Table of Content

01 March 2024, Volume 42 Issue 5

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A Five Year Retrospective Analysis and Prospect of Medication Consultation Services in Beijing Traditional Chinese Medicine Hospital

WANG Hong-lei, LI Wen-zhe, CHEN Zhan-gong, LIU Yang, CHANG Xin-yu, HAN Li-juan, FAN Zheng, WU Jian-kun

2024, 42(5):  1-4. 

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Objective Retrospective analysis of the five-year medication consultation services provided by Beijing Hospital of Traditional Chinese Medicine, identifying patterns of medication problems, sharing service experience, and improving service quality. Methods Review all medication consultation records of our hospital's medication consultation center from 2015 to 2019, classify consultation questions, and use Pareto chart method for statistics and analysis. Results The number of medication consultation services in our hospital has shown an upward trend in the past five years. A total of 61 759 questions answered, with an average daily service of 50 people. We divide the types of consultation questions into 5 categories, complex medication consultation (4 283, 6.93%), simple drug-related questions (4 892, 7.92%), other non-medical content (6 422, 10.40%), drug inventory (16 291, 26.38%), decoction questions (29 871, 48.37%). Conclusions Through the classification and statistics of outpatient medication consultation records, it can be seen that the types and proportions of consultation questions are relatively stable. Pareto analysis helps to identify the main needs of patients and promote continuous improvement in the pharmaceutical department to ensure reasonable medication use for patients.

Study on Mental Health Service Model of the Widowed Elderly from the Perspective of Strategies and Skills Learning and Development

LIU Man, LIU An-ze, SUN Xiao-ting, WANG Xue, YU Lin

2024, 42(5):  5-7. 

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With the acceleration of the aging process of the population, the number of elderly widows is also increasing. The mental health problems of the widowed elderly are also increasingly prominent, and there are widespread problems such as strong loneliness and difficulty in adapting to the role. This study builds a mental health service model for the widowed elderly based on the theory of knowledge, action and easy path. It first identifies the needs of the widowed elderly from six fields of physiology, motivation, cognition, emotion, behavior and environment, then defines intervention goals and constructs intervention measures to effectively achieve individual life goals. Improve the quality of life of the widowed elderly, and provide reference for exploring the path of social life reconstruction of the widowed elderly.

NSK-SD Nattokinase in the Treatment of Cardiovascular and Cerebrovascular High Risk Population

QIAN Shen-xian, LI Pei-zhang, CHEN Ning, ZHU Ping, AN Qi, ZHAO Xiao-yan, ZHANG Rui-fang, HU Wei-hong, LIU Xiao-ming, WU Bing-nan

2024, 42(5):  8-11. 

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Objective Nattokinase, a fermented soybean extract, has recently been shown to reduce the risk of cardiovascular and cerebrovascular disease. The purpose of this study was to evaluate the efficacy of nattokinase in the cardiovascular and cerebrovascular high-risk population in China. Methods A total of 97 cardiovascular and cerebrovascular high-risk subjects received 8000 FU nattokinase (NSK-SD) daily during the 90-day study period, and blood samples were taken at baseline, on day 30 and day 90, respectively, to detect lipids, clotting, platelet aggregation rate and D-dimer. TCD testing and carotid ultrasound were performed at baseline and day 90. Results All 97 people completed the study with good compliance. After 30 days of nattokinase treatment, plasma viscosity decreased significantly (P<0.05). After taking nattokinase for 90 days, ADP platelet aggregation rate was 300 s, maximum ADP platelet aggregation rate, D-dimer, whole blood low shear viscosity 5/s, whole blood viscosity 50/s and whole blood high shear viscosity 200/s (P<0.05). In addition, whole blood low shear viscosity 1/s decreased significantly after 30 days and 90 days of administration (P<0.05). The improvement rate of patients with different blood flow velocity and flow velocity was 71.4% and 87.5%, respectively. The improvement rates of carotid plaque and media thickening were 46.7% and 42.1%, respectively. Conclusion The intake of nattokinase in the Chinese population was significantly correlated with the improvement of platelet function, D-dimer and whole blood viscosity in the high-risk population of cardiovascular and cerebrovascular diseases, and the effect was more obvious with the extension of time, indicating that nattokinase has a significant effect on the prevention and treatment of cardiovascular and cerebrovascular diseases.

The Correlation Between Platelet Aggregation Rate and Major Cardiovascular Adverse Events in Patients with Unstable Angina Pectoris

CHEN Hai-hong, WANG Ji-wei, LIU Yi-ming

2024, 42(5):  12-15. 

