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Table of Content

    16 February 2023, Volume 41 Issue 4
    The Impact of Improving the Emergency Management Level of Fever Clinics on Public Health Emergencies
    WEN Xia, HE Shui-lian, WANG Xiao-xia, TONG Li-ling
    2023, 41(4):  1-3. 
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    Objective To analyze the influence on hospital public health emergencies by improving the level of emergency management. Methods A total of 40 medical staff in Haikou People's Hospital from June 2021 to June 2022 were randomly selected. All medical staff adopted emergency management of public health emergencies, and compared the scores of working ability, psychological flexibility and quality of life before and after management. Results The score of work ability (preparation ability, prevention ability, rescue ability) after management was higher than that before management (P<0.05). The scores of psychological resilience (optimism, strength, tenacity and total score) after management were higher than those before management (P<0.05). The scores of quality of life (environment, physical health, social relations and psychological function) after management were higher than those before management (P<0.05). Conclusion The emergency management training for the staff of fever clinic can improve their emergency management ability and ensure the smooth development of the hospital.
    Clinical Evaluation of Different Recanalization Methods in Patients with Acute Cerebral Infarction
    ZHENG Jian-xin, ZHANG Shuai-jie, SUN Wei-li
    2023, 41(4):  4-7. 
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    Objective To compare the clinical efficacy of intravenous thrombolysis, mechanical thrombectomy and bridging in the treatment of acute cerebral infarction. Methods From January 2016 to January 2019,78 patients with acute cerebral infarction were selected from the Department of Neurology, the Second Affiliated Hospital of Luohe Medical Higher Vocational School, Henan Province. They were divided into intravenous thrombolysis group (n=30) and mechanical thrombectomy group (n=25) according to different therapeutic methods, venous Thrombolysis Bridging Group (n=23) . The National Institutes of health stroke scale (NIHSS) scores before treatment, 24 hours after treatment, 14 days after treatment and Modified Rankin Scale(mRS) Scores at 90 days after treatment were compared in each group to evaluate the therapeutic effect. The patient's curative effect was compared with the analysis of NIHSS within 24 hours in the later period of treatment. Results Compared with before treatment, NIHSS scores of mechanical thrombectomy group and bridging treatment group were significantly lower 24 h and 14 d after treatment (P<0.05). NIHSS scores of mechanical thrombectomy group and bridging treatment group were lower than those of intravenous thrombolysis group (P<0.05), while NIHSS scores of mechanical thrombectomy group and bridging treatment group were similar at each time point after treatment, without statistical significance (P>0.05). After 90 days, mRS score of bridging group and mechanical thrombectomy group was significantly lower than that of intravenous thrombolysis group (P<0.05), but there was no significant difference between bridging group and mechanical thrombectomy group (P>0.05). Conclusion Intravenous thrombolysis, mechanical thrombectomy or bridging therapy can improve the neurological function of patients with acute cerebral infarction. Mechanical thrombectomy and bridging therapy can improve the neurological function earlier and have better long-term prognosis.
    Clinical Drug Resistance and Bacteriological Analysis of Bloodstream Infection in Patients with Hematological Malignancies
    HAN Xin-yu, LI Li-mei, XU Chang-rong, LYU Peng, ZHOU Qian, WANG Xiao-liang, WANG Guo-ling
    2023, 41(4):  7-11. 
