Table of Content

16 April 2024, Volume 42 Issue 8

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Analysis of Emergency Gastric Lavage Combined with Blood Purification

ZHANG Xiao-yue, LI Tan, SHAO Long-gang, LIU Ke-qin

2024, 42(8):  1-4. 

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Objective To investigate the value of emergency gastric lavage and blood purification for acute severe psychiatric poisoning. Methods A total of 85 patients with acute severe psychotic drug poisoning admitted to the emergency department of Jiangsu Second Middle School Hospital from January 2017 to January 2023 were collected retrospectively. According to the treatment plan of the patients, they were divided into conservative treatment group, gastric lavage group, blood purification group, gastric lavage and blood purification group.Basic data of each group, incidence of complications related to gastric lavage and blood purification, and prognosis related indicators of each group were collected. Results The 85 patients were 18 to 92 years, and there was no significant difference in baseline data between groups (P>0.05). Compared with the conservative treatment and blood purification groups, the incidence of gastric lavage related complications in the gastric lavage and gastric lavage and blood purification group significantly increased(P<0.05), the incidence of falling pneumonia and cardiovascular and cerebrovascular accidents were lower in the conservative treatment and gastric lavage group(P<0.05). The prognosis related indicators in the blood purification group and gastric lavage and blood purification group decreased significantly compared with the conservative treatment group and gastric lavage group, but the treatment cost did not increase significantly, and the difference was statistically significant (P<0.05). Conclusion In the treatment of acute severe psychiatric drug poisoning, gastric lavage often cannot get good benefits, but increased the complications of gastric lavage, and blood purification treatment can significantly improve patient outcomes without increasing the total hospitalization cost, and does not increase the total cost of hospital, safety is better, and it deserves being recommended in clinical recommendation.

Characteristics Analysis of Clinical Trial Registration of Mild Cognitive Impairment based on Chinese Clinical Trial Registry

YE Feng, WANG Tian, FU Dong-mei, CAI Yi-huan, WU Juan, ZENG Yi

2024, 42(8):  4-5. 

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Objective To analyze the characteristics of mild cognitive impairment(MCI)-related clinical trials based on the Chinese Clinical Trial Registry (ChiCTR), and understand the research status and trend of MCI in China. Methods All MCI clinical trials registered in ChiCTR were retrieved from the establishment of ChiCTR to December 1, 2023. The characteristics of the clinical trials were collected and analyzed. Results A total of 241 eligible trials were included. The registered trials were distributed in 21 regional areas, of which Beijing accounted for the highest number (17.01%). The largest funding source was local finance (28.63%). The most common study type was intervention research(76.76%). And 16.2% of the studies focused on the MCI with other conditions. Conclusion There was an increasing trend in the number of MCI clinical trials registered in ChiCTR. The distribution of registration organizations showed a regional imblance. The categories of interventions were diversified while the research field of MCI combined other conditions was also expanding, reflecting the trend of health needs for the aging society. However, there were still some trials that had not passed the ethical review , which suggested that the knowledge of clinical trial procedures needed to be further popularized.

Clinical and Pathological Characteristics and Immunophenotype of Endometrial Carcinoma with MELF Growth Pattern

HAN Li, XIE Yu-wen

2024, 42(8):  8-12. 

