Table of Content

01 December 2024, Volume 42 Issue 23

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Discussion on the Mechanism of the Treatment of Cervical Paralysis by the Theory of Meridians and Tendons

ZHAO Yuan-yuan, CHEN Feng

2024, 42(23):  1-4. 

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The correlation between cervical paralysis and meridians is discussed through the meridian theory, so as to propose the diagnostic method of cervical paralysis meridian lesions and acupuncture treatment, and to provide theoretical basis for the clinical application of meridian theory in the treatment of cervical paralysis.

Professor Shao Rongshi's Experience in Treating Swelling Erosive Gastritis with Splenic Deficiency, Damp-Heat and Turbid Poison

SHEN Wen, SHAO Rong-shi, ZHOU Xiao-ming, LIU Jin-di, LI Yan

2024, 42(23):  4-7. 

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Objective To introduce Professor Shao Rongshi's clinical experience in the treatment of erosive gastritis protuberans. Methods Intrinsic essence of this disease was explained through Professor Shao Rongshi's understanding of erosive gastritis protuberans in clinical practice. According to the cube of clearing heat and removing dampness and collateral method, Professor Shao Rongshi's clinical experience was introduced from four aspects of heat, dampness, deficiency and stasis in order to better guide clinical diagnosis and treatment. Conclusion The method of clearing heat, removing dampness and harmonizing collaterals by Professor Shao Rongshi, has an essential understanding of the pathogenic characteristics and pathological mechanism of this disease with significant clinical effect and good prognosis.

Exploring the Mechanism of Action of Astragalus Notoginseng Capsule in the Treatment of Coronary Heart Disease Based on Network Pharmacology and Molecular Docking Technology

LYU Jin-tai, CHENG Li-rong

2024, 42(23):  7-13. 

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Objective To explore the mechanism of action of Astragalus panax ginseng capsule in the treatment of coronary atherosclerotic heart disease (coronary heart disease) using network pharmacology and molecular docking methods. Methods The active ingredients and targets of the drug were screened by TCMSP database. Database platforms (GeneCards, DrugBank) were used to obtain coronary heart disease targets. The intersecting targets were obtained by applying venny2.1.0, and the metascape database was used for enrichment analysis. CB-DOCK2 was applied for molecular docking validation. Results Twenty-nine active ingredients of Astragalus panax ginseng capsule and 91 intersecting targets were screened; the KEGG pathway was selected as the top 5, and the molecular docking molecular docking was stabilized. Conclusion Astragalus panax ginseng capsule core ingredients quercetin, kaempferol, β-sitosterol, mangosteen, isorhamnetin, act on the core targets of TNF, AKT1, IL-6, IL-1β, PTGS2, and modulate AGE-RAGE, fluid shear stress and atherosclerosis, lipids and atherosclerosis, IL-17, and TNF signaling pathway for the treatment of coronary artery disease, and molecular docking showed that all <-5 cal/mol.

Discussion on the Action Mechanism of Laurel Branch

SONG Yong-gang, LI Chun-qiao

2024, 42(23):  14-16. 

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This paper discusses the action mechanism of Cinnamomum cassia through the discussion of Shennong Materia Medica Classic, the experience of applying Cinnamomum cassia in Treatise on Febrile Diseases, and the modern pharmacological research of Cinnamomum cassia, and illustrates the action mechanism of Cinnamomum cassia through the author's application of two cases of Guizhi Fuling Pill and Linggui Ganzao Decoction.

Thunder Fire Moxibustion Combined with Manual Massage and Electrical Stimulation in the Treatment of Postpartum Myofascial Pelvic Pain Syndrome

LI ping, HU You-bin

2024, 42(23):  23-27. 

