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ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (18): 55-58.   Abstract （545）      PDF（pc） （2018KB）（25）       Knowledge map    Save Reference | Related Articles | Metrics

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ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (23): 44-47.   Abstract （523）      PDF（pc） （1935KB）（16）       Knowledge map    Save Reference | Related Articles | Metrics

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ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (17): 29-32.   Abstract （520）      PDF（pc） （2017KB）（15）       Knowledge map    Save Reference | Related Articles | Metrics

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ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (13): 52-55.   Abstract （514）      PDF（pc） （4341KB）（14）       Knowledge map    Save Reference | Related Articles | Metrics

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ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (23): 114-116.   Abstract （493）      PDF（pc） （1934KB）（16）       Knowledge map    Save Reference | Related Articles | Metrics

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Analysis of Therapeutic Effect of Clostridium Butyricum Capsule Combined with Compound Glutamine Enteric Coated Capsule on Patients with Ulcerative Colitis GAO Xiang-jun, WANG Shu-ping ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (19): 173-176.   Abstract （487）      PDF（pc） （2122KB）（13）       Knowledge map    Save Objective To investigate the effect of clostridium butyricum capsule combined with compound glutamine enteric coated capsule on patients with ulcerative colitis. Methods A total of 120 patients with ulcerative colitis admitted to Dongchangfu People's Hospital of Liaocheng city from January 2019 to December 2021 was selected. The lottery method was divided into two groups. The control group was given Clostridium butyricum capsules, and the observation group was given compound glutamine enteric coated capsules. To compare the efficacy of the two groups, the serum tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), hypersensitive C-reactive protein (hs-CRP), IL-6, intestinal barrier function (D-lactic acid, diamine oxidase, and bacterial endotoxin), and stool, abdominal pain, mucosal diarrhea were scores. Results The effective rate of the observation group was significantly higher than control group(P<0.05). Before treatment, there was no significant difference in the levels of TNF-α, IL-2, hs-CRP and IL-6(P>0.05). After treatment, serum TNF-α, IL-2, hs-CRP and IL-6 decreased significantly(P<0.05), and serum TNF -α, IL-2, hs-CRP and IL-6 in the observation group were significantly lower(P<0.05). Before treatment, the levels of D-lactic acid, diamine oxidase and bacterial endotoxin in the two groups had no significant difference(P>0.05). After treatment, the levels of D-lactic acid, diamine oxidase and bacterial endotoxin in the two groups were significantly reduced(P<0.05), and the levels of D-lactic acid, diamine oxidase and bacterial endotoxin in the observation group were significantly lower than those in the control group(P<0.05). Before treatment, there was no significant difference in the scores of purulent stool, abdominal pain, mucosal lesions and diarrhea symptoms between the two groups(P>0.05). After treatment, the scores of purulent stool, abdominal pain, mucosal lesions and diarrhea symptoms in the two groups were significantly reduced(P<0.05), and the scores of purulent stool, abdominal pain, mucosal lesions and diarrhea in the observation group were significantly lower than those in the control group(P<0.05). Conclusion Clostridium butyricum capsule combined with compound glutamine enteric-coated capsule has significant efficacy in patients with ulcerative colitis, Reference | Related Articles | Metrics

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ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (21): 106-108.   Abstract （481）      PDF（pc） （1517KB）（4）       Knowledge map    Save Reference | Related Articles | Metrics

