Table of Content

16 August 2022, Volume 40 Issue 16

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Effect of Sirt1 on Liver Regeneration in Mice

WEI Tao, ZHOU Jing-lin, XU Shao-na, LIU Yang, LU Di, ZHU Hui-hui

2022, 40(16):  1-4. 

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Objective To investigate the role and transcriptional level of histone deacetyltransferase Sirt1 in liver regeneration after hepatectomy. Methods Three mice were randomly selected and executed at 12 h, 24 h, 48 h and 72 h postoperatively in the experimental group, and the mice in control group were executed immediately after the sham operation.The ability of liver regeneration was assessd by liver weight/body weight ratio, the degree of liver injury was detected by ALT activity detection and the transcriptional level of histone deacetyltransferase Sirt1 in mouse liver tissue was detected by real-time quantitative PCR (RT-qPCR). Results Aftter hepatectomy, the liver weight/body weight ratio in the experimental group increased gradually. compared with the control group, ALT levels in serum were higher at 12 h, 24 h and 48 h, and recovered at 72 h. At 48 h, the transcriptional level of histone deacetyltransferase Sirt1 decreased. Conclusion Liver regeneration after hepatectomy in mice might be related to the decrease of histone deacetyltransferase Sirt1 transcription, which resulted in the increase of acetylation of some proteins.

Study of Peripheral Blood Amino Acid and Bioamine Metabolism Levels and Clinical Significance in Patients with Obstructive Sleep Apnea-hypopnea Dyndromeat Multiple Time Points at Night

DOU Yuan-yuan, Wang Huan

2022, 40(16):  4-7. 

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Objective To study the metabolic levels of amino acids and biogenic amines in peripheral blood of patients with obstructive sleep apnea (OSA) at multiple time points at night and their clinical significance. Methods A total of 100 OSA patients and 100 healthy subjects admitted to the Fifth Affiliated Hospital of Xinjiang Medical University from January 2020 to April 2022 were selected as the research objects. The healthy subjects were the reference group, and OSA patients were the scientific research group. After admission, the levels of amino acid(γ-GABA), melatonin(MT) and endogenous antioxidant in 2 groups were detected, serum vitamin E(VitE) and vitamin C(VitC) were detected by phenantholine colorimetry, superoxide dismutase(SOD) was detected by xanthine oxidase method, malondialdehyde(MDA) was detected by thiobarbituric acid colorimetry. Nitric oxide synthase(NOS) and nitric oxide reductase(NO) were detected by elisa, and the levels of amino acids, melatonin, endogenous antioxidant and disease severity were compared between the two groups. Results The levels of γ-GABA and MT in the research group were lower than those in the reference group, and the differences were statistically significant (P<0.05). The levels of VitE, VitC, SOD, MDA, NOS and NO in the research group were higher than those in the control group, and the differences were statistically significant (P<0.05). With the gradual aggravation of the patient’s condition, the index values of γ-GABA and MT decreased gradually, while the index values of VitE, VitC, SOD, MDA, NOS and NO increased gradually, the difference was statistically significant (P<0.05). Conclusion The low expression of amino acids, melatonin and high expression of endogenous antioxidants in OSA patients at night are directly related to the severity of the disease. Therefore, the above results can provide reference for the treatment of the disease and are worthy of clinical application.

Study on the Efficacy of Septum Deviation Correction in Patients with Obstructive Sleep Apnea-hypopnea Dyndromeand Heart Failure

DONG Yue-feng

2022, 40(16):  8-11. 

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Objective To explore and analyze the effect of nasal septum deviation correction on obstructive sleep apnea hypopnea syndrome patients with heart failure. Methods A total of 100 patients with OSAHS complicated with heart failure admitted to Wuwei People’s Hospital of Gansu Province from June 2015 to June 2019 were selected as the research subjects, and they were divided into the traditional group and the corrected group according to the random number table method, with 50 patients in each group. The traditional group was treated with conventional treatment based on Continuous positive airway pressure (CPAP), and the correction group was treated with nasal septum deviation correction on the basis of the traditional treatment. The level of nasal volume, lung function index forced expiratory volume in one second (FEV₁), FEV/forced vital capacity (FVC), and Cervical pulse wave velocity were compared between the two groups. CfPWV, Left ventricular ejection fraction (LVEF) and blood pressure. Results After treatment, the nasal volume of the corrected group and the traditional group was significantly higher than before, with statistical significance (P<0.05). The nasal volume in the corrected group was significantly higher than that in the traditional group, with statistical significance (P<0.05). After treatment, FEV₁, FEV/FVC and other lung function indexes in the correction group and the traditional group were significantly higher than before treatment, with statistical significance (P<0.05). FEV₁, FEV/FVC and other lung function indexes in the corrected group were significantly higher than those in the traditional group, with statistical significance (P<0.05). After treatment, LVEF in the correction group and the traditional group was significantly higher than before treatment, the difference was statistically significant (P<0.05). After treatment, CfPWV in the corrected group and the traditional group was significantly lower than before treatment, the difference was statistically significant (P<0.05), and there was also a significant difference between the corrected group and the traditional group (P<0.05). The dynamic systolic blood pressure and dynamic diastolic blood pressure at 2 weeks after treatment in the correction group and the traditional group were significantly lower than before treatment (P<0.05), and the correction group was also significantly lower than the traditional group (P<0.05). Conclusion Correction of nasal septum deviation in the treatment of OSAHS complicated with heart failure can significantly improve the nasal volume of patients, improve lung function, promote the continuous reduction of ambulature blood pressure and improve the heart function of patients, which is worthy of clinical application.

