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Table of Content

    01 December 2022, Volume 40 Issue 23
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    The Value of LAMP Technology in Pathogen Detection in Patients with Severe Pneumonia
    ZHANG Wei, REN Chun-ping, ZHANG Wen-li
    2022, 40(23):  1-4. 
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    Objective To explore and analysis the values of loop-mediated isothermal amplification (LAMP) technology in pathogen detection in patients with severe pneumonia. Methods From April 2020 to April 2022, 100 cases of patients with severe pneumonia who were treated in Ningxia Hospital of Integrated Traditional Chinese and Western Medicine were selected as the research subjects. All patients were given LAMP technology and traditional sputum culture test. Traditional sputum culture test was used as the gold standard, to explore the clinical values of LAMP detection in the early diagnosis of severe pneumonia patients. Results In the 100 patients, there were 65 cases were diagnosed as single pathogen infection by traditional sputum culture, and 35 cases were combined pathogen infection. In the 100 patients, the average detection time of LAMP technology was (2.10±0.02)h, LAMP technology detected 21 cases of Streptococcus pneumoniae, 11 cases of Staphylococcus aureus, and 18 cases of methicillin-resistant Staphylococcus aureus, 15 cases of Escherichia coli, 14 cases of Pseudomonas aeruginosa, 22 cases of Acinetobacter baumannii, 10 cases of Klebsiella pneumoniae, 9 cases of Stenotrophomonas maltophilia, and 22 other cases. LAMP technology judged 62 cases of single pathogen infection and 38 cases of combined pathogen infection. The sensitivity and specificity of LAMP technology in the diagnosis of pathogen combined infection in patients with severe pneumonia were 100.00% (35/35) and 95.38% (62/65), respectively. Conclusion Severe pneumonia patients are often accompanied by pathogen co-infection. LAMP technology can accurately and fast detect pathogen co-infection in patients with severe pneumonia. It has the advantages of short time and high specificity and has good clinical application value.
    The Clinical Efficacy of Divergent Extracorporeal Shock Wave Therapy Combined with Conventional Physical Agents Therapy in Middle-Aged Patients with Chronic Non-Specific Low Back Pain
    SHI Qi, HU An-di, LUO Zhen-dong
    2022, 40(23):  4-7. 
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    Objective To explore the clinical efficacy of divergent extracorporeal shock wave therapy (ESWT) combined with conventional physical agents therapy in middle-aged patients with chronic non-specific low back pain (CNLBP). Methods The 60 middle-aged CNLBP patients undergoing rehabilitation in Jiangwan Hospital of Shanghai Hongkou District from July 2020 to June 2021 were divided into control group and experimental group by random number table method, with 30 cases in each group. The control group performed conventional physical agents therapy, including interference electric therapy, microwave therapy and ultrasound therapy, and the experimental group added the divergent extracorporeal shock wave therapy with intermoderate energy intensity to the basis of the control group treatment. Before treatment, 4 weeks after treatment and 8 weeks after treatment, visual analogue scale(VAS),Oswestry dysfunction index (ODI), finger face to distance (FFD) were adopted to evaluate the degree of low back pain and lumbar spine function, and observe the safety of the two groups. Results Before treatment, there was no significant difference between the two groups (P>0.05). After 4 weeks and 8 weeks of treatment, VAS, ODI, and FFD were reduced in both groups (P<0.05), and the experimental group values were lower than those in the control group (P<0.05). Both groups of patients had no adverse reactions during the treatment. Conclusion Divergent extracorporeal shock wave therapy combined with conventional physical agents therapy can effectively relieve the pain in middle-aged patients with chronic non-specific low back pain and thus improve their lumbar spine function.
    Effect of Endoscopic OTSC Anastomosis Clip Combined with Epinephrine on Active Bleeding of Peptic Ulcer
    Gasongyongcuo
    2022, 40(23):  7-11. 