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Objective To investigate the clinical efficacy of thunder fire moxibustion combined with manual massage and electrical stimulation on postpartum pelvic floor myofascial pain syndrome. Methods A total of 95 patients with pelvic floor myofascial pain who were treated in Linyi Maternal and Child Health Hospital from June 2022 to June 2023 were enrolled as the research subjects, and the random number was used to divide the group (33 cases), the electrical stimulation group (31 cases), and the combined group (31 cases). The changes of subjective pain and pelvic floor muscle tenderness visual analogue (VAS) score, pelvic floor muscle surface electromyography assessment and other measurement indexes were compared between the three groups before and after treatment. Results After treatment, the combined subjective pain VAS score group was better than that of the thunder fire moxibustion group and the electrical stimulation group. After treatment, the combined VAS score of pelvic floor muscle tenderness group was better than that of the electrical stimulation group and the thunder fire moxibustion group. The effective rate of the combined group was significantly higher than that of the thunder fire moxibustion group and the electrical stimulation group, and the difference was statistically significant (P<0.05). Conclusion The combination of thunder fire moxibustion combined with manual massage and electrical stimulation can effectively reduce the pain symptoms of patients with postpartum pelvic floor myofascial pain syndrome and improve the effective rate of treatment, which is worthy of clinical promotion and application.

The Effect of Yindan Xinnaotong Soft Capsule Combined with rt-PA on Cognitive Function and Blood Lipids in Patients with Ischemic Stroke

FU Xiao-ning, XU Wen-li

2024, 42(23):  31-35. 

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Objective To observe the effect of Yindan Xinnaotong soft capsule combined with recombinant tissue-type plasminogen activator (rt-PA) intravenous thrombolysis on the overall benefit level of patients with ischemic stroke. Methods Study sample source: 100 ischaemic stroke patients admitted to the Department of Neurology of Xixiang County Hospital of Traditional Chinese Medicine, sample selection time: between January 2022 and December 2023 period. The enrolled patients were divided into two groups using the random number table method, 50 cases in the control group, in which rt-PA intravenous thrombolytic therapy was carried out, and 50 cases in the combined group, in which the patients in the group were combined with Yindan Xinguintong soft capsule therapy on the basis of the control group, to compare the clinical efficacy, the recovery of neurological function [Stroke Scale (NIHSS), Modified Rankin Scale (mRs)], haemato-rheology, blood lipids [triacylglycerol (TG), total body fat (TG), total body fat (TG) and blood lipid [triacylglycerol (TG), and total body fat (TL)]. glycerol (TG), total cholesterol (TC), whole blood viscosity (WBV) and erythrocyte sedimentation rate (ESR)], oxidative stress [serum nitric oxide (NO), malondialdehyde (MDA)]. Results The treatment effect of the combined group was better than that of the control group, and the difference was statistically significant (P<0.05); there was no statistical difference between the scores of NHISS and mRs before treatment in the two groups (P>0.05). After treatment, the scores of NHISS and mRs in the combined group decreased significantly,with statistical difference (P<0.05). There was no statistical difference in the expressions of TC, TG, WBV and ESR between the two groups before treatment (P>0.05). After treatment,the expressions of TC, TG and WBV in the two groups decreased,while the expressions of ESR increased. Moreover,the decreases of TC, TG and WBV in the combined group were larger than those in the control group, and the differences were statistically significant (P<0.05), comparison of MDA and NO between the two groups before treatment, the difference was not statistically significant (P>0.05), after treatment, NO decreased and MDA increased in both groups,and the magnitude of NO decrease and MDA increase in the combined group was greater than that of the control group, and the difference was statistically significant (P<0.05). Conclusion Ischemic stroke patients in rt-PA treatment based on the combination of Yindan Xinhuantong soft capsule, the therapeutic effect is better,the patient's neurological function recovery is more complete, and is conducive to the improvement of the patient's blood lipids, blood rheology and oxidative stress response.

Diagnostic Value of TBA Combined with PGE2 in Early Gastrointestinal Bleeding

LIU Jing

2024, 42(23):  42-46. 

