Table of Content

01 August 2022, Volume 40 Issue 15

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Clinical Effect of Angong Niuhuang Pill in the Treatment of Cerebral Vasospasm after Craniocerebral Injury

XU Long-biao, HUANG Huan-ming, WU Tian-ya, ZHU Jia-ming, CHEN Shi-qi, WAN Ye-dong, WANG Guan-hua

2022, 40(15):  1-4. 

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Objective To study the therapeutic effect of Angong Niuhuang Pill on cerebral vasospasm in patients with craniocerebral injury. Methods A total of 72 patients with cerebral vasospasm admitted to Zhuji People's Hospital after craniocerebral injury from June 2019 to June 2021 were selected and divided into the control group and the treatment group, with 36 cases in each groups.The control group was treated with common treatment methods combined with basic treatment methods; the treatment group was additionally treated with Angong Niuhuang Pill on the basis of the treatment of the control group.The changes of Glass Score (GCS) before and after 14 days of treatment were compared between the two groups, and the blood flow velocity of the middle cerebral artery was measured by transcranial Doppler ultrasound and was compared between the two groups. Results The blood flow velocity of the middle cerebral artery in the treatment group was significantly lower than that in the control group at 3, 7, and 14 days after treatment, and the difference was statistically significant(P<0.05).The Glass score after treatment in the treatment group was significantly higher than that in the control group, and the difference was statistically significant(P<0.05). Conclusion Angong Niuhuang Pill has the effect of dilating blood vessels and inhibiting the inward flow of calcium ions in post-traumatic brain injury patients, thereby reducing cerebral edema, regulating cerebral blood flow, reducing the average flow rate of the middle cerebral artery, and therefore reducing the occurrence of traumatic cerebral vasospasm.

Effects of Benazepril Combined with Labetalol on Vascular Endothelial Function and Carotid Intima-media Thickness in Patients with Hypertension

Guo Xue-feng

2022, 40(15):  4-5. 

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Objective To investigate the effect of benazepril combined with labetalol on vascular endothelial function and carotid intima-media thickness in patients with hypertension. Methods Selected 300 cases of patients with who were treated in Xinjiang Production and Construction Corps Hospitalfrom January 2019 to December 2021, the random number table method is divided into two groups.The control group was treated with labetalol alone, and the observation group was treated with benazepril combined with labetalol.The clinical efficacy, pulse pressure difference, diastolic blood pressure, carotid intima-media thickness (IMT) and systolic blood pressure were compared between the two groups,and systolic blood pressure were compared between the two groups, and the levels of serum ischemia modified albumin (IMA), nitric oxide (NO), endothelin-1 (ET-1), homocysteine (Hcy) and myeloperoxidase (MPO) were measured. Results The effective rate of the observation group wassignificantly higher than control group (P<0.05). Before treatment, there was no significant difference in blood pressure and pulse pressure difference between the two groups (P>0.05). After treatment, the blood pressure and pulse pressure difference between the two groups decreased significantly (P<0.05), and the observation group was lower (P<0.05). Before treatment, there was no significant difference in the levels of serum ET-1, Hcy, NO, IMA and MPO between the two groups (P>0.05). After treatment, the levels of serum ET-1, Hcy, IMA and MPO decreased significantly (P<0.05) and NO increased significantly (P<0.05). The levels of serum ET-1, Hcy, NO, IMA and MPO in the observation group were significantly better than those in the control group (P<0.05). Before treatment, there was no significant difference in carotid IMT between the two groups (P>0.05). After treatment, the carotid IMT of the two groups decreased significantly (P<0.05), and the carotid IMT of the observation group was lower (P<0.05). Conclusion Benazepril combined with labetalol can improve vascular endothelial function, reduce carotid IMT and improve curative effect in patients with hypertension.

Risk Factors for Carotid Atherosclerosis in Patients with Type 2 Diabetes

YANG Zhen,ZHAO Jie

2022, 40(15):  8-11. 

