Table of Content

16 October 2022, Volume 40 Issue 20

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Clinical Observation of Xuanbai Chengqi Supplementing and Reducing Prescription in Improving Sepsis-Associated Acute Lung Injury

LIU Hong-shuan, LI Shuo, LIU Qing-quan, YANG Hong

2022, 40(20):  1-4. 

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Objective To observe the clinical efficacy of Xuanbai Chengqi decoction in improving (sepsis-associated acute lung injury, S-ALI). Methods A total of 80 S-ALI patients admitted to Dongzhimen Hospital of Beijing University of Chinese Medicine from January 2020 to December 2021 were selected as research subjects, and were randomly divided into treatment group and control group according to random number table method, with 40 patients in each group. The control group was treated with conventional treatment, and the treatment group was treated with Xuanbai Chengqi supplementing and reducing prescription on the basis of conventional treatment ,both groups were treated for 7 days.. The oxygenation index (PO₂/FiO₂), respiratory rate (R), 24-hour stool volume of 2 groups were observed before and after treatment. Changes of white blood cell (WBC), C-reactive protein (CRP), alanine aminotransferase (ALT), serum creatinine (SCR), acute physiology and chronic health score (APACHE Ⅱ score), serum iron ion (Fe) and other indicators. Results On the 7th day of treatment,the oxygenation index (PO₂/FiO₂), 24-hour stool volume and respiratory rate in the treatment group were higher than those in the control group and the differences were statistically significant (P<0.05); WBC, CRP, APACHE Ⅱ score and Fe in the treatment group were lower than those in the control group, the difference was statistically significant (P<0.05). There were no significant differences in ALT and SCR between the treatment group and the control group. Conclusion Xuanbai Chengqi supplementing and reducing prescription can help the patient to improve lung function, gastrointestinal function, and suppress the inflammatory response. At the same time, the prescription has a certain security to liver and kidney.

Research on Cost Management of Disease Diagnosis and Treatment nder the Multidisciplinary (MDT) Model of Public Hospitals

XING Xue-mei, WANG Bei, CHEN Zheng-hong, HU Ji-feng, ZHAO Wen-ting, ZHAO Lan

2022, 40(20):  5-8. 

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Objective With the reform of medical system putting forward higher requirements for internal operation and management of public hospitals, it is necessary to strengthen refined cost management and reduce resource waste. Increasing revenue and reducing expenditure is an important part of internal control. Methods The differences between multidisciplinary diagnosis and treatment model and traditional diagnosis and treatment model were compared, and the principles and ideas of multidisciplinary diagnosis and treatment cost accounting were proposed on the basis of sorting out the management process of multidisciplinary diagnosis and treatment, and the specific accounting methods were put forward according to the cost of multidisciplinary diagnosis and treatment center, project cost and disease cost. Results Multidisciplinary diagnosis and treatment cost accounting not only provided the basis for multidisciplinary diagnosis and treatment project charges, but also provided support for hospital internal performance distribution, and provided ideas for disease cost management. Conclusion The cost management of disease MDT model of public hospitals is a gradual process. Only by focusing on efficiency, taking into account fairness, and combining the public welfare of the hospital and scientific management methods,can the economic benefits be maximized.

Ro1e of Serum CgA Determination for Pheochromocytoma and Paraganglioma

GAO Hong-bo, DI Yu-qing, LIU Jian-tong, LI Long-min, LI Yun, ZHAO Chun-yuan, SHAO Yu-jun

2022, 40(20):  9-11. 

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Objective To explore the disease diagnosis and evaluation value of serum chromaffin A (CgA) in pheochromocytoma and paraganglioma (PPGL). Methods A total of 80 patients with PPGL who were hospitalized and treated with ¹³¹I-metaiodobenzyl guaniodine (¹³¹I-MIBG) from June 2017 to June 2021 were selected in Beijing Nuclear Industry Hospital Radionuclide Diagnostic and Treatment Center. Serum CgA levels were detected by double-antibody sandwich enzyme-linked immunosorptive assay (ELISA), and the expression and significance of CgA in metastatic and advanced PPGL were evaluated. The clinicopathological characteristics (sex, age, tumor functional status, and the presence or absence of distant metastasis) of PPGL patients were recorded, and the levels of CgA were grouped and compared. Results There was no significant difference in serum CgA level in PPGL patients with different gender, age, tumor site and tumor functional status (P>0.05). The level of CgA in PCC group and PGL group was similar, and there was no statistical significance (P>0.05). The level of CgA in the ineffective group was significantly higher than that in the effective group, and the difference was statistically significant (P<0.05). Conclusion Serum CgA determination has certain significance in the diagnosis and evaluation value of disease progression and metastatic PPGL.