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Objective To explore and analysis the correlation between platelet aggregation rate (PAR) and major cardiovascular adverse events (MACE) in patients with unstable angina. Methods From May 2021 to July 2022, 134 cases of patients with unstable angina who were hospitalized in the cardiovascular department of Kulle Hospital, Second Division, Xinjiang Production and Construction Corps were selected as the research subjects. The platelet aggregation rate of all patients at admission was measured, and the main cardiovascular adverse events of the patients were followed up and were give correlation analysis. Results All patients were followed up until May 1, 2023, with an average follow-up time of (24.10 ±1.93) months. There were 21 cases of major cardiovascular adverse events (MACE group) that accounted for 15.7%, included 3 cases of myocardial infarction, 1 case of cardiac death, 4 cases of heart failure, and 13 cases of stent thrombosis. There were no significant difference in sex, age, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, systolic blood pressure, diastolic blood pressure, smoking, alcohol consumption compared between the MACE group and the non MACE group (P>0.05). There were no significant difference in platelet count, platelet distribution width, average platelet volume, and platelet hematocrit compared between the two groups (P<0.05). The platelet aggregation rate in the MACE group were significantly higher than that in the non MACE group (P<0.05). In the 134 patients, Spearman correlation analysis showed a correlation between platelet aggregation rate and the occurrence of major cardiovascular adverse events (r=0.724, P<0.001). Multivariate logistic regression analysis showed that platelet aggregation rate was an important factor leading to major cardiovascular adverse events in patients with unstable angina during follow-up (P<0.05). Conclusion The incidence of major cardiovascular adverse events in patients with unstable angina is relatively high, and the occurrence of major cardiovascular adverse events is often accompanied by an increase in platelet aggregation rate. There is a correlation between platelet aggregation rate and the occurrence of major cardiovascular adverse events in patients with unstable angina.

Effect of High-Throughput Dialysis Combined with Jinshuibao Tablets on Vascular Endothelial Cell Growth Factor and Interleukin 1β Levels in Hemodialysis Patients with Diabetic Nephropathy

LIN Xiao-kun, ZHANG Min, LIN Zhong-fang, LU Min-ran

2024, 42(5):  16-18. 

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Objective This study intends to use the combination of high-fluxes hemodialysis and oral Jinshuibao tablets to study the effect of high-fluxes dialysis and oral Jinshuibao tablets on plasma vasular endothelial growth factor(VEGF) and interleukin-1β (IL-1β) levels in diabetic renal dialysis patients, in order to provide new treatment methods and ideas for diabetic renal dialysis patients. Methods The random numbers of 80 patients with diabetic nephropathy maintenance hemodialysis admitted to Guangdong Hospital of Integrated Traditional Chinese and Western Medicine from January 2021 to June 2022 were divided into two groups, both of which were low-flow dialysis. At the beginning of the trial, the control group was given high- fluxes of hemodialysis (HFHD), and the treatment group took 3 tablets (0.42 g/tablet) per day, TID, for three months, hemoglobin (Hb), albumin (Alb), blood creatinine (Scr), urea nitrogen (BUN) (VEGF), interleukin-1 β (IL-1β) were compared with high-throughput dialysis. Results The levels of BUN, Scr, Hb and Alb in the blood were not significant before treatment (P>0.05); BUN and Scr decreased significantly 3 months after treatment (P<0.05), Hb and Alb increased significantly 3 months after treatment (P<0.05), and Hb and Alb in the treatment group 3 months after treatment, and BUN and Scr 3 months after treatment (P<0.05). The levels of VEGF and IL-1 β in the blood decreased significantly compared with low-throughput dialysis before the trial; VEGF and IL-1 β after 3 months of treatment in the treatment group were more prominent than in the control group (P<0.05). Conclusion High-flux dialysis can improve the micro-inflammatory state of MHD patients and maintain their vascular endothelial function. High flux dialysis combined with Jinshuibao is more obvious.

Clinical Study on Treatment of Acute Nonspecific Low Back Pain with Floating Needle

HUO Qing-Yun, ZHAO Yu-Ling, LI Wei, LU- Min, TAN Guo-Zhong, YU Ao-Rui, XU Hong-Wu

2024, 42(5):  19-22. 

