Table of Content

01 January 2024, Volume 42 Issue 1

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Clinical Observation Efficacy of External Counterpulsation Combined with Yixin Decoction in Patients with Coronary Heart Disease Complicated with Cardiac Dysfunction of Qi Deficiency and Blood Stasis

ZHAO Yu-hong, TIAN Jun, NING Si-si, CUI Zhao-qiang, YAN Lei, SHI Jia-wei, YUAN Yuan

2024, 42(1):  1-4. 

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Objective To observe the clinical effect of external counterpulsation combined with traditional Chinese medicine decoction Yixin Decoction on coronary heart disease patients with qi deficiency and blood stasis type combined with cardiac insufficiency. Methods Selected 50 patients who met the inclusion criteria from January 2021 to January 2022 in the Department of Cardiovascular Medicine, Tianshan Hospital of Traditional Chinese Medicine, Changning District. They were randomly divided into an observation group (25 cases, receiving external counterpulsation + Yixin Decoction + conventional drug treatment) and a control group (25 cases, receiving Yixin Decoction + conventional drug treatment), The TCM symptom scores, cardiac function, 6-minute walking distance (6MWD), serum brain natriuretic peptide (BNP) and other changes were observed before and after treatment in the two groups of patients. Results Patients in the observation and control groups had lower TCM evidence scores and serum BNP after treatment, cardiac ejection fraction and 6-minute walking distance were higher than those before treatment (P<0.05). After treatment, the symptom scores of chest tightness and palpitation in observation group were reduced compared with control group, and the 6-minute walking distance,cardiac ejection fraction were improved compared with control group (P<0.05). Conclusion The combination of external counterpulsation with traditional Chinese medicine decoction Yixin Tang and conventional Western medicine treatment has a positive therapeutic effect on the six minute walking distance, BNP, and LVEF of patients with Qi deficiency and blood stasis type coronary heart disease combined with cardiac insufficiency compared to a simple Western medicine treatment plan. At the same time, it improves the clinical syndrome score of traditional Chinese medicine and benefits patients more in terms of quality of life.

Analysis of the Application Value of P16/Ki-67 Double Staining, TCT Cytology, and HPV Combined Detection Technology in Cervical Lesion Screening

HU Hong-xia

2024, 42(1):  4-7. 

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Objective To explore and analysis the application values of P16/Ki-67 double staining, thinprep cytological test (TCT) and human Papilloma (HPV) combined detection technology in screening cervical lesions. Methods From April 2022 to April 2023, 83 cases patients who voluntarily underwent cervical lesion screening and cervical tissue biopsy at our hospital's gynecological outpatient and inpatient clinics were collected as the study subjects. All patients received P16/Ki-67 double staining, TCT cytology, and HPV combined testing, and their positive results were recorded. At the same time, all populations underwent pathological tissue examinations and used them as the diagnostic gold standard to determine the diagnostic value. Results In the 83 patients, pathological examination showed 14 cases of normal tissue, 54 cases of CIN grade 1, 12 cases of CIN grade 2, and 3 cases of CIN grade 3, with high-grade intraepithelial neoplasia accounting for 18.07%. The combined positive rates of normal tissue, CIN 1, CIN 2, and CIN 3 were 4.76%, 10.64%, 66.67%, and 66.67%, respectively. The diagnostic sensitivity of P16/Ki-67 double staining, TCT cytology, and HPV examination for cervical lesions was 66.67% (10/15), 66.67% (10/15), 100.00% (15/15), and 66.67% (10/15), respectively. The diagnostic specificity was 91.18% (62/68), 60.29% (41/68), 17.65% (12/68), and 91.18% (62/68), respectively. Conclusion The P16/Ki-67 double staining, TCT cytology, and HPV combined detection technology can more accurately detect potential high-level lesions in patients, improve the detection rate of cervical lesions, and have good application value.

Clinical Efficacy and Impact on Disease Severity of Knee Osteoarthritis with Liver and Kidney Deficiency Treated with Knee Bi Decoction Combined with Traditional Chinese Medicine Fumigation and Washing under the Theory of "Combined Treatment of Muscles and Bones"

WANG Shao-guang, TIAN Tao, FU Qiang, ZHU Jian-kui, YIN Shao-jian, QIU Song-ming

2024, 42(1):  8-11. 

