Abstract: Objective To explore and analysis the application of genome sequencing (The mNGS technology guides the clinical effects of bronchiectasis. Methods From August 2019 to November 2022, 100 patients with bronchiectasis treated in the Fourth People's Hospital of Nanhai District, Foshan City, Guangdong Province were selected as the study subjects, 50 patients in mNGS group and 50 in control group according to random 1:1 numerical table. The control group were given bronchoscopy and alveolar lavage treatment. The mNGS group were given genome sequencing analysis and guided clinical treatment on the basis of the treatment of the control group. The treatment observation time of the two groups were 1 month, and the efficacy, changes in blood gas indicators, improvement time of clinical symptoms, adverse reactions and Changes in lung functionof the two groups were analyzed. Results The total effective rates of the mNGS group after 1 month of treatment were significantly higher than the control group (P<0.05). The arterial oxygen partial pressure and blood oxygen saturation of the two groups after 1 month of treatment were significantly higher than those before treatment (P<0.05), and the mNGS group were also significantly higher than the control group (P<0.05). The disappearance time of lung rale, cough and sputum, and the time of body temperature returning to normal in the mNGS group were significantly reduced compared with the control group (P<0.05). The incidence of adverse reactions such as headache, rash, insomnia and gastrointestinal discomfort after treatment in the mNGS group were significantly lower than that in the control group (P<0.05). After 1 month of treatment, forced expiratory volume (FEV₁) and forced vital capacity (FVC) of 1s in two groups were significantly increased compared with before treatment (P<0.05), and mNGS group was also significantly increased compared with control group (P<0.05). Conclusion Using mNGS technology to guide the clinical treatment of bronchiectasis can reduce the time for the disappearance of lung rale, cough and sputum, and the time for the temperature to return to normal, improve the treatment effect of patients, improve the arterial oxygen partial pressure and blood oxygen saturation of patients, reduce the incidence of adverse reactions, and also improve the lung function of patients.

Key words: genome sequencing technology, bronchiectasis, lung rale, arterial oxygen partial pressure, blood oxygen saturation, pulmonary function