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Objective To investigate the clinical pathological and immunophenotypic characteristics of endometrial carcinoma with microcystic, elongated, and fragmented growth patterns (MELF). Methods The clinical and pathological data of 72 cases of patients with endometrioid carcinoma who underwent hysterectomy, bilateral adnexectomy, and pelvic lymph node dissection at Bazhou People's Hospital in Xinjiang from September 2013 to January 2019 were collected, and were to determine the infiltration of MELF. The general information, clinical and pathological characteristics, immunohistochemical staining results of the patients were investigated and compared, and the prognosis of the patients were followed up. Results In the 72 patients, there were 12 cases (16.7%) were pathologically diagnosed as endometrial carcinoma with MELF growth pattern (with MELF infiltration group); There were 60 patients with endometrioid carcinoma without MELF growth pattern (without MELF infiltration group), accounted for 83.3% (60/72). There were no significant difference in body mass index, educational years, etc. compared between the group with MELF infiltration and the group without MELF infiltration (P>0.05), but there were significant difference in age and menopausal status compared between the two groups (P<0.05). There were significant differences in pathological grading, lymphatic vessel interstitial infiltration, and lymph node metastasis compared between the group with MELF infiltration and the group without MELF infiltration (P<0.05). In the group with MELF infiltration, the positive expression rates of ER, PR, Ki-67, P16, and CK were 8.3%, 16.7%, respectively 91.6%, 100.0%, and 100.0%. In the group with MELF infiltration, ER, PR, Ki-67, P16, and CK showed strong brown yellow positive expression, with the positive expression rate of 100.0%. During the follow-up period, patients did not experience any tumor metastasis or recurrence. Conclusion MELF infiltration is a special infiltration pattern that occurs in low-grade endometrial carcinoma. Patients with MELF growth pattern in endometrial carcinoma have a significantly higher LVSI positive rate and lymph node metastasis positive rate, the positive rates of ER and PR expression were significantly reduced.

Application of SaCo Visible Laryngeal Mask Airway Catheter in Patient Airway Management During Laparoscopic Cholecystectomy

HE Hong-zhi, XIE Li, OU Feng, HAN Fei, ZHAO Qi-bin, LIAO Wei-yu, JING Li-shuo, LIU Pu-ke, WANG Xiao

2024, 42(8):  12-16. 

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Objective To explore and analysis the application values of SaCo visible laryngeal mask airway catheter in patient airway management during laparoscopic cholecystectomy. Methods 92 cases of patients who underwent elective laparoscopic cholecystectomy Ankang Hospital of Traditional Chinese Medicine from December 2022 to June 2023 were selected as the study subjects. Accorded to a 1:1 random number table method, 138 patients were divided into the SaCo group of 46 cases, the WORK group of 46cases, the control group of 46 cases. The SaCo group were used SaCo visual laryngeal mask to assist in airway management, while the WORK group were used WORK catheters to assist in airway management, The control group were used Tracheal intubation to assist airway management. The patient's vital signs, perioperative indicators, complications, and pain scores were measured and recorded. Results All patients were successfully intubated at once, and there were no significant difference in central arterial pressure and heart rate compared among the SaCo group, the WORK group, the control group at T1, T2, T3, T4, and T5 time points (P>0.05). The surgical time, anesthesia time, postoperative extubation time, postoperative hospitalization time, and postoperative general feeding time in the SaCo group were significantly reduced compared to the WORK group, the control group (P<0.05). The incidence rates of complications such as throat bleeding, Hoarse voice, choking, sore throat, and Bronchospasm during extubation after operation in the SaCo group were 4.35%, and 19.57%, 21.74% in the WORK group and the control group. Compared with the WORK group and the control group, the incidence of complications in the SaCo group were significantly lower (P<0.05). The pain VAS scores of the SaCo group were significantly reduced compared to the control group, the WORK group on the 1st, 3rd, 7th, and 14th postoperative days (P<0.05). Conclusion The application of SaCo visual laryngeal mask airway catheter in patient airway management during laparoscopic cholecystectomy does not affect the patient's vital signs, can also reduce the incidence of complications, reduce trauma to patients, promote patient recovery, and alleviate patient pain.

The Effect and Mechanism of Salidroside on Natural Senescence of Hippocampal Neurons

XU Xin-ying, ZHU Lin, LIU Zi-shan, NI Qin-shuai, YU Zhu-qin

2024, 42(8):  16-20. 

