Abstract: Objective To study the effect of ligustrazine hydrochloride injection combined with urecolin on acute cerebral infarction and the levels of angiotensin Ⅱ(Ang -Ⅱ), D-dimer and high-sensitivity C-reactive protein (hs-CRP). Methods A retrospective study of 76 patients with acute cerebral infarction admitted to Shihezi People's Hospitalfrom January 2019 to December 2021 were retrospectively selected and divided into two groups according to the treatment methods, with 38 cases in each group. The control group was given Eurekrine treatment; the observation group was treated with Ligustrazine Hydrochloride Injection on the basis of Eurekrine. The two groups were treated for 14 days, and the effective rates of treatment in the two groups were observed, plasma D-dimer, angiotensin II (Ang-II), serum high-sensitivity C-reactive protein (hs-CRP) levels and cerebral blood Fluid dynamics indicators (posterior cerebral artery blood flow velocity, hematocrit level, middle cerebral artery blood flow velocity, whole blood low shear viscosity, anterior cerebral artery blood flow velocity, and whole blood high shear viscosity). Results The effective rate of the observation group was significantly higher than control group (P<0.05). Before treatment, there was no significant difference in the levels of Ang-Ⅱ, D-dimer and hs-CRP between the two groups (P>0.05). After treatment, the levels of Ang-Ⅱ, D-dimer and hs-CRP in the two groups decreased significantly (P<0.05), and the levels of Ang-Ⅱ, D-dimer and hs CRP in the observation group were significantly lower than those in the control group (P<0.05). Before treatment, there was no significant difference in hematocrit, anterior cerebral artery blood flow velocity, whole blood high shear viscosity, middle cerebral artery blood flow velocity, whole blood low shear viscosity and posterior cerebral artery blood flow velocity between the two groups (P>0.05). After treatment, all indicators in the two groups were significantly improved (P<0.05),andthe indexes in the observation group were significantly better than those in the control group (P<0.05). Conclusion Ligustrazine hydrochloride injection combined with urecolin has a significant effect on acute cerebral infarction, and its mechanism may be related to reducing the levels of Ang -Ⅱ, D-dimer and hs-CRP.

Key words: ligustrazine hydrochloride injection, eureklin, acute cerebral infarction, angiotensin II, D-dimer, high sensitivity C-reactive protein