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Objective To explore the clinical efficacy and impact on the severity of knee osteoarthritis caused by liver and kidney deficiency treated with knee bi decoction combined with traditional Chinese medicine fumigation and washing under the theory of "treating both muscles and bones". Methods A total of 80 patients with knee osteoarthritis of liver and kidney deficiency type admitted to our hospital from July 2022 to June 2023 were selected as the research subjects. The random number table method was used as the guiding basis to group the patients, and the specific groups were control group, observation group, with 40 cases in each group. The control group was treated with oral Celecoxib capsules (0.2 g once daily), while the observation group was treated with XiBi Tang combined with Chinese herbal fumigation (one dose of XiBi Tang daily, divided into morning and evening; Chinese herbal fumigation of the knee joint twice daily, half an hour each time) under the theory of "tendon and bone treatment". The clinical treatment effects, WOMAC index and ISOA indexof the two groups of patients were compared. The serum superoxide dismutase (SOD), nitric oxide (NO) and tumor necrosis factor (TNF) were compared between the two groups before and after treatment-α (TNF-α) Expression level and time for pain relief and joint function improvement. Results In terms of total effective rate of treatment, the observation group was higher than the control group (P<0.05). After treatment, the OMAC index and ISOA index of both groups of patients decreased, and the observation group was lower than the control group (P<0.05). After treatment, the SOD levels of both groups of patients increased, and the observation group was higher than the control group, including NO and TNF- α, the levels all decreased, and the observation group was lower than the control group (P<0.05). The time for pain relief and joint function improvement in the observation group was significantly lower than that in the control group (P<0.05). Conclusion Under the theory of "treating both muscles and bones", the combination of knee bi decoction and traditional Chinese medicine fumigation can improve the clinical efficacy of knee osteoarthritis with liver and kidney deficiency, reduce the severity of the condition, enhance knee joint function, improve levels of oxidative and inflammatory factors, and shorten the duration of clinical symptoms in patients.

The Value of Nutrition and Energy Intake Guidance on Blood Glucose Control and Disease Prevention in Patients with Gestational Diabetes

GUO Yu-ying

2024, 42(1):  12-15. 

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Objective To explore the clinical value of nutrition and energy intake guidance on blood sugar control and disease prevention in patients with Gestational diabetes. Methods 80 pregnant women who were diagnosed with Gestational diabetes in the Second People's Hospital of Datong County, Qinghai Province from March 2020 to April 2022 were selected as the study subjects, 40 pregnant women who did not receive nutritional guidance from March 2020 to February 2021 were set as the control group, and 40 pregnant women who received nutritional guidance from March 2021 to April 2022 were set as the study group. The differences in BMI index, weight gain, Glucose test Fasting blood sugar The difference of blood glucose level 2 h after meal and Glycated hemoglobin level before delivery, the difference of qualified rate of blood glucose control and positive rate of urinary ketone body between the two groups of pregnant women, the difference of pregnancy outcome between the two groups of pregnant women, and the difference of complications between the two groups of pregnant women. Results There was no statistically significant difference in BMI index between the two groups of pregnant women before intervention (P>0.05). After intervention, the BMI index of the study group was lower than that of the control group (P<0.05), and the weight gain of the study group was lower than that of the control group (P<0.05). There was no significant difference in fasting blood glucose, 2 h postprandial glycemic and hemoglobin 1 c levels in the two groups (P>0.05), while fasting blood glucose, 2 h postprandial glyca 1 c levels in the two groups after intervention (P<0.05), and pregnant women in the study group were lower than the control group (P<0.05). The qualified rate of blood glucose control in the study group was significantly higher than that in the control group (P<0.05), and there was no statistically significant difference in the positive rate of urinary ketone bodies between the study group and the control group (P>0.05). The incidence of macrosomia in the study group was lower than that in the control group (P<0.05), and there was no statistically significant difference in other pregnancy outcomes between the groups (P>0.05). The total incidence of complications in the study group was significantly lower than that in the control group (P<0.05). Conclusion Nutrient and energy intake guidance for pregnant women with Gestational diabetes can help to control the weight of pregnant women, improve the qualification rate of blood sugar control for pregnant women, and to a certain extent, reduce the incidence of perinatal complications of pregnant women, which has a certain value for application.