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Effect of Up Regulating miR-590-3p on Invasion and Metastasis of Pancreatic Cancer Cells and Its Mechanism WANG Ya-dong, WANG Jun-feng ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (23): 4-8.   Abstract （473）      PDF（pc） （2292KB）（42）       Knowledge map    Save Objective To observe the effect of miR-590-3p gene expression on the invasion and metastasis of human pancreatic cancer Capan-2 cells. Methods Human pancreatic cancer Capan-2 cells were divided into two groups: negative control group (NC group) and miR-590-3p up-regulated group (miR-590-3p mimics group). The expression of miR-590-3p in human normal pancreatic ductal epithelial cells hTERT-HPNE and pancreatic cancer Capan-2 cells was detected by qRT PCR. The effect of miR-590-3p on the apoptosis of Capan-2 cells was detected by flow cytometry, the effect of miR-590-3p on the proliferation of Capan-2 cells was detected by MTT test, the change of cell migration ability was detected by scratch test, and the change of cell invasion ability was detected by Transwell test, the expression of AKT/mTOR pathway related proteins was detected by Western blot. Results The expression level of miR-590-3p in Capan-2 cells of pancreatic cancer was significantly lower than that in normal pancreatic duct epithelial cells, and the expression level of miR-590-3p mRNA in miR-590-3p mimics group was significantly higher than that in NC group (P<0.05). The results of flow cytometry showed that the level of apoptosis in miR-590-3p mimics group was significantly higher than that in NC group (P<0.05). The results of cell scratch and invasion test showed that the migration and invasion ability of miR-590-3p mimics group was significantly lower than that of NC group (P<0.05). Western blot results showed that compared with the NC group, the levels of p-AKT and p-mTOR proteins in the miR-590-3p mimics group were significantly reduced. Conclusion Up regulation of miR-590-3p expression can increase the apoptosis of pancreatic cancer cells and inhibit the migration and invasion of pancreatic cancer cells. Reference | Related Articles | Metrics

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ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (22): 83-86.   Abstract （459）      PDF（pc） （1986KB）（17）       Knowledge map    Save Reference | Related Articles | Metrics

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ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (11): 195-196.   Abstract （445）      PDF（pc） （3548KB）（8）       Knowledge map    Save Reference | Related Articles | Metrics

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Clinical Observation of Graphene Light Wave Energy Sweat Room Therapy Combined with Acupuncture and Moxibustion for Insomnia after Stroke NONG Jin-li, CUI Hong-yun, CHEN Jing-jing, TAN Liang-yuan, TAN Xu-rong, CHEN Zi-yu, ZHANG Ye, YANG Pei-pei, WANG Kai-long, JIANG Min-jie, LENG Jing ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (22): 18-21.   Abstract （395）      PDF（pc） （2150KB）（58）       Knowledge map    Save Objective To observe the clinical effect of graphene light wave energy sweat room therapy combined with acupuncture and moxibustion on insomnia after stroke. Methods Using a completely randomized controlled method, 60 patients with post-stroke insomnia hospitalized in the First Affiliated Hospital of Guangxi University of Chinese Medicine from January 2022 to December 2022 were divided into control group and treatment group, with 30 cases in each group. The control group was treated with ordinary acupuncture, and the treatment group was treated with graphene light wave energy sweat chamber therapy on the basis of ordinary acupuncture. The Pittsburgh Sleep Quality Inventory (PSQI) of the two groups of patients was recorded before and 21 days after treatment, respectively Athens Insomnia Scale (AIS) and National Institutes of Health Stroke Scale (NIHSS)score were used to evaluate the sleep quality of patients and the recovery of various stroke indicators. Results After 21 days of treatment, the PSQI score, AIS score, and NIHSS score of both groups decreased compared to before treatment (P<0.01), and the treatment group was better than the control group (P<0.05). After 21 days of treatment, the total effective rate of the treatment group was better than that of the control group (P<0.05). Conclusion Both graphene light wave energy sweat steaming room therapy and ordinary acupuncture treatment can effectively improve sleep and neurological function in stroke patients, but graphene light wave energy sweat steaming room therapy is superior to ordinary acupuncture treatment. Reference | Related Articles | Metrics

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ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (16): 40-42.   Abstract （357）      PDF（pc） （1983KB）（11）       Knowledge map    Save Reference | Related Articles | Metrics