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Objective To explore the risk factors of carotid atherosclerosis in patients with type 2 diabetes. Methods A total of 125 patients with type 2 diabetes who visited the People's Hospital of Inner Mongolia Autonomous Region from January 2019 to December 2021 were selected as the research subjects. The clinical data of the two groups of patients were compared, and the risk factors of carotid atherosclerosis in patients with type 2 diabetes were analyzed. Results Among the 125 patients with type 2 diabetes, 68 patients had carotid atherosclerosis, and the incidence rate was 54.40%. The results of univariate analysis were: age, BMI, smoking history, hypertension history, diabetes duration, high density liptein cholesterol (HDL-C), regular insulin therapy, triglyceride (TG), glycosylated hemoglobin (HbA_1c) were associated with the occurrence of atherosclerosis in type 2 diabetes (P<0.05), while drinking history, regular insulin therapy, diastolic blood pressure (DBP), fasting There was no statistically difference in blood glucose (FBG), systolic blood pressure (SBP), 2 h postprandial blood glucose (2 h PBG),total cholesterol (TC) and fasting insulin (P>0.05); binary logistic regression analysis , taking the presence or absence of atherosclerosis in patients with type 2 diabetes as the dependent variable (non-sclerosis group=0, sclerosis group=1), age, BMI, smoking history, history of hypertension, duration of diabetes, HDL-C, insulin regular treatment , TG, and HbA_{1 c} are independent variables. Binary Logistic regression analysis shows that age, HDL-C, history of hypertension, diabetes duration, regular insulin therapy, TG, and HbA_{1 c} are risk factors for atherosclerosis in patients with type 2 diabetes. Conclusion Age, duration of diabetes, history of hypertension, HDL-C, regular insulin therapy, TG and HbA_{1 c} are risk factors for carotid atherosclerosis in type 2 diabetes. Preventing the above factors can delay the occurrence of carotid atherosclerosis in patients.

Effect of Ligustrazine Hydrochloride Injection Combined with Urecolin on Acute Cerebral Infarction and the Ievels of Ang - Ⅱ, D-dimer and hs-CRP

Ya Na-ren,Zhen Zuo-rui

2022, 40(15):  11-15. 

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Objective To study the effect of ligustrazine hydrochloride injection combined with urecolin on acute cerebral infarction and the levels of angiotensin Ⅱ(Ang -Ⅱ), D-dimer and high-sensitivity C-reactive protein (hs-CRP). Methods A retrospective study of 76 patients with acute cerebral infarction admitted to Shihezi People's Hospitalfrom January 2019 to December 2021 were retrospectively selected and divided into two groups according to the treatment methods, with 38 cases in each group. The control group was given Eurekrine treatment; the observation group was treated with Ligustrazine Hydrochloride Injection on the basis of Eurekrine. The two groups were treated for 14 days, and the effective rates of treatment in the two groups were observed, plasma D-dimer, angiotensin II (Ang-II), serum high-sensitivity C-reactive protein (hs-CRP) levels and cerebral blood Fluid dynamics indicators (posterior cerebral artery blood flow velocity, hematocrit level, middle cerebral artery blood flow velocity, whole blood low shear viscosity, anterior cerebral artery blood flow velocity, and whole blood high shear viscosity). Results The effective rate of the observation group was significantly higher than control group (P<0.05). Before treatment, there was no significant difference in the levels of Ang-Ⅱ, D-dimer and hs-CRP between the two groups (P>0.05). After treatment, the levels of Ang-Ⅱ, D-dimer and hs-CRP in the two groups decreased significantly (P<0.05), and the levels of Ang-Ⅱ, D-dimer and hs CRP in the observation group were significantly lower than those in the control group (P<0.05). Before treatment, there was no significant difference in hematocrit, anterior cerebral artery blood flow velocity, whole blood high shear viscosity, middle cerebral artery blood flow velocity, whole blood low shear viscosity and posterior cerebral artery blood flow velocity between the two groups (P>0.05). After treatment, all indicators in the two groups were significantly improved (P<0.05),andthe indexes in the observation group were significantly better than those in the control group (P<0.05). Conclusion Ligustrazine hydrochloride injection combined with urecolin has a significant effect on acute cerebral infarction, and its mechanism may be related to reducing the levels of Ang -Ⅱ, D-dimer and hs-CRP.

Observation on the Treatment Effect of Topiramate Tablets Combined with Lamotrigine Tablets in Epilepsy

WANG An-ying, LYU Dian-ping

2022, 40(15):  15-18. 