The Effect of Yixinshu Capsule on Left Ventricular Function and Heart Rate Variability in Patients with Heart Failure Complicated with Anxiety

MU Feng, HAO Wen-na

2024, 42(1):  15-19. 

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Objective To investigate and analysis the effects of Yixinshu capsules on left ventricular function and heart rate variability in patients with heart failure combined with anxiety. Methods 88 patients with heart failure combined with anxiety admitted to People's Hospital of Ningxia from August 2018 to January 2022 were selected as the research subjects. Accorded to the randomized numerical table method, the patients were divided into the traditional Chinese medicine group of 44 cases and the traditional Chinese medicine group of 44 cases. The traditional group were treated with conventional treatment drugs, while the traditional Chinese medicine group were treated with Yixinshu capsules on top of it, and the duration of treatment and observation for all included patients was 8 weeks. Measured and recorded the left ventricular function, heart rate variability, and changes in anxiety of patients, and follow up on the occurrence of major cardiovascular adverse events. Results The anxiety SAS scores of the Chinese medicine group and the traditional group after 8 weeks of treatment were significantly lower than those before treatment (P<0.05), and the anxiety SAS scores of the Chinese medicine group after 8 weeks of treatment were also significantly lower than those of the traditional group (P<0.05). After 8 weeks of treatment, the left ventricular ejection fraction of the traditional Chinese medicine group were significantly higher than that before treatment (P<0.05), and the left ventricular end diastolic diameter were significantly lower than that before treatment (P<0.05). There were also significant difference compared between the traditional Chinese medicine group and the traditional group (P<0.05). After 8 weeks of treatment, the PNN50 and SDANN of the traditional Chinese medicine group and the traditional group were both higher than before treatment (P<0.05). After 8 weeks of treatment, the PNN50 and SDANN of the traditional Chinese medicine group were also significantly increased compared to the traditional group (P<0.05). All patients were followed up for 1 year. The incidence of major cardiovascular adverse events such as recurrent heart failure, myocardial infarction, target vessel revascularization, and cardiac death in the traditional Chinese medicine group were significantly lower than that in the traditional Chinese medicine group (P<0.05). Conclusion Yixinshu capsule can improve left ventricular function, alleviate anxiety symptoms, and improve heart rate variability in patients with heart failure and anxiety, reducing the incidence of major cardiovascular adverse events during follow-up.

Observation on the Curative Effect of Maxingshigan Decoction Combined with Doxycycline in the Treatment of Patients with High Fever Due to Lung Disease

XIAN Xue-Mei, SHAO Jing-Tian

2024, 42(1):  20-23. 

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Objective To observe the clinical effect of Maxingshigan Decoction combined with doxycycline in the treatment of pulmonary fever. Methods A total of 100 patients with lung disease admitted to Enping Branch of Jiangmen Wuyi Hospital of Traditional Chinese Medicine from January 2021 to June 2021 were selected as research objects, and randomly divided into control group (n=50) and observation group (n=50). The control group was given doxycycline treatment, and the observation group was given doxycycline combined with Maxingshigan decoction plus or minus treatment. The therapeutic effect and the changes of related inflammatory indexes were compared between the two groups. Results The total response rate of the observation group was significantly higher than the control group, statistically significant (P<0.05). In the observation group, fever, cough and expectoration were significantly shorter than those in the control group, and the difference was significant (P<0.05). The inflammatory index was significantly lower than the control group, significant (P<0.05). The incidence of adverse reactions between the two groups was not significant (P>0.05). Conclusion Compared with doxycycline alone, Maxingshigan Decoction combined with dotetracycline has obvious advantages in the treatment of patients with lung disease and high fever. It can significantly shorten the time of disappearance of clinical symptoms and reduce related inflammatory indicators, with high safety.

Effect of Shenqi Jiangtang Capsule and Mecobalamin on diabetes Peripheral Neuropathy

LIU Yuan-chao, WANG Xiu-juan, LIU Jian-xin

2024, 42(1):  26-29. 

