Table of Content

16 October 2023, Volume 41 Issue 20

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Visual Analysis of Nearly 10 Years of Research on TCM Treatment of Heart Failure Based on CNKI

ZHANG Jun, WEN Zhi-Hao

2023, 41(20):  1-6. 

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Objective To visually analyze the literature on the treatment of heart failure by traditional Chinese medicine in CNKI database in the past 10 years, to explore the research status and development trend in this field, and to provide reference and reference for later research and clinical practice. Methods Based on the literature on the treatment of heart failure by traditional Chinese medicine included in CNKI from January 1, 2012 to April 26, 2022, the bibliometric CiteSpace.6.1.R1 software of the JAVA platform was used to analyze the included literature and draw the relevant knowledge map. Results A total of 4596 articles were included, and the number of publications in this field showed an overall upward trend, the research team was centered on Zhang Yan's team, Mao Jingyuan's team, Zhu Mingjun's team, and the research institutions were mainly Beijing University of Chinese Medicine, Tianjin University of Chinese Medicine, Hunan University of Chinese Medicine, Shandong University of Traditional Chinese Medicine, and Liaoning University of Chinese Medicine as the core. Keyword cluster analysis showed that the research hotspots mainly focused on four aspects: disease differentiation, chronic heart failure, traditional exercises, and heart function. The keyword timeline map shows that the research trend has evolved mainly in four aspects: drug research, treatment method, etiology and pathogenesis, and research method. Keyword emergence analysis shows that the recent research frontiers in this field mainly focus on "fatigue", "cardiac rehabilitation", "safety", "intestinal flora", "inflammatory factors" and other aspects. Conclusion Through visual analysis, the research team and institutions of traditional Chinese medicine in the treatment of chronic heart failure are intuitively displayed, and the research hotspots, trends and frontiers are provided, which provides reference and reference for subsequent clinical and research projects.

Prognostic and Clinical Value of the Improved Nutritional Support Program under Screening for Elderly Comorbid Patients Based on NRS-2002 Evaluation

CHEN Yan, YANG Xiao-juan, SHI Li CUI, Teng-bin*

2023, 41(20):  6-9. 

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Objective To investigate the prognosis and clinical value of the improved nutritional support program based on the Nutrition Risk Screening 2002 Scale (NRS-2002) assessment and screening for elderly critically ill patients. Methods A total of 60 elderly critically ill patients admitted to the Second Division, Xinjiang Production and Construction Corps, Korla Hospital from March 2020 to March 2022 were selected and divided into a conventional treatment group and a nutritional support treatment group according to the random number table method, 30 cases in each group; the conventional treatment group received conventional treatment, the nutritional support treatment group received the improved nutritional support program based on NRS-2002 assessment and screening; The nutritional status indicators, laboratory indicators, physical function indicators, quality of life [Abilities of Daily Living(Barthel index), health index number were compared between the two groups Table(EQ-5D index)], total hospital stay and prognosis. Results The body mass index, upper arm circumference and upper arm skinfold thickness on the day of discharge in the two groups were all higher than those before treatment, and the nutritional support treatment group on the day of discharge was higher than the conventional treatment group, and the differences were statistically significant(P<0.05). Hemoglobin, serum albumin and fasting blood glucose on the day were higher than those before treatment, while serum creatinine and total bilirubin were lower than those before treatment, and the indicators in nutritional support treatment group were significantly changed compared with those in conventional treatment group, and the differences were statistically significant(P<0.05); The swallowing function scores of the two groups on the day of discharge were lower than those before treatment, the Barthel index and EQ-5D index were higher than those before treatment, and the scores of the nutritional support treatment group were significantly changed compared with those of the conventional treatment group, and the differences were statistically significant(P<0.05); The total hospital stay in the nutritional support treatment group was shorter than that in the conventional treatment group, and the rates of re-hospitalization and new infections during the follow-up period were lower than those in the conventional treatment group, with statistically significant differences(P<0.05). Conclusion The treatment of elderly critically ill patients with improved nutritional support program based on NRS-2002 evaluation and screening has high clinical value, which is beneficial to improve the nutritional status and prognosis of patients.