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    Objective To investigate the common pathogenic bacteria analysis, clinical drug resistance and drug sensitivity results of bacterial blood stream infection (BSI) in patients with blood tumors in the People's Hospital of Inner Mongolia Autonomous Region, so as to provide clinicians with diagnosis and treatment ideas and clinical basis for anti infection treatment and reduce hospital acquired infection selection. Methods Collect and sort out the blood culture samples of hospitalized patients (a total of 194 cases) with hematological tumors and bacterial blood flow infection from January 2016 to December 2020 of the Inner Mongolia Autonomous Region People's Hospital, and the specific operation is to extract 20 mL of peripheral blood from these 194 patients, place it in a bacterial culture bottle, and then place it in a blood culture instrument to detect and collect positive samples. Use the automated instrument method and paper diffusion method to carry out bacteriological analysis, clinical drug resistance and drug sensitivity test for the detected pathogenic bacteria. Results A total of 197 strains were isolated from blood culture positive samples without repetition, of which 97 (49.24%) strains were gram-negative bacteria, mainly 58 (29.45%) strains of Escherichia coli and 20 (10.15%) strains of Klebsiella pneumoniae; The second was Gram positive bacteria, with 57 (28.93%) strains, mainly including 23 (11.68%) strains of Staphylococcus epidermidis and 11 (5.58%) strains of Staphylococcus aureus; There were 2 (1.02%) fungi and 41 (20.81%) other strains. The results of drug sensitivity test showed that Gram negative bacteria had the highest sensitivity to carbapenem antibiotics and the highest resistance to ampicillin; Gram positive bacteria had the highest sensitivity to glycopeptide antibiotics linezolid and vancomycin, and high resistance to penicillin G and erythromycin. Conclusion There are many types of pathogenic bacteria with BSI in patients with hematological tumors, mainly gram-negative bacteria, and meropenem and imipernam can be used as alternative main antibacterial drugs in the clinic; Gram-positive bacterial infection is secondary, so when severe staphylococcal bloodstream infection occurs, linezolid, vancomycin, etc. can be preferred for antibacterial therapy; Antibacterial drugs such as voriconazole and fluconazole can be applied to the treatment of clinical fungal infections.
    Prediction and Influencing Factors Analysis of the Inflection Point of Healthy Life Expectancy Attenuation in the Elderly
    ZHENG Li-xiu, MEI Yang-yang, PANG Shu-qin
    2023, 41(4):  11-14. 
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    Objective To explore the attenuation inflection point of elderly's estimated healthy life expectancy, analysis associated factors, and to provide reference for the community to provide accurate old-age services. Methods By convenience sampling method, elderly people from nine communities of Fujian Province were investigated. The life expectancy of self-care health and self-rated healthy life expectancy were used for screening. The ROC curve of age prediction estimated healthy life expectancy attenuation was plotted, and logistic analysis was used to explore associated factors. Results The best cut-off value for age prediction of life expectancy of self-care health attenuation was 85.5 years old, and the area under the ROC curve line AUC was 0.873, the most approximate index was 1.613, the diagnostic sensitivity was 66.50%, and the specificity was 94.80%; The best cut-off value of age prediction of self-rated healthy life expectancy attenuation was 85.5 years old, and the area under the ROC curve line AUC was 0.799, the most approximate index was 1.520, the diagnostic sensitivity was 57.30%, and the specificity was 94.70%; And age, illiterate, chronic disease were hazard factors, good economic conditions, surviving spouse were protective factors for estimated healthy life expectancy; Conclusion The estimated healthy life expectancy attenuation inflection point of the elderly is about 85.5 years old. The age, illiterate, chronic disease were hazard factors, good economic conditions, surviving spouse were protective factors.
    Analysis of Risk Factors of Infection and Clinical Significance of Serum PCT, TNF-α and WBC after Percutaneous Nephrolithotomy in Patients with Upper Urinary Tract Calculi
    PANG Hua, BIAN Jian-hua, LIU Wen-jie, ZHI Jing-tao
    2023, 41(4):  15-18. 
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    Objective To explore the risk factors of postoperative urinary tract infection in patients with upper urinary tract calculi and the diagnostic value of serum PCT, TNF - α and WBC for postoperative urinary tract infection. Methods The data of 118 patients with upper urinary tract calculi who underwent percutaneous nephrolithotomy in the Department of Urology, Beijing Nuclear Industry Hospital from June 2014 to June 2021 were retrospectively analyzed. Logistic regression was used to analyze the risk factors of postoperative urinary tract infection in patients; serum PCT and TNF-α expression levels in patients with or without infection were detected by ELISA, and WBC counts in peripheral blood were recorded. Diagnostic value of postoperative urinary tract infection. Results Stone size, operation time, positive urine culture and positive urine protein were the risk factors of postoperative urinary tract infection (P<0.05). AUC for PCT, TNF- α, WBC, and combined analysis curve were 0.903, 0.893, 0.854 and 0.994, respectively. Conclusions tone size, operation time and preoperative urinary tract infection are the risk factors of postoperative urinary tract infection. The combined analysis of postoperative PCT, TNF - α and WBC get the best diagnostic efficacy for urinary tract infection.
