Abstract: Objective To investigate the correlation between prostate specific antigen (PSA),prostate health index (PHI) and clinicopathological features of prostate cancer. Methods A total of 80 patients with prostate cancer diagnosed by biopsy pathology in People's Hospital of Shizhong District, Leshan City from August 2020 to August 2023 were selected as the research object and divided into malignant group, and another 80 patients diagnosed with benign prostatic hyperplasia through biopsy pathology in our hospital during the same period were selected as the benign group. The tumor tissues of the two groups were detected by immunohistochemistry, the expression of prostate specific antigen (PSA) was detected, and the positive rate was compared. The prostate health index (PHI) was calculated, and the phi level was compared. Then the positive rate of PSA and phi level in patients with prostate cancer with different clinicopathological characteristics were analyzed, and the relationship between PSA, phi and clinicopathological characteristics of prostate cancer was analyzed by logistic regression analysis. Results there were significant differences in the expression levels of PSA and phi among the two groups. The positive rate of PSA and the expression level of pHi in the malignant group were significantly higher than those in the benign group (P<0.05); In 80 patients with prostate cancer, there was no significant difference in pHi level between different ages and T stages, and there was no significant difference in PSA positive rate between different ages (P>0.05). There was significant difference in pHi level between patients with different lymph node metastasis, distant metastasis, Gleason score and risk classification, and there was no significant difference in PSA positive rate between patients with different T stages, lymph node metastasis, distant metastasis, Gleason score and risk classification (P<0.05); Multivariate logistic analysis showed that T stage, lymph node metastasis, distant metastasis and Gleason score were risk factors for PSA positive expression （95%CI：1.259~2.457、1.364~3.475、1.176~4.010、1.036~2.745;P=0.030、0.023、0.016、0.005）, as shown in Table 3. Lymph node metastasis, distant metastasis, Gleason score and risk classification were the risk factors for the increase of phi level （95%CI：1.362~3.783、0.826~2.926、1.221~3.525、0.315~1.425;P=0.042、0.031、0.026、0.011）. Conclusion The PSA positive rate and PHI expression level of prostate cancer patients are significantly increased, and T stage, lymph node metastasis, distant metastasis, and Gleason score are risk factors for PSA positive expression. Lymph node metastasis, distant metastasis, Gleason score, and risk grade are risk factors for increased PHI level.

Key words: prostate specific antigen, prostate health index, prostate cancer, clinicopathological features, relativity