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Objective To study the clinical efficacy, chronic outcome rate and safety of acute nonspecific low back pain with floating needle. Methods A total of 256 patients with acute non-specific low back pain from January 1, 2020 to June, 2023 at Shenzhen Pingle Orthopedic and Traumatology Hospital (Shenzhen Pingshan District Traditional Chinese Medicine Hospital) were selected, depending on the patient's treatment method, they were randomly divided into a floating needle group and a control group, with 129 cases in the floating needle group and 127 cases in the control group. Both groups of patients were treated with traditional Chinese medicine package, and the control group was treated with Ibuprofen codeine sustained-release tablets and Eperisone hydrochloride tablets. The floating needle group was treated with floating needle on the basis of the above treatment; Compare the clinical efficacy, lumbar pain score (VAS), lumbar dysfunction index score (ODI), and finger to ground distance (FFD) between two groups of patients. Results There was no statistically significant difference in general condition, VAS, ODI and FFD between the two groups of patients before treatment (P>0.05).After treatment, the VAS, ODI and FFD of the two groups of patients showed a significant downward trend compared to before treatment (P<0.05). The clinical efficacy, recurrence rate, VAS, ODI and FFD of the floating needle group were higher than those of the control group (P<0.05). Conclusion Floating needle treatment of acute nonspecific low back pain can quickly and efficiently reduce pain, improve low back function, reduce the recurrence rate, short-term efficacy and long-term efficacy is good, worthy of clinical application.

The Application Effect of Traditional Chinese Medicine Intervention on Promoting Blood Circulation and Resolving Stasis in Patients with Liver Cirrhosis and Malnutrition and the Influence of Serum Nutritional Indicators

QI Xi-ping, MA Rong-xia, LI Jing, HU Mei-lin

2024, 42(5):  23-25. 

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Objective To explore the application effect of traditional Chinese medicine intervention method for promoting blood circulation and resolving blood stasis on patients with liver cirrhosis and malnutrition, as well as the impact of serum nutritional indicators. Methods A total of 82 patients with cirrhosis and malnutrition who were admitted to the Second People's Hospital of Gansu Province from June 2022 to March 2023 were selected as the study objects. They were divided into observation group and control group by random number table method, with 41 cases in each group. The control group received conventional treatment of cirrhosis and nutrition intervention, and the observation group was additionally given the traditional Chinese medicine intervention method to promote blood circulation and remove blood stasis. The liver function indexes, nutritional index expression levels and complications of the two groups before and after treatment were compared. Results There was no significant difference in the levels of Alkaline phosphatase (ALP), Glutamic pyruvic transaminase (ALT), Glutamic transaminase (AST) between the two groups of patients before treatment (P>0.05). After treatment, the levels of ALP, ALT, and AST in both groups of patients decreased, and the observation group was lower than the control group (P<0.05). There was no significant difference in the nutritional indicators related to Transferrin (TRF), Prealbumin (PAB), serum albumin (Alb) and hemoglobin (Hb) between the two groups of patients before treatment (P>0.05). After treatment, the levels of TRF, PAB, Alb, and Hb in the treatment two groups increased, and the observation group was higher than the control group (P<0.05). The incidence of complications such as hepatic encephalopathy, hepatorenal syndrome, gastrointestinal bleeding, and infection in the observation group was significantly lower than that in the control group (P<0.05). Conclusion The traditional Chinese medicine intervention method of promoting blood circulation and resolving blood stasis can further improve liver function, enhance serum nutritional index levels, and reduce the incidence of complications in patients with liver cirrhosis and malnutrition. It is worthy of clinical application.

Warming-Needle Moxibustion Based Traditional Therapy Comprehensive Treatment of a Scoliosis Case

WANG Xiao-ling, HUANG Jia-yi, YANG Jing, XIE Qiu-rong, JIAN Jia-wei, JIANG Yi-zhen, YANG Wen-yi

2024, 42(5):  26-28. 

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Adult degenerative scoliosis and lumbar disc herniation are common clinical diseases, which are often accompanied by each other. Conservative treatment is usually the preferred treatment in the clinic. This paper reports a case of degenerative scoliosis with lumbar disc herniation. Based on the theory of 'the regular bone and soft jin', combined with the biomechanical characteristics of scoliosis, the traditional therapy based on Warming-needle moxibustion is applied for comprehensive treatment, which adjusts the muscle strength of both sides of the paravertebral muscles, improves the biomechanical balance of the spine, achieves the effect of promoting qi and blood circulation, removing tendons and clearing collateralization, effectively improves the symptoms of the patient and consolidates the curative effect. It is expected to provide reference for clinicians to treat such diseases.

The Therapeutic Effect of Ciwuplus Injection and Acupuncture on Senile Insomnia and Its Effect on Melatonin and Serotonin Levels

ZHU Shuang, YANG Yan, ZHANG Jun

2024, 42(5):  29-32. 