VEGF, HIF-1 α The Relationship between Angiogenesis and Biological Behavior in Epithelial Ovarian Cancer

WANG Wen, MA Jun-xia, CUI Xiu-juan, TIAN Xiang-yu

2023, 41(20):  10-13. 

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Objective To detect the expression of VEGF, HIF-1α and MVD in EOC and normal ovarian tissues and their relationship with prognosis. Methods The clinical data of 46 EOC patients were retrospectively analyzed to investigate the relationship between the clinicopathological characteristics and the expression of VEGF, HIF-1α and MVD. Immunohistochemistry was performed to measure VEGF, HIF-1α expression in normal ovarian tissues and EOCs,and MVD was determined by using immunostaining of CD34. The survival analysis was performed by using Kaplan-Meier method to determine whether the expression of VEGF, HIF-1α and MVD was associated with the overall survival of EOC patients. Results The expression of VEGF, HIF-1α and MVD in EOC tissues were correlated with FIGO stage, pathological grade and lymph node metastasis(P<0.05), but not with age or histological subtype（P>0.05）. The expressions of VEGF, HIF-1α and MVD in EOC tissues were significantly higher than those in normal ovarian tissues(P<0.05). The overall survival probability of high group of VEGF, HIF-1α and MVD was significantly lower than those of the low group(P<0.05). Conclusion Angiogenesis is closely related to the growth, metastasis and prognosis of EOC, and the expression of VEGF and MVD can be used as indicators of EOC angiogenesis. Hypoxic microenvironment plays an important role in the process of tumor angiogenesis, progression and metastasis. Tumor growth-dependent factors such as VEGF and HIF-1α are expected to become new targets for tumor therapy. Molecular biological targeted therapy targeting HIF-1α or hypoxic microenvironment may bring new hope for the treatment of advanced malignant tumors and thereby improve the prognosis of patients.

Exploring the Study of Male PE Intervention in a Multidisciplinary Collaborative Model

LI Yang, LIU Fang, WU Wei, XU Shan, XIANG Jun-lian

2023, 41(20):  14-17. 

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Objective To explore the standardized management and research scheme of male PE. Methods Collect PE patients treated in the urology male department outpatient clinic of Deyang Peaple's hospital from January 2022 to February 2023. The patients were numbered according to the order of visits, and then the patients were divided into control group and test group according to the random number table, with 30 cases in each group. The control group received oral dapoxetine hydrochloride 30 mg/time 1h before sex, along with the PE male sexual function rehabilitation instrument. The experimental group was given dapoxetine, basic ascending TCM therapy and psychological counseling therapy. The treatment duration of both groups was one course（thiety days）, and sex was guaranteed four times per month during the treatment; the effect of premature ejaculation was evaluated by the Preemulation Diagnosis Scale (PEDT) score, the record of ejaculation (IELT), the score of sexual life satisfaction and the evaluation of spouse life satisfaction. Results After 1 course of treatment, the PEDT score of the experimental group was significantly lower than that of the control group (P<0.05), the IELT time was higher than the control group (P<0.05), the sexual life satisfaction score and spouse life satisfaction were significantly increased (P<0.05), comparison of the incidence of complications between two groups of patients (P>0.05), and the symptoms resolved within 24 h. Conclusion Multidisciplinary synergistic model therapy is better in treating PE than darpoxetine and premature ejaculation therapy. In addition, psychological counseling therapy can have a deep understanding of the patient's inner feelings, relax the patient's mood, is conducive to increase the intimacy between partners, improve the sexual life satisfaction of patients and their spouses, Provide reference for clinical treatment of PE patients.

Relationship between Traditional Chinese Medicine Syndrome Types of Unstable Angina Pectoris of Coronary Heart Disease and Fibrinogen, Prothrombin Time Correlation Analysis of Thrombin Time

QI Meng, ZHOU Ying, MIAO Na, MIAO Jia-ming

2023, 41(20):  17-21. 

