Abstract: Objective To explore and analysis the curative effect of Chaihu Jialongmu Decoction on breast hyperplasia patients and its effect on serum sex hormone levels. Methods From February 2019 to July 2021, 86 cases of patients with breast hyperplasia who were diagnosed and treated in Xinjiang Production and Construction Corps Sixth Division General Hospital were selected as the research objects. Accorded to the principle of random number table method, the patients were divided into the traditional Chinese medicine group and the control group with 43 cases in each groups. The control group were given methyl testosterone treatment, and the traditional Chinese medicine group were given Chaihu Jialongmu Decoction treatment on the basis of the treatment of the control group. Results After treatment, the total effective rate in the traditional Chinese medicine group was significantly higher than that in the control group, but the differencewas not statistically significant (P>0.05). The breast lump scores and breast pain scores in two groups after treatment were significantly lower than those before treatment (P<0.05), and the breast lump scores and breast pain scores of traditional Chinese medicine group were also significantly lower than that in the control group after treatment (P<0.05). The levels of serum prolactin (PRL) and testosterone (T) in both groups after treatment were significantly lower than those before treatment (P<0.05), and the traditional Chinese medicine group were also significantly lower than that in the control group after treatment (P<0.05). The incidence of adverse reactions such as nausea, vertigo, menstrual disorders and gastrointestinal reactions during treatment in the traditional Chinese medicine group was slightly lower than that in the control group, there was no statistical significance in the incidence of adverse reactions between two groups (P>0.05). Conclusion Chaihu Jialongmu Decoction in the treatment of breast hyperplasia can improve the total effective rate of patients, reduce the occurrence of adverse reactions, and also reduce the serum PRL and T levels of patients, promote the continuous improvement of clinical symptoms of patients.

Key words: Chaihu Jialongmu Decoction, breast hyperplasia, adverse reactions, prolactin, testosterone, sex hormones