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Objective To explore the therapeutic effect of Xiwujia injection combined with acupuncture on senile insomnia and the effects on melatonin and 5-hydroxytryptamine levels. Methods A total of 80 patients with senile insomnia (liver and kidney deficiency type) admitted to Ya 'an Hospital of Traditional Chinese Medicine in Sichuan Province from December 2020 to December 2022 were randomly divided into control group (n=40) and observation group (n=40). The control group received conventional western medicine treatment, and the observation group received Ciwujia injection combined acupuncture treatment. The improvement of sleep disorder, melatonin (MT) and 5-hydroxytryptamine (5-HT) levels and adverse mood changes were compared between the two groups. Results There were no differences in sleep time, sleep time, sleep quality, sleep efficiency, daytime dysfunction, sleep disorder, sleep medication score and total score between the two groups before treatment (P>0.05). After treatment, the above scores in both groups were decreased to different degrees, and the observation group was significantly lower than the control group (P<0.05). There were no differences in MT and 5-HT levels between the two groups before treatment (P>0.05). After treatment, the levels of the above indexes were increased in different degrees in both groups, and the observation group was significantly higher than the control group (P<0.05). There was no difference in SAS and SDS scores between the two groups before treatment (P>0.05). After treatment, the levels of the above indexes were decreased to different degrees in both groups, and the observation group was significantly lower than the control group (P<0.05). Conclusion Acanthopanax injection combined with acupuncture and moxibustion can improve the sleep disorder of elderly patients with insomnia, increase the serum MT and 5-HT levels, and improve the adverse mood of patients, it is worth applying.

Effect of Adjuvant Therapy with Anluo Huaxian Wan on Anti-Liver Fibrosis in Patients with Compensated Hepatitis B Cirrhosis

LI Ling-ling, WANG Xiao, LIU Ying-guo

2024, 42(5):  33-36. 

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Objective To investigate the effect of adjuvant therapy with Anluo HuaXian Wan on anti-liver fibrosis in patients with compensated hepatitis B cirrhosis. Methods A total of 106 patients with compensated hepatitis B cirrhosis in the Department of Gastroenterology and Hepatology of Liaocheng Infectious Disease Hospital from May 2020 to May 2022 were selected for the study, the enrolled patients were divided into control group and study group according to random drawing method, 53 cases in each group. Patients in the control group were treated with tenofovir, while patients in the study group were treated with oral Anluo HuaXian Wan as adjuvant therapy. The anti-fibrotic effect, liver function, viral load, levels of various inflammatory cytokines and liver stiffness, and the safety of the drug were evaluated in both groups after 1 year of continuous treatment. Results The total effective rate of treatment was higher in the study group than in the control group, with significant differences compared between groups (P<0.05). There was no difference in the levels of liver fibrosis indexes compared between the two groups of patients before treatment (P>0.05), and the levels of liver fibrosis indexes in the study group were lower than those in the control group after treatment (P<0.05). There was no difference between the liver function indexes and HBV-DNA load levels of patients in the two groups before treatment compared with each other (P>0.05), and the liver function indexes and HBV-DNA load levels of patients in the study group were lower than those of the control group after treatment (P<0.05). There was no difference in the levels of each inflammatory cytokine and liver hardness compared between the two groups before treatment (P>0.05), and the levels of each inflammatory cytokine and liver hardness of patients in the study group were lower than those in the control group after treatment (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05), and no serious adverse reactions occurred in either group. Conclusion The adjuvant therapy of Anluo HuaXian Wan can effectively enhance the anti-liver fibrosis and anti-viral effects, inhibit the inflammatory response, and has a high safety profile, which is worthy of clinical application.

Clinical Observation and Therapeutic Analysis of Linggui Zhugan Decoction Combined with Aldosterone Inhibitors in the Treatment of Coron

BAI Bing, ZHAO Yong-qiang

2024, 42(5):  37-39. 