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Objective To analyze the therapeutic effect of topiramate tablets combined with lamotrigine tablets in epilepsy. Methods 66 patients with epilepsy in the neurology department of Qianguorluos Mongolian Autonomous County Hospital from January 2021 to December 2021 were participated in the study, and were randomly divided into two groups with 33 cases in each group. The control group was treated with lamotrigine tablets, and the observation group was treated with topiramate tablets combined with lamotrigine tablets, and the total effective rate, seizure frequency, duration, EEG results, serological indexes, incidence of adverse reactions, and quality of life scores were observed. Results The observation group had a higher total effective rate of treatment, the difference was significant(P<0.05); the frequency of epileptic seizures in the observation group was lower than that in the control group, and the seizures duration was shorter than that in the control group, the difference was significant(P<0.05); the score of quality of life in the observation group was higher than that in the control group, the difference was significant(P<0.05). The epileptiform discharges and the number of involved leads in the observation group were significantly improved, the difference was significant(P<0.05).The levels of GAL and NPY in the observation group were significantly improved, the difference was significant(P<0.05). Conclusion In the treatment of epilepsy, the use of topiramate tablets combined with lamotrigine tablets can improve the total effective rate of treatment, reduce the frequency of epileptic seizures, shorten the duration, and the treatment safety is high, the patient's condition can be effectively controlled, and the quality of life can be significantly improved, clinical value.

Clinical Application of Intra-amniotic Injection of Ethacridine Combined with Mifepristone in Induced Labor during Gestational Age of 16-26 Weeks

CHEN Lin

2022, 40(15):  18-22. 

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Objective To explore the clinical application effect of intra-amniotic injection of ethacridine combined with mifepristone in induced labor during gestational age of 16-26 weeks. Methods Sixty-eight pregnant women voluntarily requesting termination of pregnancy in the Xinyu People's Hospital were enrolled form February 2019 and February 2022. Patients were divided into observation group and control group by random number table method, 34 cases in each group. The control group were given intra-amniotic injection of ethacridine (100 mg). While the observation group were given oral mifepristone tablets (100 mg Q12 h) for 2 d. The fasting was necessary for at 2 h before and after medication, on the third day, the routine methods were applied, gave intra-amniotic injection of ethacridine (100 mg). And then they were given intra-amniotic injection of ethacridine for induced labor. The interval from medication to regular uterine contraction, interval from regular uterine contraction to fetal delivery, blood loss at 2 h after delivery, hospitalization time and induced labor effect [complete abortion (complete delivery of fetuses, fetal membranes and placenta), incomplete abortion (curettage, residual fetal membranes and placenta), abortion failure (no fetal delivery at 72 h after medication)] in both groups were observed and recorded. The pain degree of induced labor was recorded by Mulleetr method. All patients were followed up for 2 months to compare re-menstruation time and menstrual duration between the two groups. The occurrence of adverse outcomes in both groups was recorded. Results The interval from medication to regular uterine contraction, interval from regular uterine contraction to fetal delivery and blood loss at 2 h after delivery in observation group were significantly lower than those in control group (P<0.05). The complete abortion rate in observation group was significantly higher than that in control group (P<0.05), and curettage was significantly lower than that in control group (P<0.05). There was no significant difference in final success rate of induced labor, re-menstruation time or menstrual duration between the two groups (P>0.05). There was no significant difference in pain degree between the two groups (P>0.05). There were no serious adverse outcomes (tonic uterine contraction, uterine rupture) in either group.There was no statistical difference in the incidence of total adverse outcomes between the two groups (P>0.05). Conclusion The clinical application effect of intra-amniotic injection of ethacridine combined with mifepristone is significant in induced labor during gestational age of 16~26 weeks, which can shorten the time related to induced labor, reduce postpartum blood loss, increase complete abortion rate.

Effects of Traditional Chinese Medicine Nursing Intervention Applied to Patients with Lumbar Disc Herniation

ZHANG Wei

2022, 40(15):  22-24. 

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Objective To explore the effects of traditional Chinese medicine nursing intervention applied to patients with lumbar disc herniation. Methods Forty-two patients with lumbar disc herniation in Wuhan Hospital of Chinese Medicine from February 2020 to February 2021 were selected and randomly divided into control group and research group. Each group included 21 patients.The patients in control group received routine nursing intervention.The research group took traditional Chinese medicine nursing intervention based on the control group. The nursing satisfaction rate, nursing efficiency and negative emotion of patients with lumbar disc herniation in both groups were compared. Results The nursing efficiency of patients with lumbar disc herniation in research group was remarkably higher than control group, the difference was statistically significant(P<0.05). The nursing satisfaction rate of patients in the research group was significantly higher than that in the control group, the difference was statistically significant(P<0.05). Before nursing, the scores of anxiety (SAS) and depression (SDS) in the two groups were similar, and there was no statistically significant difference between the two groups (P>0.05). After nursing,the scores of SAS and SDS in the research group were significantly lower than those in the control group, the difference was statistically significant(P<0.05). Conclusion The efficacy of traditional Chinese medicine nursing intervention in patients with lumbar disc herniation is positive, which could improve the patients' nursing satisfaction and improve patients' emotional state, and worthy of clinical application.