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Objective To investigate the effect of Shenqi Jiangtang Capsule and Mecobalamin on diabetes Peripheral Neuropathy. Methods Selected 136 cases of patients with diabetes Peripheral Neuropathy who were treated in our hospital from January 2020 to December 2022, divided into two groups randomly. The control group was treated with mecobalamin, while the observation group was treated with Shenqi Jiangtang capsule combined with mecobalamin. Both groups were treated for 2 months.The scores of were evaluated, and the levels of serum C-peptide (C-P), insulin-like growth factor-1 (IGF-1), endothelin-1 (ET-1) and cystatin (Cys-C) were measured. Results The effective rate of the observation group was significantly higher than control group (P<0.05). After treatment, the scores of muscle atrophy, limb pain, limb numbness, hypoesthesia and limb cooling symptoms in the two groups were significantly lower (P<0.05), and the scores of muscle atrophy, limb pain, limb numbness, hypoesthesia and limb cooling symptoms in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the levels of serum C-P, IGF-1 were significantly increased (P<0.05), and the levels of serum ET-1 and Cys-C were significantly decreased (P<0.05). The levels of serum C-P, IGF-1 in the observation group were significantly higher than those in the control group (P<0.05), and the levels of serum ET-1 and Cys-C were significantly lower than those in the control group (P<0.05). Conclusion shenqi Jiangtang Capsule combined with mecobalamin has a significant effect on diabetes peripheral neuropathy and can significantly alleviate symptoms. Its mechanism may be related to the increase of serum neurotrophic factor levels and the decrease of ET-1 and Cys-C levels.

Curative Effect of Qianjin Weijing Decoction in the Treatment of Children with Mycoplasma Pneumoniae Pneumonia (Phlegm-Heat Closing Lung Syndrome) and Its Effect on Serum Factors

QU Xiao-hong

2024, 42(1):  30-33. 

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Objective To explore and analyze the curative effect of Qianjin Weijing Decoction in the treatment of children with mycoplasma pneumoniae pneumonia (phlegm-heat closing lung syndrome) and its effect on serum factors. Methods A total of 126 cases of pediatric mycoplasma pneumoniae pneumonia admitted to Shandong University Affiliated Children's Hospital from December 2018 to December 2020 were divided into groups by random number table method, with 63 cases in each group. Both groups received basic treatment, and the observation group was treated with Qianjin Weijin decoction plus Jiawei prescription, and the clinical effects of the two groups were compared. Results Compared with the control group,the observation group had higher total clinical efficiency, and the disappearance time of major symptoms was shortened, and the difference was statistically significant (P<0.05). Compared with the control group, the TCM syndrome score and serum factor value were lower in the observation group (P<0.05). There was no obvious gastrointestinal reaction or liver and kidney dysfunction in the two groups, and the difference was not significant (P>0.05). Conclusion Qianjin Weijing Decoction has a good clinical effect in the treatment of children with mycoplasma pneumoniae pneumonia (phlegm-heat closed lung syndrome), significantly shortens the recovery time of main symptoms, regulates serum factor levels, and has no obvious adverse reactions during the medication period, and its safety is acceptable. Get guaranteed.

Diagnosis of Breast Cancer by Color Doppler Ultrasound Combined with X-ray Molybdenum Target

LIU Li-qiang, ZHANG Wei

2024, 42(1):  43-46. 

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Objective To study the diagnostic value of color Doppler ultrasound combined with X-ray molybdenum target in breast cancer. Methods The study subjects were 82 suspected breast cancer patients admitted to our hospital from January 2020 to March 2023. All patients were examined by color Doppler ultrasound and X-ray molybdenum target. The diagnostic efficacy of color Doppler ultrasound and X-ray molybdenum target alone and in combination was observed and compared. Results Pathological examination showed that there were 45 cases of breast cancer (54.88%) and 37 cases of benign breast lesions (45.12%). Using pathological examination as the gold standard, the accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of color Doppler ultrasound examination are 71.95%, 66.67%, 78.38%, 78.95%, and 65.91%, respectively. The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of X-ray molybdenum target examination are 80.49%, 80.00%, 81.08%, 83.72%, and 76.92%, respectively. The accuracy, sensitivity, specificity, positive predictive value and negative predictive values of combined examination are 95.12%, 93.33%, 97.30%, 97.67% and 92.31% respectively. The accuracy, sensitivity, specificity, positive predictive value and negative predictive value of color ultrasound combined with X-ray molybdenum target examination in the diagnosis of breast cancer were higher than those of single examination, statistically significant difference (P<0.05). Conclusion Color Doppler ultrasound combined with X-ray molybdenum target examination can effectively improve the diagnostic efficiency of breast cancer, and has high application value.

