Abstract: Objective To explore and analysis the effects of massage combined with Xinpi Yanger Granules on intestinal microecology and immune function in children with chronic diarrhea. Methods From January 2019 to October 2021, a total of 94 children with chronic diarrhea who were diagnosed and treated in the Zhangjiagang Maternal and Child Health Center were selected as the research subjects. According to the random number table method, they were divided into the experimental group and the control group with 47 children in each group. The control group were treated with Xinpi Yanger Granules, and the test group were treated with massage based on the treatment of the control group, they were treated for 2 weeks, the changes in intestinal microecology and immune function of the children, the changes in the patient’s condition and the overall effect of treatment were detected. Results The total effective rates of the test group were significantly higher than that of the control group (P<0.05). There were no serious adverse reactions occurred. The abdominal pain and stool character scores of the test group and the control group after treatment were significantly lower than those before treatment (P<0.05), and the abdominal pain and stool character scores of the test group after treatment were also significantly lower than those of the control group (P<0.05). The relative number of Escherichia coli after treatment in the test group and the control group were lower than that before treatment (P<0.05), and the relative number of Lactobacillus were higher than that before treatment (P<0.05),the experimental group also changed more significantly than the control group, and the difference was statistically significant (P<0.05). The serum IgG and IgA levels in the test group and the control group after treatment were significantly higher than those before treatment (P<0.05), and the test group were also significantly higher than the control group (P<0.05). Conclusion The application of Tuina combined with Xingpi Yanger Granules in children with chronic diarrhea can improve the clinical symptoms, improve the therapeutic effect, and has good safety, it can also improve the intestinal microecological status and improve the immune function of children.

Key words: massage, Xingpi Yanger granules, chronic diarrhea, intestinal microecology, immune function, abdominal pain