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    Objective To investigate the clinical effect of endoscopic OTSC anastomosis clip combined with epinephrine in the treatment of active bleeding of peptic ulcer. Methods A total of 70 patients with active peptic ulcer bleeding who were treated in Yushu People’s Hospital from March 2020 to March 2022 were selected and randomly number table method divided into observation group [(adrenaline+OTSC anastomosis clip+proton pump inhibitor (PPI)] and control group (adrenaline+PPI) 35 cases each. The clinical efficacy, treatment indexes, hemoglobin and hematocrit levels, coagulation function index and adverse reactions were compared between the two groups. Results There was no significant difference in the total effective rate between the two group (P>0.05). Compared with the control group, the disappearance time of hematemesis, black stool, hemostasis, hospital stay and rebleeding rate in the observation group were significantly reduced (P<0.05). There was no significant difference in hematocrit and hemoglobin levels between the two groups before treatment (P>0.05). After treatment, the hematocrit and hemoglobin in the two groups were significantly higher than those before treatment (P<0.05), and the hematocrit and hemoglobin in the observation group were significantly higher than those in the control group (P<0.05). After treatment, compared with the control group, Pt and TT in the observation group decreased significantly (P<0.05), and Fib and PLT increased significantly (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Endoscopic OTSC anastomosis clip combined with epinephrine has significant effect and good safety in the treatment of active bleeding from peptic ulcer. At the same time, it can improve the level of hematocrit and hemoglobin, and improve the coagulation function of patients, which is worthy of clinical application.
    Effects of Semaglutide Combined with Intensive Insulin Pump Therapy on Endocrine Metabolism in Patients with Type 2 Diabetes Mellitus
    LI Yuan-hong, MA Lin-na
    2022, 40(23):  11-14. 
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    Objective To investigate and analysis the effect of semaglutide combined with intensive insulin pump therapy on endocrine metabolism in patients with type 2 diabetes mellitus (T2DM). Methods A total of 60 patients with type 2 diabetes mellitus who were treated in the Endocrinology Department of the Fourth Hospital of Harbin were selected as the research subjects from September 2021 to March 2022, according to the random number table method, the patients were divided into the semaglutide group and the control group, with 30 cases in each group. The control group was given intensive insulin pump therapy, and the semaglutide group was given semaglutide treatment on the basis of the treatment of the control group. Both groups were treated for 3 months, and the endocrine and metabolic changes of the patients were measured and recorded. Results After treatment, the fasting blood glucose and 2 h postprandial blood glucose of the semaglutide group and the control group were significantly lower than those before treatment (P<0.05), and the semaglutide group was also significantly lower than the control group (P<0.05). After treatment, the levels of total cholesterol, low-density lipoprotein cholesterol and triglyceride in the two groups were significantly lower than those before treatment (P<0.05), and high-density lipoprotein cholesterol was higher than that before treatment (P<0.05), the levels of total cholesterol, low-density lipoprotein cholesterol and triglyceride in the semaglutide group were significantly lower than those in the control group (P<0.05), and high-density lipoprotein cholesterol was higher than the control group (P<0.05). After treatment, the glycosylated hemoglobin in the two groups was significantly lower than that before treatment (P<0.05), and the C-peptide was significantly higher than that before treatment (P<0.05), the glycosylated hemoglobin in the semaglutide group was significantly lower than that in the control group (P<0.05), and the C-peptide was significantly higher than that in the control group (P<0.05). The quality of life scores of vitality, mental health, physiological function, social function, emotional function, physiological function, general health, and physical pain in the semaglutide group after treatment were significantly higher than those in the control group (P<0.05). Conclusion The application of semaglutide combined with intensive insulin pump therapy in patients with type 2 diabetes mellitus can promote the reduction of fasting blood glucose, 2 h postprandial blood glucose, and glycosylated hemoglobin levels, increase the level of C-peptide in patients, and also improve the level of blood lipids in patients and quality of life of patients.
    Effects of Modified Buyang Huanwu Decoction on Cerebral Blood Flow and Vascular Endothelial Function in Elderly Patients with Posterior Circulation Ischemic Isolated Vertigo
    LIU Shuai
    2022, 40(23):  15-18. 
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    Objective To explore and analysis the effects of Modified Buyang Huanwu Tang on cerebral blood flow and vascular endothelial function in elderly patients with posterior circulation ischemic isolated vertigo. Methods From February 2020 to February 2022, 70 elderly patients with posterior circulation ischemic isolated vertigo who were diagnosed and treated in Xuzhou Hospital of Traditional Chinese Medicine, Jiangsu Province, were selected as the research subjects, and the patients were divided into the traditional Chinese medicine group and the control group according to the principle of 1:1 by drawing lots on envelopes, with 35 cases in each group. The control group was given conventional western medicine, and the traditional Chinese medicine group was given Modified Buyang Huanwu Tang on the basis of the control group. Observe the curative effect of the two groups of patients, and compare the neurological function, daily living ability, cerebral blood flow (whole blood viscosity, fibrinogen) and serum neuropeptide Y (NPY) before and after treatment. Results The total effective rates of the traditional Chinese medicine group were significantly higher than the control group (P<0.05). After treatment, the NIHSS scores of the two groups were significantly lower than those before treatment (P<0.05), and the ADL scores were significantly higher than those before treatment (P<0.05), the NIHSS scores of the traditional Chinese medicine group were significantly lower than that in the control group, and the ADL scores were significantly higher than that in the control group. After treatment, the whole blood viscosity and fibrinogen in the two groups were significantly lower than those before treatment (P<0.05), and the traditional Chinese medicine group was also significantly lower than the control group (P<0.05). The NPY content of the two groups after treatment were significantly higher than that before treatment (P<0.05), and the traditional Chinese medicine group was also significantly higher than the control group after treatment (P<0.05). Conclusion The application of Modified Buyang Huanwu Tang in elderly patients with posterior circulation ischemic isolated vertigo can promote the improvement of cerebral blood flow, and can also improve the vascular endothelial function of patients, improve the therapeutic effect of patients, improve the state of nerve defects, and improve the quality of life, it can improve the patient’s ability of daily living.