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Objective The study was to investigate the correlation between the clinical syndromes of traditional Chinese medicine and coagulation indexes and the degree of coronary artery stenosis in patients with unstable angina pectoris (UA). Methods 120 patients admited to Wuxi Second Traditional Chinese Medicine Hospital from February 2018 to February 2020 were included in the study. Fibrinogen (FIB) level, prothrombin time (PT), thrombin time (TT), CT-1, hs-CRP and Lp-PLA2 values were determined, and eGRF values were calculated to analyze the correlation between TCM syndrome types and their correlation. Results The difference of FIB in each syndrome type was statistically significant (P<0.05). FIB level of patients with Blood stasis syndrome was significantly higher than that of the other three syndromes, and FIB level of patients with phlegm-stasis syndrome was significantly lower than that of the other three syndromes. There was no statistically significant difference in PT and TT among all syndromes（P>0.05）. There were significant statistical differences between CT-1, hs-CRP, Lp-PLA2 and eGRF of each syndrome type and the control group（P<0.05）.The CT-1 and hs CRP values of patients with Qi deficiency and blood stasis syndrome and phlegm stasis syndrome are significantly higher than those of patients with heart blood stasis obstruction syndrome and Qi yin deficiency syndrome. The Lp-PLA2 and eGRF values of patients with phlegm stasis syndrome and heart blood stasis syndrome are significantly higher than those of patients with qi deficiency and blood stasis syndrome. There were statistically significant differences in CT-1, hs CRP, Lp PLA2, and eGRF between patients with different degrees of coronary artery stenosis and the control group (P<0.05). Conclusion In 120 patients, the syndrome of qi deficiency and blood stasis > Mutual accumulation of phlegm and blood stasis > Deficiency of qi and Yin. The fibrinogen (FIB) value of the syndrome was significantly higher than that of other syndrome types. The levels of CT-1, hs-CRP, Lp-PLA2 and eGRF are closely related to the TCM syndrome type of unstable angina pectoris in patients. The expression level can help to understand the degree of coronary artery disease, provide the corresponding basis for clinical treatment, and play a role in the early prevention and treatment of coronary heart disease.

Semen Quality Analysis of 1 381 Men of Childbearing Age in Southern Changping Area of Beijing

LI Xiao, YAN Bin

2023, 41(20):  21-25. 

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Objective To investigate the semen quality of men in southern Changping District in recent two years. Methods The semen quality of reproductive-age men who came to Changping District Integrated Traditional Chinese and Western medicine hospital for semen examination during July to June in the 2021 of 2023 was analyzed retrospectively, they were divided into 5 groups according to their ages: ≤25,26~30,31~35,36~40, >40, the semen parameters were analyzed and compared, and the semen parameters were divided into 4 groups according to their ages: A, B, C, D, to compare the changes of male semen quality in recent two years. Results A total of 1,381 male semen samples were collected and sorted. The total semen quality was up to standard in 719 cases, and abnormal semen in 662 cases, there were significant differences in total sperm count, sperm motility, forward motility and survival sperm rate (P<0.05), but there were no significant differences in other parameters with age (P>0.05). The sperm concentration and total sperm count in group D were significantly lower than those in the first 3 groups (P<0.05). Conclusion The semen quality of reproductive-age men in southern Changping District can meet the WHO standard. The main semen abnormalities are sperm total motility, forward motility and survival sperm rate, the sperm concentration and the total number of sperm decreased significantly in the last six months.

Clinical Study on Wubei Powder, Xiaoxianxiong Decoction and PPI in Treating Non Erosive Reflux Disease of Liver Stomach Heat Stagnation Type

FU Yan-li, QIN Yang, LIU Huai-lei

2023, 41(20):  40-43. 

