Table of Content

16 July 2022, Volume 40 Issue 14

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The Effect of Peripheral Blood Cell Paremeters in the Patients with Refractory/Relapsed Acute B-Lymphoblastic Leukemia Treated with CD19 -CAR- T Cells

ZHANG Zhan-Qiang, ZHANG Gai-Ling, SU Yun-Chao, HE Jiu-Jiang, ZHANG Min, YANG Jun-Fang, ZHANG Xian

2022, 40(14):  1-4. 

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Objective To study the effect of peripheral blood cell paremeters in the patients with refractory/relapsed acute B-lymphoblastic leukemia treated with CD19 chimeric antigen receptor T cells (CD19-CAR-T). Methods We retrospectively analyzed the clinical data of patients with refractory/relapsed acute B-lymphoblastic leukemia treated with CD19-CAR-T cells in Beijing Ludaopei hospital from May 2017 to May 2020 . The peripheral blood cell parameters were compared between 46 patients with minimal residual disease (MRD) negative (MRD negative group) and 38 patients with minimal residual disease positive (MRD positive group) after CAR-T cells therapy. Results The mean values of leukocytes, hemoglobin, platelets and neutrophils(LHPN0) in the MRD negative group were significantly higher than those in the MRD positive group on the day of CAR-T cells transfusion, and the differencewas statistically significant (P<0.05). The mean platelet values on the 7th, 14th and 21st day (PLT7, PLT14, PLT21)after CD19-CAR-T cells transfusion were significantly higher in the MRD negative group than those in the MRD positive group, respectively, and the differencewas statistically significant (P<0.05). Conclusion The higher value of LHPN0, PLT7, PLT14, PLT21 may indicate that CD19-CAR-T cell treatment may be effective. The hematopoietic recovery is faster after CD19-CAR-T treatment than after chemotherapy.

Study on Clinical Detection Rate of Patients with Occult Fracture Diagnosed by MRI and CT

SONG Chuan-dong

2022, 40(14):  4-7. 

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Objective To study and compare the diagnostic value of magnetic resonance imaging (MRI) and computed tomography (CT) in occult fracture. Methods The clinical data of 92 patients with occult fractures of bones and joints of limbs in the Second Hospital of Harbin from May 2017 to May 2020 was analyzed. MRI and CT diagnosis were performed respectively, and the results of surgery or arthroscopy were taken as the gold standard, and the clinical diagnosis data were compared. Results Ninety-two patients were suspected to have occult fracture, 76 patients (82.61%) were diagnosed by surgery or arthroscopy; The detection rate of occult fractures in all parts of limbs by MRI was higher than that by CT (P<0.05); The detection rate of bilateral sign, bone destruction, inflatable sign and soft tissue image on MRI was significantly higher than that on CT (P<0.05). Conclusion When MRI and CT diagnose occult fracture, MRI has better clinical detection rate and can clearly show the imaging features of fracture.

Relationship Between Serum Inflammatory Index, Blood Lipid and Blood Glucose and Prognosis of Stable Coronary Heart Disease

YANG Lin, LIANG Xin, LI Quan

2022, 40(14):  8-11. 

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Objective To investigate the relationship between serum inflammatory indexes, blood lipid and blood glucose and prognosis of stable coronary heart disease. Methods One hundred and twenty patients with stable coronary heart disease treated in our hospital from February 2019 to February 2022 were selected as the research object. All patients were divided into groups according to the levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), triglyceride (TG) and fasting blood glucose (FPG).The median level of IL-6 in all patients was 2.1 ng/L, which were divided into <2.1 ng/L group (n= 54) and ≥2.1 ng/L group (n=66). The median level of hs-CRP was 1.3 mg/L, which was divided into <1.3 mg/L group (n=58) and ≥1.3 mg/L group (n=62). According to the level of TG, it was divided into <1.7 mmol/L group (n=45) and >1.7 mmol/L group (n=75), and according to the level of FPG, it was divided into <7.0 mmol/L group (n=52) and >7.0 mmol/L group (n=68). The clinical characteristics and prognosis of patients with different levels of IL-6, hs-CRP, TG and FPG were compared. Cox regression analysis was used to analyze the clinical characteristics and prognosis of IL-6, hs-CRP, TG Correlation between FPG and prognosis of patients with stable coronary heart disease. Results There were statisticalsignificant differences in cardiovascular death, renal insufficiency, myocardial infarction, heart failure, and heart failure readmission in patients with different IL-6 levels (P<0.05). There were statisticalsignificant differences in hypertension, cardiovascular death, renal insufficiency, myocardial infarction, heart failure, and heart failure readmission in patients with different hs-CRP levels (P<0.05). There were statisticalsignificant differences in renal insufficiency and heart failure readmission in patients with different TG levels (P<0.05). There were statisticalsignificant differences among patients with diabetes mellitus, renal insufficiency, and heart failure readmissions among patients with different FPG levels (P<0.05). The results of regression analysis showed that high levels of IL-6, hs-CRP, TG and FPG were independent factors affecting the poor prognosis of stable coronary heart disease (P<0.05).Conclusion IL-6 and hs-CRP are independent risk factors for cardiovascular death, myocardial infarction, heart failure and readmission of heart failure in patients with stable coronary heart disease. IL-6 and hs-CRP may be involved in the pathophysiological process of these events, while TG and FPG levels are mostly independent risk factors for readmission of renal insufficiency and heart failure.

