Exploring the Mechanism of Action of Astragalus Notoginseng Capsule in the Treatment of Coronary Heart Disease Based on Network Pharmacology and Molecular Docking Technology

Abstract

Abstract: Objective To explore the mechanism of action of Astragalus panax ginseng capsule in the treatment of coronary atherosclerotic heart disease (coronary heart disease) using network pharmacology and molecular docking methods. Methods The active ingredients and targets of the drug were screened by TCMSP database. Database platforms (GeneCards, DrugBank) were used to obtain coronary heart disease targets. The intersecting targets were obtained by applying venny2.1.0, and the metascape database was used for enrichment analysis. CB-DOCK2 was applied for molecular docking validation. Results Twenty-nine active ingredients of Astragalus panax ginseng capsule and 91 intersecting targets were screened; the KEGG pathway was selected as the top 5, and the molecular docking molecular docking was stabilized. Conclusion Astragalus panax ginseng capsule core ingredients quercetin, kaempferol, β-sitosterol, mangosteen, isorhamnetin, act on the core targets of TNF, AKT1, IL-6, IL-1β, PTGS2, and modulate AGE-RAGE, fluid shear stress and atherosclerosis, lipids and atherosclerosis, IL-17, and TNF signaling pathway for the treatment of coronary artery disease, and molecular docking showed that all <-5 cal/mol.

Key words: astragalus notoginseng capsule, coronary heart disease, network pharmacology, molecular docking, mechanism of action

CLC Number:

R285

LYU Jin-tai, CHENG Li-rong. Exploring the Mechanism of Action of Astragalus Notoginseng Capsule in the Treatment of Coronary Heart Disease Based on Network Pharmacology and Molecular Docking Technology[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(23): 7-13.

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