Abstract: Objective To explore the clinical effect of air enema in patients with acute intussusception, and to monitor the expression level of high mobility group protein 1 (HMGB 1) in different periods. Methods The Xinjiang production and construction corps 13 division red star hospital since January 2017 to December 2022 admitted 68 cases of acute intussusception children as the observation of the study, enrolled children are given simple air enema treatment, choose the same period in the Xinjiang production and construction corps 13 division red star hospital health examination 68 cases of healthy children as a control group, observe the clinical effect of air enema treatment of acute intussusception and the clinical significance of HMGB 1 monitoring. Results In 68 children of the observation group, 66 cases were successfully reset, with a success rate of 97.06%. After successful reduction, 53 children (80.30%) had mild diarrhea, all of them improved after treatment, and no other adverse reactions were found. 2 patients were transferred to surgery after failed reduction. HMGB1, IL-6, TNF-α in the observation group before and after treatment. The levels were significantly higher than those of the healthy control group, but decreased significantly after treatment (P<0.05). After treatment, 7 children recurred, and the level of HMGB1 in the recurred children was significantly higher than that in the non-recurred group, with a statistically significant difference between the groups (P<0.05). Conclusion The clinical effect of acute intussusception is significant, the recurrence rate of children is low, and the level of HMGB 1 and TNF- αand IL-6 are significantly reduced, which has certain diagnostic significance for the diagnosis of acute intussusception and deserves attention.

Key words: acute intussusception, air enema, HMGB1, monitor