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Objective To investigate the effect and mechanism of salidroside delaying natural aging of primary hippocampal neurons. Methods Rat hippocampal neurons were isolated and then cultured into aging neurons, which were randomly divided into short-term (ST) group, long-term (LT) group, salidroside low- and high-concentration (10 µM and 20 µM) groups, positive drug cycloastragenol group (5 µM). Cell count method (CCK-8) was used to detect hippocampal neurons survival rate, senescence-associated β-galactosidase (SA-β-gal) staining kit was used to detect the hippocampus neuron aging, the apoptotic rate of hippocampal neurons was detected by flow cytometry, the expression of telomerase reverse transcriptase (TERT) was detected by western blot, PCR-ELISA method was used to detect telomerase activity of hippocampal neurons. Results Compared with the ST group, the hippocampal neurons appeared neuron degeneration, cell body contraction, and the cell survival rate decreased significantly (P<0.01), while SA-β-gal positive rate increased significantly in LT group (P<0.01). The apoptotic rate of neurons was significantly increased (P<0.01), while telomerase activities and TERT expression of neurons decreased obviously (P<0.01). Compared with LT group, the neuronal survival rate treated with salidroside and cycloastragenol were significantly increased (P<0.05), while SA-β-gal positive rate and apoptotic rate of neurons was significantly decreased (P<0.05), and the telomerase activities and TERT expression were significantly increased (P<0.01). Conclusion Salidroside could reduce the neuronal apoptosis and increase the telomerase activity to delay the senescence of hippocampal neurons.

Effect of Shulidie Combined with Acupoint Application on SAA Levels in Elderly Patients with Stable Chronic Obstructive Pulmonary Disease

WANG Qiong

2024, 42(8):  27-30. 

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Objective To explore the effect of Shulidie combined with acupoint application on the levels of amyloid A (SAA) in elderly patients with stable chronic obstructive pulmonary disease (COPD). Methods 200 stable elderly patients with chronic obstructive pulmonary disease (COPD) admitted to Baiyin First People's Hospital from June 2022 to November 2022 were selected as the study subjects. They were divided into an observation group and a control group using a random number table method, with 100 cases in each group. The control group patients were treated with inhalation of suletide, while the observation group patients were treated with suletide combined with acupoint application. The TCM syndrome score, lung function, and SAA expression levels of the two groups of patients were compared before and after treatment, and the quality of life before and after treatment was evaluated using the St. George's Respiratory Questionnaire (SGRQ). Results After treatment, the TCM syndrome scores related to chest tightness, shortness of breath, phlegm, and cough in the observation group were lower than those in the control group (P<0.05); After treatment, the FVC, FEV₁, FEV₁/FVC, and PEF in the observation group were higher than those in the control group, while SAA was lower than those in the control group (P<0.05); After treatment, the observation group had lower disease impact, limited activity, respiratory symptoms, and SGRQ total score than the control group (P<0.05). Conclusion The combination of Suletide and acupoint application has a significant therapeutic effect on elderly patients with stable chronic obstructive pulmonary disease, which can alleviate related symptoms, improve lung function, reduce SAA expression levels, and improve patient quality of life.

TLR4/NF- κBp65 the Effect of High Expression of on the Proliferation, Invasion, and Metastasis of Skin Squamous Cell Carcinoma

LIU Li

2024, 42(8):  37-40. 

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Objective To explore and analysis the effects of Toll like receptor 4 (TLR4)/nuclear factor NF-κBp65 high expression on the proliferation, invasion, and metastasis of skin squamous cell carcinoma. Methods Human skin squamous cell carcinoma A431 cell line with logarithmic growth phase were divided into three groups - blank group, control group, and experimental group. They were transfected with DMEM medium, pc3.0 empty vector, and pc3.0-NF-κBp65, respectively vector. All the cells were used to detect the expression of proliferation, invasion, and metastasis in skin squamous cell carcinoma. Results After 24 and 48 hours of transfection, the expression of TLR4 and NF-κBp65 in the experimental group were significantly higher than that of the blank group and control group (P<0.05), and there were no significant difference compared between the blank group and control group (P>0.05). The cell proliferation index of the experimental group were significantly lower than that of the blank group and control group (P<0.05), and there were no significant difference compared between the control group and the blank group (P>0.05). The cell invasion index and cell metastasis index of the experimental group were significantly lower than those of the blank group and control group (P<0.05), while there were no significant difference compared between the control group and the blank group (P>0.05). The expression level of Caspase-9/Myc protein in the experimental group were significantly higher that of the blank group and control group (P<0.05), and there were no significant difference compared between the blank group and control group (P>0.05). Conclusion TLR4/NF- κBp65 high expression can inhibit the proliferation, metastasis, and invasion of skin squamous cell carcinoma cells, as well as promote the expression of Caspase-9/Myc protein, thereby exerting promote apoptotic effect on tumor cells.

