Abstract: Objective To explore and analysis the clinical effects of Radix Pseudostellariae Formula Granules+Hydroxymetazoline Hydrochloride Spray in the treatment of children's Sinusitis. Methods A total of 80 cases of children with Sinusitis who were treated in n Bijie Traditional Chinese Medicine Hospital from September 2022 to June 2023 were selected as the study subjects. Accorded to the principle of 1:1 random envelope drawing, 80 children were divided into the Pseudostellaria group of 40 cases and the control group of 40 cases. Both groups of children were received endoscopic surgery. The control group were treated with hydroxymethylazoline hydrochloride spray, and the Pseudostellaria group were treated with Pseudostellaria formula granules on the basis of the control group. Both groups were observed for 4 weeks, and were to determine the treatment effects of the two groups of children. Results After 4 weeks of treatment, the total effective rates of the Pseudostellaria group were 97.50%, while the control group were 85.00%. The Pseudostellaria group were significantly higher than the control group (P<0.05). After 4 weeks of treatment, the pain VAS scores of the Pseudostellaria group and the control group were significantly lower than before treatment (P<0.05), and the pain VAS scores of the Pseudostellaria group after 4 weeks of treatment were also lower than the control group (P<0.05). After 4 weeks of treatment, the serum Interleukin 2 and Interleukin 6 levels in the Pseudostellaria group and the control group were significantly lower than those before treatment (P<0.05), and the serum Interleukin 2 and Interleukin 6 levels in the Pseudostellaria group after 4 weeks of treatment were also significantly lower than those in the control group (P<0.05). The incidence of adverse reactions such as epistaxis, nasal dryness, Sleep disorder and dizziness during the 4-week treatment period in the Pseudostellaria group were 5.00%, while that in the control group were 22.50%. The incidence of adverse reactions in the Pseudostellaria group were significantly lower than that in the control group (P<0.05). Conclusion Pseudostellaria formula granule+hydroxymethylazoline hydrochloride spray can alleviate clinical symptoms, improve the overall therapeutic effect of children with Sinusitis, inhibit the expression of serum Interleukin 2 and Interleukin 6, and reduce the incidence of adverse reactions.

Key words: pseudostellaria formula granule, hydroxymetazoline hydrochloride spray, children, sinusitis, interleukin 2, adverse reactions