Research Progress of Traditional Chinese Medicine on Chronic Plantar Aponeurotitis Based on the Theory of “Equal Emphasis on Muscles and Bones”

QIAO Liang, QIAN Guo-wei, HAN Ning, XU Jing-ren

2024, 42(1):  59-62. 

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How to correctly diagnose and treat plantar aponeurosis, improve and stabilize the curative effect, reduce the pain of patients is the focus of current medical research. Paying equal attention to muscle and bone is the core concept of traditional Chinese medicine in the treatment of bone injury diseases. Its core is a penetrating portrayal of the concept of minimally invasive and non-invasive. It is a guideline for the relationship between bone and soft tissue in the human body, which has important guiding significance in clinical treatment. Under the guidance of this theory, modern clinic also carries out more comprehensive treatment for the disease. However, this theory is not supported by sufficient clinical evidence. According to the clinical characteristics of plantar aponeurosis, combined with the understanding of traditional Chinese medicine, we believe that the key pathogenesis of plantar aponeurosis is "bone dislocation, tendon out of groove, tendon bone disharmony". Based on this understanding, this paper attempts to explore a new way of diagnosis and treatment of plantar aponeurosis.

Analysis of the Mechanism of Taohong Siwu Decoction in the Treatment of Melasma Based on Network Pharmacology and Molecular Docking

XIE Yu-sha, ZHANG Peng-cheng, TIAN Li-ming, KE Dan

2024, 42(1):  66-71. 

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Objective To explore the main components, related targets and pathways of Taohong Siwu Decoction (THSWD) in the treatment of Melasma based on network pharmacology and molecular docking techniques. Methods The TCMSP, SwissTargetPrediction, SymMap, GeneCards, STITCH and CTD databases were used to search for the active ingredients of THSWD, while the gene targets of Melasma were found out through the Drugbank, GeneCards, OMIM, TTD and DisGeNET databases. Then the connections of the ingredients and targets were obtained. After that Cytoscape 3.9.1 and STRING were used in order to build a protein-protein interaction (PPI) network. With the help of Metascape database, the intersection targets were enriched and analyzed in Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Finally, the molecular docking of active ingredients and core targets were performed by AutoDockTools 1.5.7. Results 11139 potential targets were identified from THSWD and the key active ingredients were folic acid, quercetin, β-Carotenoids, (+)-catechins, lignans, etc. 53 therapeutic targets for melasma were found, in which the core targets were ALB, VEGFA, CD4, ESR1 and CREB1. GO analysis obtained 509 biological processes, 32 cell compositions, and 47 molecular functional items. KEGG analysis concluded a total of 189 signal pathways. The molecular docking results showed that the relevant active components in the regulatory network had high binding activity with core target genes. Conclusion According to network pharmacology and molecular docking, these results predict that THSWD plays its therapeutic role on Melasma through a comprehensive regulatory network of multiple active ingredients, multiple targets and multiple pathways.

Research and Practice on the Cultivation Model of Applied Medical Talents Based on the Integration of Industry and Education

PENG Jin-xiang, XU Xin-hua, WU Guang-yang, XIA Yuan-Ling, WU Feng

2024, 42(1):  72-75. 

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In the context of the new medical science, the cultivation of medical talents in applied universities is facing a disconnect from social production activities. Research and practice on the cultivation mode of applied medical talents at our university through consulting domestic and foreign references. In combination with the needs of social medical institutions and enterprises, application-oriented colleges and universities optimize talent training programs, adjust professional orientation, build an industry university integration model and evaluation system, build a "double qualified" teacher team, strengthen the construction of professional groups, optimize the curriculum system, establish industrial colleges, build a practice teaching base, build a smart teaching platform, and learn practice education platform. The results indicate that in the collaborative education of industry and education, applied universities can share social medical resources, improve the enthusiasm of medical students, enhance their clinical practice abilities, and cultivate applied medical talents suitable for social job needs.