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Objective To study the effect of Linggui Zhugan decoction combined with aldosterone inhibitors in the treatment of coronary heart disease and heart failure. Methods Selected 80 cases of patients with coronary heart disease and heart failure from January 2018 to December 2022, divided into two groups randomly. The control group was treated with aldosterone inhibitor spironolactone, while the observation group was treated with Linggui Zhugan decoction. The symptom scores of chest and hypochondriac pain, palpitations, facial edema, shortness of breath, dark complexion and night sweating fatigue in the two groups were evaluated, and the left ventricular end systolic volume (LVESV), stroke volume (SV), left ventricular end diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), cardiac index (CI) and left ventricular end systolic diameter (LVESD) in the two groups were measured. Results The effective rate of the observation group was significantly higher than control group (P<0.05). Before treatment, there was no significant difference in the scores of chest and hypochondriac pain, palpitations, facial limb edema, shortness of breath, dark complexion, and night sweating fatigue between the two groups (P>0.05). After treatment, the scores of chest and hypochondriac pain, palpitations, facial limb edema, shortness of breath, dark complexion, and night sweating fatigue in the two groups were significantly reduced (P<0.05), and the scores of chest and hypochondriac pain, palpitations, facial limb edema, shortness of breath, dark complexion, and night sweating fatigue in the observation group were lower (P<0.05). Before treatment, there was no significant difference in LVESV, SV, LVEDD, LVEF, CI, and LVESD between the two groups (P>0.05). After treatment, the LVESV, SV, LVEDD, LVEF, CI, and LVESD of the two groups were significantly improved (P<0.05), and the LVESV, SV, LVEDD, LVEF, CI, and LVESD of the observation group were significantly better than those of the control group (P<0.05). Conclusion Linggui Zhugan Tang combined with aldosterone inhibitor spironolactone has a significant therapeutic effect on patients with coronary heart disease and heart failure, which can significantly alleviate symptoms and improve heart function.

The Role of Anticardiolipin Antibody Levels in Missed Miscarriage and Its Correlation with EMAb

WANG Li

2024, 42(5):  40-43. 

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Objective The role of anticardiolipin antibody level in residual abortion was explored, and its correlation with the level of anti-endometrial antibody (the endometrial antibodies, EMAb) was analyzed. Methods A total of 200 patients with missed abortion who received treatment in our hospital from October 2019 to August 2022 were selected as the study group, and 200 normal pregnant women who received physical examination in our hospital at the same time were selected as the control group. By comparing the differences in serum antiardiolipin antibody level and EMAb level between the two groups, the correlation between the antianticardiolipin antibody level and EMAb level was explored, and the diagnostic efficacy of the anticardiolipin antibody level and EMAb was calculated by drawing ROC (Receiver operating characteris) curve. Results The levels of anticardiolipin antibody IgG, anticardiolipin antibody IgA, anticardiolipin antibody IgM, and EMAb in the study group were significantly higher than those in the control group (P<0.05). The serum EMAb levels of patients in the study group were positively correlated with their levels of anticardiolipin IgG antibodies, IgA antibodies, and IgM antibodies (r=0.552, r=0.586, r=0.417, P<0.05). The area under curve (AUC) of serum anticardiolipin IgG antibodies, anticardiolipin IgA antibodies, anticardiolipin IgM antibodies, and EMAb for missed abortion were 0.930 (95%CI: 0.886~0.974, P<0.05), 0.972 (95%CI: 0.940~1.000, P<0.05), 0.990 (95%CI: 0.979~1.000, P<0.05), and 0.959 (95%CI: 0.927~0.990, P<0.05). Conclusion The level of anti-cardiolipin antibody and EMAb level in women with retained abortion were significantly increased, and the level of anti-cardiolipin antibody showed a positive correlation with EMAb, and the level of anti-cardiolipin antibody and EMAb had certain reference value for retained abortion.

Effect of Active Fixed Electrodes on Ventricular Pacing Parameters in Patients Undergoing Pacemaker Placement

LIU Yi-ming, LYU Jing

2024, 42(5):  44-47. 

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Objective To explore and analysis the effects of active fixed electrodes on ventricular pacing parameters in patients undergoing pacemaker implantation. Methods A total of 85 cases of patients who were admitted to Korla Hospital of the Second Division of Xinjiang Production and Construction Corps from January 2020 to April 2023 and required the placement of an implantable pacemaker were selected as the research subjects. Accorded to the random dice principle, 85 patients were divided into the active group of 43 cases and the passive group of 42 cases. The active group were treated with right ventricular outflow tract septum and Higgins bundle pacing using active fixation electrodes, while the passive group were treated with right ventricular apical pacing using passive fixation electrodes. The changes in ventricular pacing parameters were recorded and observed in both groups. Results The ventricular pacing parameters-pacing threshold, impedance, and P-wave amplitude immediately after pacemaker implantation in the active group were significantly lower than those in the passive group (P<0.05), and the current were significantly reduced compared to the passive group (P<0.05). The electrode placement time and exposure time of the active group were significantly increased compared to the passive group (P<0.05). The incidence of pacemaker system infection, lower limb deep vein thrombosis, pacemaker electrode dislocation, pacemaker dysfunction and other complications were 2.33% in the active group and 19.05% in the passive group 7 days after electrode implantation, which were significantly lower in the active group than in the passive group (P<0.05). The lower limb immobilization time, hospitalization time, and temporary cardiac pacing electrode retention time in the active group were significantly reduced compared to the passive group (P<0.05). Conclusion The application of actively fixation electrodes in patients undergoing pacemaker implantation can improve ventricular pacing parameters,increase electrode insertion time and exposure time, reduce ventricular asynchronous electrical stimulation caused by right apex pacing, reduce the incidence of complications, and improve the overall prognosis of patients.