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Objective To evaluate the clinical effect of Wubei Powder and Xiaoxianxiong Decoction combined with PPI in the treatment of non erosive reflux disease of liver stomach heat stagnation type. Method A total of 92 patients with non-erosive reflux disease of liver and stomach depression heat were selected from the spleen and Stomach Disease Department of Hongze District Hospital of Traditional Chinese Medicine, Huai 'an City from July 2019 to July 2022. SAS9.2 software was used to randomly divide the patients into 2 groups, 48 in the treatment group and 44 in the control group. The treatment group was given Wubei Powder and Xiaoxianxiong Decoction, take Lansoprazole enteric coated tablets at the same time. Lansoprazole enteric coated tablets in the control group. Both groups were treated for 8 weeks. Observe the changes of symptoms, TCM syndrome scores, Zung Self Rating Anxiety Scale, Zung Self Rating Depression Scale and SF-36 quality of life scores of the two groups before and after treatment. Results The total effective rate in the treatment group was higher than that in the control group. The clinical efficacy of the treatment group was significantly better than the control group(P<0.05). After treatment, the single score of TCM syndromes in the two groups decreased significantly, and the four scores of heartburn, acid regurgitation, poststernal burning pain and epigastric burning pain in the treatment group were significantly lower than those in the control group(P<0.05). After treatment, the SAS, SDS scores and quality of life scores of patients in the two groups decreased significantly, and the SAS, SDS scores and quality of life scores in the treatment group were significantly lower than those in the control group(P<0.05). Conclusion Wubei powder combined with Xiaoxianxiong decoction and PPI can effectively improve the symptoms, psychological status and quality of life of patients with non erosive reflux disease of liver stomach heat stagnation type.

Analysis of Serum proGRP Combined with NLR for Lymph Node Metastasis Factors and the Diagnosis of Thyroid Cancer

XU Wu-shan WEI Xiao-juan

2023, 41(20):  57-60. 

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Objective The relationship of serum gastrin-releasing peptide precursor (proGRP) combined with neutrophil/lymphocyte ratio (NLR) on lymph node metastasis and the diagnosis of thyroid cancer were analyzed. Methods The 140 patients with thyroid nodules admitted to Xi'an Aerospace General Hospital between January 2020 and January 2023 were selected as the study object, with pathological results as the gold standard, 70 patients with thyroid cancer were taken as the observation group, the other 70 patients with benign thyroid nodules as the control group, and the patients were divided into metastasis group (n=33) and non metastasis group (n=37). The diagnostic efficacy of serum proGRP and NLR in thyroid cancer and lymph node metastasis was calculated by comparing the difference of serum proGRP and NLR index values respectively. Results The proGRP and NLR values of patients in observation group were higher than those of control group, the difference was statistically significant(P<0.05), and the serum proGRP and NLR values of patients in metastasis group were higher than those of non-metastasis group, and the difference was statistically significant(P<0.05); the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of serum proGRP and NLR index were respectively higher than that of each index alone, and the difference was statistically significant(P<0.05); the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of serum proGRP combined with NLR index to predict thyroid cancer with lymph node metastasis were higher than that of each index alone, and the difference was statistically significant(P<0.05). Conclusion Serum proGRP combined with NLR has high diagnostic value for thyroid cancer, and the two are closely related to thyroid cancer with lymph node metastasis, so the index detection in advance has certain predictive value for the risk of lymph node metastasis.

Rehabilitation Effect of Kegel Exercise Combined with Acupoint Massage on Patients with Postpartum Urinary Incontinence

JIN Xin-xin, ZHANG Li-li, YAN Yan-yan

2023, 41(20):  73-76. 

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Objective To investigate the rehabilitation effect of Kegel exercise combined with acupoint massage on postpartum patients with urinary incontinence. Methods A total of 96 patients with postpartum urinary incontinence admitted to the postpartum clinic of the Affiliated Hospital of Binzhou Medical College from March 2021 to September 2022 were selected and randomly divided into control group and experimental group with 48 cases, respectively. The control group received rehabil-itation exercise with Kegel exercise, and the experimental group received rehabilita-tion exercise with Kegel exercise combined with acupoint massage. The recovery effect was observed after 4 weeks. Results The weight of urine pad in the experime-ntal group was lower than that in the control group at 1h, and the difference was statistically significant (P<0.05). There was no significant difference in self-esteem between the two groups (P>0.05). The quality of life score of the experimental group was higher than that of the control group, and the difference was statistically significant (P<0.05). The treatment satisfaction rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion Kegel exercise combined with acupoint massage can effectively improve the pelvic floor function, self-confidence and quality of life of patients with postpartum urinary incontinence.