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Objective To investigate the diagnostic value of total bile acid (TBA) combined with prostaglandin E2 (PGE2) in early gastrointestinal bleeding. Methods From July 2018 to July 2023, 105 cases of patients with gastrointestinal bleeding in Beijing Changping District Hospital of Integrative Medicine were retrospectively analyzed. All patients were diagnosed by gastroscopy. Patients were grouped according to the amount of bleeding. Patients with a bleeding volume of<500 mL were divided into a mild group (n=40), patients with a bleeding volume of 800-1000 mL were divided into a moderate group (n=25), and patients with a bleeding volume of>1500mL were divided into a severe group (n=10). Another 40 healthy people who came to our hospital for physical examination during the same period were selected as the control group. The expression levels of TBA and PGE2 in the four groups were compared, and the correlation between TBA and PGE2 and the severity of gastrointestinal bleeding was analyzed. The receiver operating characteristic (ROC) curve was established to analyze the diagnostic threshold of TBA and PGE2 for early gastrointestinal bleeding. Results The expression levels of TBA and PGE2 in the severe group higher than those in the moderate group, mild group and control group, and the level of PGE2 was significantly lower than those in the moderate group, mild group and control group (P<0.05); Spearman correlation analysis showed that TBA was positively correlated with the severity of gastrointestinal bleeding (P<0.05), while PGE2 was negatively correlated with the severity of gastrointestinal bleeding (P<0.05); The critical value of TBA is 11.32 μ The diagnostic index reached the maximum value of 1.678 at the concentration of 1.678 mol/L. the sensitivity and specificity for the diagnosis of early gastrointestinal bleeding were 81.27% and 79.46%, respectively. When the critical value of PGE2 was 95.26 pg/mL, the diagnostic index reached the maximum value of 1.689, and the sensitivity and specificity for the diagnosis of early gastrointestinal bleeding were 84.95% and 81.26%, respectively. Conclusion TBA combined with PGE2 detection plays a positive role in improving the diagnosis rate of early gastrointestinal bleeding, and is correlated with the severity of gastrointestinal bleeding μ 26 pg/ml, and timely take relevant measures for intervention.

Diagnostic Value of CRP LDH PCT Combined with SF in the Severity and Prognosis of Mycoplasma Infection in Children

NING Xin-ping, ZHOU Xiao-ping

2024, 42(23):  56-59. 

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Objective To analyze the diagnostic value of C-reactive protein (CRP), lactate dehydrogenase (LDH), procalcitonin (PCT) combined with ferritin (SF) in the severity and prognosis of mycoplasma infection in children. Methods Clinical data of 150 children with mycoplasma pneumoniae infection admitted to Dali County Hospital from July 2019 to May 2022 were retrospectively analyzed. Among them, 82 cases were mild (mild group) and 68 cases were severe (severe group). Serum CRP, LDH, PCT and SF levels of the two groups were detected, and Pearson correlation analysis was used to analyze the relationship between CRP, LDH, PCT and SF levels and clinical pulmonary infection score (CPIS score). The area under ROC curve (AUC) was used to evaluate the predictive efficacy of CRP, LDH, PCT and SF in poor prognosis. Results The levels of CRP, LDH, PCT and SF in the severe group were higher than those in the mild group (P<0.05). By Pearson correlation analysis, serum CRP, LDH, PCT and SF levels were positively correlated with CPIS score (P<0.05). All patients were followed up, of which 118 were cured and 32 had poor prognosis. Multivariate Logistic regression analysis showed that serum CRP, LDH, PCT and SF were independent predictors of poor prognosis (P<0.05). Through ROC curve analysis, the AUC of serum CRP, LDH, PCT combined with SF predicting poor prognosis in children with Mycoplasma pneumoniae infection was 0.912, significantly higher than the single indicator CRP of 0.666, LDH of 0.589, PCT of 0.712, and SF of 0.683. Conclusion Serum CRP, LDH, PCT and SF are closely related to the severity of mycoplasma infection in children.The combination of these four factors has a good efficacy in predicting poor prognosis of children,which is worthy of further study and application.

