Research Progress on the Effect of Exercise Therapy on Diabetes Peripheral Neuropathy

Abstract

Abstract: Patients with diabetic peripheral neuropathy (DPN) often present with pain, numbness, paresthesia starting in the distal part of the foot and associated with decreased mobility and increased risk of ulceration and amputation. Exercise therapy is used a form of exercise to improve the disease state. This review focuses on the effects of exercise therapy on symptoms, neurological function, gait stability, balance ability, and quality of life in DPN. It is designed to provide a basis for the rehabilitation treatment of DPN.

Key words: diabetic peripheral neuropathy, exercise therapy, diabetic

CLC Number:

R587.2

YUE Yan, LIAO Shun-qi, DENG Min. Research Progress on the Effect of Exercise Therapy on Diabetes Peripheral Neuropathy[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(11): 17-20.

References

[1] OGURTSOVA K, DA ROCHA FERNANDES J D, HUANG Y, et al. IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040[J]. Diabetes Res Clin Pract,2017,128:40-50.
[2] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2020年版)[J].国际内分泌代谢杂志,2021,41(5):482-548.
[3] 张涛静,龚燕冰,周晖,等.糖尿病周围神经病变的中西医诊治[J].中华中医药杂志, 14,29(8):2433-2436.
[4] 庞国明,闫镛,朱璞,等.糖尿病周围神经病变中医诊疗规范初稿[J].中华中医药杂志,2010,25(2):260-264.
[5] SLOAN G, SELVARAJAH D, TESFAYE S.Pathogenesis, diagnosis and clinical management of diabetic sensorimotor peripheral neuropathy[J]. Nature Reviews Endocrinology,2021,17(7):400-420.
[6] VADIVELOO T, JEFFCOATE W, DONNAN P T, et al.Amputation-free survival in 17,353 people at high risk for foot ulceration in diabetes: a national observational study[J]. Diabetologia,2018,61(12):2590-2597.
[7] SLOAN G, SHILLO P, SELVARAJAH D, et al.A new look at painful diabetic neuropathy[J]. Diabetes Res Clin Pract,2018,144:177-191.
[8] MARTIN C L, ALBERS J W, POP-BUSUI R.Neuropathy and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study[J]. Diabetes Care,2014,37(1):31-38.
[9] ZHANG P, LU J, JING Y, et al.Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis[J]. Ann Med,2017,49(2):106-116.
[10] 王国凤,徐宁,尹冬,等.糖尿病周围神经病变的诊断和治疗新进展[J].中国全科医学,2012,15(15):1661-1663,1667.
[11] LEE C M, CHANG C C, PAN M Y, et al.Insufficient early detection of peripheral neurovasculopathy and associated factors in rural diabetes residents of Taiwan: a cross-sectional study[J]. BMC Endocr Disord,2014,14:89.
[12] KIOSKLI K, SCOTT W, WINKLEY K, et al.Psychosocial Factors in Painful Diabetic Neuropathy: A Systematic Review of Treatment Trials and Survey Studies[J]. Pain Med,2019,20(9):1756-1773.
[13] FELDMAN E L, CALLAGHAN B C, POP-BUSUI R, et al.Diabetic neuropathy[J]. Nat Rev Dis Primers,2019,5(1):42.
[14] RICHNER M, FERREIRA N, DUDELE A, et al.Functional and Structural Changes of the Blood-Nerve-Barrier in Diabetic Neuropathy[J]. Front Neurosci,2018,12:1038.
[15] FELDMAN E L, NAVE K A, JENSEN T S, et al.New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain[J]. Neuron,2017,93(6):1296-1313.
[16] COLBERG S R, SIGAL R J, YARDLEY J E, et al.Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association[J]. Diabetes Care,2016,39(11):2065-2079.
[17] VRÁ TNÁ E, HUSÁ KOVÁ J, JAROŠ KOVÁ R, et al.Effects of a 12-Week Interventional Exercise Programme on Muscle Strength, Mobility and Fitness in Patients With Diabetic Foot in Remission: Results From BIONEDIAN Randomised Controlled Trial[J]. Front Endocrinol (Lausanne), 2022,13:869128.
[18] GALLÉ F, DI ONOFRIO V, MIELE A, et al.Effects of a community-based exercise and motivational intervention on physical fitness of subjects with type 2 diabetes[J]. Eur J Public Health,2019,29(2):281-286.
[19] 黄琨,邓宗娟,张珏,等.同伴教育及运动疗法对老年糖尿病周围神经病变患者生活质量的影响[J].中国老年学杂志,2022,42(21):5248-5251.
[20] BROWN R, SHARAFI A, SLADE J M, et al.Lower extremity MRI following 10-week supervised exercise intervention in patients with diabetic peripheral neuropathy[J]. BMJ Open Diabetes Res Care,2021,9(1):e002312.
