Clinical Study of Apatinib Combined with Albumin-bound Paclitaxel in the Treatment of Distant Metastasis after Surgery for Esophageal Cancer

Abstract

Abstract: Objective To investigate the efficacy and adverse effects of apatinib combined with albumin-bound paclitaxel in the treatment of patients with distant metastases after esophageal cancer. Methods A retrospective analysis was performed on 70 patients with distant metastasis after esophageal cancer admitted to Tai'an Cancer Hospital from March 2019 to January 2022, according to the treatment plan, 35 cases were divided into treatment group (paclitaxel albumin-binding combination with apatinib for injection) and 35 cases in the control group (paclitaxel albumin-binding chemotherapy for single-agent injection), and the short-term efficacy, disease-free progression, and adverse reactions of the two groups were observed. Results The difference was statistically significant compared with the objective response rate (ORR) and the disease control rate (DCR) between the treatment group and the control group (P<0.05). There were statistical differences between the median PFS of the treatment group and the control group (P<0.05). There were no significant differences in white blood cell decrease, platelet decrease, abnormal liver function, and gastrointestinal reactions during treatment (P>0.05), The symptoms of hypertension, proteinuria, and hand-foot syndrome in the treatment group were tolerated during oral apatinib, and alleviated after symptomatic treatment, and there was no significant difference between the two groups (P>0.05). Conclusion Apatinib combined with albumin-bound paclitaxel in patients with distant metastasis after esophageal cancer surgery has good local control rate, prolonged disease-free progression, and less adverse reactions.

Key words: esophageal cancer, apatinib, paclitaxel

CLC Number:

R730.5

LI Liang, QI Di, LI Yu, YUAN Lei, WANG E, ZHU Jun-di, GENG Xiao-meng, LI Wen-wen, REN Wei. Clinical Study of Apatinib Combined with Albumin-bound Paclitaxel in the Treatment of Distant Metastasis after Surgery for Esophageal Cancer[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(15): 16-19.

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