Research Progress on Factors of Lower Extremity Deep Vein Thrombosis after Total Knee Replacement

CUI Yu-hao, HUANG Li-xin

2024, 42(23):  66-69. 

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Total knee arthroplasty (TKA) is an effective method for treating terminal knee joint diseases, which can effectively eliminate knee joint pain, significantly improve postoperative function of the affected limb, and have a low mortality rate. It has been widely used in clinical practice. However, TKA patients are mainly elderly and are prone to developing lower limb venous thrombosis, especially deep vein thrombosis (DVT), after surgery. If the thrombus falls off, it can lead to secondary pulmonary embolism, seriously threatening the patient's life safety. This article reviews the risk factors for lower limb DVT in patients undergoing TKA surgery.

Application of network teaching platform combined with realistic case-based learing method in nursing teaching of neurology department

HU Zhe, LI jie, FU Jing-na, MU Jun, XU Jie, SU Rong, YANG Jun-xing

2024, 42(23):  79-82. 

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Objective To mobilize the learning enthusiasm, cultivate the independent learning ability, clinical thinking ability, improve the humanistic caring ability and teamwork ability of nursing students, and thus improve the overall nursing level of nursing students, achieve the expected teaching effect and improve the quality of clinical nursing teaching through the implementation of the network teaching platform combined with realistic case-based learning (CBL) method in nursing teaching of neurology department. Methods From September 2022 to September 2023, 80 cases of nursing students practicing in the ward of the Department of Encephalopathy of Dongzhimen Hospital Beijing University of Chinese Medicine were enrolled in this study, using district group randomization method they were divided into observation group and the control group. Every 5 people were in a district group, according to the principle of random into the observation group or control group. The 40 cases in the control group were taught by the traditional teaching method, and the other 40 cases in the observation group were taught by the network teaching platform combined with realistic CBL method. We then compared the two groups of nursing students' theoretical and operational assessment scores, clinical thinking ability, self-directed learning skills, and humanistic caring ability. Results The theoretical and operational assessment scores, clinical thinking ability, self-directed learning skills and humanistic caring ability of nursing students in the observation group were all higher than those in the control group (P<0.05). Conclusion The network teaching platform combined with realistic CBL method can enhance the overall nursing level of nursing students and improve the quality of clinical nursing teaching.

Reflection and Reform of Teachers' Innovation and Entrepreneurship Education in Medical Colleges and Universities in the Post-Epidemic Era of Digital Intelligence

LI Jie-han, ZHANG You-liang, XU Yi

2024, 42(23):  83-87. 

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Innovation is the foundation of entrepreneurship, and entrepreneurship is the carrier of innovation, and medical schools have long taken the cultivation of innovation and entrepreneurship ability of medical students as an important goal of talent cultivation. In the context of the post epidemic digital intelligence era, the innovation and entrepreneurship education teaching mode of medical students is facing a major transformation, and it also puts forward a new requirement for teachers in medical schools, that is, to improve the teaching ability of innovation and entrepreneurship education. This study starts from exploring the importance of the teaching ability of innovation and entrepreneurship education of medical school teachers, and elaborates on the challenges and opportunities as well as the problems faced by teachers' innovation and entrepreneurship education and teaching in the college school in the post-epidemic digital intelligence era. At the same time, it puts forward suggestions to change the innovation and entrepreneurship education system with respect to the popularization of digital intelligence teaching, the change of educational philosophy, the optimization of teaching content, practical training, the cultivation of scientific research ability, and the improvement of incentive mechanism and evaluation system.

Survey on Overweight and Obesity Among Primary and Middle School Students in Hohhot

FENG Qian-qian, WU Shu-li, JIA Fu-hua, WANG Cheng-long

2024, 42(23):  88-91. 

