Table of Content

16 January 2023, Volume 41 Issue 2

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The Relationship between Serum S100A12, sRAGE and Microvascular Complications in Patients with Type 2 Diabetes Mellitus

MA Lin-na, LI Yuan-hong

2023, 41(2):  1-4. 

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Objective To explore and study the relationship between serum S100A12, receptor for advanced glycation end-products (RAGE) and microvascular complications in patients with type 2 diabetes mellitus. Methods A total of 96 patients with type 2 diabetes who were diagnosed and treated in Harbin Fourth Hospital from February 2021 to December 2021 were retrospectively selected as the research subjects to determine the occurrence of microvascular complications.The four parameters of platelet, serum S100A12 and sRAGE contents in all patients were detected, and the correlation and influencing factors of serum S100A12 and sRAGE in type 2 diabetes patients with microvascular complications were analyzed. Results There were 36 cases of diabetic microvascular complications (combined group) occurred in the 96 cases that accounted for 37.50%, included 20 cases of diabetic peripheral neuropathy, 10 cases of diabetic nephropathy, and 6 cases of diabetic retinopathy. The platelet distribution width and mean platelet volume in the combined group were significantly higher than those in the control group, the difference is statistically significant (P<0.05), and the platelet count and platelet volume were significantly lower than those in the control group, the difference is statistically significant (P<0.05). The serum levels of S100A12 and sRAGE in the combined group were significantly higher than those in the control group, the difference is statistically significant (P<0.05). In the 96 patients, Pearson analysis showed that serum S100A12 and sRAGE levels were positively correlated with the occurrence of microvascular complications (P<0.05). Multivariate stepwise Logistic regression analysis showed that serum S100A12 and sRAGE levels were important risk factors for microvascular complications (P<0.05). Conclusion Type 2 diabetes patients are often accompanied by microvascular complications, and diabetic peripheral neuropathy is more common. The serum levels of S100A12 and sRAGE in patients with diabetes microvascular complications are decreased. There is a correlation between serum S100A12 and sRAGE in type 2 diabetes patients and the occurrence of microvascular complications.

Clinical Study of Internal Fixation of Pelvic Fractures with Cannulated Screws Assisted by 3D Printing Guides

YIN Chun-yun, ZHANG Yi-wen, LIU Zhi-ze

2023, 41(2):  4-8. 

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Objective Exploring and analyzing the clinical study of 3D printing guide plate-assisted internal fixation with cannulated screws in the treatment of pelvic fractures. Methods Used prospective research methods, From May 2019 to May 2022, 71 cases of patients with pelvic fractures who were diagnosed and treated in the Golmud People's Hospital were selected as the research objects, and the patients were divided into 35 cases in the 3D printing group and the cannulated screw group of 36 cases accorded to the random number table method. The cannulated screw group was given cannulated screw internal fixation treatment, and the 3D printing group was given 3D printing guide plate adjuvant therapy based on the treatment of the cannulated screw group, and the changes of imaging parameters of the two groups were observed. Results There was no significant difference in incision length, operation time and intraoperative fluoroscopy times compared between the two groups (P>; 0.05). The intraoperative blood loss and fracture healing time of the 3D printing group were significantly shorter than those of the cannulated screw group (P>; 0.05). In the 3D printing group, the incidence of complications such as pin tract infection, sacral nerve injury, venous thrombosis, and incision infection at 3 months after surgery was lower than cannulated screw group(P<; 0.05). The pelvic incident angle and pelvic inclination angle were significantly lower in both groups at 3 months after surgery than at 1 day before surgery (P<; 0.05), and the 3D printing group was also significantly lower than that in the cannulated screw group (P<; 0.05). The excellent and good rate of pelvic Majeed score 3 months after 3D printing group was significantly higher than cannulated screw group (P<; 0.05). Conclusion Internal fixation of pelvic fractures with cannulated screws assisted by 3D printing guide plate can reduce the trauma to patients, promote fracture healing, reduce the occurrence of complications, and also improve the imaging parameters of patients and improve the pelvic function of patients.