Preliminary Study on the Effect of Emotional Therapy Combined with Peer Support on Compliance and Psychological Status in Elderly Hypertensive Patients

LIU Ping, XU Ya-qing

2024, 42(1):  108-112. 

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Objective To analyze the clinical effects of peer support in elderly patients with hypertension. Methods 118 elderly patients with hypertension who were treated in geriatrics department of Zhejiang Integrated Traditional Chinese and Western Medicine Hospital from October 2018 to October 2019 were randomly divided into two groups: control group (n=58) and observation group (n=59) by computer random coding method. The control group was given routine nursing intervention, while the observation group was given peer support intervention on the basis of routine nursing. The self-management, Blood pressure level and quality of life of the two groups were observed and compared. Results Compared with before intervention, After the intervention, the scores of medication, diet, mood, work and rest, exercise management and condition monitoring in the two groups increased significantly (P<0.05). After intervention, The blood pressure in the observation group was significantly lower than that in the control group (P<0.05). Conclusion Peer support intervention in patients with hypertension can significantly improve the self-management level of patients, patients' blood pressure and quality of life. This method has high clinical application value and is worthy of application and promotion.

Application of Graded Intervention Based on Cross Theoretical Models in Patients with Cerebral Infarction after Thrombolytic Therapy

YAO Hui-juan

2024, 42(1):  154-158. 

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Objective To explore the application effect of graded intervention based on cross theoretical models in patients with cerebral infarction after thrombolytic therapy. Methods This study used a prospective randomized controlled analysis and included 96 patients with cerebral infarction who underwent thrombolytic therapy in the Department of Neurology, Juye County People's Hospital, Shandong from January 2021 to December 2022 as the study subjects. They were randomly divided into an intervention group and a control group based on a random number table, with 48 patients in each group. The control group received graded intervention nursing, while the intervention group received graded nursing intervention based on a cross theoretical model. Both groups received 4 weeks of intervention. The neurological impairment function [neurological deficit (NIHSS) score], limb function [Fugl-Meyer exercise scale (FMA) score], self-care ability [self-care ability scale (ESCA) score], activities of daily living ability [Barthel index (BI) score] and nursing risk events were compared between the two groups before and after intervention. Results After 3 months of intervention, the NIHSS score of the two groups significantly decreased, while the FMA score significantly increased. The NIHSS score of the intervention group was lower than that of the control group, while the FMA score was higher than that of the control group (P<0.05). After 3 months of intervention, the scores of self-care ability and BI in both groups increased, and the intervention group was higher than the control group (P<0.05). The incidence of nursing risk events in the intervention group after nursing intervention was significantly lower than that in the control group (P<0.05). Conclusion The graded intervention based on a cross theoretical model has significant effects on the improvement of neurological and limb functions in patients with cerebral infarction after thrombolytic therapy, improving their self-care ability and daily living activities, and reducing the occurrence of risk events in nursing interventions.

Analysis of the Effect of Applying the Whole Health Education Model to Patients with Type 2 Diabetes

WANG Wen-na, XING Shao-zhi, ZHANG Ying, CHENG Qing-yan

2024, 42(1):  161-164. 

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Objective To investigate the evaluation of the effect of applying the whole health education model to implement health education for first-time hospitalized type 2 diabetes patients. Methods 130 patients with type 2 diabetes hospitalized in the endocrinology department of Binzhou Medical Hospital from June 1, 2021 to December 1, 2022 were selected by convenient sampling method, and were divided into the observation group of 65 patients and the control group of 65 patients. The control group was given conventional health education intervention, and the observation group was given the whole health education model intervention on the basis of conventional health education. The changes of general self-efficacy(GSES), self-management ability(SDSCA), fasting blood glucose, 2-hour postprandial blood glucose and glycosylated hemoglobin(HbA_1c) before and after the intervention were compared between the two groups. Results After the intervention, GSES, SDSCA, fasting glucose, 2-hour postprandial glucose, and glycosylated hemoglobin (HbA_1c) were better in both groups than before the intervention (P<0.05), and the observation group was better than the control group (P<0.05). Conclusion The whole health education model can improve the self-efficacy and self-management ability of type 2 diabetes patients, which is beneficial to glycemic control and stability.