Clinical Study on Treatment of Cancer-related Insomnia in Patients with Lung Cancer by Pressing Beans at Ear Points Combined with Chaihu Shugan Powder

ZHONG Zu-jun

2022, 40(20):  12-15. 

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Objective To explore the clinical effect of ear point pressing bean combined with Chaihu Shugan powder on cancer-related insomnia in patients with lung cancer. Methods A total of 80 patients with insomnia caused by lung cancer in Sanshui District People's Hospital from January 2021 to January 2022 were randomly divided into the observation group (pressing beans at ear points+Chaihu Shugan powder plus or minus formula) and the control group (estazolam). The clinical effects of the two groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group (P<0.05). There was no significant difference in the levels of CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺ between the two groups before treatment and after 3 days of treatment (P>0.05). After 7 days of treatment, the levels of CD3⁺, CD4⁺, CD4⁺/CD8⁺ in the observation group were significantly higher than those before treatment (P<0.05); the levels of CD4⁺ in the control group were significantly higher than those before treatment (P<0.05). And the levels of CD3⁺, CD4⁺, CD4⁺/CD8⁺ in the observation group were significantly higher than those in the control group after 7 days (P<0.05). There was no significant difference in Aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN) and blood creatinine (Cr) levels between the two groups (P>0.05). After treatment, the TCM symptom score and SCL-90 score of the two groups were significantly lower than those before treatment (P<0.05), and the TCM symptom score and SCL-90 score of the observation group were significantly lower than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05). Conclusion Auricular Point Pressing bean combined with Chaihu Shugan powder has a significant clinical effect in the treatment of cancer-related insomnia in patients with lung cancer. It can effectively improve immune function and has a good safety. It is worthy of clinical promotion.

Clinical Effect of Triple Local External Therapy on Alopecia Areata

WANG Yan-qing, WANG Hai-hong, SONG Ju-yan, DU Ya-ting

2022, 40(20):  16-18. 

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Objective To explore the clinical efficacy of triple local external therapy in the treatment of alopecia areata. Methods Selected 100 patients with alopecia areata from December 2021 to March 2022 in Guiyang First People's Hospital, which were randomly divided into two groups, 50 patients in each group. The experimental group was treated with triamcinolone acetonide compound solution intralesional injection+plum blossom needle pricking+topical scalp nutrition repair dressing, while the control group was only treated with triamcinolone acetonide compound solution intralesional injection. Alopecia areata severity score (SALT) and Chinese version of dermatological quality of life index (DLQI) were used to evaluate the clinical efficacy and recurrence rate of the two groups. Results There was no significant difference in salt scores between the two groups before treatment and at the first month of treatment (P>0.05). The salt scores of the experimental group at the second and third months of treatment were significantly lower than those of the control group (P<0.05); The effective rate in the experimental group was higher than that in the control group (P<0.05); There was no significant difference in the DLQI score between the two groups before treatment (P>0.05), and the DLQI score of the experimental group was significantly lower than that of the control group after treatment (P<0.05); There were no local or systemic adverse reactions in both groups. Conclusion The triple local external therapy is effective in the treatment of alopecia areata.

Visual Analysis of Research Status of Traditional Chinese Medicine for Ulcerative Colitis Based on Web of Science

HUANG Wei, LI Tao

2022, 40(20):  19-24. 

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Objective To analyse the international research status and hot spots of Traditional Chinese Medicine（TCM）for Ulcerative colitis (UC) in recent decade. Methods The literatures on TCM for UC in the core database of web of science from 2011 to 2021 were searched. The cooperation among authors, countries and institutions was analyzed by CiteSpace software. Cluster analysis and emergent word analysis were performed for keywords. The co-citation of cited journals was analyzed, and the visualization map was drawn and analyzed. Results A total of 304 articles were included, including 15 core authors, and HUANGAN WU was the representative of high yield authors; China was the core countries of research; Shanghai University of Traditional Chinese Medicine and China Academy of Chinese Medical Sciences were the core research institutions; GASTROENTEROLOGY was the core journal; The research focus mainly focuses on the treatment research of traditional Chinese medicine, acupuncture and moxibustion, as well as the research on the onset mechanism of traditional Chinese medicine. The research on qing dai may be the research trend in the future. Conclusion The research hotspots and frontiers of TCM for UC are distinct, which can provide reference for further research in the future.

Therapeutic Effect of Radiofrequency Hyperthermia Combined with Drug Infusion on Malignant Serous Cavity Effusion

LIU Juan, LI Xin-hong, LIU Jing-jing, LIU Su-rong, ZHU Jiao, SUN Dang-li

2022, 40(20):  25-27. 