Effect of Paclitaxel Injection Combined with Carboplatin on Immune Function in Patients with Ovarian Cancer

YU Xia, QI Hui-li, ZHANG Chun-hong

2024, 42(8):  40-44. 

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Objective To investigate the effect of paclitaxel injection combined with carboplatin on immune function in patients with ovarian cancer. Methods 70 patients with ovarian cancer admitted to Shihezi People's Hospital of Xinjiang from January 2019 to January 2023 were retrospectively analyzed, according to treatment methods, the patients were divided into observation group (n=35) and control group (n=35). The control group was treated with carboplatin after confirmed pathological diagnosis and hospitalization, and the observation group was treated with paclitaxel injection combined with carboplatin after confirmed pathological diagnosis and hospitalization. The clinical efficacy, the expression level of tumor marker angiogenesis factor before and after treatment, and the immune function changes of the two groups were compared. Results The objective remission rate and disease control rate of the observation group were significantly higher than those of the control group (P<0.05); There was no significant difference in the levels of bFGF, VEGF angiogenic factor, CA125, and Cyfra21-1 tumor markers between the two groups of patients before treatment (P>0.05). After treatment, the levels of bFGF, VEGF angiogenic factor, CA125, and Cyfra21-1 tumor markers decreased in both groups of patients, and the observation group was lower than the control group (P<0.05); Before treatment, there was no significant difference in the CD4⁺, CD3⁺, and CD4⁺/CD8⁺values between the two groups of patients. After treatment, the CD4⁺, CD3⁺, and CD4⁺/CD8⁺ values of the two groups of patients decreased, and the observation group was higher than the control group (P<0.05). Conclusion The combination of paclitaxel injection and carboplatin has a significant therapeutic effect on ovarian cancer, which can inhibit tumor progression, reduce the expression levels of tumor markers and angiogenic factors, and alleviate immune function damage in patients during chemotherapy. It is worthy of clinical application and promotion.

The Study for the Effect of Sarcopenia on the Myocardial Structure in Patients with Coronary Heart Disease

YU Xi, LIU Zhen-chao, SUN Hao-yang, ZHOU Chun-li, YU Zhu-qin

2024, 42(8):  44-47. 

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Objective To compare the myocardial structure differences between the patients coronary heart disease (CHD) with or without sarcopenia, so to explore the effect of sarcopenia on the myocardial structure of CHD. Methods Selected 122 CHD patients who were hospitalized in the Department of Cardiology, Songshan Hospital of Qingdao Medical College from June 2022 to December 2022. Dual-emission X-ray absorptiometry and ultrasonic cardiography were used to detect the patient's skeletal muscle and heart-related parameters. Multivariate stepwise regression was applied to analysis the relationship between myocardial structure and skeletal muscle related parameters. Results The left ventricular mass (LVM) and left ventricular end diastolic dimension (LVDd) of CHD patients with sarcopenia was significantly lower than those of non-sarcopenia patients (t=-2.272, P=0.025; t=-3.929,P<0.001) while the relative wall thickness (RWT) of CHD patients with sarcopenia was significantly higher than that of non-sarcopenia patients (t=2.232, P=0.035). Stepwise regression show that waist circumference (WC) and lower-limb skeletal muscle mass (LSMM) were positively related to the LVDd (r=0.181, P<0.001; r=0.320, P<0.020) and LVM (r=1.62, P<0.001; r=2.14, P=0.020). Conclusion Sarcopenia might significantly indice the decreases of the LVDd and LVM in CHD patientsa, which the mechanism still needs to be further studied.

