Abstract: Objective To investigate the effect of Suzi Jiangqi Decoction combined with budesonide on patients with chronic obstructive pulmonary disease in stable stage. Methods Selected 80 cases of patients with chronic obstructive pulmonary disease from January 2019 to December 2021, divided into two groups randomly. The control group was treated with budesonide alone, and the observation group was treated with Suzi Jiangqi Decoction. The pulmonary function [peak expiratory flow (PEF), forced expiratory volume in the first second (FEV₁), maximum mid respiratory flow (MMEF), and forced expiratory volume in the first second (FEV₁/FVC)] of the two groups were measured to assess the changes in quality of life, and serum interleukin-17 (IL-17), intercellular adhesion molecule-1 (ICAM-1), C-reactive protein (CRP), chemokine 13 (CXCL13), and tumor necrosis factor (TNF-α) were detected. Results The effective rate of the observation group was significantly higher than control group (P<0.05). Before treatment, there was no significant difference in PEF, FEV₁/FVC, MMEF and FEV₁ between the two groups (P>0.05). After treatment, PEF, FEV₁/FVC, MMEF and FEV₁ in the two groups were significantly increased (P<0.05), and PEF, FEV₁/FVC, MMEF and FEV₁ in the observation group were significantly higher (P<0.05). Before treatment, there was no significant difference between the two groups in chest distress, cough, housework, expectoration, going out, sleep, energy, climbing score and CAT total score (P>0.05). After treatment, the chest distress, cough, housework, expectoration, going out, sleep, energy, climbing score and CAT total score of the two groups were significantly reduced (P<0.05), and the observation group were lower (P<0.05). Serum IL-17, ICAM-1, CRP, CXCL13 and TNF- α in both groups before treatment has no significant difference(P>0.05), after treatment, serum IL-17, ICAM-1, CRP, CXCL13 and TNF-α decreased significantly (P<0.05), and the levels of IL-17, ICAM-1, CRP, CXCL13 and TNF-α in the observation group were lower (P<0.05). Conclusion Suzi Jiangqi Decoction combined with budesonide has a significant effect on patients with chronic obstructive pulmonary disease in stable stage, which can significantly improve lung function, improve quality of life, and reduce inflammatory reaction, and is worthy of promotion.

Key words: Su Zi Jiang Qi tang, budesonide, stable period, chronic obstructive pulmonary disease