    The ApplicationValue of Personalized "Shorten Warm Ischemia Time" Technique In Laparoscopic Nephrectomy in Patients with T1 Renal Tumors
    TANG Zhong-shan
    2022, 40(23):  18-21. 
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    Objective To investigate the application value of personalized “shortening warm ischemia time” technique in laparoscopic nephrectomy for patients with T1 renal tumors. Methods A total of 126 patients with T1 stage renal tumor who were admitted to Yellow River Central Hospital from March 2019 to March 2021 were selected for retrospective analysis, and divided into conventional group (n=62) and individualized technique group (n=64), perioperative indicators, renal function levels, complications and recurrence were compared between the two groups. Results There was no significant difference in intraoperative blood loss, operation time, negative margins rate and hospital stay between the two groups (P>0.05); Because subgroups 1, 2, and 3 in the individualized technology group did not block the renal artery, there was no warm ischemia time, and the warm ischemia time in subgroups 4 and 5 was shorter than that in the conventional group (P<0.05); There was no statistical significance difference in the levels of blood creatinine (Scr) and glomerular filtration rate (eGFR) in the preoperative group (P>0.05). After treatment, the Scr and eGFR in the conventional group were decreased compared with those before treatment (P<0.05), and there was no statistically significant difference change in the personalized technology group (P>0.05), the levels of Scr and eGFR in the individualized technique group were higher than those in the conventional group (P<0.05); the complication rate in the individualized technique group was lower than the conventional group (P<0.05). Comparison of recurrence rates between the two groups, the difference was not statistically significant (P>0.05). Conclusion The improved laparoscopic nephrectomy based on the personalized “shortening warm ischemia time” technique is beneficial to the recovery of patients with T1 renal tumors, and maximizes the protection of renal function, with fewer complications and high safety.
    Clinical Study on the Efficacy and Safety of Shenling Baizhu Powder in the Prevention and Treatment of Delayed Diarrhea Caused by Irinotecan
    LIU Jia-yun, WU Guan-nan, HUAN Xiang-kun, LIU Fu-kun, LIU Shen-lin
    2022, 40(23):  22-25. 
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    Objective To investigate the efficacy and safety of Shenling Baizhu powder in the prevention and treatment of delayed diarrhea caused by irinotecan(CPT-11). Methods A total of 60 patients with advanced colorectal cancer in the Department of Gastrointestinal Oncology, Jiangsu Provincial Hospital of Traditional Chinese Medicine between January 2019 and August 2021 were retrospectively selected and divided into an observation group (n=30) and a control group (n=30) according to whether they took traditional Chinese medicine or not. The treatment group started to take Shenling Baizhu Powder orally on the 1st day before chemotherapy, 2 times a day, 1 bag (100 mL) at a time, for 2 consecutive cycles of chemotherapy; the control group was treated with chemotherapy alone. The grade of delayed diarrhea caused by CPT-11, physical condition evaluation (KPS score), immune status (the levels of CD4+, CD8+ and CD3+) and adverse reactions were compared between the two groups. Results Compared with the delayed diarrhea incidence rate of 46.67% (14/30) in the control group, the delayed diarrhea incidence rate of 26.67% (8/30) in the observation group was slightly reduced with no difference (P>0.05). The improvement rate of KPS score of 53.33% (16/30) in the observation group was slightly higher than 40.00% (12/30) in the control group, and there was no difference after comparison (P>0.05). After treatment, the levels of CD4+, CD8+ and CD3+ in the two groups were significantly higher than those before treatment (P<0.05), and the levels of CD4+, CD8+ and CD3+ in the observation group were significantly higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions (myelosuppression, liver and kidney function damage, nausea and vomiting, oral ulcers and loss of appetite) between the two groups (P>0.05). Conclusion Shenling Baizhu Powder can prevent and treat delayed diarrhea caused by irinotecan, it can slightly reduce the incidence of diarrhea, improve physical and immune status, and improve the curative effect with good safety.