    Analysis of the Value of Microbiological Examination Combined with Vaginal Secretion Specimen Quintuple Examination in Patients with Cervicitis
    MENG Si-tong
    2023, 41(4):  18-22. 
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    Objective To explore and analysis the values of microbiological examination combined with penta test of vaginal secretion specimens in patients with cervicitis, so as to promote the early detection of cervicitis. Methods From January 2020 to July 2022, 78 cases of patients with cervicitis who were diagnosed and treated in our hospital were selected as the research subjects. All patients were given microbiological examination combined with vaginal secretion specimen quintuple examination. At the same time, histopathological examination was given and the diagnostic value was judged. Results In the 78 patients, there were 32 cases were classified as CIN grade Ⅰ, 28 cases of CIN gradeⅡ, 10 cases of CIN gradeⅢ, and 8 cases of cervical cancer by microbiological examination combined with vaginal secretion specimen quintuple examination. The pathological diagnosis was CIN gradeⅠ in 33 cases, CIN gradeⅡ in 24 cases, CIN gradeⅢ in 11 cases, and cervical cancer in 10 cases. The accuracy rates of microbiological examination combined with vaginal secretion specimen quintuple examination in diagnosing CIN gradeⅠ, CIN gradeⅡ, CIN gradeⅢ and cervical cancer were 96.97%(32/33), 82.14%(23/28), 70.00%(7/10), 100.00%(8/8). The total diagnostic accuracy rate was 89.74%(70/78), and there were 8 cases were error diagnosis. Spearsman analysis showed that age at menarche, smoking, blood sugar, pregnancy, parity were correlated to the error diagnosis (P<0.05). Multivariate logistic regression analysis showed that age at menarche, smoking, blood sugar, pregnancy and parity were the main independent risk factors for the error diagnosis of microbiological examination combined with vaginal secretion specimen quintuple examination (P<0.05). Conclusion Microbiological examination combined with vaginal secretion specimen quintuple examination can help clinicians to judge the condition of patients with cervicitis early, but there are also some error diagnosis. Menarche, smoking, blood sugar, pregnancy and parity were the important reasons for error diagnosis.
    Application Value of Magnifying Glass OE Pattern Combined with Lugol's Staining Pattern in the Diagnosis of Early Esophageal Cancer and Precancerous Lesions
    XU Yan-ling, SHI Xia, DONG Lei, LIU Zhi-juan, LI Nai-han
    2023, 41(4):  22-25. 
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    Objective To explore the application value of magnifying glass OE pattern combined with Lugol's staining pattern in the diagnosis of early esophageal cancer and precancerous lesions. Methods The clinical data of 40 patients with suspected esophageal mucosal lesions admitted to the outpatient clinic of Rizhao Hospital of Traditional Chinese Medicine from November 2019 to November 2021 were retrospectively analyzed. All patients underwent endoscopy with electronic gastroscope. Endoscopy was performed under the magnifying glass OE mode and Lugol's staining mode, respectively. The pathological examination results were used as the gold standard to analyze and compare the magnifying glass OE mode and the magnifying glass OE mode combined with Lugol's. The sensitivity, accuracy, specificity, negative predictive value (NPV), positive predictive value (PPV) of staining pattern for the diagnosis of early esophageal cancer and precancerous lesions, and analysis of magnifying glass OE pattern and Lugol's staining to detect early esophageal cancer and cancer The relationship between pre-lesion and pathological examination results. Results Among 40 patients with suspected esophageal mucosal lesions, 28 were diagnosed with early esophageal cancer and precancerous lesions after pathological examination, including 8 early esophageal cancer, 10 mild dysplasia,6 moderate dysplasia, and severe dysplasia. There were 4 cases of dysplasia; the remaining 12 cases were esophagitis or erosion or ulcer. Among them, 22 cases were positive in magnifying glass OE mode, and 27 cases were positive in magnifying glass OE mode combined with Lugol's staining mode. The accuracy and sensitivity of combined detection in the diagnosis of early esophageal cancer and precancerous lesions were higher than that of single detection with magnifying glass OE mode (P<0.05); Kappa test showed that the concordance between magnifying glass OE mode and pathological diagnosis was fair (Kappa value=0.479, P=0.001);the concordance between combined detection and pathological diagnosis was excellent (Kappa=0.826,P<0.001).ConclusionThe magnifying glass OE mode combined with Lugol's staining mode has higher accuracy and sensitivity in the diagnosis of early esophageal cancer and precancerous lesions,which can provide an important reference for early treatment.