Clinical Significance of FHIT Protein and mRNA in Esophageal Carcinoma Dodson TB

CHEN Peng

2023, 41(2):  9-12. 

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Objective To analyze the expression and clinical significance of FHIT protein and mRNA in esophageal carcinoma. Methods A total of 60 samples from patients with esophageal cancer in Chifeng Hospital from March 2019 to October 2021 were retrospectively selected as the case group and 60 samples from patients with normal esophageal tissue in the endoscopy room were selected as the control group. The expression of FHIT protein and mRNA in the two groups were statistically analyzed, and the correlation between FHIT mRNA in the case group and clinicopathological parameters was analyzed. Results Compared with the normal tissues of the control group, the deletion and weak expression rates of FHIT protein in the cancer tissues and adjacent tissues of the case group were higher, and the normal expression rates were lower, the diffierence was statistically signicant (P<0.05). Compared with adjacent tissues, the expression rate of FHIT protein deletion in cancer tissues was higher, and the weak and normal expression rates were lower, the diffierence was statistically signicant (P<0.05). Compared with the normal tissue of the control group, the deletion rate of FHIT mRNA in the cancer tissue and paracancerous tissue of the case group was higher, the diffierence was statistically signicant (P<0.05), and compared with the paracancerous tissue, the deletion rate of FHIT mRNA in the cancer tissue was higher, the diffierence was statistically signicant (P<0.05). Compared with patients with stage I, the FHIT protein deletion rate and mRNA deletion rate of patients with stage Ⅱ+Ⅲ+Ⅳ in the case group were higher, the diffierence was statistically signicant (P<0.05). Compared with well-differentiated patients, the expression rate of FHIT protein deletion and mRNA deletion rate were higher in patients with low and medium differentiation, the diffierence was statistically signicant (P<0.05). Compared with patients without lymph node metastasis, the FHIT protein deletion rate and mRNA deletion rate of patients with lymph node metastasis were higher, the diffierence was statistically signicant (P<0.05). Conclusion The loss expression rate of FHIT protein and mRNA in esophageal carcinoma tissues is increased, which can provide effective basis for clinical diagnosis, treatment and prognosis.

Therapeutic Effect of Niuhuang Shangqing Capsule Combined with Zexie Decoction in the Treatment of Acute Otitis Externa and Its Effect on the Level of Inflammatory Factors

WANG Li

2023, 41(2):  12-15. 

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Objective To explore the effect of Niuhuang Shangqing Capsule combined with Zexie decoction on the curative effect and inflammatory factor levels in the treatment of acute otitis externa. Methods Selected from June 2017 to June 2022 in Wuxi huishan district hospital for treatment of 80 cases of acute external otitis, according to the random number table was divided into observation group (n=40) and control group (n=40), two groups are given basic treatment acetate triamcinonide biconazole cream daub for a week, the control group with Zexie Decoction on basic treatment, observation group in basic treatment with Niuhuang Shangqing Capsule combined with Zexie Decoction treatment, are treated for a week. The clinical efficacy, disappearance time of clinical symptoms and treatment time, interleukin-6 (IL-6) level, C-reactive protein (CRP) level, tumor necrosis factor-α (TNF-α) level, visual analogue scale (VAS), health survey Short Form (SF-36) score, and adverse reactions were compared between the two groups. Results The total effective rate in the observation group was significantly higher than that in the control group (P<0.05). The disappearance time of swelling, disappearance time of pain, disappearance time of secretions and treatment time in the observation group were significantly shorter than those in the control group (P<0.05). There were no significant differences in the levels of IL-6, CRP and TNF-α between the two groups before treatment (P>0.05), but the levels of IL-6, CRP and TNF-α in the two groups after treatment were decreased, and the observation group was significantly lower than the control group (P<0.05). There was no significant difference in VAS score and SF-36 score between the two groups before treatment (P>0.05), VAS score decreased and SF-36 score increased in the two groups after treatment, and VAS score in the observation group was significantly lower than that in the control group, and SF-36 score was significantly higher than that in the control group (P<0.05). The total incidence of adverse reactions such as rash, dizziness and nausea was no significant difference between the two groups (P>0.05). Conclusion In the basic treatment, using Niuhuang Shangqing Capsule combined with Zexie Decoction to treat patients with acute external otitis, can significantly improve the clinical treatment effect, shorten the symptom improvement time and treatment time, reduce the body inflammatory reaction and pain, improve the quality of life of patients, with high safety, is worthy of clinical use.

