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Analysis of the Application of Insect Drugs in Rheumatoid Arthritis
MENG Yuan-hang, LIANG Jia, YANG Wei-bin
ZHONGHUA YANGSHENG BAOJIAN
2025, 43 (8):
1-6.
Objective To investigate the application of insect drugs in the treatment of rheumatoid arthritis (RA) by famous old Chinese medicine, and to provide some reference for the clinical application of insect drugs. Methods In this study, the modern medical records of traditional Chinese medicine practitioners using insect drugs to treat RA were collected, a structured medical records database was built, and the frequency statistics, association analysis and cluster analysis of prescriptions were carried out using the cloud platform of ancient and modern medical records to present the application rules of insect drugs in RA in the form of data. Results There were 115 statistical data of symptoms and 32 types of symptoms, among which the most frequent were the syndrome of blood stasis blocking collaterals and the syndrome of damp-heat blocking. There were 188 prescriptions of insect-containing drugs, involving 213 kinds of traditional Chinese medicine, of which 28 kinds were insect-containing drugs, and high-frequency insect-containing drugs included pangolin, scorpion, and Wuzao snake. From the perspective of prescription composition, the proportion of insect drugs in prescriptions is not high. From the point of view of dosage, the dosage of insect drugs in the prescription is small. From the point of view of TCM flavor, the use of the four qi middle-temperature drugs and flat drugs is the most frequent, and the use of the five tastes of Gan, Xin and bitter is the most frequent, mainly under the liver and spleen channels. A total of 21 insect-containing drug pairs were obtained by association rules, including 6 pairs with frequency ≥30 times, and 1 group of multi-flavor drug combinations and 3 groups of drug pairs were obtained by cluster analysis. Conclusion Pangolin, scorpion, Wuzao snake, Earthdragon, centipede and other insect drugs are commonly used in the prescription of traditional Chinese medicine in the treatment of RA, and most of them are used in combination with the drugs for toning deficiency, dispelling wind and removing dampness, promoting blood circulation and removing blood stasis, among which the scorpion and Astragalus pair are used most frequently.
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