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Clinical Study on Lowering Blood Lipid Level by Lifestyle Control Combined with Nattokinase (NK) - Red Yeast Rice (RYR) Capsules YU Feng-chun, ZHOU Yang, ZHANG Xin-yu, FAN Cheng-zhe, LI Hui-jun, SONG Zhe, CHEN Zhi-gang, BI Qi ZHONGHUA YANGSHENG BAOJIAN    2024, 42 (4): 15-19.   Abstract （336）      PDF（pc） （2358KB）（34）       Knowledge map    Save Objective To study the efficacy and safety of lifestyle control combined with Nattokinase Red yeast rice(NK-RYR) capsules in reducing blood lipids. Methods Hyperlipidemia volunteers were recruited according to inclusion and exclusion criteria, and randomly divided into NK-RYR capsules group (lifestyle control + NK-RYR capsules) with 20 cases and lifestyle control group (lifestyle control alone) with 10 cases according to the ratio of 2:1. Lifestyle control was carried out in both groups during the experiment. The NK-RYR capsules group received Chongjian NK-RYR capsules (1.35g bid) at the same time, for a total of 90 days. All subjects were interviewed on 0 d, 30 d, 60 d and 90 d after enrollment, and the four items of blood lipids, liver and kidney function and adverse events at each site were recorded on 0d and 90d. Four items of blood lipids, changes of liver and kidney function and adverse events before and after the two groups were compared. Results Low density lipoprotein cholesterol (LDL-C) was significantly decreased in the NK-RYR capsules group before and after the test (P<0.05). total cholesterol (TC) decreased significantly (P<0.05); There was no significant difference in LDL-C and TC levels in lifestyle control group (P>0.05). There was no significant difference in High density lipoprotein cholesterol (HDL-C) between the two groups before and after each test (P>0.05). There was no significant difference in triglyceride (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum creatinine before and after the trial between the two groups (P>0.05), and no adverse events occurred during the trial between the two groups. Conclusion Compared with lifestyle control alone, the combination of lifestyle control and NK-RYR capsules can reduce LDL-C and TC levels in hyperlipidemia patients. Reference | Related Articles | Metrics

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Analysis of the Efficacy of Ieccitonin and Teriparatide in Osteoporosis in Elderly Women HAN Mei ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (15): 12-15.   Abstract （332）      PDF（pc） （2053KB）（36）       Knowledge map    Save Objective To explore the efficacy of leccitonin combined with teriparatide on osteoporosis in elderly women. Methods 100 patients elderly female with osteoporosis who were hospitalized in China Hospital of Heibo Bay District, Wuhai City, Inner Mongolia from January 2019 to June 2022 were selected for the study. The patients were divided into observation group and control group, with 50 cases in each group. The patients in the control group were treated with triiodol, while the patients in the observation group were treated with calcitonin combined with triiodol. The clinical effects of the two groups were compared, before and after treatment, bone metabolism marker type 1 collagen carboxyterminal cross-linked end peptide (CTx) and bone mineral density (BMD), blood calcium (Ca) and 25 hydroxyvitamin D (25-OH-D) and sex hormone [follicle hormone (FSH), progesterone (P), estradiol (E2)] levels. Results The total response rate of the observation group was significantly higher than that of the control group (P<0.05). There was no significant difference between the first carboxyl crosslinked peptide (CTx) and BMD of type 1 collagen (P>0.05), CTx, and BMD were increased after treatment, And the observation group was higher than the control group (P<0.05). There was no significant difference in 25-OH-D and Ca levels between the two groups (P>0.05), 25-OH-D and Ca levels were increased in two groups, And the observation group was higher than the control group (P<0.05). After treatment, FSH, P, E2 were decreased, And the observation group was significantly lower than the control group (P<0.05). Conclusion Which improved the bone metabolism and bone density of the elderly female patients. The increase of calcium and vitamin D levels in blood and the increase of sex hormone levels are worthy of clinical application. Reference | Related Articles | Metrics