Task-Driven Practical Teaching Reform Oriented by Post Competency-Taking Medical Laboratory Technology Major in Higher Vocational Colleges as an Example

ZHANG Yu-guo, SHEN Fei-fei, ZHANG Wei-kai, YANG Quan-zhong

2024, 42(8):  71-74. 

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Practice teaching is the key to cultivate students ' practical ability, innovation ability and improve the core competitiveness of employment. In order to adapt to the development of medical laboratory industry and the demand of post employment, promote the connection between students ' theory and practice, effectively connect the posts of employers, shorten the transition period of employment, and improve students ' sense of professional belonging and identity. Guided by job requirements, through task-driven practical teaching reform, students can complete the teaching tasks of practical courses with high quality in a good teaching situation, and improve their post competency and practical ability.

Application of "Integration of Theory, Deficiency and Reality" Teaching Mode in Comprehensive Practical Training Course of Clinical Nursing Skills

MAO Zhi-hui

2024, 42(8):  74-77. 

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Objective To explore the value of implementing the teaching mode of "integration of theory, deficiency and reality" in the comprehensive practical training course of clinical nursing skills. Methods A total of 62 students from our school from September 2020 to February 2021 were randomly selected and divided into two classes A and B. 31 students in class A were used as the control group and the conventional teaching method was adopted. 31 students in class B were used as the observation group. The teaching mode of "integration of theory, deficiency and reality" was adopted. The knowledge, attitude and ability of the two groups were compared, including the three-dimensional degree of theoretical performance, operation performance and comprehensive scene simulation performance, Attitude includes three dimensions of learning attitude, self-efficacy and learning satisfaction, and ability includes three dimensions of autonomous learning ability, innovation ability and problem-solving ability. Results There was no significant difference between the two groups (P<0.05). The operation performance and comprehensive scene simulation performance of the observation group were significantly higher than those of the control group (P<0.05). The scores of learning attitude, self-efficacy and learning satisfaction in the observation group were higher than those in the control group (P<0.05). The scores of independent learning ability, innovation ability and problem-solving ability in the observation group were higher than those in the control group(P<0.05). Conclusion In the clinical nursing skills comprehensive practical training course, the implementation of the teaching mode of "integration of reason, virtuality and reality" can significantly improve students' knowledge mastery and problem-solving ability, improve their learning attitude, and the teaching effect is significantly better than the traditional teaching method, which can be popularized in teaching.

Nursing Care of a Patient with Severe Multiple Injury Complicated with Septic Shock

SANG Xiao-ming, LI Yu-li, WANG Xiao-ting, LIU Zhu-yu

2024, 42(8):  159-162. 

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To summarize the nursing experience of a patient with severe multiple injury complicated with septic shock. Under the guarantee of the integrated trauma treatment model, the early cluster treatment and nursing measures of sepsis were adopted, and the joint management was carried out in infection control, airway clearance, sedation and analgesia and delirium prevention. After the treatment and nursing of the multi-disciplinary team, the surgical incision of the patient healed well. After 3 months of follow-up, the body function of the patient basically recovered, and the expected treatment and nursing effect was achieved.

The Value of Tumor Marker Serum miR-429, CEA, AFF3, CA199 in the Diagnosis of Pancreatic Cancer

LIU Yong-sheng

2024, 42(8):  163-166. 

