The Impact of Novel Thrombotic Markers t-PAIC, PIC, TM, TAT Levels on Adverse Maternal and Infant Outcomes Related to Coagulation Function in Pregnant Women with ITP
YAN Fang, DING Sheng-hua, YUE Rui, HUANG Lu-jie, WANG Mi, ZHANG Xing-hang, LIU Bo-xin
2025, 43(1):
13-17.
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Objective To investigate the application value of new thrombosis markers tissue plasminogen activation inhibitory complex (t-PAIC), plasmin antiplasmin complex (PIC), thrombomodulin (TM) and thrombin-antithrombin complex (TAT) in predicting coagulation-related adverse maternal and infant outcomes in pregnant women with primary immune thrombocytopenia (ITP). Methods A total of 83 women with ITP who were 32+6 to 34+6 weeks pregnant and diagnosed at the Third Hospital of Xi'an from January 2021 to January 2023 were selected. They were divided into the adverse outcome group (Bad End Group, BE group, n=22) and the control group (Control Group, CG group, n=61) based on whether adverse maternal and neonatal events occurred. All subjects were tested for serum t-PAIC, PIC, TM, TAT at 35+6 weeks of gestation using the ELISA method. General baseline data and maternal and neonatal outcome events were collected. The receiver operating characteristic curve (ROC) was used to analyze the potential diagnostic efficacy of serum t-PAIC, PIC, TM, and TAT in predicting the adverse maternal and infant outcomes related to coagulation function in ITP pregnant women. Results The incidence of adverse maternal and infant Outcomes related to coagulation function in 83 women with ITP was 26.51%. The serum levels of t-PAIC, PIC, TM, TAT in the BE group were higher than those in the control group. ROC curve analysis suggested that t-PAIC, PIC, TM, TAT are reliable indicators for predicting adverse maternal and neonatal outcomes of infant outcomes related to coagulation function women with ITP (P<0.05 for all). The cut-off values for each indicator were t-PAIC 9.283 ng/mL, PIC 1.075μg/mL, TM 7.285 TU/mL, TAT 3.737 ng/mL, and the combined diagnostic efficiency of the four indicators was superior to the predictive ability of a single indicator (AUC=0.901(0.823,0.979), P<0.001). Conclusion Serum t-PAIC, PIC, TM, TAT can effectively predict adverse maternal and neonatal outcomes of infant outcomes related to coagulation function in women with ITP. The combined detection can effectively improve the diagnostic accuracy and is expected to become a potential blood biochemical marker for predicting adverse maternal and neonatal outcomes of infant outcomes related to coagulation function in women with ITP.