Study on the Effect of the Combination of Intravenous Infusion Azithromycin and Kangfu Xiaoyan Suppositories in the Treatment of Chronic Adnexitis

TANG Chao

2022, 40(16):  12-15. 

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Objective To evaluate the efficacy of the combined regimen of intravenous infusion of azithromycin and Kangfu Xiaoyan Suppository in treating patients with chronic adnexitis. Methods A total of 64 patients with chronic adnexitis admitted to Jiaozhou Second People’s Hospital from January 2020 to January 2021 were selected as the research objects, and were divided into control group and experimental group according to random number table method, with 32 cases in each group. Patients in the control group were treated with azithromycin intravenous drip, and patients in the experimental group were treated with azithromycin intravenous drip combined with Kangfu xiaoyan Shuan. The levels of inflammatory factors, symptom improvement time, hospitalization days, total effective rate and incidence of adverse reactions were compared between the two groups before and after treatment. Results After treatment, the incidence of drowsiness, vomiting, dizziness and other adverse reactions in the experimental group was significantly lower than that in the control group, with statistical significance (P<0.05). The levels of interleukin-10, TUMOR necrosis factor-ɑ and interleukin-6 in experimental group were significantly lower than those in control group, while the level of interleukin-2 was significantly higher than that in control group, the differences were statistically significant (P<0.05). The improvement time of abnormal leucorrhea symptoms, lumbosacral soreness symptoms and lower abdominal distension symptoms in the experimental group was significantly shorter than that in the control group, and the length of hospitalization was also significantly shorter than that in the control group, with statistical significance (P<0.05). The total effective rate in experimental group was significantly higher than that in control group, and the difference was statistically significant (P<0.05). Conclusion For patients with chronic adnexitis, azithromycin intravenous drip combined with Kangfu xiaoyan suppositories can inhibit inflammatory reaction, effectively reduce the risk of complications, and improve the clinical efficacy, which is worthy of clinical application.

Predictive Value Analysis of the Combined Detection of Serum Somatostatin and Calcitonin Gene-Related Peptide Expression Levels in Patients with Gastrointestinal Recovery after Laparoscopic Cholecystectomy

TONG Wan-yong, TANG Shui-bin

2022, 40(16):  15-18. 

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Objective To investigate the predictive value of detection of serum somatostatin(SS) and calcitonin gene-related peptide(CGRP) in predicting gastrointestinal function recovery of patients after laparoscopic cholecystectomy. Methods A total of 200 patients undergoing laparoscopic cholecystectomy who were admitted to the Second People’s Hospital of Kashgar from January 2017 to December 2020 were included as research subjects, all patients were divided into well recovered group and poor recovered group according to recovery condition of gastrointestinal function. All clinical data were collected, the expression levels of serum SS and CGRP of all patients were detected by ELISA, the predictive value each index was evaluated by receiver operating characteristic curve(ROC). Results The sexuality, age, BMI, ASA grading, operation time, PACU residence time, total liquid intake and blood loss of two groups had no statistically significant difference(P>0.05), the good group was shorter than the poor group in terms of the time to first exhaust after operation, the time to first defecation after operation and the recovery time of bowel sounds,the difference was statistically significant(P<0.05). The expression levels serum SS and CGRP of poor recovered group were higher than well recovered group, the difference was statistically dignificant (P<0.05). ROC analysis showed that the AUC, sensitivity and specificity of SS+CGRP were higher than separate detection of two indexes. Conclusion The expression levels of serum SS and CGRP could be important factors in predicting recovery condition of gastrointestinal function after laparoscopic cholecystectomy, and combined detection of two indexes had higher predictive value, while could provide reference for early intervention and improvement of postoperative recovery.

Analysis of Factors Influencing Quality of Life and Cardiovascular Complications of Patients after Interventional Treatment of Coronary Heart Disease

ZHOU Fa-qiang, SUN Xiang-li

2022, 40(16):  19-21. 

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Objective To analyze the influencing factors of quality of life and cardiovascular complications in patients with coronary heart disease after interventional therapy. Methods A retrospective research of 145 patients with coronary heart disease who underwent interventional therapy in Gaotang County People’s Hospital of Shandong Province from January 2018 to December 2020 was included in this study to analyze the main factors affecting the quality of life of patients. The quality of life of the patients after treatment was evaluated by the Brief Health Status Questionnaire (SF-36), and a good group (107 cases, with a good score) and a general group (36 cases, with an average score) were generated. Factors affecting quality of life and cardiovascular complications. Results After treatment, there were significant differences in the quality of life scores of patients with different age, economic level, work and smoking status, and diabetes, and all had significant effects on the quality of life score (P<0.05). The patients in the good group had cardiovascular complications. The total incidence of postoperative restenosis and non-fatal myocardial infarction was lower than the general group, and the difference was statistically significant(P<0.05). Conclusion The quality of life of patients with coronary heart disease after interventional therapy is related to the patient’s age, economic level, work and smoking status, and diabetes,and patients with higher quality of life scores have a lower incidence of postoperative restenosis and nonfatal myocardial infarction.

Research Advances in Ehealth Literacy

SHAO Shuang-yang, LIU Ying, WANG bing, REN Jing-jing

2022, 40(16):  67-70. 

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The concept of ehealth literacy is developing dynamically. After Norman C D first put forward the definition of ehealth literacy, different scholars have supplemented and improved it successively, and relevant research has gradually increased and become a hot spot at present. Based on this, this paper summarizes the research objects, evaluation tools and research on ehealth literacy in disease management, so as to provide reference for the iterative update of ehealth literacy evaluation tools and intervention strategies of ehealth literacy in the future.