    Effect of Chai Hu Jia Long Mu Decoction on Patients with Hyperplasia of Mammary Glands and Serum Sex Hormone Levels
    WANG Jian-jun
    2023, 41(4):  26-29. 
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    Objective To explore and analysis the curative effect of Chaihu Jialongmu Decoction on breast hyperplasia patients and its effect on serum sex hormone levels. Methods From February 2019 to July 2021, 86 cases of patients with breast hyperplasia who were diagnosed and treated in Xinjiang Production and Construction Corps Sixth Division General Hospital were selected as the research objects. Accorded to the principle of random number table method, the patients were divided into the traditional Chinese medicine group and the control group with 43 cases in each groups. The control group were given methyl testosterone treatment, and the traditional Chinese medicine group were given Chaihu Jialongmu Decoction treatment on the basis of the treatment of the control group. Results After treatment, the total effective rate in the traditional Chinese medicine group was significantly higher than that in the control group, but the differencewas not statistically significant (P>0.05). The breast lump scores and breast pain scores in two groups after treatment were significantly lower than those before treatment (P<0.05), and the breast lump scores and breast pain scores of traditional Chinese medicine group were also significantly lower than that in the control group after treatment (P<0.05). The levels of serum prolactin (PRL) and testosterone (T) in both groups after treatment were significantly lower than those before treatment (P<0.05), and the traditional Chinese medicine group were also significantly lower than that in the control group after treatment (P<0.05). The incidence of adverse reactions such as nausea, vertigo, menstrual disorders and gastrointestinal reactions during treatment in the traditional Chinese medicine group was slightly lower than that in the control group, there was no statistical significance in the incidence of adverse reactions between two groups (P>0.05). Conclusion Chaihu Jialongmu Decoction in the treatment of breast hyperplasia can improve the total effective rate of patients, reduce the occurrence of adverse reactions, and also reduce the serum PRL and T levels of patients, promote the continuous improvement of clinical symptoms of patients.
    Clinical Observation on the Treatment of Anorexia in Children with Spleen Dysfunction Type by Acupuncture Point Dredging and Pain Point Massage
    WU Yi-wen
    2023, 41(4):  29-33. 
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    Objective To explore and observe the clinical effect of meridian point dredging combined with pain point rubbing and tuina in the adjuvant treatment of anorexia in children with spleen dysfunction. Methods From December 2020 to September 2022, 78 cases of anorexia in children with spleen insufficiency diagnosed and treated in our hospital were selected as the research objects, and the children were divided into the study group and the control group with 39 cases in each group accorded to the principle of random number table method. The control group was given zinc gluconate treatment, and the study group was given meridian point dredging and pain point rubbing and tuina treatment on the basis of the treatment of the control group. Both groups were treated and observed for 4 weeks. The therapeutic effects, clinical symptoms, 1/2 gastric emptying time, serum zinc and leptin content were observed in the two groups. Results After treatment, the total effective rate of the study group was slightly higher than that of the control group, but there was no difference between the two groups (P>0.05). The 1/2 gastric emptying time of the two groups after treatment was significantly lower than that before treatment (P<0.05). The serum zinc and leptin contents of the two groups after treatment were significantly higher than those before treatment (P<0.05). After treatment, the serum zinc and leptin contents of the study group were significantly higher than those of the control group (P<0.05). The food intake and appetite TCM syndrome scores of the two groups after treatment were significantly lower than those before treatment (P<0.05), and the food intake and appetite TCM syndrome scores of study group was also significantly lower than the control group after treatment (P<0.05). Conclusion The adjuvant therapy of meridian point dredging and pain point rubbing and tuina in the treatment of anorexia in children with spleen insufficiency can improve serum zinc and leptin levels, it can shorten 1/2 gastric emptying time, promote the relief of clinical symptoms in children, improve the therapeutic effect.
