with the differences being statistically significant (P<0.05). Conclusion The combination of appropriate traditional Chinese medicine techniques and palliative care can improve the negative emotions of end-stage cancer patients, help them gain the meaning of life, and improve their quality of life.

Clinical Observation of Ultrasound-Guided Traditional Chinese Medicine Fascial Knife Combined with Ozone Injection in the Treatment of Periarthritis of the Shoulder

JIANG Rui-guo, SONG Li-juan, REN Chang-ji, KONG Fan-hao, LI Yan-sheng, JIANG Rui-min, MOU Heng-zhi, DONG Zhen-bin

2025, 43(10):  170-173. 

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Objective To explore and analyze the clinical effect of ultrasound-guided traditional Chinese medicine (TCM) fascial knife combined with ozone in the treatment of periarthritis of the shoulder. Methods A total of 92 patients with periarthritis of the shoulder who were treated in the of Pain in Qingzhou People's Hospital from January 2023 to April 2024 were selected for this study.They were divided into two groups according to the treatment methods: the ultrasound-guided TCM fascial knife combined with ozone injection treatment group (Group A) and the treatment group (Group B), with 46 cases in each group. After one month of treatment,the overall effective rate,constant score, and visual anal scale (VAS) score were evaluated. Results After 1 month of treatment, the total response rate was higher than group B,statistically significant difference (P<0.05). After 1 month of treatment, Constant scores and VAS scores in both groups improved significantly compared with before treatment, and group A improved more significantly compared with group B, with A statistically significant difference (P<0.05). Conclusion The clinical efficacy of treating periarthritis of the shoulder with traditional Chinese medicine's Jingjin knife combined with ozone injection under the guidance of color Dop ultrasound is definite.It can significantly improve shoulder joint function and obviously alleviate shoulder pain, which is superior to conventional treatment.

Value of CA153, CA125 and CEA Combined Tests in Diagnosis and Prognosis Assessment of Breast Cancer

LI Wei, ZHOU Wu-song

2025, 43(10):  174-178. 

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Objective To evaluate the value of combined detection of serum carbohydrate antigen 153 (CA153), carbohydrate antigen 125 (CA125) and carcinoembryonic antigen (CEA) in the diagnosis and prognosis of breast cancer (BC). Methods The clinical case data of 112 BC patients (breast cancer group) who were initially treated in Yantai Laiyang Central Hospital from January 2017 to June 2019, and 50 patients with benign breast lesions (benign control group) who visited the hospital during the same period were collected.Serum CA153,CA125 and CEA were detected in both groups. Results The serum levels of CA153,CA125 and CEA in breast cancer group were higher than those in benign control group,and the difference was statistically significant(P<0.05).The sensitivity,accuracy and negative predictive value of serum CA153 and CA125 combined with CEA in the diagnosis of BC were higher than those of single serum markers, and the differences were statistically significant (P<0.05).The 5-year no-event incidence rate in the BC serum CA153, CA125, and CEA high-level expression group was lower than that of the low-level expression group, which was statistically significant (P<0.05). Conclusion CA153,CA125 combined with CEA can improve the diagnostic value of BC, and the long-term prognosis of patients with high expression of CA153 and CA125 is worse.

Observation on the Efficacy of Cyproheptadine Combined with Ibuprofen in the Treatment of Vestibular Migraine

LU Shi-gang

2025, 43(10):  189-193. 

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Objective To explore the clinical effect of cyproheptadine combined with ibuprofen on acute vestibular migraine with dizziness and vertigo. Methods A total of 105 patients with vestibular migraine were prospectively selected from March 2020 to March 2024 in the Department of Neurology, Shan County Central Hospital, Jining Medical College. The patients were divided into two groups by random number table method. 53 patients in the observation group were treated with cyprohepidine combined with ibuprofen. Control group 52 cases were treated with betahistine mesylate and ibuprofen. Patients in both groups continued to take medication for 3 days, during which the degree of dizziness, duration, degree of headache, duration and other data were recorded in detail, and statistical analysis was carried out. Results Before treatment, there was no difference in vestibular symptom index (VSI) score and duration of dizziness between the two groups (P>0.05). After treatment, the VSI score and duration of dizziness and vertigo in both groups were lower than before treatment, and the observation group was lower than the control group, with statistical significance (P<0.05). Before treatment, there was no difference in visual analogue scale (VAS) score and headache duration between the two groups (P>0.05). After treatment, VAS scores and headache duration of both groups were lower than before treatment, and observation group was lower than control group, the difference was statistically significant (P<0.05). There was no difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Combined treatment with cyprohepidine and ibuprofen can significantly reduce the degree of vertigo and shorten the duration of vertigo and headache, which has clinical application value.