Abstract: Objective To explore and analysis the correlation between cerebrospinal fluid lysophosphatidic acid (LPA) level and neurological deficit in patients with cerebral infarction (CI). Methods From March 2020 to November 2022,67 patients with cerebral infarction treated in Changping District Hospital of Integrated Traditional Chinese and Western Medicine in Beijing were selected as the study objects. All patients were scored with the National Institute of Health stroke scale (NIHSS) at admission, and the level of lysophosphatidic acid in cerebrospinal fluid was detected and analyzed. Results In the 67 patients, the average NIHSS score for neurological deficits were (18.32±2.15) points, with 17 cases (severe group) scoring above 21 points. There were no significant difference in gender, body mass index, education level, and comorbidities compared between the severe group and the non severe group (P>0.05). There were significant difference in age, onset to hospital admission time between the two groups (P<0.05). There were no significant difference in blood glucose, homocysteine, total cholesterol, and triglyceride levels between the two groups (P>0.05), while the low-density lipoprotein cholesterol levels in the severe group were higher than those in the non severe group (P<0.05). The level of lysophosphatidic acid in cerebrospinal fluid of severe group were significantly higher than that of non severe group (P<0.05). Pearson analysis showed that NIHSS score were positively correlated with age, time from onset to admission, and cerebrospinal fluid lysophosphatidic acid level (P<0.05). Logistic regression analysis showed that age, the time from onset to admission, and the level of lysophosphatidic acid in cerebrospinal fluid were the important factors influencing NIHSS scores in patients with cerebral infarction (P<0.05). Conclusion The neurological deficit status of patients with cerebral infarction is relatively serious. The worse the neurological deficit status of patients with cerebral infarction, the higher the level of lysophosphatidic acid in cerebrospinal fluid. The level of lysophosphatidic acid in cerebrospinal fluid of patients with cerebral infarction is related to the neurological deficit status.

Key words: cerebral infarction, neurological dysfunction status, cerebrospinal fluid, lysophosphatidic acid, correlation, multi factor analysis, low density lipoprotein cholesterol