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Observation on the Curative Effect of Maxingshigan Decoction Combined with Doxycycline in the Treatment of Patients with High Fever Due to Lung Disease XIAN Xue-Mei, SHAO Jing-Tian ZHONGHUA YANGSHENG BAOJIAN    2024, 42 (1): 20-23.   Abstract （324）      PDF（pc） （1575KB）（74）       Knowledge map    Save Objective To observe the clinical effect of Maxingshigan Decoction combined with doxycycline in the treatment of pulmonary fever. Methods A total of 100 patients with lung disease admitted to Enping Branch of Jiangmen Wuyi Hospital of Traditional Chinese Medicine from January 2021 to June 2021 were selected as research objects, and randomly divided into control group (n=50) and observation group (n=50). The control group was given doxycycline treatment, and the observation group was given doxycycline combined with Maxingshigan decoction plus or minus treatment. The therapeutic effect and the changes of related inflammatory indexes were compared between the two groups. Results The total response rate of the observation group was significantly higher than the control group, statistically significant (P<0.05). In the observation group, fever, cough and expectoration were significantly shorter than those in the control group, and the difference was significant (P<0.05). The inflammatory index was significantly lower than the control group, significant (P<0.05). The incidence of adverse reactions between the two groups was not significant (P>0.05). Conclusion Compared with doxycycline alone, Maxingshigan Decoction combined with dotetracycline has obvious advantages in the treatment of patients with lung disease and high fever. It can significantly shorten the time of disappearance of clinical symptoms and reduce related inflammatory indicators, with high safety. Reference | Related Articles | Metrics

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Clinical Study on Pediatric Xiaoer Xiaoji Cough Oral Liquid Combined with Montelukast Sodium and Terbutaline in the Treatment of Chronic Cough Variant Asthma in Children GU Fu-rong, FAN Hai-ting ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (23): 31-34.   Abstract （313）      PDF（pc） （2096KB）（15）       Knowledge map    Save Objective To observe the clinical effect of xiaoer Xiaoji cough oral liquid combined with Montelukast sodium and Terbutaline in the treatment of chronic cough variant asthma CVA in children. Methods From January 2018 to December 2022, sixty patients with CVA were selected and randomly divided into treatment group and control group, with 30 Datients in each group. The control group was given atomized terbutaline, oral Montelukast sodium chewable tablets. On the basis of control group, xiaoer Xiaoji cough oral liquid was added to the treatment group, 3 times/day, 15~20 mL/time, for 14 consecutive days. The percentage of eosinophil granulosis (EOS), the level of hypersensitive C-reactive protein (hs-CRP), the duration of cough remission, clinical efficacy, and the incidence of adverse events were recorded and statistically analyzed before and after treatment. Results After treatment, EOS and hs-CRP in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the remission time of cough in treatment group was shorter than that in control group, and the difference was statistically significant (P<0.05). The effective rate of treatment group was higher than control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse events between the two groups (P>0.05). Conclusion Pediatric xiaoer Xiaoji cough oral liquid combined with Montelukast sodium and Terbutaline in the treatment of children's CVA can more effectively reduce blood inflammation indicators, improve cough symptoms faster, the incidence of adverse events during the treatment process did not increase, which is worthy of further clinical recommendation. Reference | Related Articles | Metrics

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ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (13): 93-96.   Abstract （301）      PDF（pc） （4462KB）（10）       Knowledge map    Save Reference | Related Articles | Metrics