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Objective To explore and analysis the values of combined diagnosis of tumor markers serum miR-429, CEA, AFF3, CA199 in pancreatic cancer. Methods From August 2018 to December 2022, 105 cases of patients with pancreatic cancer diagnosed and treated in Inner Mongolia Autonomous Region Mental Health Center were selected as the pancreatic cancer group, and 105 cases of patients with benign pancreatic nodules diagnosed and treated in th same hospital were selected as the benign group at the same time. The levels of serum miR-429, CEA, AFF3, and CA199 in both groups were detected. And the positive rate was calculated and diagnostic values were evaluated. Results The levels of serum CEA, AFF3, CA199 in the pancreatic cancer group were significantly higher than those in the control group (P<0.05), and the relative expression level of serum miR-429 was also significantly higher than that in the control group (P<0.05). The positive rates of serum miR-429, CEA, AFF3, CA199 expression in pancreatic cancer group were 74.29%, 80.00%, 84.76%, 90.48%, significantly higher than 4.76%, 5.71%, 3.81%, 6.67% in the control group (P<0.05). In the 210 patients with pancreatic cancer, the expression levels of serum miR-429, CEA, AFF3 and CA199 were correlated with histological differentiation, clinical stage and lymph node metastasis (P<0.05). There were 104 cases of pancreatic cancer were diagnosed by tumor marker serum miR-429, CEA, AFF3 and CA199. The sensitivity and specificity of tumor marker serum miR-429, CEA, AFF3 and CA199 in differential diagnosis of pancreatic cancer were 98.10% (103/105) and 99.05% (104/105) respectively. The positive predictive value were 99.04% (103/104), and the negative predictive value were 98.11% (104/106). ROC analysis showed that the maximum area under the curve of serum miR-429, CEA, AFF3, CA199 combined diagnosis of pancreatic cancer was 0.920, and the consistency of Kappa test on the tumor markers combined diagnosis was 0.874. Conclusion High expression of serum miR-429, CEA, AFF3, CA199 is often associated with pancreatic cancer, which is related to the pathological characteristics of patients. The combination of serum miR-429, CEA, AFF3, CA199 has relatively high sensitivity and specificity in the diagnosis of pancreatic cancer.

A Clinical Study on the Diagnosis of Pulmonary Nodules by Texture Analysis with Computed Tomography

GENG Jia-hong, WAN Jan, ZHOU Chao

2024, 42(8):  167-170. 

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Objective To investigate and analyze the clinical value of computed tomography texture analysis for the diagnosis of pulmonary nodules. Methods A total of 86 cases with pulmonary nodules who were underwent consultation at Jinhu County Hospital of Traditional Chinese Medicine from February 2019 to May 2022 were selected for the study, and 18 nodules were pathologically diagnosed as malignant nodules (malignant group), while 68 nodules as benign nodules (benign group). All patients were given conventional CT with computed tomography texture analysis to record imaging features and quantify texture parameters. Results All patients' images showed grade 4-6 branches, and there was no significant difference in the CT image quality score in the malignant group compared with the benign group (P>0.05). The percentages of lobar, vacuolar, pleural depression, and bronchial inflation signs in the malignant group were 88.89%, 77.78%, 72.22%, and 83.33%, which were significantly higher than those in the benign group, which were 32.35%, 33.82%, 27.94%, and 32.35% (P<0.05). The CT values of main pulmonary artery, lobar artery, segmental artery and subsegmental artery were significantly higher in the malignant group compared with the benign group (P<0.05). The parameters associated with computed tomographic texture analysis-entropy, skewness, and maximum value-were significantly higher in the malignant group compared with the benign group (P<0.05). Among 86 patients, computed tomography texture analysis diagnosed malignant nodules in 17 cases and benign nodules in 69 cases, for which the sensitivity and specificity of computed tomography texture analysis for the diagnosis of pulmonary nodules were 88.89% (16/18) and 98.52% (67/68). Conclusion The application of computed tomography texture in pulmonary nodules can provide texture features that cannot be observed by the naked eye, allowing quantitative assessment of pulmonary nodules, with good sensitivity and specificity in the diagnosis of benign and malignant pulmonary nodules.

The Expression Significance of Serum MCP-1, hsCRP, and SIgA in Acute Pelvic Inflammatory Disease and Their Correlation with Disease Severity

ZHANG Jin-yin

2024, 42(8):  184-187. 

