Abstract: Objective To investigate the clinical effect and safety of scraping and scraping along the meridian in the treatment of chemotherapy-induced leukopenia. Methods The clinical data of 50 patients with leukopenia caused by chemotherapy admitted to Rizhao traditional Chinese medicine hospital from February 2022 to December 2022 were retrospectively analyzed. 25 patients who received recombinant human granulocyte stimulating factor treatment were set as the control group, and 25 patients who received recombinant human granulocyte stimulating factor combined with Meridian Scraping Therapy were set as the observation group. White blood cell division, blood routine index, immune function, liver and kidney function and adverse reactions were compared between the two groups. Results After treatment, the leukocyte division of the observation group was lower than that of the control group (P<0.05); the white blood cell count (WBC), neutrophil count (NE), hemoglobin (Hgb) and red blood cell count (RBC) in the observation group were higher than those in the control group after treatment, and the difference was statistically significant (P<0.05); after treatment, the level of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in the observation group was higher than that in the control group, and the level of CD8⁺ was lower than that in the control group (P<0.05); there was no significant difference in liver and kidney function between the two groups before and after treatment (P>0.05); there was no significant difference in adverse reactions between the two groups (P>0.05). Conclusion Scraping along the meridian can improve the therapeutic effect of chemotherapy-induced leukopenia, accelerate the normalization of WBC and NE, improve leukocyte differentiation, and enhance the immune function of the body. It has no obvious effect on liver and kidney functions, and is safe and reliable.

Key words: chemotherapy, leukopenia, scraping along the meridian, quality of life