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Effect of Xiaochaihu Powder Combined with Paediatric Paracetamol Pseudoephedrine Tablets on Gastrointestinal Cold and the Expression of Serum Inflammatory Factors ZHU Wei, WANG Li-jun ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (23): 28-30.   Abstract （293）      PDF（pc） （2078KB）（34）       Knowledge map    Save Objective To investigate the effect of Xiaochaihu powder combined with paediatric paracetamol and pseudoephedrine tablets in the treatment of gastrointestinal cold and its influence on the expression of serum inflammatory factors. Methods From January 2022 to January 2023, 100 children with gastrointestinal cold who were treated in Jilin Provincial Maternal and Child Health Hospital were selected as the research subjects. Accorded to the principle of 1:1 random envelope drawing, 100 children were divided into two groups: the control group (50 cases) and the experimental group (50 cases). The control group were treated with paediatric paracetamol pseudoanesthesia tablets. The experimental group were treated with Xiaochaihu powder on the basis of the treatment of the control group. The two groups were treated and observed for 7 days, The therapeutic effect and the expression of serum inflammatory factors in the two groups were observed and recorded. Results After treatment, the total effective rates of the experimental group were 98.00%, which were significantly higher than that of the control group (84.00%, P<0.05). The disappearance time of cough, runny nose, stuffy nose, fever, lung rale and other symptoms in the experimental group were significantly lower than that in the control group (P<0.05). The incidence rates of adverse reactions such as headache, dizziness, nausea and vomiting, general soreness and dry mouth in the experimental group during the treatment period were 6.00%, and there were no significant difference compared with 8.00% in the control group (P>0.05). The C-reactive protein and lymphocyte counts in the two groups after treatment were significantly lower than those before treatment (P<0.05), and the C-reactive protein and lymphocyte counts in the experimental group after treatment were also significantly lower than those in the control group (P<0.05). After treatment, the contents of IgG and IgA in the two groups were significantly higher than those before treatment (P<0.05). After treatment, the contents of IgG and IgA in the experimental group were significantly higher than those in the control group (P<0.05). Conclusion Xiaochaihu powder combined with paediatric paracetamol pseudoephedrine tablets can promote the relief of clinical symptoms, improve the treatment effect, and will not increase the occurrence of adverse reactions. It can also effectively inhibit the expression of inflammatory factors and improve the immune function of children. Reference | Related Articles | Metrics

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Analysis for the Combination of Thiamphenicol Hydrochloride and Colistin Transdermal Patch in the Treatment of Tic Disorders LUO Hua-rong, YE Zi-shan ZHONGHUA YANGSHENG BAOJIAN    2024, 42 (7): 40-43.   Abstract （293）      PDF（pc） （1621KB）（21）       Knowledge map    Save Objective To explore the clinical efficacy of thiamphenicol combined with colistin transdermal patch in the treatment of tic disorders. Methods A total of 119 children with tic disorders admitted to the pediatric outpatient clinic of the Third People's Hospital of Longgang from May 2022 to May 2023 were selected as the study subjects, they were randomly divided into three groups. The combined group of 41 cases were treated with thiamphenicol combined with colistin transdermal patch. The thiamphenicol group of 39 cases were treated with oral thiamphenicol hydrochloride tablets. The colistin group of 39 cases were treated with a single colistin transdermal patch. Ttreatment of the three groups lasted 8 weeks. The Yale Grade Tourette Syndrome Score (YGTSS), treatment efficiency, and dangerous events were recorded through the whole study. Results The YGTSS scores of children in the three groups were lower at 8 w and 12 w after treatment compared with those before treatment, and the YGTSS scores of the combined group were lower compared with those of the other two single-administration groups (P<0.05), and the differences in YGTSS scores of the single thiabendazole group compared with those of the single colestipol group were not statistically significant at 8w and 12w after treatment (P>0.05). The total effective rate of the three groups were 87.8% in the combined group, 82.05% in the tiapride group and 84.62% in the clonidine group (P>0.05). The incidence rates of adverse reactions in the three groups were 17.07% in the combined group, 12.82% in the tiapride group, and 10.26 % in the clonidine group, 12.82% and 10.26% (P>0.05), and among the adverse events there were no critical serious events. Conclusion Thiopride hydrochloride, colistin transdermal patch, and the combination of treatment modalities have more objective efficacy in the therapeutic effect of tic disorders, and no critical adverse events and dangerous situation, but by combining thiopride hydrochloride and colistin treatment modalities can be better control of children's tic conditions within the same period of time, and the therapeutic effect is more accurate, and it is worth to be popularized. Reference | Related Articles | Metrics

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ZHONGHUA YANGSHENG BAOJIAN    2023, 41 (14): 41-45.   Abstract （255）      PDF（pc） （4993KB）（11）       Knowledge map    Save Reference | Related Articles | Metrics