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Objective To investigate the effect of radiofrequency hyperthermia combined with drug infusion in patients with malignant serous effusion. Methods A prospective selection of 80 patients with malignant serous effusion admitted to the No. 521 Hospital of the Weapon Industry from November 2021 to May 2022 was conducted. The patients in the group were treated with closed thoracic drainage by central venous catheter, and the patients in the experimental group were treated with radiofrequency hyperthermia combined with drug perfusion. Both groups were treated for 2 courses of treatment. The treatment efficiency of the two groups of patients was compared, and the quality of life, fibrin degradation products (FDP) and blood D-dimer level were compared before and after treatment. Results The treatment effective rate of the patients in the experimental group was higher than that in the control group,the difference was statistically significant (P< 0.05). The level of FDP and blood D-dimer were increased, and the change in the experimental group was greater than that in the control group,the difference was statistically significant (P< 0.05). After treatment,the quality of life scores of patients in both groups increased,and the increase of patients in the experimental group was greater than that in the control group,the difference was statistically significant(P< 0.05). Conclusion For patients with malignant serous effusion,radiofrequency hyperthermia combined with drug perfusion therapy has better curative effect, can significantly increase the level of FDP and D-dimer, and improve their quality of life, which has application value.

The Clinical Effect and Complications of Modified Miccoli Operation in the Treatment of Papillary Thyroid Carcinoma

WEI Qiang

2022, 40(20):  48-50. 

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Objective To investigate the clinical effect of endoscopic-assisted thyroidectomy through small neck incision (modified Miccoli) in papillary thyroid carcinoma and its effect on complications. Methods From October 2019 to October 2020, 64 patients with papillary thyroid cancer who were admitted to the Second People's Hospital of Dongying City were selected and grouped by random number table method, and 32 patients in the control group were treated with conventional open papillary thyroid cancer resection,32 cases in the observation group were treated with the modified Miccoli procedure. The surgical indexes and complication rates of the two groups were observed. Results The operation time of the patients in the observation group was longer than that in the control group, with a statistical difference (P<0.05);the length of hospital stay and incision in the observation group were shorter than that in the control group, with a statistical difference (P<0.05); there was no statistical difference intraoperative bleeding between the two groups (P>0.05);there was no statistical difference in the complication rates between the two groups (P>0.05). Conclusion For the clinically treated patients with papillary thyroid carcinoma, the modified Miccoli operation is effective in the treatment process, and there was no increase in the complication rates.

Research Progress of Isokinetic Muscle Strength Training Combined with Electromagnetic Field on Rapid Rehabilitation of Anterior Cruciate Ligament Reconstruction after Military Training Injury

SHANG Hui-juan, ZHANG jia-yi, WU Xiang-bo, SUN Ya-chao, ZENG Jia-hao, XIE Xiao-wen, ZHANG Xiao-chen, WANG Hao, ZHANG Qian, FEI Ying-jun, GAO Jun-feng, ZHANG Bin

2022, 40(20):  54-57. 

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The injury of anterior cruciate ligament of knee is one of the most common military training injurie types, and the injured anterior cruciate ligaments are normally treated by reconstructive surgery. But postoperative complications such as joint pain, swelling, and limited range of motion often occur. It often takes a long time to restore normal knee function after surgery, which significant reduces the effectiveness of troops. This paper summarizes the research progress of rehabilitation after anterior cruciate ligament reconstruction from the perspective of isokinetic muscle strength training and electromagnetic field therapy. We suggest that it is effective to prevent military training injury by routine muscle parameter isokinetic testing and formulation of individualized rehabilitation program based on the testing results. In addition, the accurate rehabilitation program with combination of isokinetic muscle force and electromagnetic field with specific parameters is an important measure to accelerate the recovery time of officers and soldiers after anterior cruciate ligament reconstruction in the future.

Progress in Noncoding RNA Regulation Oral Squamous Cell Carcinoma Proliferation

JIANG Yu-feng, XU Xin-li, CAO Xiao-hua

2022, 40(20):  58-60. 

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Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in oral and maxillofacial region. It often metastases to local lymph nodes, and distant metastasis may occur in late stage, which seriously affects the survival and quality of life of patients. Noncoding RNAs are widely found in eukaryotes, RNAs that cannot encode proteins, including miRNAs, LncRNAs, circRNAs, etc. The regulatory relationship between non-coding RNAs in the proliferation of OSCC has become a research hotspot, and it has been proved that non-coding RNAs play an important regulatory role in the occurrence and development of OSCC. At present, the specific regulatory mechanism of non-coding RNAs in the occurrence and development of OSCC has not been fully clarified, and it has become a scientific problem that needs to be solved urgently in basic and clinical practice. Therefore, we review the mechanisms of noncoding RNA regulation OSCC proliferation to provide theory foundation for OSCC diagnosis and treatment.