[21] MONTEIRO R L, FERREIRA J, SILVA É Q, et al.Foot-ankle therapeutic exercise program can improve gait speed in people with diabetic neuropathy: a randomized controlled trial[J]. Sci Rep,2022,12(1):7561.
[22] STRECKMANN F, BALKE M, CAVALETTi G, et al.Exercise and Neuropathy: Systematic Review with Meta-Analysis[J]. Sports Med,2022,52(5):1043-1065.
[23] UMPIERRE D, RIBEIRO P A, KRAMER C K, et al.Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: a systematic review and meta-analysis[J]. Jama,2011,305(17):1790-1799.
[24] 刘晓歌,王旭.基于气血理论探讨糖尿病认知障碍[J].中医药学报,2021,49(6):5-8.
[25] 李杨,卢秉久.卢秉久教授“六经为川,肠胃为海”思想辨治非酒精性脂肪性肝病经验[J].云南中医中药杂志,2021,42(2):10-12.
[26] CARBONE S, DEL BUONO M G, OZEMEK C, et al. Obesity, risk of diabetes and role of physical activity, exercise training and cardiorespiratory fitness[J]. Prog Cardiovasc Dis,2019,62(4):327-333.
[27] 张福蓉. 太极拳运动对2型糖尿病患者肠道菌群及宿主代谢影响的研究[D].成都:成都中医药大学,2020.
[28] GHOLAMI F, NAZARI H, ALIMI M.Cycle Training improves vascular function and neuropathic symptoms in patients with type 2 diabetes and peripheral neuropathy: A randomized controlled trial[J]. Exp Gerontol, 2020,131:110799.
[29] SEYEDIZADEH S H, CHERAGH-BIRJANDI S, HAMEDI NIA M R. The Effects of Combined Exercise Training (Resistance-Aerobic) on Serum Kinesin and Physical Function in Type 2 Diabetes Patients with Diabetic Peripheral Neuropathy (Randomized Controlled Trials)[J]. J Diabetes Res,2020,2020:6978128.
[30] 杨晓荣,刘连勇,杨玲,等.抗阻力运动对2型糖尿病周围神经病变的影响[J].中南大学学报(医学版),2020,45(10):1185-1192.
[31] KLUDING P M, PASNOOR M, SINGH R, et al.The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy[J]. J Diabetes Complications,2012,26(5):424-429.
[32] SINGLETON J R, MARCUS R L, JACKSON J E, et al.Exercise increases cutaneous nerve density in diabetic patients without neuropathy[J]. Ann Clin Transl Neurol,2014,1(10):844-849.
[33] DIXIT S, MAIYA A G, SHASTRY B A.Effect of aerobic exercise on peripheral nerve functions of population with diabetic peripheral neuropathy in type 2 diabetes: a single blind, parallel group randomized controlled trial[J]. J Diabetes Complications,2014,28(3):332-339.
[34] 胡慧英,张征宇.运动干预在老年糖尿病周围神经病变患者中的应用效果[J].中华全科医学,2020,18(5):769-772.
[35] MONTEIRO R L, FERREIRA J, SILVA É Q, et al.Feasibility and Preliminary Efficacy of a Foot-Ankle Exercise Program Aiming to Improve Foot-Ankle Functionality and Gait Biomechanics in People with Diabetic Neuropathy: A Randomized Controlled Trial[J]. Sensors (Basel),2020,20(18):5129.
[36] BACARIN T A, SACCO I C, HENNIG E M.Plantar pressure distribution patterns during gait in diabetic neuropathy patients with a history of foot ulcers[J]. Clinics (Sao Paulo),2009,64(2):113-120.
[37] THUKRAL N, KAUR J, MALIK M.A Systematic Review and Meta-analysis on Efficacy of Exercise on Posture and Balance in Patients Suffering from Diabetic Neuropathy[J]. Curr Diabetes Rev,2021,17(3):332-344.
[38] MELESE H, ALAMER A, HAILU TEMESGEN M, et al.Effectiveness of Exercise Therapy on Gait Function in Diabetic Peripheral Neuropathy Patients: A Systematic Review of Randomized Controlled Trials[J]. Diabetes Metab Syndr Obes,2020,13:2753-2764.
[39] SURYANI M, SAMEKTO W, HERI N, et al.Effect of foot-ankle flexibility and resistance exercise in the secondary prevention of plantar foot diabetic ulcer[J]. J Diabetes Complications,2021,35(9):107968.
[40] ABDELBASSET W K, ALRAWAILI S M, NAMBI G, et al.Therapeutic effects of proprioceptive exercise on functional capacity, anxiety, and depression in patients with diabetic neuropathy: a 2-month prospective study[J]. Clin Rheumatol,2020,39(10):3091-3097.
[41] 魏兰涛,马晓君,郑鑫,等.低强度有氧运动对糖尿病周围神经病变患者生活质量的影响[J].河南医学研究,2020,29(23):4408-4410.
[42] IZGU N, GOK METIN Z, KARADAS C, et al.Progressive Muscle Relaxation and Mindfulness Meditation on Neuropathic Pain, Fatigue, and Quality of Life in Patients With Type 2 Diabetes: A Randomized Clinical Trial[J]. J Nurs Scholarsh,2020,52(5):476-487.
[43] AHN S, SONG R.Effects of Tai Chi Exercise on glucose control, neuropathy scores, balance, and quality of life in patients with type 2 diabetes and neuropathy[J]. J Altern Complement Med,2012,18(12):1172-1178.