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Objective To investigate the current situation of overweight and obesity among primary and middle school students in Hohhot, and to provide a reference for the intervention measures of overweight and obesity in children in Hohhot. Methods In March 2024,18 377 primary and middle school students in urban and suburban counties of Hohhot were sampled, and the height and weight were measured. Overweight and obesity were judged according to body quality index (BMI), and the prevalence of overweight and obesity among primary and middle school students in this region was statistically analyzed. Results The total detection rate of overweight in Hohhot was 16.17%, and the detection rate of overweight in boys and girls was 18.22% and 14.13% respectively; the total detection rate of obesity was 20.54%,the detection rate of obesity in boys and girls was 25.64% and 15.47% respectively.The detection rate of overweight in urban and suburban counties was 16.42% and 15.92% respectively, and the detection rate of obesity in urban and suburban counties was 20.39% and 20.68% respectively. The obesity rate of Han nationality was 20.06% and that of Mongolian nationality was 22.91%. Overweight and obesity among primary and middle school students were statistically significant with academic section, gender and ethnic group (P<0.001), but not regional. The rate of overweight in all urban boys was higher than that in girls, and the difference was significant (P<0.001);The overweight rate of boys in primary schools in suburban counties was higher than that of girls, and the difference was significant (P<0.001), and the detection rate of overweight between boys and girls in middle and high schools was not significant (P>0.05).In urban areas, the obesity rate of boys was higher than girls, and the difference was statistical significant (P<0.001); in suburban counties, boys were higher than girls, and the difference was statistical significant (P<0.001). From the ethnic group, the overweight detection rate of Han and Mongolian boys was higher than that of girls, and the difference was statistically significant (P<0.001);the obesityrate of Han, Mongolian and other ethnic boys was higher than that of girls, and the difference was statistically significant (P<0.001). Conclusion The problem of overweight and obesity among primary and middle school students in Hohhot is very serious. The problem of overweight and obesity among primary school students and boys is relatively prominent, which is a high risk factor for obesity prevention and control, so we should pay close attention to the above related key groups.

Analysis of Allergen Detection Results of Patients with Allergic Diseases in 2023 in a Hospital in Zibo City, Shandong Province

CAO Cheng, XUE Jun-yu, YANG Ji-xia, XU Hui, ZHAO Feng

2024, 42(23):  92-96. 

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Objective To analyze the detection results of patients with allergic diseases in 2023 in a hospital in Zibo city, Shandong province, and to provide reference for the prevention and treatment of patients with allergic diseases in this area. Methods A total of 596 patients with allergic diseases admitted to Zibo Municipal Hospital from January 2023 to December 2023 were collected, and serum total IgE and allergen specific IgE(sIgE) results were extracted from all patients, and grouped according to gender, different age groups, months and diseases, and total IgE detection values and sIgE positive rates were statistically analyzed. Results The total positive rate of total IgE was 52.18%,there were significant differences in total IgE among different sex, age and disease groups (P<0.05). The top 3 positive rates of inhalation allergens were fungal mixture(penicillium punctata/Aspergillus fumigatus/cladosporium alternativa/cladosporium cladosporium)(32.05%),household dust mite/Dermatophagoides culinae (29.87%) and Myrtle powder(25.00%). The top 3 positive rates of food allergens were Sea fish/sea crab(8.39%), milk (6.04%) and soybean (4.70%). The positive rate of inhalation allergen detection (17.90%) was higher than that of food allergen detection (4.50%), the difference was statistically significant (P<0.05).There were statistically significant differences among different allergens in different gender, age, season and disease groups (P<0.05). Conclusion The epidemiological characteristics of total IgE and sIgE in Zibo area were investigated, which is helpful for the diagnosis and prevention of allergic diseases in this area.

Application of Mindfulness Decompression and Diary Style Psychological Guidance in Middle-aged and Young Patients With Schizophrenia

SONG Xiao-shuang, WANG Xue, LIU Fang-jie

2024, 42(23):  107-111. 