Using the Methodology of Traditional Chinese Medicine to Solve the Development Bottleneck of Artificial Intelligence Diagnosis Technology of Traditional Chinese Medicine

WANG Qian, WU Hong-yan, PENG Wen-wen, ZHAI Li-ping, ZHUANG Yan-shuang, GU Xin, ZHOU Yuan-yuan

2023, 41(20):  77-80. 

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The development of artificial intelligence technology in the field of traditional Chinese medicine diagnosis has gone through decades. Although some achievements have been made, there is a big bottleneck in the overall development, and it is difficult to brethrough in a short time. The author believes that the biggest reason for the development bottleneck lies in the way of thinking of researchers. The author believes that the research on intelletualization of traditional Chinese medicine must have the thinking mode of traditional Chinese medicine, and the research should be conducted under the guidance of the methodology of traditional Chinese under the guidance of the methodology of traditional Chinese medicine, so as to break through these development bottlenecks and realize the p-r e causes and solutions of the development bottleneck of artificial ogress of artificial intelligence technology. This paper expounds the causes and solutions of the development bottleneck of artificial intelligence technology in the field of TCM diagnosis from the unique perspective of TCM methodology, and provides new research ideas for the development of TCM intelligence.

Application of SOAP Evalution Record Method in Clinical Teaching of Rehabilition Medicine

YANG Shu-ming, HUANG Gui-ling, WANG Hong-wei, ZHANG Jing, YUAN Lu-lu, SUN Xiu-li, YAN Xue, XIN Bao-qiong

2023, 41(20):  84-87. 

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Objective To explore the application effect of SOAP assessment recording method in rehabilitation practice. Methods The clinical students of Grade 2018 and 2019 in Jiangsu Medical Vocational College were divided into two groups: the control group (n=23,used the traditional teaching mode to practice) and observation group (n=29, used the SOAP evaluation record method teachin to practice), and the teaching evaluation and teaching satisfaction of the two groups of students after practice were evaluated. Results The total score of theoretical assessment and clinical practice ability of the observation group were significantly higher than those in the control group (P<0.05), the students in the observation group were better than those in the control group in stimulating learning interest, grasping basic knowledge, clinical thinking and teaching methods (P<0.05). Conclusion The teaching practice of SOAP evaluation recording method has achieved satisfactory teaching effect, which is obviously superior to the traditional teaching method.

Investigation on the prevalence of Alzheimer's Disease and Correlation Analysis of AD7C-NTP in Middle-Aged and Elderly People Undergoing Physical Examination in Zigong Area

Zheng Ge, Bi Bing, Zhu Jing, Guo Jiu-chang

2023, 41(20):  90-93. 

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Objective To investigate the prevalence of Alzheimer's disease and the correlation between AD7C-NTP in middle-aged and elderly people undergoing physical examination in Zigong area. Methods From January 2021 to June 2022, 1 460 subjects were selected to undergo physical examinations in the Health Management Department of the First People's Hospital of Zigong City. In addition to routine physical examination, 1 460 patients were also tested for Alzheimer's disease related neurofilament protein AD7c-NTP. Based on the results of AD7c-NTP, subjects with abnormally elevated urinary AD7C-NTP were selected and divided into normal AD7C-NTP group (n=1 250) and AD7C-NTP-elevated group (n=210). Blood biochemical index data were collected and compared between the two groups. At the same time, people with high AD7c-NTP were screened for Alzheimer's disease through simple mental state examination (MMSE) and MRI, and according to the Clinical Dementia Rating Scale (CDR). Analyze the differences in AD7C-NTP levels in different degrees of AD. Results Among the 1 460 examinees, there were 210 cases with abnormal increase in urine AD7c-NTP, accounting for 14.38%. There were differences in serum Cr, TBIL, GLU, TC, and LDL between individuals with abnormal AD7c-NTP elevation and normal individuals (P<0.05); Among the 210 individuals with high AD7C-NTP levels, 152 (72.38%) were diagnosed with AD, and there were differences in AD7C-NTP levels among AD patients with different cognitive impairments (P<0.05); The level of AD7c-NTP is positively correlated with Cr, GLU, TC, and LDL (P<0.05), negatively correlated with MMSE, and not significantly correlated with TBIL (P>0.05). Conclusion There is a correlation between AD7c-NTP levels and cognitive function, which can be used as one of the auxiliary methods for early screening of AD; The level of AD7c-NTP is correlated with Cr, GLU, TC, and LDL, and high Cr, GLU, TC, and LDL are one of the risk factors for the onset of AD.

