Abstract: Objective ToMethodsexplore and analysis the correlation between humoral immune function and dehydration acidosis in children with rotavirus group A infectious diarrhea. Methods From July 2021 to December 2022, 80 cases of children with group A rotavirus infectious diarrhea diagnosed and treated in the 924 Hospital of the Joint Service Support Force of the People's Liberation Army of China were selected as the rotavirus group, and the other 80 cases of children with non-rotavirus infectious diarrhea diagnosed and treated in our hospital were selected as the control group. After admission, all children were judged the occurrence of dehydrated acidosis, and their humoral immune function were tested and correlation analysis were performed. Results The incidence rates of dehydration acidosis in rotavirus group were 13.75%, and that in control group were 2.50%, the incidence rates of dehydration acidosis in rotavirus group were significantly higher than that in control group (P<0.05). The contents of serum IgA, IgM and IgG in rotavirus group were significantly lower than those in control group (P<0.05). In the rotavirus group, Spearman analysis showed that there were negative correlation between dehydrated acidosis and serum IgA, IgM and IgG levels (P<0.05). Multiple dichotomy logistic regression analysis showed that the contents of serum IgA, IgM and IgG were important risk factors for dehydration acidosis in children with rotavirus group A infectious diarrhea (P<0.05). Conclusion Children with group A rotavirus infectious diarrhea are often accompanied by dehydration acidosis, and humoral immune function will also decline. There is a correlation between humoral immune function and dehydration acidosis in children with group A rotavirus infectious diarrhea.

Key words: group A rotavirus, infectious diarrhea, dehydration acidosis, humoral immune function, relevance, multi-factor analysis