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Objective To explore the intervention effect of mindfulness decompression and diary style psychological guidance in middle-aged and young SP patients. Methods A total of 94 middle-aged and young SP patients from April 2022 to July 2023 who were admitted in the Fourth People's Hospital of Liaocheng were selected, and randomly divided into the intervention group and control group with 47 patients in each group. The shame, psychological resilience, self-management ability, and social function in both groups were compared. Results After intervention, SSMI-C scores in both groups were decreased,and the intervention group was lower than the control group, and the difference was statistically significant (P<0.05). After intervention, CD-RISC scores in both groups were increased,and the intervention group was higher than the control group, and the difference was statistically significant (P<0.05).After intervention,SSMIS scores in both groups were increased,And the score of intervention group was higher than that of control group, which was significant (P<0.05). After intervention, PSP scores in both groups were increased ,And the intervention group was higher than the control group, and the difference was statistically significant (P<0.05). Conclusion The application of mindfulness decompression and diary style psychological guidance in middle-aged and young SP patients can reduce shame,enhance psychological resilience,and promote self-management ability and social function improvement.

Application of HAPA Voncept and Path Based Health Education in Nutritional Management of Esophageal Cancer Radiotherapy Patients

LIU Hua-xin, ZHANG Jing, YUN Dan-ya

2024, 42(23):  114-117. 

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Objective To explore the effect of applying the Health Behavior Process (HAPA) concept and path based health education in nutritional management of esophageal cancer radiotherapy patients. Methods A total of 86 esophageal cancer radiotherapy patients from November 2020 to November 2023 who were admitted in Nei Meng Gu Autonomous Region People's Hospital were selected, and randomly divided into the intervention group (n=43, HAPA concept and path based health education) and the control group (n=43, routine nutrition management). The cancer-related fatigue, self-management ability, and health behavior in both groups were compared. Results After intervention, the PFS-R scores in both groups were decreased (P<0.05), and the AHSMSRS scores and HPLP-II scores were increased (P <0.05). The PFS-R scores of intervention group was lower than the control group (P<0.05), and the AHSMSRS scores and HPLP-II scores higher than the control group (P<0.05). Conclusion The application of HAPA concept and pathway based health education in nutritional management of esophageal cancer radiotherapy patients can improve cancer-related fatigue, enhance self-management ability, and promote the formation of healthy behaviors.

Application of Professor Wang Wenjian's "Analogous Syndrome Complex in the Same Disease" in the Treatment of Recurrent Oral Ulcers

WANG Ying-jue, ZHAO Jia-jing, LIU Hui-zhu, GU Jia-ming, YANG Xiao-yue, ZHANG Lei, WANG Wen-jian

2024, 42(23):  165-169. 

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Recurrent oral ulcers have a self healing mechanism that is not fully understood in modern medicine. However, they are prone to recurrence and are very painful, affecting the daily life of patients. Its pathogenesis is divided into external factors (six pathogenic factors transforming into fire) and internal factors (heart fire, liver fire, stomach fire). Professor Wang Wenjian, based on clinical application and experience summary, selected Huanglian, Yujin, Tufuling, Jinque Root, Yangti Root, and Danshen as the basic formulas. Based on the theory of "analogous syndrome complex in the same disease", Individualized treatment was carried out for different types of syndromes. The theory of "analogous syndrome complex in the same disease" can quickly grasp the main contradictions and key issues of diseases, improve therapeutic effects, and also help clarify the scientific connotation of traditional Chinese medicine theory, opening up new treatment ideas.

Enlightenment of Life-gate Theory to Health Management of the Elderly

YUAN yuan, GUO Yu-sha, ZHANG Meng, JIANG Xiao

2024, 42(23):  169-172. 

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Elderly health is paramount for individual, family, and social stability, with aging populations posing diverse health demands. Based on the traditional Chinese medicine(TCM) concept of the Life-gate, fundamental to life activities and geriatric health, it deepens health awareness, facilitates lifestyle improvements, promotes mental wellbeing, and fosters tailored health strategies, addressing imbalances in personalized care. Overall, integrating Life-Gate theory significantly strengthens the theoretical and practical foundations of self-health management for the elderly, enhancing the process of healthy aging and their quality of life.