Efficacy of Ursodeoxycholic Acid and Conventional Western Medicine in Treating Bile Reflux Gastritis Combined with Helicobacter Pylori Infection and Its Effect on IL-8 and PGE2

ZHAO Xing

2024, 42(1):  168-171. 

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Objective To investigate the therapeutic effect of ursodeoxycholic acid and conventional western medicine on bile reflux gastritis (BRG) combined with Helicobacter pylori(Hp) infection and its effect on interleukin-8 (IL-8) and prostaglandin E2 (PGE2). Methods A total of 100 BRG patients with positive Helicobacter pylori respiratory test admitted in Bayannur City Hospital from May 2019 to May 2021 were selected for the study. They were randomly divided into observation group and control group, with 50 cases in each group. The control group received conventional western treatment (clarithromycin + omeprazole + amoxicillin), and the observation group added ursodeoxycholic acid therapy to conventional western treatment. The clinical efficacy of the two groups was compared. The levels of serum interleukin-8 (IL-8), prostaglandin E₂ (PGE₂), gastrin (GAS), motilin (MTL), cholecystokinin (CCK) and adverse reactions were detected by enzyme-linked immunosorbent assay before and after treatment. Results The total effective rate of the observation group was significantly higher than that of the control group (P<0.05); After treatment, the level of serum IL-8 in the two groups was lower than that in the control group, while the level of PGE₂ in the observation group was higher than that in the control group (P<0.05); After treatment, the serum CCK level of the two groups decreased, the level of MTL and GAS in the observation group was lower than that in the control group, and the level of MTL and GAS in the observation group was higher than that in the control group (P<0.05); There was no serious adverse reaction in the two groups, and there was no significant difference in the comparison of mild adverse reactions (P>0.05), but the eradication rate of Hp in the observation group was higher than that in the control group (P<0.05). Conclusion Adding ursodeoxycholic acid on the basis of conventional Western medicine can improve the clinical effect of bile reflux gastritis complicated with Hp infection, reduce the inflammatory reaction of patients, improve gastric motility, regulate gastrointestinal hormones, increase the eradication rate of Hp, and the safety of the drug is better.

The Application of Yunnan Baiyao Cotton Tamponade under Nasal Endoscope in Children with Intractable Epistaxis

LIU Xiao-long, XIA Ying

2024, 42(1):  172-175. 

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Objective To explore and analysis the application values of Yunnan Baiyao cotton patch under nasal endoscope in the treatment of intractable epistaxis in children. Methods From January 2022 to January 2023, 89 children with intractable epistaxis who were treated in the Otolaryngology department of Shizuishan Hospital of Traditional Chinese Medicine were selected as the study subjects. Accorded to the principle of randomly flipping coins, the children were divided into white medicine group (45 cases) and control group (44 cases). All children were treated with endoscopic surgery. The control group were treated with erythromycin cotton tamponade, and the Baiyao group were treated with Yunnan Baiyao cotton tamponade. The therapeutic effects of the two groups were observed and recorded. Results One month after treatment, the total effective rate of the Baiyao group were 97.78%, which were significantly higher than that of the control group (81.82%, P<0.05). The time of dissipation, number of epistaxis, time, and volume of nosebleed were significantly reduced compared with the control group (P<0.05). At one month after treatment, the nasal endoscopic grading of the Baiyao group were mostly grade 1 and grade 2, while that of the control group were mostly grade 2 and grade 3. There were significant differences between the two groups (P<0.05). The nasal cilia transmission speed of the two groups after 1 month of treatment were significantly higher than that before treatment (P<0.05), and the nasal cilia transmission speed of the Baiyao group after 1 month of treatment were also significantly higher than that of the control group (P<0.05). Conclusion The application of Yunnan white powder cotton patch in children can significantly reduce clinical symptoms, improve the treatment effect of patients, improve the classification of nasal endoscopy in children, and speed up the transmission speed of nasal cilia.