Abstract: Objective To explore the clinical effect of cyproheptadine combined with ibuprofen on acute vestibular migraine with dizziness and vertigo. Methods A total of 105 patients with vestibular migraine were prospectively selected from March 2020 to March 2024 in the Department of Neurology, Shan County Central Hospital, Jining Medical College. The patients were divided into two groups by random number table method. 53 patients in the observation group were treated with cyprohepidine combined with ibuprofen. Control group 52 cases were treated with betahistine mesylate and ibuprofen. Patients in both groups continued to take medication for 3 days, during which the degree of dizziness, duration, degree of headache, duration and other data were recorded in detail, and statistical analysis was carried out. Results Before treatment, there was no difference in vestibular symptom index (VSI) score and duration of dizziness between the two groups (P>0.05). After treatment, the VSI score and duration of dizziness and vertigo in both groups were lower than before treatment, and the observation group was lower than the control group, with statistical significance (P<0.05). Before treatment, there was no difference in visual analogue scale (VAS) score and headache duration between the two groups (P>0.05). After treatment, VAS scores and headache duration of both groups were lower than before treatment, and observation group was lower than control group, the difference was statistically significant (P<0.05). There was no difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Combined treatment with cyprohepidine and ibuprofen can significantly reduce the degree of vertigo and shorten the duration of vertigo and headache, which has clinical application value.

Key words: cyproheptadine, ibuprofen, dizziness, vertigo, vestibular migraine, adverse reaction