Therapeutic Effect of Niuhuang Shangqing Capsule Combined with Zexie Decoction in the Treatment of Acute Otitis Externa and Its Effect on the Level of Inflammatory Factors

Abstract

Abstract: Objective To explore the effect of Niuhuang Shangqing Capsule combined with Zexie decoction on the curative effect and inflammatory factor levels in the treatment of acute otitis externa. Methods Selected from June 2017 to June 2022 in Wuxi huishan district hospital for treatment of 80 cases of acute external otitis, according to the random number table was divided into observation group (n=40) and control group (n=40), two groups are given basic treatment acetate triamcinonide biconazole cream daub for a week, the control group with Zexie Decoction on basic treatment, observation group in basic treatment with Niuhuang Shangqing Capsule combined with Zexie Decoction treatment, are treated for a week. The clinical efficacy, disappearance time of clinical symptoms and treatment time, interleukin-6 (IL-6) level, C-reactive protein (CRP) level, tumor necrosis factor-α (TNF-α) level, visual analogue scale (VAS), health survey Short Form (SF-36) score, and adverse reactions were compared between the two groups. Results The total effective rate in the observation group was significantly higher than that in the control group (P<0.05). The disappearance time of swelling, disappearance time of pain, disappearance time of secretions and treatment time in the observation group were significantly shorter than those in the control group (P<0.05). There were no significant differences in the levels of IL-6, CRP and TNF-α between the two groups before treatment (P>0.05), but the levels of IL-6, CRP and TNF-α in the two groups after treatment were decreased, and the observation group was significantly lower than the control group (P<0.05). There was no significant difference in VAS score and SF-36 score between the two groups before treatment (P>0.05), VAS score decreased and SF-36 score increased in the two groups after treatment, and VAS score in the observation group was significantly lower than that in the control group, and SF-36 score was significantly higher than that in the control group (P<0.05). The total incidence of adverse reactions such as rash, dizziness and nausea was no significant difference between the two groups (P>0.05). Conclusion In the basic treatment, using Niuhuang Shangqing Capsule combined with Zexie Decoction to treat patients with acute external otitis, can significantly improve the clinical treatment effect, shorten the symptom improvement time and treatment time, reduce the body inflammatory reaction and pain, improve the quality of life of patients, with high safety, is worthy of clinical use.

Key words: Niuhuang Shangqing Capsule, Zexie Decoction, acute external otitis, curative effect, inflammatory cytokines

CLC Number:

R764.1+1

WANG Li. Therapeutic Effect of Niuhuang Shangqing Capsule Combined with Zexie Decoction in the Treatment of Acute Otitis Externa and Its Effect on the Level of Inflammatory Factors[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(2): 12-15.

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