Abstract: Objective To investigate the predictive value of aquaporin 1 (AQP1) and interleukin 37 (IL-37) in the second trimester of pregnancy on the occurrence of preeclampsia in high-risk pregnant women. Methods The 70 middle-pregnancy patients with high risk of predicting preeclampsia in early pregnancy admitted to Lianyungang First People's Hospital from January 2020 to December 2020 were selected as the study subjects. Among them, 22 pregnant women with preeclampsia were divided into the pre eclampsia group. Among them, 48 pregnant women without preeclampsia and with normal blood pressure were divided into the non preeclampsia group. In addition, 30 healthy non high risk pregnant women who came to our hospital for physical examination at the same time were selected as the control group to compare the AQP1 The expression level of IL-37 and the predictive value of AQP1 and IL-37 on the occurrence of preeclampsia in high-risk pregnant women were analyzed by using the ROC curve. All parturients were followed up and recorded postpartum neonatal status in 70 pregnant women with high risk of preeclampsia. Twenty newborns with Apgar score less than 7, amniotic fluid pollution degree of Ⅲ, and fetal heart rate of more than 180 beats/min were divided into the group with poor pregnancy outcome. The remaining 50 pregnant women were divided into the group with good pregnancy outcome. The general clinical characteristics of the two groups of parturients and the related clinical indicators in the second trimester of pregnancy were compared, and AQP1 The predictive value of IL-37 on adverse pregnancy outcome in preeclampsia. Results The expression levels of AQP1 and IL-37 in the third trimester of pregnancy were significantly different among the three groups. The expression levels of AQP1 and IL-37 in the pre-eclampsia group were significantly higher than those in the non-pre-eclampsia group and the control group (P<0.05); the predictive sensitivity and specificity of combination of AQP1 and IL-37 for preeclampsia were significantly higher than that of single prediction of AQP1 and IL-37, the predicted average threshold was calculated by predicting the highest and lowest thresholds, which were 14.58 μg/L for AQP1 and 234.62 pg/mL for IL-37; there was no significant difference in the age, body mass index, pregnancy times, birth times, family history of hypertension and history of hypertension before pregnancy between the poor pregnancy outcome group and the good pregnancy outcome group (P>0.05), but there were significant difference in the levels of DBP, SBP, urinary protein, AQP1 and IL-37 in the second trimester of pregnancy (P<0.05); the results of logistic regression analysis showed that urinary protein, AQP1 and IL-37 were independent influencing factors of adverse pregnancy outcome in high-risk pregnant women with preeclampsia (P<0.05). Conclusion The levels of AQP1 and IL-37 in the second trimester of pregnancy have important predictive value for pre eclampsia in high-risk pregnant women, and their predictive threshold values are respectively 14.58 μg/L, 234.62 pg/mL, and the combination of the two has higher prediction efficiency. At the same time, AQP1 and IL-37 in the second trimester can also predict the occurrence of adverse pregnancy outcomes in high-risk pre eclampsia pregnant women. Therefore, clinical intervention should be carried out for pregnant women with elevated levels of AQP1 and IL-37 in the second trimester to prevent adverse pregnancy outcomes.

Key words: aquaporin 1, interleukin 37, pre eclampsia, high risk pregnant women, adverse pregnancy outcome