Misdiagnosis and Misdiagnosis of Ascites Caused by Heart Failure with Polycystic Peritoneal Mesothelioma: A Case Report

LI Dong-dong, LIU Bao-qing, QIU Huan

2024, 42(23):  172-176. 

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Objective To investigate the clinical characteristics and causes of misdiagnosis of refractory ascites caused by benign multicystic peritoneal mesothelioma. Methods A case of benign multicystic peritoneal mesothelioma with grade Ⅳ cardiac function was misdiagnosed retrospectively. Results This patient had paroxysmal dyspnea after coronary stenting 5 years ago, aggravated with abdominal distension, and went to the hospital for 3 months. At admission, bilateral pleural effusion accompanied by a large amount of peritoneal effusion. Echocardiography showed "EF value 23%". Other examinations did not indicate other organic and abdominal infectious diseases, and cardiac peritoneal effusion was considered. After receiving anti heart failure treatment, the symptoms did not improve significantly. Further examination revealed polycystic solid lesions in the peritoneum, which was diagnosed as "polycystic mesothelioma of the peritoneum". Due to poor systemic tolerance, the patient did not receive any relevant treatment and died of circulatory failure 2 months after admission. Conclusion The incidence of peritoneal mesothelioma is extremely low, lack of specific symptoms and examination. If refractory ascites can not be explained by the primary disease, the possibility of peritoneal mesothelioma should be alert, so as to avoid misdiagnosis.

Analysis of the Differential Diagnostic Value of Serum PCT, SAA, and ACE2 in Lung Infection During Chemotherapy in Non-small Cell Lung Cancer Patients

YU Tian-liang, SHEN Li-mei

2024, 42(23):  192-196. 

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Objective To explore the differential diagnostic value of serum PCT, SAA, and ACE2 levels in lung infection during chemotherapy in non-small cell lung cancer (NSCLC) patients. Methods A retrospective analysis was conducted on the clinical data of 80 NSCLC patients who underwent chemotherapy in Wuwei People's Hospital from January 2020 to December 2022 and developed lung infections during the chemotherapy period, as well as 50 NSCLC patients who were not infected during chemotherapy during the same period. They were included in the infected and uninfected groups, respectively. Compare the levels of serum PCT, SAA, and ACE2 in each group, and analyze the differential diagnostic value of individual and combined detection of serum PCT, SAA, and ACE2 in lung bacterial and viral infections in NSCLC chemotherapy patients using receiver operating characteristic (ROC) curves. Results The levels of serum PCT, SAA and ACE2 in infected group were significantly higher than those in non-infected group (P<0.05). The serum PCT, SAA and ACE2 levels of bacterial infection patients were significantly higher than those of the other two types of infection, the serum PCT level of viral infection patients was significantly lower than that of fungal infection patients, the serum SAA level was significantly higher than that of fungal infection patients, and the serum ACE2 level of bacterial infection patients was significantly higher than that of viral infection group (P<0.05). There was no significant difference in serum ACE2 level between viral infection and fungal infection (P>0.05). The AUCs of PCT and SAA were 0.964 (95%CI: 0.926~1.000) and 0.920 (95%CI: 0.856~0.984), respectively, and the cutoff values were ≥47.4 ng/mL and ≥44.9 μg/mL, respectively. The sensitivity and specificity of PCT combined with SAA were 94.74% and 95.24%, respectively. The AUCs of PCT and SAA were 1.000 (95%CI: 1.000~1.000) and 0.965 (95%CI: 0.914~0.984), respectively, and the cutoff values were ≤8.4 ng/mL and ≥16.1 μg/mL, respectively. Conclusion Serum PCT and SAA levels have good differential diagnostic value for lung infection in non-small cell lung cancer patients during chemotherapy, and the combination of the two indicators is more effective.