Abstract: Objective To study the clinical value of serum carcinoembryonic antigen (CEA), carbohydrate antigen 125(CA125) and carbohydrate antigen 153(CA153) in the diagnosis of lung cancer. Methods From March 2018 to March 2023, 96 patients with highly suspected lung cancer in Jiangyin Fifth People's Hospital were taken as the research object. Serum CEA, CA125 and CA153 levels of all patients were measured at the time of admission,and the consistency between the diagnosis results of CEA, CA125 and CA153 for lung cancer and the gold standard was analyzed with pathological results as the gold standard. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of CEA, CA125 and CA153 in the diagnosis of lung cancer were calculated, and the diagnostic efficacy of CEA,CA125 and CA153 in the diagnosis of lung cancer was analyzed by using the receiver's working curve (ROC). Results Among 98 highly suspected lung adenocarcinoma patients, 80 were positive and 18 were negative. The consistency between the combined detection of lung adenocarcinoma and the gold standard is higher than that of CEA, CA125, and CA153 alone. The sensitivity,accuracy and negative predictive value of combined detection in the diagnosis of lung cancer were significantly higher than those of CEA, CA125 and CA153 alone (P<0.05), while the specificity and positive predictive value were not significantly different from those of CEA, CA125 and CA153 alone (P>0.05). ROC curve shows that the combined detection has higher accuracy for lung cancer than CEA, CA125 and CA153 alone. Conclusion CEA, CA125 and CA153 have good diagnostic value for lung cancer, and their combined use can effectively improve the diagnostic efficiency and have high application value.

Key words: CEA, CA125, CA153, joint detection, lung cancer