Analysis of Therapeutic Effect of Ultrasound-Guided Microwave Ablation and Traditional Thyroid Surgery on Thyroid Benign Tumor

ZHANG Zong-xian

2024, 42(5):  48-50. 

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Objective To explore the difference of clinical effect between ultrasound-guided microwave ablation and traditional thyroid surgery in the treatment of thyroid benign tumor. Methods Eighty patients with thyroid benign tumor diagnosed by general surgery department of the Second People's Hospital of Jining City from January 2020 to January 2023 and conforming to the surgical indications were included as the analysis objects. Based on the difference of surgical treatment schemes,the patients were divided into the traditional group and the observation group, with 40 cases in each group.The traditional group patients were treated with traditional thyroid surgery,while the observation group patients were treated with ultrasound guided microwave ablation.The therapeutic effect was evaluated from the therapeutic effect,clinical indicators, complications and Thyroid hormones indicators of the two types of surgery. Results The effective rate of thyroid benign tumor treatment in the observation group was higher than that in the traditional group, with a statistically significant difference (P<0.05). In terms of surgical indicators, the observation group had shorter surgical time and hospital stay than the traditional group, and the intraoperative blood output was lower than the traditional group,with a statistically significant difference (P<0.05). The incidence of postoperative complications in the observation group was lower than that in the traditional group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the detection of serum free Triiodothyronine (FT3), serum free Tetraiodothyronine(FT4), and Thyroid-stimulating hormone (TSH) before operation between the two groups. The FT3 and FT4 indexes of patients in the observation group after operation were higher than those in the traditional group, and the TSH indexes were lower than those in the traditional group,with a statistically significant difference (P<0.05). Conclusion The efficacy and safety of ultrasound-guided microwave ablation for patients with thyroid Benign tumor can meet the clinical needs and reduce the possible adverse effects on patients.

To Analyze the Diagnostic Value of CT and MRI in Brain Glioma

HOU Sheng-nan

2024, 42(5):  51-54. 

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Objective To analyze the diagnostic value of CT and MRI in gliomas. Methods Eighty patients with suspected glioma admitted to Tongliao City Keerqin District First People's Hospital from January 2018 to January 2023 were selected as the research objects. CT and MRI examinations were performed respectively to summarize the imaging features of glioma in CT and MRI examinations. Pathological examination results were taken as the gold standard to analyze the diagnostic value of CT and MRI alone and combined examination for glioma. Results Low density lesions were the most common CT scan, and floral ring enhancement was the most common enhanced CT scan. High signal on T2WI and low signal on T1WI were the most common manifestations of MRI. Enhanced MRI mainly showed edge enhancement and nodule enhancement. The sensitivity, specificity and accuracy of CT, MRI and combined CT and MRI in the diagnosis of glioma were 76.92%, 90.38% and 96.15%, 75.00%, 85.71% and 96.43%, and 76.25%, 88.75% and 96.25%, respectively. The positive predictive values were 85.11%, 92.16%, 98.04%, and the negative predictive values were 63.64%, 82.76%, 93.10%, respectively. The above indexes were higher than those detected by CT alone (P<0.05). ROC curve analysis showed that CT, MRI and combined examination had certain diagnostic value for glioma. Conclusion CT combined with MRI has high diagnostic value for gliomas, which can display the range and image features of the lesion and provide imaging basis for the clinical diagnosis and treatment of gliomas.

Exploring the Relationship between Inadequate Health Preservation and the Pathogenesis of Insomnia Based on "Su Wen: Ancient Naivety Theory"

GUO Mei-si, LUO Shu-fen, WANG Guan-ying, YUAN Xiang-mei, ZHANG Zhen

2024, 42(5):  71-73. 