Study on the Effectiveness of Acupoint Combined with Pediatric Massage Application in the Treatment of Nonspecific Chronic Cough in Children

LI Hui, YU Xin, CONG De-yu

2023, 41(2):  29-31. 

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Objective To analysis the clinical effectiveness and value of Acupoint combined with pediatric massage application in the treatment of children with nonspecific chronic cough. Methods A total of 80 children with non-specific chronic cough admitted to the department of Pediatrics, Weihai maternal and child health hospital from March 2020 to March 2021 were selected as the research objects and divided into the control group and the study group according to the random number table method, with 40 cases in each group. Two groups of children in montelukast sodium oral granules treatment is given priority to, on this basis, the control group of children, massage therapy was used in this research by acupoints sticking, infantile tuina combined scheme, compared two groups of children with asthma symptoms, cough, sputum, cough turnaround time, forced vital capacity, forceful exhalation volume in the first second, the quality of life score and clinical treatment. Results After treatment, the improvement time of asthma, expectoration and cough in the study group was shorter than that in the control group, and the difference was statistically significant (P<0.05). The forced vital capacity and forceful exhalation volume in the first second in the study group were higher than those in the control group, and the differences was statistically significant (P<0.05). The quality of life score of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). The total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion Acupoint application combined with pediatric massage is better than massage in the treatment of children with non-specific chronic cough, which can effectively promote the improvement of disease and improve the quality of life of children, and is worthy of clinical application.

The Influence of Diet Culture on Children's Nutrition Development and Related Suggestions

WANG Tian-kun, LI Sheng-ping, LAN Mei, ZHU Yu-zhao, ZHAO Yong

2023, 41(2):  59-62. 

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The Chinese traditional diet culture has a long development history, and plays a vital role in the healthy development of children. Excellent food culture can shape children's correct values, noble moral accomplishment, rich cultural deposits, and social emotions. However, the food culture, such as food waste, and poor cooking methods, may hinder the growth and development of children, and form poor eating behaviors, such as picky eating and partial eating, resulting in dietary imbalance and frequent gastrointestinal food-borne diseases, affecting their physical and mental health. Therefore, developing an excellent diet culture to promote the healthy growth of children's all-round development of body and mind is very important, and this needs the government-related departments, social organizations, families, schools, various groups take efforts together to create a good diet culture environment, promote children to form a correct concept of diet and health behavior.

Investigation and Analysis of the Current Situation of VTE Prevention in Geriatric Departments in Hangzhou

ZHOU Xiao-li, XING Jing-jing, LI Ju-Fei, MAO Yi-Hong

2023, 41(2):  77-81. 

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Objective To investigate and analyze the current status of VTE prevention in geriatric departments of tertiary hospitals in Hangzhou, to organize and summarize the current status of VTE prevention, and to provide reference for further behavioral interventions. Methods A convenience sampling method was used to investigate the current status of VTE prevention in the geriatric departments of 16 hospitals in Hangzhou, and 120 nurses in their wards were surveyed by a self-administered questionnaire based on the theory of knowledge, trust, and competence. Results Nurses in geriatric wards scored (6.37±2.23) points on the current knowledge of VTE prevention, with a good grasp of basic VTE concepts and a score of 86.11%, and a lower score on risk factors for VTE, clinical manifestations and functional exercise, with scores of 61.02%, 60.78% and 50.78%. Multiple linear regression analysis showed that age, hierarchy, whether or not they were specialist nurses, and working years all had an effect on VTE prevention knowledge scores, the difference is statistically significant (P<0.05), respectively. Conclusion Nurses in geriatric departments of tertiary hospitals in Hangzhou have a one-sided knowledge of VTE prevention, VTE-related training is not well targeted, and the implementation of preventive measures in clinical practice Feasibility is controversial, and more managers are needed to specifically improve clinical VTE implementation pain points.

