Abstract: Objective To explore the diagnostic efficacy of brain natriuretic peptide (BNP) combined with troponin (cTnT) in unstable angina pectoris with chronic heart failure in coronary heart disease and the predictive value of adverse cardiovascular events after interventional surgery. Methods Select Tianshui first people's hospital from May 2020 to May 2023 admitted patients: 85 cases of coronary heart disease unstable angina with chronic heart failure as chronic heart failure group, 85 cases of pure coronary heart disease unstable angina without complicated chronic heart failure group as a chronic heart failure, 85 cases of healthy volunteers as a control group. Compare the expression levels of BNP and cTnT in three groups of patients, and establish a receiver characteristic (ROC) working curve to analyze the diagnostic efficacy of BNP combined with cTnT in unstable angina pectoris with chronic heart failure. Subsequently, 85 patients with unstable angina pectoris complicated by chronic heart failure who underwent PCI were divided into two groups: non MACE group (n=64) and MACE group (n=21). The clinical characteristics of the two groups of patients were compared, and the predictive value of BNP and cTnT for adverse cardiovascular events after percutaneous coronary intervention in unstable angina pectoris complicated by chronic heart failure was analyzed. Results There was a significant difference in the levels of BNP and cTnT among the three groups of subjects. The levels of BNP and cTnT in the chronic heart failure group were significantly higher than those in the non chronic heart failure group and the control group (P<0.05); The combination of BNP and cTnT is superior to a single test in the diagnosis of unstable angina pectoris with chronic heart failure in coronary heart disease (P<0.05); There was no significant difference in gender, BMI, comorbidities, drinking history, and smoking history between the non MACE group and the MACE group (P>0.05). There was a significant difference in age, cardiac function grading, left ventricular ejection fraction, TIMI score, BNP, and cTnT expression levels between the two groups (P<0.05); The results of logistic regression analysis showed that BNP and cTnT were independent risk factors for adverse cardiovascular events after intervention in unstable angina pectoris with chronic heart failure (P<0.05). Conclusion BNP combined with cTnT can improve the diagnostic efficacy of unstable angina pectoris with chronic heart failure, and BNP and cTnT are independent risk factors for the main cardiac blood events after interventional surgery for unstable angina pectoris with chronic heart failure. It is suggested that in clinical practice, patients with unstable angina pectoris and chronic heart failure complicated by elevated BNP and cTnT should take timely measures to prevent cardiovascular adverse events.

Key words: brain natriuretic peptide, troponin, coronary heart disease, unstable angina pectoris, chronic heart failure, adverse cardiovascular events