    Advances in Clinical Research on the Treatment of Rheumatoid Arthritis by External Treatment of Traditional Chinese Medicine
    YANG Wan-lin, YAO Peng-yu, CHEN Chao
    2022, 40(23):  61-66. 
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    Rheumatoid arthritis is a kind of the Chronic, multiple and autoimmune diseases, RA belongs to the category of traditional Chinese medicine “Bi Zheng”, through the CNKI, WanFang, VIP and others database, such as external treatment of TCM treatment of RA in recent years the high quality of literature, statistics, conclude and analysis from disease knowledge, etiology and pathogenesis of TCM for RA disease theory. The TCM external treatment include TCM topical therapy, TCM ion introduction, Fumigation and washing therapy, Moxibustion therapy, Medicine wine hammer percussion, Acupuncture therapy, Wax therapy and other aspects of the treatment of TCM treatment of RA clinical research, the treatment of rheumatoid arthritis is dedicated to provide you with more clinical thinking and reference, in order to play the TCM in the treatment of RA of a greater advantage.
    Efficacy Analysis of 12 F Pigtail Catheter in Thoracoscopic Lung Cancer Resection
    HE Xiao-yong, WANG Dao-meng, QIAN Bin
    2022, 40(23):  157-160. 
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    Objective To preliminarily explore the clinical effect of 12 F pigtail catheter in patients undergoing thoracoscopic lung cancer resection. Methods A retrospective analysis of 225 cases of patients with lung cancer who underwent thoracoscopy from January 2020 to December 2021 in Jiangdu People’s Hospital of Yangzhou City, 12 F pigtail tube was used for the thin chest tube in the thin tube group, and 28 F and 32 F silicone drainage tubes were used for the thick tube group. The postoperative recovery and the occurrence of complications in the two groups were observed, and the expression levels of serum interleukin-32 (IL-32) were detected at 1, 3and 7 d after operation. Results There was no significant difference in postoperative catheterization time between two groups (P>0.05). The days using oral analgesic and postoperative hospital stay in the thin drainage tube group were significantly shorter than those in the thick drainage tube group, the difference was statistically significant (P<0.05). Additionally, there were no significant differences were found in the time of drainage tube placement, postoperative atelectasis, subcutaneous emphysema, tube blockage, fever, lung infection and other complications compared between the two groups, the difference was not statistically significant (P>0.05). The serum IL-32 expression levels in the thin tube group were significantly lower than those in the thick tube group at 1, 3 and 7 d after operation, the difference was statistically significant (P<0.05). Conclusion On the premise of ensuring the drainage effect, the 12 F pigtail catheter can relieve postoperative pain and shorten the hospitalization time of patients undergoing thoracoscopic lung cancer resection, without increasing the related risks, and can effectively inhibit the expression of serum IL-32.
    Effect of Airway Clearance Technique combined with Tanreqing Injection on Patients with Stroke associated Pneumonia undergoing Tracheotomy
    LUO Hui, WU Ying, TONG Lin, TAN Hua-qiao, CHEN Cheng
    2022, 40(23):  161-164. 
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    Objective To investigate the effect of airway clearance technique combined with Tanreqing Injection on patients with stroke associated pneumonia undergoing tracheotomy. Methods A total of 80 patients with stroke-related pneumonia who underwent tracheotomy in Liqun Hospital of Putuo District, Shanghai and Tongji Hospital Affiliated to Tongji University, Shanghai from February 2019 to February 2022 were selected and randomly divided into observation group (gas Dao clearing technique + Tanreqing injection) and control group (airway clearing technique) with 40 cases each. The clinical efficacy, National Institutes of Health Stroke Scale (NIHSS) score and Clinical Pulmonary Infection Score (CPIS), procalcitonin (PCT) and white blood cell count (WBC) levels before and after treatment, and extubation time, extubation success rate and antibiotic use time were compared between the two groups. Results The total effective rate of the observation group, was significantly higher than the control group (P<0.05). The NIHSS score and CPIS score in the observation group were significantly lower than those in the control group (P<0.05). After treatment, PCT and WBC levels in both groups were significantly lower than those before treatment (P<0.05). The levels of PCT and WBC in the observation group were significantly lower than those in the control group (P<0.05). The extubation time, extubation success rate and antibiotic use time in the observation group were significantly shorter than those in the control group (P<0.05). Conclusion Airway clearance technique combined with Tanreqing injection is effective in the treatment of patients with stroke associated pneumonia after tracheotomy. It can effectively improve their neurological function, control lung infection, reduce the level of serum inflammatory factors, shorten the time of extubation, and improve the success rate of extubation.
