Abstract: Objective To investigate the common pathogenic bacteria analysis, clinical drug resistance and drug sensitivity results of bacterial blood stream infection (BSI) in patients with blood tumors in the People's Hospital of Inner Mongolia Autonomous Region, so as to provide clinicians with diagnosis and treatment ideas and clinical basis for anti infection treatment and reduce hospital acquired infection selection. Methods Collect and sort out the blood culture samples of hospitalized patients (a total of 194 cases) with hematological tumors and bacterial blood flow infection from January 2016 to December 2020 of the Inner Mongolia Autonomous Region People's Hospital, and the specific operation is to extract 20 mL of peripheral blood from these 194 patients, place it in a bacterial culture bottle, and then place it in a blood culture instrument to detect and collect positive samples. Use the automated instrument method and paper diffusion method to carry out bacteriological analysis, clinical drug resistance and drug sensitivity test for the detected pathogenic bacteria. Results A total of 197 strains were isolated from blood culture positive samples without repetition, of which 97 (49.24%) strains were gram-negative bacteria, mainly 58 (29.45%) strains of Escherichia coli and 20 (10.15%) strains of Klebsiella pneumoniae; The second was Gram positive bacteria, with 57 (28.93%) strains, mainly including 23 (11.68%) strains of Staphylococcus epidermidis and 11 (5.58%) strains of Staphylococcus aureus; There were 2 (1.02%) fungi and 41 (20.81%) other strains. The results of drug sensitivity test showed that Gram negative bacteria had the highest sensitivity to carbapenem antibiotics and the highest resistance to ampicillin; Gram positive bacteria had the highest sensitivity to glycopeptide antibiotics linezolid and vancomycin, and high resistance to penicillin G and erythromycin. Conclusion There are many types of pathogenic bacteria with BSI in patients with hematological tumors, mainly gram-negative bacteria, and meropenem and imipernam can be used as alternative main antibacterial drugs in the clinic; Gram-positive bacterial infection is secondary, so when severe staphylococcal bloodstream infection occurs, linezolid, vancomycin, etc. can be preferred for antibacterial therapy; Antibacterial drugs such as voriconazole and fluconazole can be applied to the treatment of clinical fungal infections.

Key words: blood tumor, blood stream infection, drug-resistant, pathogens