Effect of Anesthesia Machine Disinfector on the Incidence of Respiratory Circuit Microorganisms and Pulmonary Infection in Anesthesia Machine.

WENG Wei-bin, CHEN E, SHENG Dan-ying, ZHENG Hai-yan, LIN Xue-feng, JIN Chi, FENG Jie

2023, 41(2):  150-153. 

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Objective To explore the influence of anesthesia machine disinfector on the incidence of pipeline microorganism and pulmonary infection, so as to provide basis for future clinical application. Methods The 20 anesthesia machines used in Yueqing People's Hospital from March 2020 to March 2022 were selected as the research objects. The anesthesia machines were divided into experimental group and control group with 10 in each group by random number method. The experimental group was disinfected with an anaesthetic machine disinfector. The control group was disinfected with routine disinfection procedures. The sampling site, sampling time, microbial monitoring methods and postoperative pulmonary infection rate of patients were statistically analyzed. Results There was a significant difference between the two groups in the detection results of gram-positive bacteria, gram-negative bacteria and fungi (P<0.05). The monitoring sites of the number of positive bacterial culture cases were compared. The monitoring samples were taken at the expiratory end, the outlet of the soda lime tank, the inlet of the soda lime pipe, the inside of the bellows, the one-way valve at the inspiratory end, the inspiratory end, and the one-way valve at the expiratory end. The difference between the two groups was statistically significant (P<0.05). After operation, the incidence of pulmonary infection in the experimental group was lower than that in the control group, with a statistically significant difference (P<0.05). Conclusion The disinfection method of anesthesia machine disinfector can reduce the residual amount of microorganisms in the respiratory pipeline, and the standardized disinfection method of the respiratory circuit can well reduce the incidence of pulmonary infection, which is worthy of clinical promotion.

Application Effects of Cervical Vascular Ultrasound in the Judgment of Collateral Circulation in Patients with Internal Carotid Artery Occlusion

SU Juan, JIA Chun-hua

2023, 41(2):  157-160. 

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Objective To explore the application effects of cervical vascular ultrasound in the judgment of collateral circulation in patients with internal carotid artery occlusion. Methods From August 2018 to January 2022, 72 cases of stroke patients who were diagnosed and treated in our hospital's neurosurgery department were selected as the research subjects. All patients were given cervical vascular ultrasound examination,imaging features were recorded,and the formation of collateral circulation were judged and given diagnostic value analysis. Results Among 72 patients, internal carotid artery angiography determined that internal carotid artery collateral circulation formed in 42 cases, accounting for 58.33%; Collateral circulation was not formed in 30 cases, accounting for 41.67%. There was statistical significance in the ultrasonic determination results of the degree of cervical vascular stenosis between the two groups(P<0.05). There was significant difference between the two groups in the ultrasonic evaluation results of the nature of cervical vascular plaques(P<0.05). A total of 41 cases were judged as collateral circulation by cervical vascular ultrasound. The sensitivity and specificity of cervical vascular ultrasound in the determination of collateral circulation in patients with internal carotid artery occlusion were 97.62% and 100.00%. ROC curve analysis showed that the area under the curve of cervical vascular ultrasound in the determination of collateral circulation in patients with internal carotid artery occlusion was 0.773. Conclusion Cervical vascular ultrasound has high sensitivity and specificity in judging collateral circulation in patients with internal carotid artery occlusion, and it can effectively determine the characteristics of cervical vascular stenosis and plaque. means of inspection.