    Effect of Acupuncture Combined with Yang Sheng Yi Zhi Decoction on Coagulation Function and Neurological Function in Patients with Cerebral Infarction
    MAO A-wen, ZHANG Jun
    2023, 41(4):  36-39. 
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    Objective To explore and analysis the effects of acupuncture combined with Health Nourishing and Intelligence Nourishing Soup on coagulation function and neurological function in patients with cerebral infarction. Methods From February 2018 to March 2022, 86 cases of patients with cerebral infarction diagnosed and treated in our hospital were selected as the research subjects. Accorded to the random number table method principle of 1:1, the patients were divided into the acupuncture group of 43 cases and the traditional group of 43 cases. The traditional group were treated with Health Nourishing and Intelligence Nourishing Soup, and the acupuncture group were treated with acupuncture on the basis of the traditional group. Results After treatment, the total effective rates of the acupuncture group was higher than that of the traditional group, but there was no statistically significant difference (P>0.05). The incidence rates of complications such as pulmonary infection, urinary tract infection, venous thrombosis and bedsore in the acupuncture group was significantly lower than that in the traditional group (P<0.05). The scores of cognitive function and daily living ability in both groups after treatment were significantly higher than those before treatment (P<0.05), and the scores of acupuncture group after treatment were also significantly higher than those in the traditional group (P<0.05). The prothrombin time and activated partial prothrombin time of the two groups after treatment were significantly higher than those before treatment (P<0.05), and the acupuncture group after treatment were also significantly higher than that of the traditional group (P<0.05). Conclusion The application of acupuncture combined with Health Nourishing and Intelligence Nourishing Soup in patients with cerebral infarction can improve cognitive function, daily living ability and neurological function, reduce the occurrence of complications, and improve the coagulation function of patients.
    Changes of Bone Mineral Density and Bone Microstructure in Elderly Patients with Osteoporosis by Traditional Chinese Medicine Yijinjing
    CHEN Hong
    2023, 41(4):  39-42. 
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    Objective To investigate the effects of traditional Chinese medicine Yijinjing on the changes of bone mineral density and bone microstructure in elderly patients with osteoporosis. Methods Eighty-eight elderly patients with osteoporosis who were diagnosed and treated in the Affiliated Hospital of Traditional Chinese Medicine of Nanyang Medical College from August 2018 to December 2021 were selected as the research objects. Accorded to the 1:1 allocation principle of the random number table methods, the patients were divided into Yijinjing group and control group with 44 cases in each group. The control group were given traditional aerobic exercise and weight-bearing exercise for rehabilitation, and the Yijinjing group were given traditional Chinese medicine Yijinjing rehabilitation on the basis of the rehabilitation of the control group. The rehabilitation and exercise were observed in both groups for 6 months, and changes in bone mineral density and bone microstructure were detected and recorded. Results After rehabilitation, the total effective rates of Yijinjing group was higher than that in control group, but there was no statistical significance between two groups (P>0.05). The bone mineral density of the lumbar spine L2-L4 in the Yijinjing group and the control group after rehabilitation were significantly higher than that before treatment (P<0.05), and the Yijinjing group were also significantly higher than the control group after rehabilitation (P<0.05). The distance of trabecular bone after rehabilitation in the two groups were significantly higher than that before rehabilitation (P<0.05), and the thickness of trabecular bone were significantly lower than that before rehabilitation (P<0.05). The content of serum calcium and phosphorus in Yijinjing group and control group after rehabilitation were higher than those before rehabilitation (P<0.05), and the Yijinjing group after rehabilitation were also significantly higher than that in control group (P<0.05). Conclusion The application of traditional Chinese medicine Yijinjing in elderly patients with osteoporosis can improve bone mineral density and overall rehabilitation effect, improve the bone microstructure of patients, and promote the increase of blood calcium and blood phosphorus content in patients.
    Research Progress of Acupuncture in the Treatment of Insomnia
    GU Ya-qi, DING Rui, SHEN Wen-xuan, CHEN Xin-yu, DONG Zhen-zhen
    2023, 41(4):  55-58. 
