Expression of Long Non-Coding RNA MEG3 in Papillary Thyroid Carcinoma and Its Relationship with Clinical Prognosis

Abstract

Abstract: Objective To investigate the expression level of long non-coding RNA MEG3 in patients with papillary thyroid carcinoma (PTC) and its relationship with clinicopathological features and prognosis. Methods A total of 78 patients who were treated for papillary thyroid cancer in my Hospital from April 2020 to March 2022 were selected as the study objects. Cancer tissue and para-cancer tissue (distance from the edge of cancer tissue>1cm) were taken from patients during operation; lncRNA MEG3 expression levels were detected by fluorescence quantitative PCR. The PTC patients were followed up for 24 months. Clinical data and clinicopathological features of patients were collected and analyzed. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of MEG3 on PTC patients Kaplan-Meier and multi-factor Logistics regression analysis were used to analyze the 3-year survival of patients and the factors affecting the poor prognosis of PTC. Results MEG3 expression level in patients with PTC was lower than that in control group , and the difference was statistically significant (P<0.05); The expression level of MEG3 was correlated with tumor differentiation, TNM stage and lymph node metastasis in PTC patients (P<0.05), was not related to patient gender, age, tumor diameter, number of lesions (P>0.05), the MEG3 expression level in the poor prognosis group was lower than that in the favourable prognosis group , and the difference was statistically significant (P<0.05). The area under ROC curve of MEG3 for the diagnosis of thyroid papillary carcinoma was 0.882, the diagnostic sensitivity was 82.1%, and the specificity was 79.5%. The survival rate of patients with high MEG3 expression was significantly higher than that of patients with low MEG3 expression. Low MEG3 expression, low tumor differentiation, TNM stage Ⅲ-Ⅳ, and lymph node metastasis were independent risk factors for poor prognosis in patients with papillary thyroid carcinoma (P<0.05). Conclusion MEG3 is low expression in patients with PTC, which may be involved in the occurrence and development of PTC. MEG3 is an independent risk factor affecting the prognosis of patients with PTC, and can be used as a potential marker for the prognosis evaluation of PTC.

Key words: papillary thyroid carcinoma, lncRNA MEG3, clinical features, prognosis

CLC Number:

R737.9

CHEN Ying, DUAN Wen-ping, WANG Fang-fang, WU Xi-jiang, HUANG Ting-ting, ZHANG Feng-ying. Expression of Long Non-Coding RNA MEG3 in Papillary Thyroid Carcinoma and Its Relationship with Clinical Prognosis[J]. ZHONGHUA YANGSHENG BAOJIAN, 2025, 43(10): 7-11.

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