Abstract: Objective To explore the application value of magnifying glass OE pattern combined with Lugol's staining pattern in the diagnosis of early esophageal cancer and precancerous lesions. Methods The clinical data of 40 patients with suspected esophageal mucosal lesions admitted to the outpatient clinic of Rizhao Hospital of Traditional Chinese Medicine from November 2019 to November 2021 were retrospectively analyzed. All patients underwent endoscopy with electronic gastroscope. Endoscopy was performed under the magnifying glass OE mode and Lugol's staining mode, respectively. The pathological examination results were used as the gold standard to analyze and compare the magnifying glass OE mode and the magnifying glass OE mode combined with Lugol's. The sensitivity, accuracy, specificity, negative predictive value (NPV), positive predictive value (PPV) of staining pattern for the diagnosis of early esophageal cancer and precancerous lesions, and analysis of magnifying glass OE pattern and Lugol's staining to detect early esophageal cancer and cancer The relationship between pre-lesion and pathological examination results. Results Among 40 patients with suspected esophageal mucosal lesions, 28 were diagnosed with early esophageal cancer and precancerous lesions after pathological examination, including 8 early esophageal cancer, 10 mild dysplasia,6 moderate dysplasia, and severe dysplasia. There were 4 cases of dysplasia; the remaining 12 cases were esophagitis or erosion or ulcer. Among them, 22 cases were positive in magnifying glass OE mode, and 27 cases were positive in magnifying glass OE mode combined with Lugol's staining mode. The accuracy and sensitivity of combined detection in the diagnosis of early esophageal cancer and precancerous lesions were higher than that of single detection with magnifying glass OE mode (P<0.05); Kappa test showed that the concordance between magnifying glass OE mode and pathological diagnosis was fair (Kappa value=0.479, P=0.001);the concordance between combined detection and pathological diagnosis was excellent (Kappa=0.826,P<0.001).ConclusionThe magnifying glass OE mode combined with Lugol's staining mode has higher accuracy and sensitivity in the diagnosis of early esophageal cancer and precancerous lesions,which can provide an important reference for early treatment.

Key words: early esophageal cancer, precancerous lesions, Lugol's staining pattern