Abstract: Objective To analyze the therapeutic effect of topiramate tablets combined with lamotrigine tablets in epilepsy. Methods 66 patients with epilepsy in the neurology department of Qianguorluos Mongolian Autonomous County Hospital from January 2021 to December 2021 were participated in the study, and were randomly divided into two groups with 33 cases in each group. The control group was treated with lamotrigine tablets, and the observation group was treated with topiramate tablets combined with lamotrigine tablets, and the total effective rate, seizure frequency, duration, EEG results, serological indexes, incidence of adverse reactions, and quality of life scores were observed. Results The observation group had a higher total effective rate of treatment, the difference was significant(P<0.05); the frequency of epileptic seizures in the observation group was lower than that in the control group, and the seizures duration was shorter than that in the control group, the difference was significant(P<0.05); the score of quality of life in the observation group was higher than that in the control group, the difference was significant(P<0.05). The epileptiform discharges and the number of involved leads in the observation group were significantly improved, the difference was significant(P<0.05).The levels of GAL and NPY in the observation group were significantly improved, the difference was significant(P<0.05). Conclusion In the treatment of epilepsy, the use of topiramate tablets combined with lamotrigine tablets can improve the total effective rate of treatment, reduce the frequency of epileptic seizures, shorten the duration, and the treatment safety is high, the patient's condition can be effectively controlled, and the quality of life can be significantly improved, clinical value.

Key words: topiramate tablets, lamotrigine tablets, epilepsy, effect