The Study for the Effect of Sarcopenia on the Myocardial Structure in Patients with Coronary Heart Disease

Abstract

Abstract: Objective To compare the myocardial structure differences between the patients coronary heart disease (CHD) with or without sarcopenia, so to explore the effect of sarcopenia on the myocardial structure of CHD. Methods Selected 122 CHD patients who were hospitalized in the Department of Cardiology, Songshan Hospital of Qingdao Medical College from June 2022 to December 2022. Dual-emission X-ray absorptiometry and ultrasonic cardiography were used to detect the patient's skeletal muscle and heart-related parameters. Multivariate stepwise regression was applied to analysis the relationship between myocardial structure and skeletal muscle related parameters. Results The left ventricular mass (LVM) and left ventricular end diastolic dimension (LVDd) of CHD patients with sarcopenia was significantly lower than those of non-sarcopenia patients (t=-2.272, P=0.025; t=-3.929,P<0.001) while the relative wall thickness (RWT) of CHD patients with sarcopenia was significantly higher than that of non-sarcopenia patients (t=2.232, P=0.035). Stepwise regression show that waist circumference (WC) and lower-limb skeletal muscle mass (LSMM) were positively related to the LVDd (r=0.181, P<0.001; r=0.320, P<0.020) and LVM (r=1.62, P<0.001; r=2.14, P=0.020). Conclusion Sarcopenia might significantly indice the decreases of the LVDd and LVM in CHD patientsa, which the mechanism still needs to be further studied.

Key words: sarcopenia, coronary heart disease, left ventricular mass, ultrasonic cardiography

CLC Number:

R256.2

YU Xi, LIU Zhen-chao, SUN Hao-yang, ZHOU Chun-li, YU Zhu-qin. The Study for the Effect of Sarcopenia on the Myocardial Structure in Patients with Coronary Heart Disease[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(8): 44-47.

References

[1] 刘震超,王云,宋梅,等.骨骼肌减少症[M].北京:科学技术文献出版社, 2021:1-2.
[2] 刘震超,刘光,王悦,等.女性肌少症病人HIIE后相关炎性细胞因子的反应[J]. 青岛大学学报(医学版),2023,59(2):269-273.
[3] WANG M, HU S, ZHANG F, et al.Correlation between sarcopenia and left ventricular myocardial mass in chronic heart failure patients[J]. Aging Med,2020,3(2): 138-141.
[4] LIN J, LOPEZAC E F, JIN Y F, et al.Age-related cardiac muscle sarcopenia: Combining experimental and mathematical modeling to identify mechanisms[J]. Exp Gerontol,2008,43(4):296-306.
[5] KENG B M H, GAO F, TEO LLY, et al. Associations between skeletal muscle and myocardium in aging: A Syndrome of “Cardio-Sarcopenia”?[J]. Am Geriat Soc,2019,67(12):2568-2573.
[6] CAMPOS A M, MOURA F A, SANTOS S N, et al.Sarcopenia, but not excess waist circumference or increased caloric intake, is associated with coronary subclinical atherosclerosis in the very elderly[J]. Atherosclerosis,2017,258(2):138-144.
[7] KIM T N, CHOI K M.The implications of sarcopenia and sarcopenic obesity on cardiometabolic disease[J]. J Cell Biochem,2015,116(7):1171-1178.
[8] PAN Y S, YU H Y, RUAN J, et al.Study on correlation between Teiindex and left ventricular mass in patients with coronary artery disease[J]. J Med Imaging,2011,21(8):1171-1173.
[9] CHEN L K, WOO J, ASSANTACHAI P, et al.Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment[J]. J Am Med Direct Assoc,2020,21(3):300-307.
[10] YANG M, HU X, XIE LL, et al. Screening sarcopenia in Community-Dwelling Older Adults: SARC-F vs SARC-F combined with Calf circumference (SARC-CalF)[J]. J Am Med Direct Assoc,2018,19(3):277.e1-277.e8.
[11] 中华医学会心血管病学分会介入心脏病学组,中华医学会心血管病学分会动脉粥样硬化与冠心病学组,中国医师协会心血管内科医师分会血栓防治专业委员会,等.稳定性冠心病诊断与治疗指南[J].中华心血管病杂志,2018,46(9): 680-694.
[12] NICHOLS S, O’DOHERTY A F, TAYLOR C, et al. Low skeletal muscle mass is associated with low aerobic capacity and increased mortality risk in patients with coronary heart disease–a CARE CR study[J]. Clin Physiol Funct Imaging,2018,39(1):93-102.
[13] MESSERLI F H, SUNDGAARD-RIISE K, REISIN E D, et al.Dimorphic cardiac adaptation to obesity and arterial hypertension[J]. Ann Inter Med,1983,99(6):757-761.
[14] LORELL B H, CARABELLO B A.Left ventricular hypertrophy: pathogenesis, detection, and prognosis[J]. Circulation,2000,102(4):470-479.
[15] WONG C, O’MOORE-SULLIVAN T, LEANO R, et al. Alterations of left ventricular myocardial characteristics associated with obesity[J]. Circulation,2004,110(19):3081-3087.
[16] CANOY D, CAIRNS B J, BALKWILL A, et al.PP50 body mass index, waist circumference and incident coronary heart disease in the million women study[J]. J Epidemiol Comm Health,2013,67(Suppl 1):A69.
[17] STRÖHLE A, WORM N. Healthy obesity? Why the adiposity paradox is only seemingly paradox[J]. Med Monatssch Pharm,2014,37(2):54-64.
[18] JOHANNESSEN K A, MYGLAND A, GILHUS N E, et al.Left ventricular function in myasthenia gravis[J]. Am J Cardiol,1992,69(1):129-132.
[19] LAVINE K J, SIERRA O L.Skeletal muscle inflammation and atrophy in heart failure[J]. Heart Fail Rev,2017,22(2):179-189.
[20] PAN Y S, YU H Y, RUAN J, et al.Study on correlation between left ventricular peak filling rate and left ventricular mass in patients with coronary artery disease[J]. Guangxi Med J,2012,34(1):23-25.
[21] VANNAN M A, TAYLOR D J E. Ventricular remodeling after myocardial infarction[J]. Heart,1992,68(3):257-259.