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    Insomnia is a disease that often troubles people in modern society. Lack of adequate sleep time and good sleep quality coupled with the pressure of daily life constantly produces a vicious circle, causing great damage to people's physical and psychological health. Acupuncture for insomnia is safe, efficient, through the analysis of the literature on the treatment for insomnia by ordinary acupuncture and acupuncture coupled with other methods in the nearly five years,the research progress of filiform acupuncture, special needle acupuncture, acupuncture coupled with moxibustion, acupuncture coupled with massage, acupuncture coupled with cupping and acupuncture coupled with traditional Chinese medicine was further summarized.This thesis brings forward a few problems in the recent research, hoping to provide valuable evidence and enlightenment for clinic.
    Research Progress of Icariin in the Treatment of Osteoporosis
    ZHU Yuan-chao, QIN Hao-tian, LIU Su, CHEN Yi-xiao, ZHANG Geng, LIAO Shuai, WENG Jian, YU Fei, ZENG Hui
    2023, 41(4):  58-62. 
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    Osteoporosis is a chronic disease characterized by bone loss and structural damage of bone tissue. It has a high incidence rate in middle-aged and elderly people, especially in postmenopausal women. The disease seriously threatens the physical and mental health of patients and brings heavy burden to their families. Because of its side effects and high price, the use of drugs for the treatment of osteoporosis has been affected. Epimedium, a traditional Chinese medicine, is safe to use and easy to obtain. It is widely used in the treatment of orthopedic diseases. Previous studies have confirmed that icariin, the main component of epimedium, has a good application prospect in the treatment of osteoporosis. It can promote the proliferation and differentiation of osteoblasts and BMSCs by up regulating the expression of osteogenic markers ALP, RUNX2, BMP-2, etc., and achieve bone regeneration and bone formation. In this process, Wnt/ β- Catenin, OPG/RANK/RANKL and other signaling pathways play an important role. Based on this, this article reviews the effect and possible mechanism of icariin on osteoporosis.
    Research Progress in the Prevention and Treatment of Bleeding Disorders with Shenfu Injection Based on the Theory of Warming Yang and Tonifying Qi and Regulating Blood
    GAO Yuan
    2023, 41(4):  62-65. 
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    In modern medicine, the occurrence of hemorrhagic diseases is mostly concentrated in the heart, brain, lung, gastrointestinal organs, etc. The treatment of these diseases is mainly based on hemostasis and coagulation after bleeding and anticoagulation and antithrombosis, which are all symptomatic treatments based on a single organ. Based on the warming properties of Shenfu injection and the widespread and convenient use of this medicine in clinical practice, the therapeutic progress of Shenfu injection in the treatment of bleeding disorders is reviewed, with a view to applying the therapeutic concepts of Qi and Blood together and two-way regulation in Chinese and Western medicine in the future.
    To Explore the Feasibility and Superiority of Laparoscopic Total Hysterectomy with Lateral Bladder Entry and Hierarchical Separation
    JIANG Rong-mei
    2023, 41(4):  172-175. 
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    Objective To evaluate the feasibility and superiority of laparoscopic transvesical dissection in total hysterectomy. Methods 60 patients with uterine leiomyoma who were admitted to Zaoqiang County People's Hospital of Hengshui City, Hebei Province from January 2020 to August 2021 and underwent total hysterectomy (TLH) were included. All the subjects were divided into the control group (30 cases were included, using direct entry method) and the observation group (30 cases were included, using lateral entry method). The intraoperative indicators, recovery and follow-up between the groups were evaluated. Results Compared with the control group, the average bleeding volume, the average operation time, the average time out of bed and the average hospitalization time in the observation group were less (P<0.05), but there was no difference in the average anal exhaust time and the average body temperature five days after operation between the two groups (P>0.05); during the follow-up of 3 months, except for 3 cases of chronic abdominal pain in the control group, the vaginal broken ends and abdominal wall wounds in both groups recovered well, and there were no complications such as dysuria and pelvic adhesion thickening. Conclusion TLH performed by bladder lateral approach in patients with uterine leiomyoma has the advantages of less trauma, less time out of bed and hospitalization, strong feasibility, and is worth popularizing.