Abstract: Objective To explore the clinical application effect of intra-amniotic injection of ethacridine combined with mifepristone in induced labor during gestational age of 16-26 weeks. Methods Sixty-eight pregnant women voluntarily requesting termination of pregnancy in the Xinyu People's Hospital were enrolled form February 2019 and February 2022. Patients were divided into observation group and control group by random number table method, 34 cases in each group. The control group were given intra-amniotic injection of ethacridine (100 mg). While the observation group were given oral mifepristone tablets (100 mg Q12 h) for 2 d. The fasting was necessary for at 2 h before and after medication, on the third day, the routine methods were applied, gave intra-amniotic injection of ethacridine (100 mg). And then they were given intra-amniotic injection of ethacridine for induced labor. The interval from medication to regular uterine contraction, interval from regular uterine contraction to fetal delivery, blood loss at 2 h after delivery, hospitalization time and induced labor effect [complete abortion (complete delivery of fetuses, fetal membranes and placenta), incomplete abortion (curettage, residual fetal membranes and placenta), abortion failure (no fetal delivery at 72 h after medication)] in both groups were observed and recorded. The pain degree of induced labor was recorded by Mulleetr method. All patients were followed up for 2 months to compare re-menstruation time and menstrual duration between the two groups. The occurrence of adverse outcomes in both groups was recorded. Results The interval from medication to regular uterine contraction, interval from regular uterine contraction to fetal delivery and blood loss at 2 h after delivery in observation group were significantly lower than those in control group (P<0.05). The complete abortion rate in observation group was significantly higher than that in control group (P<0.05), and curettage was significantly lower than that in control group (P<0.05). There was no significant difference in final success rate of induced labor, re-menstruation time or menstrual duration between the two groups (P>0.05). There was no significant difference in pain degree between the two groups (P>0.05). There were no serious adverse outcomes (tonic uterine contraction, uterine rupture) in either group.There was no statistical difference in the incidence of total adverse outcomes between the two groups (P>0.05). Conclusion The clinical application effect of intra-amniotic injection of ethacridine combined with mifepristone is significant in induced labor during gestational age of 16~26 weeks, which can shorten the time related to induced labor, reduce postpartum blood loss, increase complete abortion rate.

Key words: ethacridine, mifepristone, induced labor