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The Book of Huangdi Neijing was the earliest existing medical literature in China, which was also called the three wonders together with Yijing and Shennong Bencaojing. This book comprehensively expounded the basic contents of the theoretical system of TCM, which had become the theoretical basis and sources of the development of TCM and was praised as the ancestors of TCM. At the beginning of Huangdi Neijing, it was said that the causes of human′s diseases lied in wrong-health-preserving methods. In order to guide TCM health preservation and clinical practice, this paper deeply analyzed the causes and pathogenesis of insomnia caused by wrong-health-preser-ving methods from seven aspects,including excessive drinking, arrogance, having sex after drinking, not living on time, violating the laws of the seasons, eating and drinking without restraint, hurting the Shenzhi, following the principle of integrity and innovation, based on the First Chapter of Shanggu Tianzhen in Suwen of Huangdi Neijing.

Research Progress of Hope Level and Self-Management Ability of Elderly Patients with Diabetes Mellitus

JIANG Ling-yu, WANG Qi, LIU Xiang-rong

2024, 42(5):  77-80. 

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Hope level is a dynamic and intrinsic therapeutic force, and individual attitudes and behaviors will be changed because of hope. Hope level is associated with self-management ability, and positive hope will enhance patients' self-management awareness, and scientific self-management can regulate patients' own behaviors. We review the concepts, measurement tools, influencing factors, and clinical applications of hope and self-management ability in elderly diabetic patients, aiming to effectively improve patients' clinical indicators and promote the hope of curing the disease.

Network Pharmacology Analysis of Epimedium in the Treatment of Osteoporotic Fracture

ZHANG Wen-zheng, LI Chun-pu, CHEN Lei, GUO Dong-mei, LI Jun, ZHANG Yuan-yuan, WEI Kai-bin, ZHANG Ya

2024, 42(5):  81-85. 

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Objective To identify the the molecular mechanism of epimedium in the treatment of osteoporotic fracture based on network pharmacology. Methods The main active components and targets of epimedium was screened in the Chinese Medicine Computing System Pharmacology Analysis Platform (TCMSP), and a prediction for osteoporotic fracture targets in GeneCards database, OMIM database, PharmGkb database, TTD database and DrugBank database was performed. The common targets of epimedium and osteoporotic fracture were got by Venn diagrams. Cytoscape3.6.1 was used to construct a Chinese medicine-ingredient-disease-target regulation network, then establish a protein-protein interaction network through the STRING data platform, and finally use the R language and Bioconductor platform for gene ontology enrichment analysis and gene interaction (KEGG) pathway analysis. Results The treatment of osteoporotic fracture with epimedium is mainly through 23 active components, 193 key targets and 155 biological signaling pathways. The main active constituents of the drug were quercetin, kaempferol and luteolin. The key targets were AKT1, TP53, Jun, HSP90AA1, CASP3, etc. The key pathway was Lipid and atherosclerosis signaling pathway. Conclusion This study shows the action characteristic of epimedium in the treatment of osteoporotic fracture may be achieved by multi-components, multi-targets and multi-biological signaling pathways through network pharmacology,and it provide a scientific theoretical basis for the further research and experiments．

Experience and Practice in the Construction of Human Anatomy Ideological and Political Demonstration Course in Henan Province

ZHANG Xiao-fang

2024, 42(5):  86-88. 

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Since General Secretary Xi Jinping delivered an important speech at the National Conference on Ideological and Political Work in Universities in 2016, the teaching teams have strengthened their ideological and political work capacity and formulated three levels of course goals for ideological and political cultivation: personal cultivation,professional ethics,and ideal beliefs.Through the construction of an ideological and political materials library, reform of teaching methods,and innovative evaluation mechanisms,and the establishment of a relatively complete curriculum ideological and political system,they have helped students grow into medical professionals with both integrity and competence.As a result, their curriculum has been recognized as an exemplary ideological and political course in Henan Province in 2023.

Exploration of the Distribution of Multidrug-Resistant Bacterial Infections in a Tertiary Traditional Chinese Medicine Hospital in Gansu Province

LI Xiao, ZHANG Xiu-juan, YANG Li-ping, SHI Li-li, WU Wei

2024, 42(5):  96-98. 