    Effects of Massage combined with Xingpi Yanger Granules on Intestinal Microecology and Immune Function in Children with Chronic Diarrhea
    FAN Xia
    2022, 40(23):  164-167. 
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    Objective To explore and analysis the effects of massage combined with Xinpi Yanger Granules on intestinal microecology and immune function in children with chronic diarrhea. Methods From January 2019 to October 2021, a total of 94 children with chronic diarrhea who were diagnosed and treated in the Zhangjiagang Maternal and Child Health Center were selected as the research subjects. According to the random number table method, they were divided into the experimental group and the control group with 47 children in each group. The control group were treated with Xinpi Yanger Granules, and the test group were treated with massage based on the treatment of the control group, they were treated for 2 weeks, the changes in intestinal microecology and immune function of the children, the changes in the patient’s condition and the overall effect of treatment were detected. Results The total effective rates of the test group were significantly higher than that of the control group (P<0.05). There were no serious adverse reactions occurred. The abdominal pain and stool character scores of the test group and the control group after treatment were significantly lower than those before treatment (P<0.05), and the abdominal pain and stool character scores of the test group after treatment were also significantly lower than those of the control group (P<0.05). The relative number of Escherichia coli after treatment in the test group and the control group were lower than that before treatment (P<0.05), and the relative number of Lactobacillus were higher than that before treatment (P<0.05),the experimental group also changed more significantly than the control group, and the difference was statistically significant (P<0.05). The serum IgG and IgA levels in the test group and the control group after treatment were significantly higher than those before treatment (P<0.05), and the test group were also significantly higher than the control group (P<0.05). Conclusion The application of Tuina combined with Xingpi Yanger Granules in children with chronic diarrhea can improve the clinical symptoms, improve the therapeutic effect, and has good safety, it can also improve the intestinal microecological status and improve the immune function of children.
    The Values of High-frequency Ultrasonography in Differential Diagnosis of Partial and Full-thickness Small Tear Rotator Cuff Injuries
    XIE Ze-wei
    2022, 40(23):  168-171. 
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    Objective To explore and analysis the values of high-frequency ultrasound in the differential diagnosis of partial and full-thickness small tear rotator cuff injuries. Methods From October 2020 to January 2022, 70 cases of patients with partial and full-thickness small tear rotator cuff injuries who were diagnosed and treated in The Sixth Division Hospital of Xinjiang Production and Construction Corps were selected as the research subjects. All patients were given arthroscopy and high-frequency ultrasonography, the images characteristics were recorded and determined the diagnostic values. Results In the 70 patients, there were 50 cases of partial small tear rotator cuff injury (partial group) and 20 cases of full-thickness small tear rotator cuff injury (full-thickness group) were diagnosed by arthroscopy. There was no significant difference compared between the two groups in terms of injury site, time from injury to ultrasound, body mass index, gender, and age (P>0.05). In the full-thickness group, the proportions of ultrasonographic features such as hydrocele, rotator cuff calcification, tendon degeneration, and tendon thickening were significantly higher than the partial group(P<0.05). The myofascial thickness, infraspinatus tendon thickness and supraspinatus tendon thickness in the full-thickness group were significantly higher than those in the full-thickness group, the difference is statistically significant (P<0.05). In the 70 patients, there were 19 cases were diagnosed as full-thickness small tear rotator cuff injury by high frequency ultrasound, and 51 cases were partial small tear type rotator cuff injury. The sensitivity and specificity of high-frequency ultrasonography in the differential diagnosis of partial and full-thickness small tear rotator cuff injuries were 90.0% (18/20) and 98.0% (49/50), respectively, Kappa value is 0.893. The ROC curve showed that the area under the curve of high-frequency ultrasound for differential diagnosis of partial and full-thickness small tear rotator cuff injuries was 0.914. Conclusion Full-thickness small tear rotator cuff injuries are mainly manifested by hydrocele, rotator cuff calcification, tendon degeneration, and tendon thickening on ultrasound, especially the thickness of myofascial, infraspinatus and supraspinatus tendons. In addition, high-frequency ultrasonography has high sensitivity and specificity in the differential diagnosis of partial and full-thickness small tear rotator cuff injuries, with a high degree of concordance with the diagnosis of arthroscopy.