Abstract: Sort out the articles related to "deteriorated case" and "preventing from improper treatment" to explore their theoretical origins and connotations, which will affect the treatment of modern diseases.There are different opinions on the concept of "deteriorated case", such as wrong medication leads to disease,there are too many diseases in the Taiyang and Shaoyang,and there is no disease name available, so it is called "deteriorated case" and so on. However, the research and analysis of the relevant literature of "preventing from improper treatment" is insufficient and the records are scattered. Through the study of traditional Chinese medicine literature and summarizing the famous docters of all generations, it is considered that "deteriorated case" is the abnormal change of the primary disease due to loss of treatment and wrong treatment,and the syndrome is complex.The disease and syndrome without the clinical characteristics of the six meridians is the original meaning. "Preventing from improper treatment" is further developed with the general principles of treatment. Further confirmed that"deteriorated case" and "preventing from improper treatment" are the names and measures of disease and syndrome,and abundantly develop the concept of "prevention of disease". Studying the concept and development of "deteriorated case" and "preventing from improper treatment" and giving examples of the pathogenesis and treatment of clinical chronic urticaria and sleep disorders, promote the development of basic research and clinical standard treatment of Traditional Chinese Medicine.

Key words: deteriorated case, preventing from improper treatment, Zhang Zhong-jing, basic theory of chinese medicine, clinical treatment