Abstract: Objective To investigate the effect of Zixian Zhuyun decoction combined with clomiphene citrate on infertility with polycystic ovary syndrome. Methods 84 cases of polycystic ovary syndrome infertility patients admitted to the Department of Reproductive Medicine of Shandong Liaocheng People's Hospital from September 2020 to September 2021 were selected, and the random number table method was divided into two groups. The control group was treated with clomiphene citrate alone, and the observation group was treated with Zixian Zhuyun Decoction. The 1-year pregnancy rate and excellent ovulation rate of the two groups were recorded, the levels of luteinizing hormone (LH), estradiol (E₂), testosterone (T) and follicle stimulating hormone (FSH) were detected, the TCM syndromes of the two groups were evaluated, and the ovarian volume and endometrial thickness of the two groups were compared. Results The 1-year pregnancy rate and excellent egg discharge rate in the observation group were significantly higher than that in the control group (P<0.05). Before treatment, there was no significant difference in the levels of LH, E₂, T and FSH between the two groups (P>0.05). After treatment, the LH and T levels in two groups decreased, and the levels of E₂ and FSH both increased (P<0.05), and the changes in the observation group were more obvious (P<0.05). Before treatment, the scores of irritability, irregular menstruation, dizziness and tinnitus, emotional depression, waist and knee weakness and chest and rib fullness in the two groups had no significant difference (P>0.05). After treatment, the scores of irritability, irregular menstruation, dizziness and tinnitus, emotional depression, waist and knee weakness and chest and rib fullness in the two groups were significantly reduced (P<0.05), and the observation group was more significant (P<0.05). Before treatment, there was no significant difference in ovarian volume and endometrial thickness between the two groups (P>0.05). After treatment, ovarian volume decreased and endometrial thickness increased in two groups (P<0.05), and changes were more pronounced in the observation group (P<0.05). Conclusion Clomiphene citrate combined with purple fairy help pregnancy soup has a significant effect on polycystic ovary syndrome infertility, can significantly improve the pregnancy rate, reduce symptoms, reduce ovarian volume, increase endometrial thickness.

Key words: Zixian Zhuyun decoction, clomiphene citrate, sterility, polycystic ovary syndrome