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Objective Explore the distribution of multidrug-resistant bacterial infections in a tertiary traditional Chinese medicine hospital in Gansu Province. Methods The clinical test results of multidrug-resistant bacteria from a tertiary traditional Chinese medicine hospital in Gansu Province from 2019 to 2022 were selected, used the "Hospital Infection and Infectious Disease Real Time Monitoring Platform" to retrospectively analyze the MDRO detection rate, key monitoring MDRO distribution composition, infection departments, and source distribution of infection samples. Results A total of 1 360 MDRO positive cases were collected after eliminating duplicate samples from 2019 to 2022. The distribution of MDRO under key monitoring was in the order of carbapenem resistant Acinetobacter baumannii (CR-AB), methicillin resistant Staphylococcus aureus (MRSA), carbapenem resistant Pseudomonas aeruginosa (CR-PA), carbapenem resistant Enterobacteriaceae (CRE), vancomycin resistant Enterococcus (VRE), the detection rate of CR-AB showed a decreasing trend; The key monitoring departments for MDRO infection were widely distributed, with infection rates mainly in the departments of Intensive Care Medicine, Osteomyelitis, Pulmonary Disease and Encephalopathy, accounted for 34.71%, 10.51%, 7.79% and 6.47%. The clinical test specimens were mainly composed of sputum and wound secretions, accounted for 45.00% and 26.62%. Conclusion The infection of multidrug-resistant bacteria in this hospital has been on the rise in recent years, and further strengthening of relevant infection prevention and control work is needed

Monitoring and Analysis of HFMD Vaccination Rate and Suspected Abnormal Vaccination Response in Qixia City in 2022

LIN Zhi-ren

2024, 42(5):  99-101. 

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Objective To investigate the vaccination rate of hand, foot and mouth disease in Qixia City in 2022 year, and to monitor the occurrence of suspected abnormal reactions to vaccination. Methods Used cluster random sampling method, 1 090 cases of preschool children and their parents who resided in Qixia City from January 2022 to December 2022 were selected as the research subjects. The vaccination status of hand, foot and mouth disease and the occurrence of suspected abnormal vaccination reactions were investigated and monitored, and the general information of the children were investigated and multivariate analysis were conducted. Results There were 824 cases were fully vaccinated, 166 cases were partially vaccinated, and 100 cases were not vaccinated in the 1090 cases of preschool children with a vaccination rate of 90.83%. Multiple logistic stepwise regression analysis showed that parental education level, local residence time, parental occupation, and monthly family income were important factors affected the vaccination rate of hand, foot, and mouth disease in a certain area in 2022 year (P<0.05). There were 15 cases of suspected abnormal reactions to vaccination, with an incidence rate of 1.38%. All cases were reported in a timely manner within 48 hours, with a timely reporting rate of 100.0%. 13 cases had general reactions, accounting for 86.67%; 1 case of routine reaction, accounted for 6.67%. There was 1 case of coincidence, accounted for 6.67%, and there were no vaccination accidents, psychogenic reactions, vaccine quality accidents, etc. 14 cases were cured, 1 case was improved, and there were no sequelae. Conclusion The vaccination rate for hand, foot and mouth disease in Qixia City in 2022 year needs to be improved. The main factors affecting the vaccination rate are parents' education level, local residence time, parents' occupation, and family monthly income. There are still suspected abnormal reactions to vaccination, which have been reported in a timely manner, mostly general reactions, and the prognosis and outcome effects are relatively high.

Effect of Eye Exercises Machine on Vision Improvement of Children

SHEN Yu, GAO Lei, LI Juan-juan, MENG Jia, GU Fang, ZOU Yan, TONG Jun-long, ZHANG Rong-hua

2024, 42(5):  163-166. 

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Objective To explore the effect of eye exercises machine for improvement of vision of children. Methods A total of 18 third grade classes of primary schools from Hangzhou, Wenzhou, Ningbo and Huzhou were selected, among them 9 were intervention group, and others were control group. Students of intervention group used eye exercises machine instead of normal eye exercises, and those of control group did eye exercises. Visual acuity optometry and questionnaire for ocular symptoms were completed at the beginnings and ends of first and second terms. Results 713 students were included. There was no significant difference of myopia prevalence between intervention and control group (38.58% VS 37.73%, χ²=0.028, P=0.866). After age, gender, dominant hand, outdoor time, lamp types and myopia prevalence of parents were adjusted, among 3 times of visual acuity optometry after intervention, students of intervention group who were diagnosed myopia once were significantly more than those of control group (OR=0.39, 95%CI=0.22~0.71, P=0.002). Before intervention, there were no significant differences of ocular symptoms between two groups (P>0.05). After two terms of intervention, prevalence of blurred vision of intervention group was lower than that of control group (29.25% VS 40.37%, χ²=10.139, P=0.001). Conclusion Eye exercises machine could improve ocular symptoms of children, and might had protective effects on those with unstable vision and probably nearsighted.