Seroepidemiological Study of Hepatitis B Children in a Region after Planned Immunization with Hepatitis B Vaccine

Lu Yan

2023, 41(20):  96-100. 

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Objective To investigate the prevalence of hepatitis B among children in a certain area after the planned immunization with hepatitis B vaccine through seroepidemiological studies. Methods The study were conducted from February 2019 to December 2020. Used the multi-stage stratified random cluster sampling method, 300 cases of children who completed the planned immunization of hepatitis B vaccine in a certain area were selected as the study subjects. The seroepidemiological tests were carried out on all children, and general data of children were investigated and Spearman correlation analysis was carried out. Multivariate analysis of influencing factors of HBV infection was carried out by Logistic regression. Results In the 300 children, serum HBsAg positive was 6.00%, serum anti-HBc 10.67% and serum HBsAb 9.33% . In 6 children of hepatitis B, the prevalence was 2.00%, including 6 men and 0 women. There was no difference in the prevalence of male and female populations (P>0.05). Spearman analysis showed that there were correlation between male, being deliverd in hospital under county level, cesarean section, preterm delivery, father's HBsAg positive, mother's HBsAg positive, delayed vaccination, low birth weight and hepatitis B infected (P<0.05). Logistic regression analysis showed that father's HBsAg positive, delayed vaccination and mother's HBsAg positive were the risk factors for hepatitis B disease in certain area after hepatitis B vaccine immunization (P<0.05). Conclusion The prevalence rate of hepatitis B among children in a certain area after the planned immunization of hepatitis B vaccine is relatively low. The risk factors for the prevalence of hepatitis B are HBsAg positive children guardians and untimely vaccination, and preventive management should be actively strengthened.

Correlation Between Serum Renal Function Indices and Uremia Complicated with Heart Failure and Its Prognostic Value

LU Jing-yan

2023, 41(20):  178-181. 

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Objective To explore the correlation between serum renal function index and uremia complicated with heart failure and its prognostic value. Methods 80 patients with uremia complicated with heart failure admitted to Lanzhou First People's Hospital from January 2020 to January 2023 were selected as the study subjects. All patients were divided into groups according to Killip classification, including 22 patients with grade Ⅱ, 38 patients with grade Ⅲ, and 20 patients with grade Ⅳ, and 40 patients with simple uremia treated in our hospital during the same period were selected as the control group. The expression levels of serum renal function related indices in the four groups were compared, and the correlation between serum renal function indicators and uremia complicated with heart failure was analyzed. Subsequently, 80 patients with uremia complicated with heart failure were divided into death group (n=20) and the rest into survival group (n=60). The clinical general situation and the expression level of serum renal function indicators were compared between the two groups, and the prognostic value of serum renal function indices for uremia complicated with heart failure was analyzed by logistic regression analysis. Results The levels of SCR, BUN, CysC, UA and other related indices of renal function in the four groups were significantly higher in patients with grade Ⅳ than those in patients with grade Ⅰ, Ⅱ and control group (P<0.05); Spearman correlation analysis showed that there was a positive correlation between serum renal function indexes of SCR, BUN, CysC, UA and uremia complicated with heart failure (P<0.05); there was no significant difference in sex, age, BMI, diabetes, hypertension, hyperlipidemia, inducement of heart failure, BUN between the survival group and the death group (P>0.05), but there were significant differences between the survival group and the death group in old myocardial infarction, left ventricular ejection fraction, SCR, CysC, UA levels (P<0.05). The results of logistic regression analysis showed that SCR (OR=2.546, 95% CI：1.364~3.475), CysC (OR=2.774, 95% CI：1.876~4.010) and UA (OR=0.326, 95% CI：0.251~0.765) were independent predictors of the prognosis of uremia complicated with heart failure (P<0.05). Conclusion There is a significant correlation between serum renal function indices and the severity of uremia complicated with heart failure, and the higher the level of post-table of renal function related to SCR, CysC and UA may predict the poor prognosis of patients.