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Objective To investigate and analysis the expression of serum secretory immunoglobulin A (sIgA), Monocyte chemoattractant protein-1 (MCP-1) and hypersensitive C-reactive protein (hs-CRP) in acute pelvic inflammation (API) and their correlation with the severity of the disease. Methods From July 2021 to May 2023, 79 cases of patients with acute pelvic inflammatory disease diagnosed and treated in a hospital were selected as the pelvic inflammatory disease group, and the other 79 cases of healthy women were selected as the health group at the same time. The contents of sIgA, MCP-1, and hs-CRP in the two groups were detected, and the disease severity of the patients were scored and analyzed. Results There was no difference in age, body mass index, years of education, heart rate, and fasting blood glucose between the two groups (P>0.05). The levels of serum monocyte chemoattractant protein-1, hypersensitive C-reactive protein, and secretory immunoglobulin A in the pelvic inflammatory disease group were significantly different from those in the healthy group (P<0.05); Logistic regression analysis showed that serum levels of secretory immunoglobulin A, monocyte chemotactic protein-1, and hypersensitive C-reactive protein were important factors affecting the disease in patients with acute pelvic inflammatory disease (P<0.05); Spearman analysis was used to demonstrate a negative correlation between disease severity scores and serum secretory immunoglobulin A levels in patients with acute pelvic inflammatory disease, and a positive correlation with monocyte chemotactic protein-1 and hypersensitive C-reactive protein levels (P<0.05). Conclusion The patients with acute pelvic inflammatory disease have a large amount of leucorrhea and obvious symptoms of lumbosacral distention and pain, which are often accompanied by high expression of serum Monocyte chemoattractant protein-1 and hypersensitive C-reactive protein, and also accompanied by low expression of serum secretory immunoglobulin A, and are related to the severity of the disease.

Diagnosis and Prognostic Prediction of Acute Myocardial Infarction Combined with Heart Failure in the Elderly by ACA, ACE, and Serum Zinc Ion Concentrations

WANG Lu

2024, 42(8):  192-196. 

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： Objective To explore the diagnostic and prognostic prediction of anticardiolipin antibodies (ACA), angiotensin converting enzyme (ACE), and serum zinc ion concentration in elderly patients with acute myocardial infarction and heart failure. Methods A total of 84 patients with acute myocardial infarction combined with heart failure admitted to the People's Hospital of Inner Mongolia Autonomous Region from March 2020 to March 2023 were selected and divided into the heart failure group, and 80 patients with simple acute myocardial infarction without complicated heart failure treated in the same period were selected as the non-heart failure group. By comparing ACA, ACE, and serum zinc ion concentration, the subject characteristic (ROC) working curve was established to analyze the diagnostic value of ACA, ACE and serum zinc ion on acute myocardial infarction combined with heart failure in the elderly. Subsequently, 84 patients with acute myocardial infarction and heart failure were divided into death group (n=20), and the remaining patients were divided into survival group (n=64). The clinical general situation of the two groups was compared, and the predictive value of ACA, ACE and serum zinc ion concentration on the prognosis of acute myocardial infarction with heart failure was analyzed. Results ACA and ACE were significantly higher in the heart failure group than that in the non-heart failure group, and the zinc ion concentration was significantly lower than that in the non-heart failure group (P<0.05). The diagnostic efficacy of the combination of ACA, ACE, and serum zinc ions in elderly patients with acute myocardial infarction combined with heart failure is better than that of a single test. There was no significant difference in sex, age, BMI, diabetes, hypertension, hyperlipidemia, left ventricular ejection fraction, number of stents, and length of stents between the survival group and the death group (P>0.05). There was significant difference in Killip grade, old myocardial infarction, ACA, ACE, and serum zinc concentration between the survival group and the death group (P<0.05). The results of logistic regression analysis showed that Killip grade, ACA, ACE and serum zinc ions were independent predictors of the outcome of acute myocardial infarction with heart failure. Conclusion The combination of ACA, ACE, and serum zinc ion concentration has high diagnostic value for acute myocardial infarction with heart failure, and clinical practice can consider predicting the prognosis of patients with acute myocardial infarction with heart failure through ACA, ACE, and serum zinc ion concentration.