Abstract: Objective To evaluate the feasibility and superiority of laparoscopic transvesical dissection in total hysterectomy. Methods 60 patients with uterine leiomyoma who were admitted to Zaoqiang County People's Hospital of Hengshui City, Hebei Province from January 2020 to August 2021 and underwent total hysterectomy (TLH) were included. All the subjects were divided into the control group (30 cases were included, using direct entry method) and the observation group (30 cases were included, using lateral entry method). The intraoperative indicators, recovery and follow-up between the groups were evaluated. Results Compared with the control group, the average bleeding volume, the average operation time, the average time out of bed and the average hospitalization time in the observation group were less (P<0.05), but there was no difference in the average anal exhaust time and the average body temperature five days after operation between the two groups (P>0.05); during the follow-up of 3 months, except for 3 cases of chronic abdominal pain in the control group, the vaginal broken ends and abdominal wall wounds in both groups recovered well, and there were no complications such as dysuria and pelvic adhesion thickening. Conclusion TLH performed by bladder lateral approach in patients with uterine leiomyoma has the advantages of less trauma, less time out of bed and hospitalization, strong feasibility, and is worth popularizing.

Key words: laparoscopic transvesical layer separation, total hysterectomy, feasibility, superiority