Effect of Compound Sophora Flavescens Injection Combined with Chemotherapy in Patients with Colorectal Cancer

ZHAO Hua, ZHAO Wei-wei, MA Shu-mei

2022, 40(14):  12-15. 

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Objective To analysis of compound Sophora flavescens injection combined with chemotherapy in research object with colorectal cancer. Methods Sixty-four patients with colorectal cancer treated in Binzhou Central Hospital from August 2019 to July 2021 were random grouping ,there was two groups with 32 cases in each group. The research object in the control group were treated with routine chemotherapy, and the patients in the study group were treated with compound Sophora flavescens injection on the basis of routine chemotherapy. Before and after treatment,the clinical efficacy, immune cells [T lymphocyte differentiation Cluster 4⁺ (CD4⁺), differentiation cluster 8⁺ (CD8⁺), CD4⁺ / CD8⁺ and natural killer cells (NK)] and quality of lifequestionnaire (QLQ-C30) scores ,and the rates of bone marrow suppression, gastrointestinal reaction and abnormal liver function were compared. Results The total effective rate of the study group was higher than that of the control group (P<0.05). In the comparison of CD4⁺, CD8⁺, CD4⁺ / CD8⁺ and NK levels before treatment, there was no difference between the two groups (P>0.05); The level of CD4⁺and CD4⁺ / CD8⁺ and NK cells in the study group after treatment, was higher than the control group (P<0.05), and the level of CD8⁺ was lower than that in the control group (P<0.05). There was no difference in QLQ-C30 score between the two groups before treatment (P>0.05); After treatment, the scores of body, social function, emotion, cognition and role of QLQ-C30 were higher than the control group (P<0.05). The incidence of gastrointestinal reaction and bone marrow suppression in the study group was lower than that in the control group (P<0.05); There was no difference in the rate of abnormal liver function between the two groups (P>0.05). Conclusion The application of compound Sophora flavescens injection in patients with colorectal cancer on the basis of routine chemotherapy has significant effect, further improves immune function, alleviates adverse reactions of chemotherapy, and ensures the quality of life. It has clinical application value.

Community Intervention Study on High Risk Groups of Cardiovascular and Cerebrovascular Diseases in Wujiang District, Suzhou

DONG Xiao-ying, SHEN Li-jun, ZHOU Wen-ting, LU Jian-fang, HE Yuan

2022, 40(14):  15-18. 

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Objective To explore the effect of health management platform on high-risk groups of cardiovascular and cerebrovascular diseases, observe and evaluate the quality of life. Methods A questionnaire survey was used to collect 1000 high-risk permanent residents of cardiovascular and cerebrovascular diseases in Zhenze Town, our district from January 2021 to February 2022.There were 500 patients in both groups. The patients in the control group were given health education, guiding medication and urging the improvement of lifestyle during the first questionnaire survey. The intervention group was based on the control group. In addition, the patients in the intervention group continued to be given health education, guiding medication and Supervise and urge the improvement of lifestyle and other interventions once for 6 months, with a total of 6 interventions and guidance. After the intervention and guidance, compare the awareness rate of chronic diseases, medication rate, quality of life score and the incidence of cardio cerebrovascular time between the two groups.Results After treatment, the awareness rate and medication rate of chronic diseases in the intervention group were significantly higher than those in the control group(P<0.05); The quality of life score of the intervention group was lower than that of the control group, and the difference was statistically significant(P<0.05); The incidence of cardiovascular events in the intervention group was lower than that in the control group, and the difference was statistically significant(P<0.05).Conclusion Regular health education and life intervention of health management platform can improve the awareness rate, medication rate and quality of life of high-risk groups of cardiovascular and cerebrovascular diseases, and reduce the occurrence of cerebrovascular events.

Treatment of Diabetic Skin Pruritus Based on“Harmonize Ying and Wei to Dispel Wind” by Professor Wang Xiaoyun

WANG Cong, WANG Xiao-yun, JIA Da-peng

2022, 40(14):  18-20. 

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Diabetes mellitus with skin itching pruritus is the most common complication of diabetes mellitus, mainly manifested by stubborn pruritus, which seriously affects normal work and life and easily causes infection. Modern medicine is based on symptomatic treatment. And there is no better treatment available.Traditional Chinese medicine(TCM) has a long history of diagnosis and treatment of pruritus, and a definite therapeutic effect. Professor Wang Xiaoyun studied ancient medical books and analysed on the pathogenetic characteristics of xiaoke disease in TCM, and concluded that diabetes with pruritus is mainly caused by disharmony between ying and wei, and a bad wind takes the chance to disturb the normal order of normal human body.And the treatment principle of harmonizing ying and wei, and nourishing blood to dispel the wind was adopted. The treatment methods of Guizhi Tang were developed,which had a significant therapeutic effect. This paper summarizes professor Wang Xiaoyun’s analysis of the cause and pathogenesis, clinical manifestations, treatment principles, prescription and treatment experience of diabetes mellituswith skin pruritus based on TCM. The diagnosis and treatment of the disease are analyzedin the form of a medical case example.