Abstract: Objective To explore the efficacy of leccitonin combined with teriparatide on osteoporosis in elderly women. Methods 100 patients elderly female with osteoporosis who were hospitalized in China Hospital of Heibo Bay District, Wuhai City, Inner Mongolia from January 2019 to June 2022 were selected for the study. The patients were divided into observation group and control group, with 50 cases in each group. The patients in the control group were treated with triiodol, while the patients in the observation group were treated with calcitonin combined with triiodol. The clinical effects of the two groups were compared, before and after treatment, bone metabolism marker type 1 collagen carboxyterminal cross-linked end peptide (CTx) and bone mineral density (BMD), blood calcium (Ca) and 25 hydroxyvitamin D (25-OH-D) and sex hormone [follicle hormone (FSH), progesterone (P), estradiol (E₂)] levels. Results The total response rate of the observation group was significantly higher than that of the control group (P<0.05). There was no significant difference between the first carboxyl crosslinked peptide (CTx) and BMD of type 1 collagen (P>0.05), CTx, and BMD were increased after treatment, And the observation group was higher than the control group (P<0.05). There was no significant difference in 25-OH-D and Ca levels between the two groups (P>0.05), 25-OH-D and Ca levels were increased in two groups, And the observation group was higher than the control group (P<0.05). After treatment, FSH, P, E₂ were decreased, And the observation group was significantly lower than the control group (P<0.05). Conclusion Which improved the bone metabolism and bone density of the elderly female patients. The increase of calcium and vitamin D levels in blood and the increase of sex hormone levels are worthy of clinical application.

Key words: ecalcitonin, teripatide, osteoporosis, elderly female, bone mineral density, 25 hydroxyvitamin D, sex hormone